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Lithium Induced Birth Defect

MedGen UID:
476131
•Concept ID:
C3274498
•
Congenital Abnormality

Definition

Congenital abnormalities, mainly cardiovascular malformations, which develop in a fetus when the mother uses lithium medication during pregnancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLithium Induced Birth Defect

Professional guidelines

PubMed

Risk factors for clozapine-induced central nervous system abnormalities in Japanese patients with treatment-resistant schizophrenia.
Kitagawa K, Uekusa S, Matsuo K, Moriyama K, Yamamoto T, Yada Y, Kodama M, Kishi Y, Yoshio T
Asian J Psychiatr 2021 Jun;60:102652. Epub 2021 Apr 6 doi: 10.1016/j.ajp.2021.102652. PMID: 33866283
Weighing the Risks: the Management of Bipolar Disorder During Pregnancy.
Thomson M, Sharma V
Curr Psychiatry Rep 2018 Mar 17;20(3):20. doi: 10.1007/s11920-018-0882-2. PMID: 29549608
Collaborative management of women with bipolar disorder during pregnancy and postpartum: pharmacologic considerations.
Ward S, Wisner KL
J Midwifery Womens Health 2007 Jan-Feb;52(1):3-13. doi: 10.1016/j.jmwh.2006.09.002. PMID: 17207745

Recent clinical studies

Etiology

Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes.
Fornaro M, Maritan E, Ferranti R, Zaninotto L, Miola A, Anastasia A, Murru A, Solé E, Stubbs B, Carvalho AF, Serretti A, Vieta E, Fusar-Poli P, McGuire P, Young AH, Dazzan P, Vigod SN, Correll CU, Solmi M
Am J Psychiatry 2020 Jan 1;177(1):76-92. Epub 2019 Oct 18 doi: 10.1176/appi.ajp.2019.19030228. PMID: 31623458
Dose-Dependent Teratology in Humans: Clinical Implications for Prevention.
Koren G, Berkovitch M, Ornoy A
Paediatr Drugs 2018 Aug;20(4):331-335. doi: 10.1007/s40272-018-0294-0. PMID: 29725877
Lithium Use in Pregnancy and the Risk of Cardiac Malformations.
Patorno E, Huybrechts KF, Bateman BT, Cohen JM, Desai RJ, Mogun H, Cohen LS, Hernandez-Diaz S
N Engl J Med 2017 Jun 8;376(23):2245-2254. doi: 10.1056/NEJMoa1612222. PMID: 28591541Free PMC Article
Mood stabilizers in pregnancy: a systematic review.
Galbally M, Roberts M, Buist A; Perinatal Psychotropic Review Group
Aust N Z J Psychiatry 2010 Nov;44(11):967-77. doi: 10.3109/00048674.2010.506637. PMID: 21034180
Teratogenesis associated with antibipolar agents.
Nguyen HT, Sharma V, McIntyre RS
Adv Ther 2009 Mar;26(3):281-94. Epub 2009 Mar 28 doi: 10.1007/s12325-009-0011-z. PMID: 19330496

Diagnosis

Clinical Risk Factors for Therapeutic Lithium-Associated Electrocardiographic Changes in Patients With Bipolar Disorder.
Chen PH, Kao YH, Chang CK, Lin YK, Lin YF, Chen YJ
J Clin Psychopharmacol 2020 Jan/Feb;40(1):46-53. doi: 10.1097/JCP.0000000000001164. PMID: 31834090
Pregnancy outcome following in utero exposure to lithium: a prospective, comparative, observational study.
Diav-Citrin O, Shechtman S, Tahover E, Finkel-Pekarsky V, Arnon J, Kennedy D, Erebara A, Einarson A, Ornoy A
Am J Psychiatry 2014 Jul;171(7):785-94. doi: 10.1176/appi.ajp.2014.12111402. PMID: 24781368
When lithium hurts: a look at Ebstein anomaly.
Osiro S, Tiwari KJ, Mathenge N, Rodriguez JR, Tubbs RS, Loukas M
Cardiol Rev 2013 Sep-Oct;21(5):257-63. doi: 10.1097/CRD.0b013e318280c966. PMID: 23269033
Drug exposure in pregnancy and heart defects.
Matok I, Pupco A, Koren G
J Cardiovasc Pharmacol 2011 Jul;58(1):20-4. doi: 10.1097/FJC.0b013e31821c471b. PMID: 21499119
Managing bipolar disorder during pregnancy: weighing the risks and benefits.
Viguera AC, Cohen LS, Baldessarini RJ, Nonacs R
Can J Psychiatry 2002 Jun;47(5):426-36. doi: 10.1177/070674370204700503. PMID: 12085677

Therapy

Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes.
Fornaro M, Maritan E, Ferranti R, Zaninotto L, Miola A, Anastasia A, Murru A, Solé E, Stubbs B, Carvalho AF, Serretti A, Vieta E, Fusar-Poli P, McGuire P, Young AH, Dazzan P, Vigod SN, Correll CU, Solmi M
Am J Psychiatry 2020 Jan 1;177(1):76-92. Epub 2019 Oct 18 doi: 10.1176/appi.ajp.2019.19030228. PMID: 31623458
Dose-Dependent Teratology in Humans: Clinical Implications for Prevention.
Koren G, Berkovitch M, Ornoy A
Paediatr Drugs 2018 Aug;20(4):331-335. doi: 10.1007/s40272-018-0294-0. PMID: 29725877
Teratogenesis associated with antibipolar agents.
Nguyen HT, Sharma V, McIntyre RS
Adv Ther 2009 Mar;26(3):281-94. Epub 2009 Mar 28 doi: 10.1007/s12325-009-0011-z. PMID: 19330496
Mood drugs.
Baldessarini RJ
Dis Mon 1977 Nov;24(2):1-65. doi: 10.1016/s0011-5029(77)80016-3. PMID: 21061
Lithium teratogenicity.
Schou M, Amdisen A
Lancet 1971 May 29;1(7709):1132. doi: 10.1016/s0140-6736(71)91869-1. PMID: 4102651

Prognosis

Clinical Risk Factors for Therapeutic Lithium-Associated Electrocardiographic Changes in Patients With Bipolar Disorder.
Chen PH, Kao YH, Chang CK, Lin YK, Lin YF, Chen YJ
J Clin Psychopharmacol 2020 Jan/Feb;40(1):46-53. doi: 10.1097/JCP.0000000000001164. PMID: 31834090
When lithium hurts: a look at Ebstein anomaly.
Osiro S, Tiwari KJ, Mathenge N, Rodriguez JR, Tubbs RS, Loukas M
Cardiol Rev 2013 Sep-Oct;21(5):257-63. doi: 10.1097/CRD.0b013e318280c966. PMID: 23269033
QT alterations in psychopharmacology: proven candidates and suspects.
Alvarez PA, Pahissa J
Curr Drug Saf 2010 Jan;5(1):97-104. doi: 10.2174/157488610789869265. PMID: 20210726
Teratogenesis associated with antibipolar agents.
Nguyen HT, Sharma V, McIntyre RS
Adv Ther 2009 Mar;26(3):281-94. Epub 2009 Mar 28 doi: 10.1007/s12325-009-0011-z. PMID: 19330496
Managing bipolar disorder during pregnancy: weighing the risks and benefits.
Viguera AC, Cohen LS, Baldessarini RJ, Nonacs R
Can J Psychiatry 2002 Jun;47(5):426-36. doi: 10.1177/070674370204700503. PMID: 12085677

Clinical prediction guides

Clinical Risk Factors for Therapeutic Lithium-Associated Electrocardiographic Changes in Patients With Bipolar Disorder.
Chen PH, Kao YH, Chang CK, Lin YK, Lin YF, Chen YJ
J Clin Psychopharmacol 2020 Jan/Feb;40(1):46-53. doi: 10.1097/JCP.0000000000001164. PMID: 31834090
Pregnancy outcome following in utero exposure to lithium: a prospective, comparative, observational study.
Diav-Citrin O, Shechtman S, Tahover E, Finkel-Pekarsky V, Arnon J, Kennedy D, Erebara A, Einarson A, Ornoy A
Am J Psychiatry 2014 Jul;171(7):785-94. doi: 10.1176/appi.ajp.2014.12111402. PMID: 24781368
QT alterations in psychopharmacology: proven candidates and suspects.
Alvarez PA, Pahissa J
Curr Drug Saf 2010 Jan;5(1):97-104. doi: 10.2174/157488610789869265. PMID: 20210726
Teratogenesis associated with antibipolar agents.
Nguyen HT, Sharma V, McIntyre RS
Adv Ther 2009 Mar;26(3):281-94. Epub 2009 Mar 28 doi: 10.1007/s12325-009-0011-z. PMID: 19330496
The use of psychiatric drugs in pregnancy and lactation.
Arnon J, Shechtman S, Ornoy A
Isr J Psychiatry Relat Sci 2000;37(3):205-22. PMID: 11084808

Recent systematic reviews

Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes.
Fornaro M, Maritan E, Ferranti R, Zaninotto L, Miola A, Anastasia A, Murru A, Solé E, Stubbs B, Carvalho AF, Serretti A, Vieta E, Fusar-Poli P, McGuire P, Young AH, Dazzan P, Vigod SN, Correll CU, Solmi M
Am J Psychiatry 2020 Jan 1;177(1):76-92. Epub 2019 Oct 18 doi: 10.1176/appi.ajp.2019.19030228. PMID: 31623458
Psychotropics in pregnancy: safety and other considerations.
Oyebode F, Rastogi A, Berrisford G, Coccia F
Pharmacol Ther 2012 Jul;135(1):71-7. Epub 2012 Mar 28 doi: 10.1016/j.pharmthera.2012.03.008. PMID: 22483705
Mood stabilizers in pregnancy: a systematic review.
Galbally M, Roberts M, Buist A; Perinatal Psychotropic Review Group
Aust N Z J Psychiatry 2010 Nov;44(11):967-77. doi: 10.3109/00048674.2010.506637. PMID: 21034180

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