U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant Gastrointestinal Stromal Tumor

MedGen UID:
465816
•Concept ID:
C3179349
•
Neoplastic Process
Synonym: Gastrointestinal Stromal Sarcoma
SNOMED CT: Gastrointestinal stromal tumor, malignant (128756002); Gastrointestinal stromal sarcoma (128756002); Gastrointestinal stromal sarcoma (420120006); Malignant GIST (gastrointestinal stromal tumor) (128756002)

Definition

A gastrointestinal stromal tumor that is characterized by large size (diameter greater than 10 cm for gastric localization and greater than 5 cm for intestinal localization) or more than 5 mitotic figures per 50 high power fields. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Gastrointestinal Stromal Tumor

Professional guidelines

PubMed

Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article

Recent clinical studies

Etiology

Malignant gastrointestinal stromal tumor presenting with hemoperitoneum in puerperium: report of a case with review of the literature.
Varras M, Vlachakos N, Akrivis C, Vasilakaki T, Skafida E
World J Surg Oncol 2010 Nov 7;8:95. doi: 10.1186/1477-7819-8-95. PMID: 21054898Free PMC Article
The radiology of gastrointestinal stromal tumours (GIST).
King DM
Cancer Imaging 2005 Dec 15;5(1):150-6. doi: 10.1102/1470-7330.2005.0109. PMID: 16361144Free PMC Article
Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells.
Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L
Arch Pathol Lab Med 2004 Apr;128(4):440-3. doi: 10.5858/2004-128-440-MGLAGS. PMID: 15043462
Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread.
Burkill GJ, Badran M, Al-Muderis O, Meirion Thomas J, Judson IR, Fisher C, Moskovic EC
Radiology 2003 Feb;226(2):527-32. doi: 10.1148/radiol.2262011880. PMID: 12563150

Diagnosis

Malignant gastrointestinal stromal tumor in association with Russell body gastritis-A case report.
Bozhkova DM, Koleva-Ivanova MS, Belovejdov VT, Dikov DI
Indian J Pathol Microbiol 2021 Jun;64(Supplement):S89-S91. doi: 10.4103/IJPM.IJPM_842_19. PMID: 34135145
Malignant gastrointestinal stromal tumor of the tongue: case report and review of the literature.
Ibrahim HH, Ahmad MS, Eskaf WA, Schuütz P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 May;111(5):e24-9. doi: 10.1016/j.tripleo.2010.12.024. PMID: 21497732
The radiology of gastrointestinal stromal tumours (GIST).
King DM
Cancer Imaging 2005 Dec 15;5(1):150-6. doi: 10.1102/1470-7330.2005.0109. PMID: 16361144Free PMC Article
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells.
Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L
Arch Pathol Lab Med 2004 Apr;128(4):440-3. doi: 10.5858/2004-128-440-MGLAGS. PMID: 15043462
Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread.
Burkill GJ, Badran M, Al-Muderis O, Meirion Thomas J, Judson IR, Fisher C, Moskovic EC
Radiology 2003 Feb;226(2):527-32. doi: 10.1148/radiol.2262011880. PMID: 12563150

Therapy

Supraclavicular lymph node metastases from malignant gastrointestinal stromal tumor of the jejunum: A case report with review of the literature.
Ma C, Hao SL, Liu XC, Nin JY, Wu GC, Jiang LX, Fancellu A, Porcu A, Zheng HT
World J Gastroenterol 2017 Mar 14;23(10):1920-1924. doi: 10.3748/wjg.v23.i10.1920. PMID: 28348499Free PMC Article
Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review.
Boehm S, Rothermundt C, Hess D, Joerger M
Gerontology 2010;56(3):303-9. Epub 2009 Nov 26 doi: 10.1159/000262450. PMID: 19940466
Imatinib mesylate neoadjuvant treatment for rectal malignant gastrointestinal stromal tumor.
Hou YY, Zhou Y, Lu SH, Qi WD, Xu C, Hou J, Tan YS
World J Gastroenterol 2009 Apr 21;15(15):1910-3. doi: 10.3748/wjg.15.1910. PMID: 19370794Free PMC Article
The radiology of gastrointestinal stromal tumours (GIST).
King DM
Cancer Imaging 2005 Dec 15;5(1):150-6. doi: 10.1102/1470-7330.2005.0109. PMID: 16361144Free PMC Article
Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article

Prognosis

Malignant gastrointestinal stromal tumor of the tongue: case report and review of the literature.
Ibrahim HH, Ahmad MS, Eskaf WA, Schuütz P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 May;111(5):e24-9. doi: 10.1016/j.tripleo.2010.12.024. PMID: 21497732
Malignant gastrointestinal stromal tumor presenting with hemoperitoneum in puerperium: report of a case with review of the literature.
Varras M, Vlachakos N, Akrivis C, Vasilakaki T, Skafida E
World J Surg Oncol 2010 Nov 7;8:95. doi: 10.1186/1477-7819-8-95. PMID: 21054898Free PMC Article
Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor.
Zhang Y, Cao H, Wang M, Zhao WY, Shen ZY, Shen DP, Ni XZ, Wu ZY, Shen YY, Song YY
World J Gastroenterol 2010 Oct 7;16(37):4716-24. doi: 10.3748/wjg.v16.i37.4716. PMID: 20872974Free PMC Article
Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells.
Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L
Arch Pathol Lab Med 2004 Apr;128(4):440-3. doi: 10.5858/2004-128-440-MGLAGS. PMID: 15043462

Clinical prediction guides

ACRIN 6665/RTOG 0132 phase II trial of neoadjuvant imatinib mesylate for operable malignant gastrointestinal stromal tumor: monitoring with 18F-FDG PET and correlation with genotype and GLUT4 expression.
Van den Abbeele AD, Gatsonis C, de Vries DJ, Melenevsky Y, Szot-Barnes A, Yap JT, Godwin AK, Rink L, Huang M, Blevins M, Sicks J, Eisenberg B, Siegel BA
J Nucl Med 2012 Apr;53(4):567-74. Epub 2012 Mar 1 doi: 10.2967/jnumed.111.094425. PMID: 22381410Free PMC Article
Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review.
Boehm S, Rothermundt C, Hess D, Joerger M
Gerontology 2010;56(3):303-9. Epub 2009 Nov 26 doi: 10.1159/000262450. PMID: 19940466
The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000.
Tran T, Davila JA, El-Serag HB
Am J Gastroenterol 2005 Jan;100(1):162-8. doi: 10.1111/j.1572-0241.2005.40709.x. PMID: 15654796
Malignant gastrointestinal stromal tumor originating in the lesser omentum, complicated by rapidly progressive glomerulonephritis and gastric carcinoma.
Nakaya I, Iwata Y, Abe T, Yokoyama H, Oda Y, Nomura G
Intern Med 2004 Feb;43(2):102-5. doi: 10.2169/internalmedicine.43.102. PMID: 15005250
Secondary amyloidosis and gastrointestinal stromal tumors. A case report and discussion of pathogenesis.
Overstreet K, Barone RM, Robin HS
Arch Pathol Lab Med 2003 Apr;127(4):470-3. doi: 10.5858/2003-127-0470-SAAGST. PMID: 12683877

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...