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Appendix Serrated Lesions and Polyps

MedGen UID:
474393
•Concept ID:
C3272760
•
Neoplastic Process
Synonyms: Appendix Sessile Serrated Adenoma; Appendix Sessile Serrated Adenoma/Polyp; Appendix Sessile Serrated Polyp; Appendix SSA; Appendix SSA/P; Appendix SSP

Definition

Polyps that arises from the appendix. They are characterized by the presence of serrated glands and the absence of generalized dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix Serrated Lesions and Polyps

Professional guidelines

PubMed

Differential diagnosis of appendiceal serrated lesions and polyps and low-grade appendiceal mucinous neoplasm: analysis of 88 cases.
Lu Y, Qi C, Xu H, Jin M
J Cancer Res Clin Oncol 2022 Jul;148(7):1761-1769. Epub 2021 Aug 9 doi: 10.1007/s00432-021-03757-6. PMID: 34368907
Colorectal Serrated Lesions: A Current View on Clinical, Morphological, Molecular, and Genetic Diagnostic Criteria.
Mikhaleva LM, Vandysheva RA, Midiber KY, Vasyukova OA, Pechnikova VV, Patsap OI, Beylerli O, Somasundaram SG, Kirkland CE, Aliev G
Curr Med Chem 2021;28(41):8496-8516. doi: 10.2174/0929867328666210715125428. PMID: 34984965

Recent clinical studies

Etiology

Appendiceal sessile serrated lesions are distinct from their right-sided colonic counterparts and may be precursors for appendiceal mucinous neoplasms.
Chezar K, Minoo P
Hum Pathol 2022 Apr;122:40-49. Epub 2022 Feb 1 doi: 10.1016/j.humpath.2022.01.008. PMID: 35121004
Colorectal Serrated Lesions: A Current View on Clinical, Morphological, Molecular, and Genetic Diagnostic Criteria.
Mikhaleva LM, Vandysheva RA, Midiber KY, Vasyukova OA, Pechnikova VV, Patsap OI, Beylerli O, Somasundaram SG, Kirkland CE, Aliev G
Curr Med Chem 2021;28(41):8496-8516. doi: 10.2174/0929867328666210715125428. PMID: 34984965
Molecular profiling of appendiceal serrated lesions, polyps and mucinous neoplasms: a single-centre experience.
Munari G, Businello G, Mattiolo P, Pennelli G, Sbaraglia M, Borga C, Pucciarelli S, Spolverato G, Mescoli C, Galuppini F, Sommariva A, Bellan E, Lonardi S, Loupakis F, Luchini C, Dei Tos AP, Fassan M
J Cancer Res Clin Oncol 2021 Jul;147(7):1897-1904. Epub 2021 Mar 12 doi: 10.1007/s00432-021-03589-4. PMID: 33712927Free PMC Article
Serrated lesions of the appendix in serrated polyposis patients.
Bettington M, Brown IS, Rosty C
Pathology 2016 Jan;48(1):30-4. Epub 2015 Dec 18 doi: 10.1016/j.pathol.2015.11.012. PMID: 27020206
Serrated lesions of the appendix: do they differ from their colorectal counterparts?
Yuyucu Karabulut Y, Savaş B, Kurşun N, Ensar A
Turk J Gastroenterol 2014 Feb;25(1):29-34. doi: 10.5152/tjg.2014.4056. PMID: 24918127

Diagnosis

A practical guide to serrated appendiceal lesions.
Requena DO, Yantiss RK
Semin Diagn Pathol 2024 Sep;41(5):243-249. Epub 2024 Jul 10 doi: 10.1053/j.semdp.2024.07.001. PMID: 39084918
Differential diagnosis of appendiceal serrated lesions and polyps and low-grade appendiceal mucinous neoplasm: analysis of 88 cases.
Lu Y, Qi C, Xu H, Jin M
J Cancer Res Clin Oncol 2022 Jul;148(7):1761-1769. Epub 2021 Aug 9 doi: 10.1007/s00432-021-03757-6. PMID: 34368907
Colorectal Serrated Lesions: A Current View on Clinical, Morphological, Molecular, and Genetic Diagnostic Criteria.
Mikhaleva LM, Vandysheva RA, Midiber KY, Vasyukova OA, Pechnikova VV, Patsap OI, Beylerli O, Somasundaram SG, Kirkland CE, Aliev G
Curr Med Chem 2021;28(41):8496-8516. doi: 10.2174/0929867328666210715125428. PMID: 34984965
Serrated lesions of the appendix: do they differ from their colorectal counterparts?
Yuyucu Karabulut Y, Savaş B, Kurşun N, Ensar A
Turk J Gastroenterol 2014 Feb;25(1):29-34. doi: 10.5152/tjg.2014.4056. PMID: 24918127
Primary epithelial neoplasms and other epithelial lesions of the appendix (excluding carcinoid tumors).
Misdraji J, Young RH
Semin Diagn Pathol 2004 May;21(2):120-33. doi: 10.1053/j.semdp.2004.11.005. PMID: 15807472

Therapy

Serrated lesions of the appendix: a morphologic and immunohistochemical appraisal.
Bellizzi AM, Rock J, Marsh WL, Frankel WL
Am J Clin Pathol 2010 Apr;133(4):623-32. doi: 10.1309/AJCP1UJPX6UURLCH. PMID: 20231616

Prognosis

A practical guide to serrated appendiceal lesions.
Requena DO, Yantiss RK
Semin Diagn Pathol 2024 Sep;41(5):243-249. Epub 2024 Jul 10 doi: 10.1053/j.semdp.2024.07.001. PMID: 39084918
Molecular profiling of appendiceal serrated lesions, polyps and mucinous neoplasms: a single-centre experience.
Munari G, Businello G, Mattiolo P, Pennelli G, Sbaraglia M, Borga C, Pucciarelli S, Spolverato G, Mescoli C, Galuppini F, Sommariva A, Bellan E, Lonardi S, Loupakis F, Luchini C, Dei Tos AP, Fassan M
J Cancer Res Clin Oncol 2021 Jul;147(7):1897-1904. Epub 2021 Mar 12 doi: 10.1007/s00432-021-03589-4. PMID: 33712927Free PMC Article
Primary epithelial neoplasms and other epithelial lesions of the appendix (excluding carcinoid tumors).
Misdraji J, Young RH
Semin Diagn Pathol 2004 May;21(2):120-33. doi: 10.1053/j.semdp.2004.11.005. PMID: 15807472

Clinical prediction guides

The role of advanced endoscopy in appendiceal polyp management and outcomes.
Justiniano CF, Ozgur I, Liska D, Valente MA, Steele SR, Gorgun E
Surg Endosc 2024 Apr;38(4):2267-2272. Epub 2024 Mar 4 doi: 10.1007/s00464-024-10726-w. PMID: 38438673Free PMC Article
Differential diagnosis of appendiceal serrated lesions and polyps and low-grade appendiceal mucinous neoplasm: analysis of 88 cases.
Lu Y, Qi C, Xu H, Jin M
J Cancer Res Clin Oncol 2022 Jul;148(7):1761-1769. Epub 2021 Aug 9 doi: 10.1007/s00432-021-03757-6. PMID: 34368907
Underwater EMR of adenomas of the appendiceal orifice (with video).
Binmoeller KF, Hamerski CM, Shah JN, Bhat YM, Kane SD
Gastrointest Endosc 2016 Mar;83(3):638-42. Epub 2015 Sep 14 doi: 10.1016/j.gie.2015.08.079. PMID: 26375437
Serrated lesions of the appendix: do they differ from their colorectal counterparts?
Yuyucu Karabulut Y, Savaş B, Kurşun N, Ensar A
Turk J Gastroenterol 2014 Feb;25(1):29-34. doi: 10.5152/tjg.2014.4056. PMID: 24918127

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