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Anemia of prematurity

MedGen UID:
472907
•Concept ID:
C0158996
•
Disease or Syndrome
Synonyms: Anemia of Prematurity; anemia of prematurity; AOP
SNOMED CT: Anemia of prematurity (47100003)
 
Monarch Initiative: MONDO:0001239

Definition

A blood disorder characterized by low hemoglobin levels in premature neonates that usually spontaneously resolves within 3-6 months post birth. A combination of factors including the transition from the liver to the bone marrow for erythropoiesis in a neonate, blood loss experienced during delivery, the shortened life span of fetal blood cells, and an acclimation to a relatively hyperoxic environment outside the womb can predispose a neonate to this condition. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnemia of prematurity

Professional guidelines

PubMed

Reticulocyte hemoglobin content changes after treatment of anemia of prematurity.
Nii M, Okamoto T, Sugiyama T, Aoyama A, Nagaya K
Pediatr Int 2022 Jan;64(1):e15330. doi: 10.1111/ped.15330. PMID: 36321339
Erythropoietin--not yet a standard treatment for anemia of prematurity.
Wilimas JA, Crist WM
Pediatrics 1995 Jan;95(1):9-10. PMID: 7770317
Anemia of prematurity: the prospects for avoiding blood transfusions by treatment with recombinant human erythropoietin.
Dallman PR
Adv Pediatr 1993;40:385-403. PMID: 8249712

Recent clinical studies

Etiology

Clinical Outcomes, Blood Utilization, and Ethical Considerations for Pediatric Patients in a Bloodless Medicine and Surgery Program.
Lo BD, Pippa A, Sherd I, Scott AV, Thomas AJ, Hendricks EA, Ness PM, Chaturvedi S, Resar LMS, Frank SM
Anesth Analg 2024 Feb 1;138(2):465-474. Epub 2024 Jan 12 doi: 10.1213/ANE.0000000000006776. PMID: 38175737
Differences in Cerebral Tissue Oxygenation in Preterm Neonates Receiving Adult or Cord Blood Red Blood Cell Transfusions.
Pellegrino C, Papacci P, Beccia F, Serrao F, Cantone GV, Cannetti G, Giannantonio C, Vento G, Teofili L
JAMA Netw Open 2023 Nov 1;6(11):e2341643. doi: 10.1001/jamanetworkopen.2023.41643. PMID: 37934499Free PMC Article
Effect of Early Erythropoietin on Retinopathy of Prematurity: A Stratified Meta-Analysis.
Fischer HS, Reibel NJ, Bührer C, Dame C
Neonatology 2023;120(5):566-576. Epub 2023 Jun 27 doi: 10.1159/000530126. PMID: 37369177
Anemia of prematurity.
Salsbury DC
Neonatal Netw 2001 Aug;20(5):13-20. doi: 10.1891/0730-0832.20.5.13. PMID: 12144218
Erythropoietin in obstetrics.
Vora M, Gruslin A
Obstet Gynecol Surv 1998 Aug;53(8):500-8. doi: 10.1097/00006254-199808000-00023. PMID: 9702790

Diagnosis

Neonatal Anemia.
German KR, Juul SE
Curr Pediatr Rev 2023;19(4):388-394. doi: 10.2174/1573396319666221121140627. PMID: 36411551
Neonatal anemia.
Aher S, Malwatkar K, Kadam S
Semin Fetal Neonatal Med 2008 Aug;13(4):239-47. Epub 2008 Apr 14 doi: 10.1016/j.siny.2008.02.009. PMID: 18411074
Anemia of prematurity.
Salsbury DC
Neonatal Netw 2001 Aug;20(5):13-20. doi: 10.1891/0730-0832.20.5.13. PMID: 12144218
Erythropoietin.
Erslev AJ
Leuk Res 1990;14(8):683-8. doi: 10.1016/0145-2126(90)90094-p. PMID: 2201820
Anemia of prematurity.
Stockman JA 3rd
Clin Perinatol 1977 Sep;4(2):239-57. PMID: 332429

Therapy

Differences in Cerebral Tissue Oxygenation in Preterm Neonates Receiving Adult or Cord Blood Red Blood Cell Transfusions.
Pellegrino C, Papacci P, Beccia F, Serrao F, Cantone GV, Cannetti G, Giannantonio C, Vento G, Teofili L
JAMA Netw Open 2023 Nov 1;6(11):e2341643. doi: 10.1001/jamanetworkopen.2023.41643. PMID: 37934499Free PMC Article
Red Blood Cell Transfusion Thresholds for Anemia of Prematurity.
Holzapfel LF, Rysavy MA, Bell EF
Neoreviews 2023 Jun 1;24(6):e370-e376. doi: 10.1542/neo.24-6-e370. PMID: 37258497Free PMC Article
Neonatal Anemia.
German KR, Juul SE
Curr Pediatr Rev 2023;19(4):388-394. doi: 10.2174/1573396319666221121140627. PMID: 36411551
Erythropoietin in anemia of prematurity.
Juul S
J Matern Fetal Neonatal Med 2012 Oct;25(Suppl 5):80-4. doi: 10.3109/14767058.2012.716987. PMID: 23025776
Neonatal anemia.
Aher S, Malwatkar K, Kadam S
Semin Fetal Neonatal Med 2008 Aug;13(4):239-47. Epub 2008 Apr 14 doi: 10.1016/j.siny.2008.02.009. PMID: 18411074

Prognosis

Anemia of Prematurity and Oral Feeding Milestones in Premature Infants.
Viswanathan S, Jadcherla S
Am J Perinatol 2021 May;38(6):553-559. Epub 2019 Nov 27 doi: 10.1055/s-0039-1700488. PMID: 31777047
Use of potassium adsorption filter for the removal of ammonia and potassium from red blood cell solution for neonates.
Fujita H, Teratani M, Hazama Y, Nakahara M, Asaka H, Nishimura S
Transfusion 2018 Oct;58(10):2383-2387. Epub 2018 Sep 4 doi: 10.1111/trf.14897. PMID: 30178874
Human recombinant erythropoietin and the incidence of retinopathy of prematurity: a multiple regression model.
Suk KK, Dunbar JA, Liu A, Daher NS, Leng CK, Leng JK, Lim P, Weller S, Fayard E
J AAPOS 2008 Jun;12(3):233-8. doi: 10.1016/j.jaapos.2007.08.009. PMID: 18589385
Use and safety of elevated dosages of vitamin E in infants and children.
Mino M
Int J Vitam Nutr Res Suppl 1989;30:69-80. PMID: 2507708
Anemia of prematurity. Current concepts in the issue of when to transfuse.
Stockman JA 3rd
Pediatr Clin North Am 1986 Feb;33(1):111-28. doi: 10.1016/s0031-3955(16)34972-0. PMID: 3513096

Clinical prediction guides

Differences in Cerebral Tissue Oxygenation in Preterm Neonates Receiving Adult or Cord Blood Red Blood Cell Transfusions.
Pellegrino C, Papacci P, Beccia F, Serrao F, Cantone GV, Cannetti G, Giannantonio C, Vento G, Teofili L
JAMA Netw Open 2023 Nov 1;6(11):e2341643. doi: 10.1001/jamanetworkopen.2023.41643. PMID: 37934499Free PMC Article
Anemia of Prematurity and Oral Feeding Milestones in Premature Infants.
Viswanathan S, Jadcherla S
Am J Perinatol 2021 May;38(6):553-559. Epub 2019 Nov 27 doi: 10.1055/s-0039-1700488. PMID: 31777047
The role of erythropoietin in the anemia of prematurity.
Doyle JJ
Semin Perinatol 1997 Feb;21(1):20-7. doi: 10.1016/s0146-0005(97)80016-x. PMID: 9190030
Anemia of prematurity. Current concepts in the issue of when to transfuse.
Stockman JA 3rd
Pediatr Clin North Am 1986 Feb;33(1):111-28. doi: 10.1016/s0031-3955(16)34972-0. PMID: 3513096
Fetal and adult hemoglobins in premature infants with observations on the mechanism of the anemia of prematurity.
SCHULMAN I, SMITH CH
AMA Am J Dis Child 1953 Sep;86(3):354-7. PMID: 13091330

Recent systematic reviews

Clinical Outcomes Related to the Gastrointestinal Trophic Effects of Erythropoietin in Preterm Neonates: A Systematic Review and Meta-Analysis.
Ananthan A, Balasubramanian H, Rao S, Patole S
Adv Nutr 2018 May 1;9(3):238-246. doi: 10.1093/advances/nmy005. PMID: 29767696Free PMC Article

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