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Esophageal Neuroendocrine Tumor G2

MedGen UID:
459487
•Concept ID:
C2987261
•
Neoplastic Process

Definition

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Neuroendocrine Tumor G2

Recent clinical studies

Etiology

Percutaneous transhepatic intraportal biopsy using gastroscope biopsy forceps for diagnosis of a pancreatic neuroendocrine neoplasm: A case report.
Wang GC, Huang GJ, Zhang CQ, Ding Q
World J Gastroenterol 2023 Feb 21;29(7):1235-1242. doi: 10.3748/wjg.v29.i7.1235. PMID: 36926671Free PMC Article
Safety and efficacy of the FLOT regimen in the Polish population - an analysis of the prospective trial.
Marcisz-Grzanka K, Winiarek M, Pałucki J, Wieszczy P, Olesiński T, Jóźwiak M, Samsel R, Sułkowska U, Kolasińska-Ćwikła A, Wyrwicz LS
Neoplasma 2022 Dec;69(6):1445-1450. Epub 2022 Nov 11 doi: 10.4149/neo_2022_220720N734. PMID: 36353936
Nationwide registry for patients with neuroendocrine neoplasm of pancreas, gastrointestinal tract, lungs, bronchi, or thymus in Japan.
Masui T, Ito T, Komoto I, Kojima S, Kasai Y, Tanabe M, Hara K, Hirano S, Okusaka T, Ichikawa Y, Kinugasa Y, Kokudo N, Kudo A, Sakurai A, Sugihara K, Date H, Haruma K, Hijioka S, Hirata K, Yamano H, Sakamine M, Kikuchi T, Fukushima M, Imamura M, Uemoto S
Int J Clin Oncol 2022 May;27(5):840-849. Epub 2022 Feb 18 doi: 10.1007/s10147-022-02130-y. PMID: 35178624Free PMC Article
Phase 1/2 Trial of Pembrolizumab and Concurrent Chemoradiation Therapy for Limited-Stage SCLC.
Welsh JW, Heymach JV, Guo C, Menon H, Klein K, Cushman TR, Verma V, Hess KR, Shroff G, Tang C, Skoulidis F, Jeter M, Comeaux N, Patel RR, Chen D, Ozgen T, Nguyen QN, Chang JY, Altan M, Zhang J, Papadimitrakopoulou VA, Simon GR, Byers LA, Glisson B
J Thorac Oncol 2020 Dec;15(12):1919-1927. Epub 2020 Sep 8 doi: 10.1016/j.jtho.2020.08.022. PMID: 32916308Free PMC Article

Diagnosis

Percutaneous transhepatic intraportal biopsy using gastroscope biopsy forceps for diagnosis of a pancreatic neuroendocrine neoplasm: A case report.
Wang GC, Huang GJ, Zhang CQ, Ding Q
World J Gastroenterol 2023 Feb 21;29(7):1235-1242. doi: 10.3748/wjg.v29.i7.1235. PMID: 36926671Free PMC Article
Nationwide registry for patients with neuroendocrine neoplasm of pancreas, gastrointestinal tract, lungs, bronchi, or thymus in Japan.
Masui T, Ito T, Komoto I, Kojima S, Kasai Y, Tanabe M, Hara K, Hirano S, Okusaka T, Ichikawa Y, Kinugasa Y, Kokudo N, Kudo A, Sakurai A, Sugihara K, Date H, Haruma K, Hijioka S, Hirata K, Yamano H, Sakamine M, Kikuchi T, Fukushima M, Imamura M, Uemoto S
Int J Clin Oncol 2022 May;27(5):840-849. Epub 2022 Feb 18 doi: 10.1007/s10147-022-02130-y. PMID: 35178624Free PMC Article
Endoscopic submucosal dissection for foregut neuroendocrine tumors: an initial study.
Li QL, Zhang YQ, Chen WF, Xu MD, Zhong YS, Ma LL, Qin WZ, Hu JW, Cai MY, Yao LQ, Zhou PH
World J Gastroenterol 2012 Oct 28;18(40):5799-806. doi: 10.3748/wjg.v18.i40.5799. PMID: 23155323Free PMC Article
Use of the succinate dehydrogenase inhibition test in assessing the heat sensitivity of tumor cells.
Kohnoe S, Maehara Y, Takahashi I, Yoshida M, Emi Y, Kusumoto T, Sugimachi K
Oncology 1993 Nov-Dec;50(6):500-4. doi: 10.1159/000227236. PMID: 8233294

Therapy

Safety and efficacy of the FLOT regimen in the Polish population - an analysis of the prospective trial.
Marcisz-Grzanka K, Winiarek M, Pałucki J, Wieszczy P, Olesiński T, Jóźwiak M, Samsel R, Sułkowska U, Kolasińska-Ćwikła A, Wyrwicz LS
Neoplasma 2022 Dec;69(6):1445-1450. Epub 2022 Nov 11 doi: 10.4149/neo_2022_220720N734. PMID: 36353936
Phase 1/2 Trial of Pembrolizumab and Concurrent Chemoradiation Therapy for Limited-Stage SCLC.
Welsh JW, Heymach JV, Guo C, Menon H, Klein K, Cushman TR, Verma V, Hess KR, Shroff G, Tang C, Skoulidis F, Jeter M, Comeaux N, Patel RR, Chen D, Ozgen T, Nguyen QN, Chang JY, Altan M, Zhang J, Papadimitrakopoulou VA, Simon GR, Byers LA, Glisson B
J Thorac Oncol 2020 Dec;15(12):1919-1927. Epub 2020 Sep 8 doi: 10.1016/j.jtho.2020.08.022. PMID: 32916308Free PMC Article

Prognosis

Safety and efficacy of the FLOT regimen in the Polish population - an analysis of the prospective trial.
Marcisz-Grzanka K, Winiarek M, Pałucki J, Wieszczy P, Olesiński T, Jóźwiak M, Samsel R, Sułkowska U, Kolasińska-Ćwikła A, Wyrwicz LS
Neoplasma 2022 Dec;69(6):1445-1450. Epub 2022 Nov 11 doi: 10.4149/neo_2022_220720N734. PMID: 36353936
Nationwide registry for patients with neuroendocrine neoplasm of pancreas, gastrointestinal tract, lungs, bronchi, or thymus in Japan.
Masui T, Ito T, Komoto I, Kojima S, Kasai Y, Tanabe M, Hara K, Hirano S, Okusaka T, Ichikawa Y, Kinugasa Y, Kokudo N, Kudo A, Sakurai A, Sugihara K, Date H, Haruma K, Hijioka S, Hirata K, Yamano H, Sakamine M, Kikuchi T, Fukushima M, Imamura M, Uemoto S
Int J Clin Oncol 2022 May;27(5):840-849. Epub 2022 Feb 18 doi: 10.1007/s10147-022-02130-y. PMID: 35178624Free PMC Article

Clinical prediction guides

Phase 1/2 Trial of Pembrolizumab and Concurrent Chemoradiation Therapy for Limited-Stage SCLC.
Welsh JW, Heymach JV, Guo C, Menon H, Klein K, Cushman TR, Verma V, Hess KR, Shroff G, Tang C, Skoulidis F, Jeter M, Comeaux N, Patel RR, Chen D, Ozgen T, Nguyen QN, Chang JY, Altan M, Zhang J, Papadimitrakopoulou VA, Simon GR, Byers LA, Glisson B
J Thorac Oncol 2020 Dec;15(12):1919-1927. Epub 2020 Sep 8 doi: 10.1016/j.jtho.2020.08.022. PMID: 32916308Free PMC Article
Endoscopic submucosal dissection for foregut neuroendocrine tumors: an initial study.
Li QL, Zhang YQ, Chen WF, Xu MD, Zhong YS, Ma LL, Qin WZ, Hu JW, Cai MY, Yao LQ, Zhou PH
World J Gastroenterol 2012 Oct 28;18(40):5799-806. doi: 10.3748/wjg.v18.i40.5799. PMID: 23155323Free PMC Article

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