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Severe Bronchopulmonary Dysplasia

MedGen UID:
476148
Concept ID:
C3274515
Disease or Syndrome

Definition

Bronchopulmonary dysplasia that results in severe respiratory complications. The infants with severe symptoms are usually premature, have low birth weight, and the oxygen and ventilation support requirements are increased. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSevere Bronchopulmonary Dysplasia

Professional guidelines

PubMed

Truog WE, Lewis TR, Bamat NA
Neoreviews 2020 Jul;21(7):e454-e468. doi: 10.1542/neo.21-7-e454. PMID: 32611563
Amin RS, Rutter MJ
Clin Perinatol 2015 Dec;42(4):857-70. doi: 10.1016/j.clp.2015.08.011. PMID: 26593083
Guaman MC, Gien J, Baker CD, Zhang H, Austin ED, Collaco JM
Am J Perinatol 2015 Aug;32(10):960-7. Epub 2015 Mar 4 doi: 10.1055/s-0035-1547326. PMID: 25738785Free PMC Article

Recent clinical studies

Etiology

Gupta S, Subhedar NV, Bell JL, Field D, Bowler U, Hutchison E, Johnson S, Kelsall W, Pepperell J, Roberts T, Sinha S, Stanbury K, Wyllie J, Hardy P, Juszczak E; Baby-OSCAR Collaborative Group
N Engl J Med 2024 Jan 25;390(4):314-325. doi: 10.1056/NEJMoa2305582. PMID: 38265644Free PMC Article
Giesinger RE, Rios DR, Chatmethakul T, Bischoff AR, Sandgren JA, Cunningham A, Beauchene M, Stanford AH, Klein JM, Ten Eyck P, McNamara PJ
Am J Respir Crit Care Med 2023 Aug 1;208(3):290-300. doi: 10.1164/rccm.202212-2291OC. PMID: 37209133Free PMC Article
Hundscheid T, Onland W, Kooi EMW, Vijlbrief DC, de Vries WB, Dijkman KP, van Kaam AH, Villamor E, Kroon AA, Visser R, Mulder-de Tollenaer SM, De Bisschop B, Dijk PH, Avino D, Hocq C, Zecic A, Meeus M, de Baat T, Derriks F, Henriksen TB, Kyng KJ, Donders R, Nuytemans DHGM, Van Overmeire B, Mulder AL, de Boode WP; BeNeDuctus Trial Investigators
N Engl J Med 2023 Mar 16;388(11):980-990. Epub 2022 Dec 6 doi: 10.1056/NEJMoa2207418. PMID: 36477458
Watterberg KL, Walsh MC, Li L, Chawla S, D'Angio CT, Goldberg RN, Hintz SR, Laughon MM, Yoder BA, Kennedy KA, McDavid GE, Backstrom-Lacy C, Das A, Crawford MM, Keszler M, Sokol GM, Poindexter BB, Ambalavanan N, Hibbs AM, Truog WE, Schmidt B, Wyckoff MH, Khan AM, Garg M, Chess PR, Reynolds AM, Moallem M, Bell EF, Meyer LR, Patel RM, Van Meurs KP, Cotten CM, McGowan EC, Hines AC, Merhar S, Peralta-Carcelen M, Wilson-Costello DE, Kilbride HW, DeMauro SB, Heyne RJ, Mosquera RA, Natarajan G, Purdy IB, Lowe JR, Maitre NL, Harmon HM, Hogden LA, Adams-Chapman I, Winter S, Malcolm WF, Higgins RD; Eunice Kennedy Shriver NICHD Neonatal Research Network
N Engl J Med 2022 Mar 24;386(12):1121-1131. doi: 10.1056/NEJMoa2114897. PMID: 35320643Free PMC Article
Ancel PY, Goffinet F; EPIPAGE-2 Writing Group, Kuhn P, Langer B, Matis J, Hernandorena X, Chabanier P, Joly-Pedespan L, Lecomte B, Vendittelli F, Dreyfus M, Guillois B, Burguet A, Sagot P, Sizun J, Beuchée A, Rouget F, Favreau A, Saliba E, Bednarek N, Morville P, Thiriez G, Marpeau L, Marret S, Kayem G, Durrmeyer X, Granier M, Baud O, Jarreau PH, Mitanchez D, Boileau P, Boulot P, Cambonie G, Daudé H, Bédu A, Mons F, Fresson J, Vieux R, Alberge C, Arnaud C, Vayssière C, Truffert P, Pierrat V, Subtil D, D'Ercole C, Gire C, Simeoni U, Bongain A, Sentilhes L, Rozé JC, Gondry J, Leke A, Deiber M, Claris O, Picaud JC, Ego A, Debillon T, Poulichet A, Coliné E, Favre A, Fléchelles O, Samperiz S, Ramful D, Branger B, Benhammou V, Foix-L'Hélias L, Marchand-Martin L, Kaminski M
JAMA Pediatr 2015 Mar;169(3):230-8. doi: 10.1001/jamapediatrics.2014.3351. PMID: 25621457

Diagnosis

Callaway DA, Wang Y, Lingappan K, Pogoriler JE, Laje P, Nilan K, Kirpalani H, Zhang H
Pediatr Pulmonol 2023 Jul;58(7):2068-2075. Epub 2023 May 3 doi: 10.1002/ppul.26433. PMID: 37133233Free PMC Article
Jensen EA, Whyte RK, Schmidt B, Bassler D, Vain NE, Roberts RS; Canadian Oxygen Trial Investigators
Am J Respir Crit Care Med 2021 Nov 15;204(10):1192-1199. doi: 10.1164/rccm.202105-1150OC. PMID: 34428130Free PMC Article
Bamat NA, Zhang H, McKenna KJ, Morris H, Stoller JZ, Gibbs K
Neoreviews 2020 Jul;21(7):e442-e453. Epub 2020 Jul 1 doi: 10.1542/neo.21-7-e442. PMID: 32611562
Amin RS, Rutter MJ
Clin Perinatol 2015 Dec;42(4):857-70. doi: 10.1016/j.clp.2015.08.011. PMID: 26593083
Ambalavanan N, Mourani P
Birth Defects Res A Clin Mol Teratol 2014 Mar;100(3):240-6. Epub 2014 Mar 10 doi: 10.1002/bdra.23241. PMID: 24616323

Therapy

Gupta S, Subhedar NV, Bell JL, Field D, Bowler U, Hutchison E, Johnson S, Kelsall W, Pepperell J, Roberts T, Sinha S, Stanbury K, Wyllie J, Hardy P, Juszczak E; Baby-OSCAR Collaborative Group
N Engl J Med 2024 Jan 25;390(4):314-325. doi: 10.1056/NEJMoa2305582. PMID: 38265644Free PMC Article
Zhu X, Li F, Shi Y, Feng Z, De Luca D; Nasal Oscillation Post-Extubation (NASONE) Study Group
JAMA Netw Open 2023 Jul 3;6(7):e2321644. doi: 10.1001/jamanetworkopen.2023.21644. PMID: 37399009Free PMC Article
Hundscheid T, Onland W, Kooi EMW, Vijlbrief DC, de Vries WB, Dijkman KP, van Kaam AH, Villamor E, Kroon AA, Visser R, Mulder-de Tollenaer SM, De Bisschop B, Dijk PH, Avino D, Hocq C, Zecic A, Meeus M, de Baat T, Derriks F, Henriksen TB, Kyng KJ, Donders R, Nuytemans DHGM, Van Overmeire B, Mulder AL, de Boode WP; BeNeDuctus Trial Investigators
N Engl J Med 2023 Mar 16;388(11):980-990. Epub 2022 Dec 6 doi: 10.1056/NEJMoa2207418. PMID: 36477458
Watterberg KL, Walsh MC, Li L, Chawla S, D'Angio CT, Goldberg RN, Hintz SR, Laughon MM, Yoder BA, Kennedy KA, McDavid GE, Backstrom-Lacy C, Das A, Crawford MM, Keszler M, Sokol GM, Poindexter BB, Ambalavanan N, Hibbs AM, Truog WE, Schmidt B, Wyckoff MH, Khan AM, Garg M, Chess PR, Reynolds AM, Moallem M, Bell EF, Meyer LR, Patel RM, Van Meurs KP, Cotten CM, McGowan EC, Hines AC, Merhar S, Peralta-Carcelen M, Wilson-Costello DE, Kilbride HW, DeMauro SB, Heyne RJ, Mosquera RA, Natarajan G, Purdy IB, Lowe JR, Maitre NL, Harmon HM, Hogden LA, Adams-Chapman I, Winter S, Malcolm WF, Higgins RD; Eunice Kennedy Shriver NICHD Neonatal Research Network
N Engl J Med 2022 Mar 24;386(12):1121-1131. doi: 10.1056/NEJMoa2114897. PMID: 35320643Free PMC Article
Steinhorn RH
Pediatr Crit Care Med 2010 Mar;11(2 Suppl):S79-84. doi: 10.1097/PCC.0b013e3181c76cdc. PMID: 20216169Free PMC Article

Prognosis

Watterberg KL, Walsh MC, Li L, Chawla S, D'Angio CT, Goldberg RN, Hintz SR, Laughon MM, Yoder BA, Kennedy KA, McDavid GE, Backstrom-Lacy C, Das A, Crawford MM, Keszler M, Sokol GM, Poindexter BB, Ambalavanan N, Hibbs AM, Truog WE, Schmidt B, Wyckoff MH, Khan AM, Garg M, Chess PR, Reynolds AM, Moallem M, Bell EF, Meyer LR, Patel RM, Van Meurs KP, Cotten CM, McGowan EC, Hines AC, Merhar S, Peralta-Carcelen M, Wilson-Costello DE, Kilbride HW, DeMauro SB, Heyne RJ, Mosquera RA, Natarajan G, Purdy IB, Lowe JR, Maitre NL, Harmon HM, Hogden LA, Adams-Chapman I, Winter S, Malcolm WF, Higgins RD; Eunice Kennedy Shriver NICHD Neonatal Research Network
N Engl J Med 2022 Mar 24;386(12):1121-1131. doi: 10.1056/NEJMoa2114897. PMID: 35320643Free PMC Article
Bell EF, Hintz SR, Hansen NI, Bann CM, Wyckoff MH, DeMauro SB, Walsh MC, Vohr BR, Stoll BJ, Carlo WA, Van Meurs KP, Rysavy MA, Patel RM, Merhar SL, Sánchez PJ, Laptook AR, Hibbs AM, Cotten CM, D'Angio CT, Winter S, Fuller J, Das A; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
JAMA 2022 Jan 18;327(3):248-263. doi: 10.1001/jama.2021.23580. PMID: 35040888Free PMC Article
Ancel PY, Goffinet F; EPIPAGE-2 Writing Group, Kuhn P, Langer B, Matis J, Hernandorena X, Chabanier P, Joly-Pedespan L, Lecomte B, Vendittelli F, Dreyfus M, Guillois B, Burguet A, Sagot P, Sizun J, Beuchée A, Rouget F, Favreau A, Saliba E, Bednarek N, Morville P, Thiriez G, Marpeau L, Marret S, Kayem G, Durrmeyer X, Granier M, Baud O, Jarreau PH, Mitanchez D, Boileau P, Boulot P, Cambonie G, Daudé H, Bédu A, Mons F, Fresson J, Vieux R, Alberge C, Arnaud C, Vayssière C, Truffert P, Pierrat V, Subtil D, D'Ercole C, Gire C, Simeoni U, Bongain A, Sentilhes L, Rozé JC, Gondry J, Leke A, Deiber M, Claris O, Picaud JC, Ego A, Debillon T, Poulichet A, Coliné E, Favre A, Fléchelles O, Samperiz S, Ramful D, Branger B, Benhammou V, Foix-L'Hélias L, Marchand-Martin L, Kaminski M
JAMA Pediatr 2015 Mar;169(3):230-8. doi: 10.1001/jamapediatrics.2014.3351. PMID: 25621457
Ambalavanan N, Mourani P
Birth Defects Res A Clin Mol Teratol 2014 Mar;100(3):240-6. Epub 2014 Mar 10 doi: 10.1002/bdra.23241. PMID: 24616323
Steinhorn RH
Pediatr Crit Care Med 2010 Mar;11(2 Suppl):S79-84. doi: 10.1097/PCC.0b013e3181c76cdc. PMID: 20216169Free PMC Article

Clinical prediction guides

Fontijn S, Balink SJA, Bonte M, Andrinopoulou ER, Duijts L, Kroon AA, Ciet P, Pijnenburg MW
Eur J Radiol 2023 Dec;169:111168. Epub 2023 Oct 24 doi: 10.1016/j.ejrad.2023.111168. PMID: 37897957
Ambalavanan N, Weese-Mayer DE, Hibbs AM, Claure N, Carroll JL, Moorman JR, Bancalari E, Hamvas A, Martin RJ, Di Fiore JM, Indic P, Kemp JS, Dormishian A, Krahn KN, Qiu J, Dennery PA, Ratcliffe SJ, Troendle JF, Lake DE; Prematurity-related Ventilatory Control (Pre-Vent) Investigators
Am J Respir Crit Care Med 2023 Jul 1;208(1):79-97. doi: 10.1164/rccm.202210-1971OC. PMID: 37219236Free PMC Article
Jensen EA, Whyte RK, Schmidt B, Bassler D, Vain NE, Roberts RS; Canadian Oxygen Trial Investigators
Am J Respir Crit Care Med 2021 Nov 15;204(10):1192-1199. doi: 10.1164/rccm.202105-1150OC. PMID: 34428130Free PMC Article
Sharma A, Xin Y, Chen X, Sood BG
Pediatr Neonatol 2020 Jun;61(3):290-299. Epub 2019 Dec 23 doi: 10.1016/j.pedneo.2019.12.001. PMID: 32217025
Brener Dik PH, Niño Gualdron YM, Galletti MF, Cribioli CM, Mariani GL
Arch Argent Pediatr 2017 Oct 1;115(5):476-482. doi: 10.5546/aap.2017.eng.476. PMID: 28895695

Recent systematic reviews

Lim G, Kim YJ, Chung S, Park YM, Kim KS, Park HW
J Korean Med Sci 2022 Apr 25;37(16):e127. doi: 10.3346/jkms.2022.37.e127. PMID: 35470601Free PMC Article
Phattraprayoon N, Ungtrakul T, Soonklang K, Susantitaphong P
PLoS One 2022;17(4):e0265876. Epub 2022 Apr 4 doi: 10.1371/journal.pone.0265876. PMID: 35377893Free PMC Article
King BC, Gandhi BB, Jackson A, Katakam L, Pammi M, Suresh G
Neonatology 2019;116(2):100-114. Epub 2019 Jun 4 doi: 10.1159/000496462. PMID: 31163418
Steinhorn RH
Pediatr Crit Care Med 2010 Mar;11(2 Suppl):S79-84. doi: 10.1097/PCC.0b013e3181c76cdc. PMID: 20216169Free PMC Article

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