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Double orifice mitral valve

MedGen UID:
488869
•Concept ID:
C0344770
•
Congenital Abnormality
Synonyms: Double-orifice mitral valve; Mitral valve, double orifice
SNOMED CT: Double orifice of mitral valve (253402005)
 
HPO: HP:0011568
Monarch Initiative: MONDO:0019819
Orphanet: ORPHA95474

Definition

The left atrio-ventricular connection consists of two anatomically distinct orifices separated by accessory fibrous tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDouble orifice mitral valve
Follow this link to review classifications for Double orifice mitral valve in Orphanet.

Professional guidelines

PubMed

Current management of severe congenital mitral stenosis: outcomes of transcatheter and surgical therapy in 108 infants and children.
McElhinney DB, Sherwood MC, Keane JF, del Nido PJ, Almond CS, Lock JE
Circulation 2005 Aug 2;112(5):707-14. Epub 2005 Jul 25 doi: 10.1161/CIRCULATIONAHA.104.500207. PMID: 16043648

Recent clinical studies

Etiology

Echocardiographic diagnosis of congenital double orifice mitral valve malformation: A case report.
Li H, Wang H, Zhang W, Cheng L
J Clin Ultrasound 2021 Jun;49(5):509-511. Epub 2020 Dec 10 doi: 10.1002/jcu.22954. PMID: 33305418
Atypical Shone's complex diagnosed by echocardiography.
Ma XJ, Huang GY, Liang XC, Liu XQ, Jia B
Pediatr Cardiol 2011 Apr;32(4):442-8. Epub 2011 Jan 29 doi: 10.1007/s00246-011-9886-y. PMID: 21279339
Percutaneous and off-pump treatments for functional mitral regurgitation.
Fukamachi K
J Artif Organs 2008;11(1):12-8. Epub 2008 Apr 15 doi: 10.1007/s10047-007-0399-7. PMID: 18414987
Mitral valve reserve in double-orifice technique: an exercise echocardiographic study.
Agricola E, Maisano F, Oppizzi M, De Bonis M, Torracca L, La Canna G, Alfieri O
J Heart Valve Dis 2002 Sep;11(5):637-43. PMID: 12358399
Two-dimensional echocardiographic findings in double orifice mitral valve.
Trowitzsch E, Bano-Rodrigo A, Burger BM, Colan SD, Sanders SP
J Am Coll Cardiol 1985 Aug;6(2):383-7. doi: 10.1016/s0735-1097(85)80176-5. PMID: 4019924

Diagnosis

Young Man With Coarctation of the Aorta.
Beltran Ontiveros LD, Salazar JFF, Zanella HR
JAMA Cardiol 2023 Jun 1;8(6):622. doi: 10.1001/jamacardio.2023.0853. PMID: 37133843
Double-orifice mitral valve repair.
Gonzalez T, Vera F, Ruiz E
Cardiol Young 2019 Feb;29(2):214-215. Epub 2018 Dec 4 doi: 10.1017/S1047951118001890. PMID: 30511602
Double-orifice mitral valve associated with atrioventricular canal defects.
Rhissassi J, El Malki H, Benmessaoud FA, El Kandoussi T, Laaroussi M
Pan Afr Med J 2016;23:199. Epub 2016 Apr 15 doi: 10.11604/pamj.2016.23.199.8676. PMID: 27347288Free PMC Article
Double-orifice mitral valve.
Evrengül H, Ozcan EE
Turk Kardiyol Dern Ars 2011 Oct;39(7):625. doi: 10.5543/tkda.2011.01604. PMID: 21983777
Double-orifice mitral valve.
Lee DI, Ha JW, Chung B, Kim Y, Chun KJ, Rim SJ, Chung N
Clin Cardiol 1999 Jun;22(6):425. doi: 10.1002/clc.4960220613. PMID: 10376184Free PMC Article

Therapy

Novel arm-width-expandable transcatheter edge-to-edge repair system: Preclinical experiment and first-in-human study.
Long Y, Li W, Chen S, Li M, Hou S, Pan C, Zhou D, Pan W, Ge J
Catheter Cardiovasc Interv 2023 Aug;102(2):301-309. Epub 2023 Jul 20 doi: 10.1002/ccd.30758. PMID: 37471710
A novel user-friendly transcatheter edge-to-edge mitral valve repair device in a porcine model.
Pan W, Pan C, Jilaihawi H, Wei L, Tang Y, Zhou D, Ge J
Catheter Cardiovasc Interv 2019 Jun 1;93(7):1354-1360. Epub 2018 Nov 15 doi: 10.1002/ccd.27976. PMID: 30443976
Isolated double-orifice mitral valve in octogenarian.
Graham FJ, Jenkins SMM
Eur Heart J Cardiovasc Imaging 2018 Aug 1;19(8):957. doi: 10.1093/ehjci/jey066. PMID: 29688294
Percutaneous and off-pump treatments for functional mitral regurgitation.
Fukamachi K
J Artif Organs 2008;11(1):12-8. Epub 2008 Apr 15 doi: 10.1007/s10047-007-0399-7. PMID: 18414987
Mitral valve reserve in double-orifice technique: an exercise echocardiographic study.
Agricola E, Maisano F, Oppizzi M, De Bonis M, Torracca L, La Canna G, Alfieri O
J Heart Valve Dis 2002 Sep;11(5):637-43. PMID: 12358399

Prognosis

Isolated double orifice mitral valve in a young asymptomatic woman.
Pizzino F, Piccione MC, Trio O, Zito C, Monaco M, Carerj S
J Cardiovasc Med (Hagerstown) 2016 Dec;17 Suppl 2:e161-e163. doi: 10.2459/JCM.0000000000000308. PMID: 26204470
Isolated double-orifice mitral valve: a case report.
Krisai P, Wein B, Kaufmann BA
BMC Cardiovasc Disord 2015 Dec 18;15:172. doi: 10.1186/s12872-015-0168-0. PMID: 26681334Free PMC Article
Atypical Shone's complex diagnosed by echocardiography.
Ma XJ, Huang GY, Liang XC, Liu XQ, Jia B
Pediatr Cardiol 2011 Apr;32(4):442-8. Epub 2011 Jan 29 doi: 10.1007/s00246-011-9886-y. PMID: 21279339
Mitral valve reserve in double-orifice technique: an exercise echocardiographic study.
Agricola E, Maisano F, Oppizzi M, De Bonis M, Torracca L, La Canna G, Alfieri O
J Heart Valve Dis 2002 Sep;11(5):637-43. PMID: 12358399
Two-dimensional echocardiographic findings in double orifice mitral valve.
Trowitzsch E, Bano-Rodrigo A, Burger BM, Colan SD, Sanders SP
J Am Coll Cardiol 1985 Aug;6(2):383-7. doi: 10.1016/s0735-1097(85)80176-5. PMID: 4019924

Clinical prediction guides

Echocardiographic diagnosis of congenital double orifice mitral valve malformation: A case report.
Li H, Wang H, Zhang W, Cheng L
J Clin Ultrasound 2021 Jun;49(5):509-511. Epub 2020 Dec 10 doi: 10.1002/jcu.22954. PMID: 33305418
Isolated double orifice mitral valve in a young asymptomatic woman.
Pizzino F, Piccione MC, Trio O, Zito C, Monaco M, Carerj S
J Cardiovasc Med (Hagerstown) 2016 Dec;17 Suppl 2:e161-e163. doi: 10.2459/JCM.0000000000000308. PMID: 26204470
Isolated double-orifice mitral valve: a case report.
Krisai P, Wein B, Kaufmann BA
BMC Cardiovasc Disord 2015 Dec 18;15:172. doi: 10.1186/s12872-015-0168-0. PMID: 26681334Free PMC Article
Mitral valve repair for double-orifice mitral valve.
Duan QJ, Gao Z
Heart Lung Circ 2014 Dec;23(12):e267-9. Epub 2014 Aug 19 doi: 10.1016/j.hlc.2014.08.002. PMID: 25194958
The straddling mitral valve: morphological observations and clinical implications.
Freedom RM, Bini R, Dische R, Rowe RD
Eur J Cardiol 1978 Aug;8(1):27-50. PMID: 689069

Recent systematic reviews

Surgical outcomes of double-orifice mitral valve repair in patients with atrioventricular canal defects: a systematic review and meta-analysis.
Ghosh S, Halder V, Mittal A, Mishra A, Haranal M, Aggarwal P, Singh H, Barwad P, Naganur S, Thingnam SKS
Cardiol Young 2023 Sep;33(9):1506-1516. Epub 2023 Jul 31 doi: 10.1017/S1047951123002664. PMID: 37518865

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