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Functional disorder of polymorphonuclear neutrophil

MedGen UID:
507745
•Concept ID:
C0016808
•
Disease or Syndrome
Synonyms: Functional Disorder of PMNs; Functional Disorder of Polymorphonuclear Neutrophils
SNOMED CT: Functional disorder of polymorphonuclear neutrophil (1197483002)

Definition

A disorder caused by a dysfunction of polymorphonuclear neutrophils (PMNs). [from NCI]

Professional guidelines

PubMed

Neutrophil extracellular traps: A novel target for the treatment of stroke.
Zhao Z, Pan Z, Zhang S, Ma G, Zhang W, Song J, Wang Y, Kong L, Du G
Pharmacol Ther 2023 Jan;241:108328. Epub 2022 Dec 6 doi: 10.1016/j.pharmthera.2022.108328. PMID: 36481433
Advances of exosomes in periodontitis treatment.
Lin H, Chen H, Zhao X, Ding T, Wang Y, Chen Z, Tian Y, Zhang P, Shen Y
J Transl Med 2022 Jun 21;20(1):279. doi: 10.1186/s12967-022-03487-4. PMID: 35729576Free PMC Article
Diagnosis and management of leukocytoclastic vasculitis.
Fraticelli P, Benfaremo D, Gabrielli A
Intern Emerg Med 2021 Jun;16(4):831-841. Epub 2021 Mar 13 doi: 10.1007/s11739-021-02688-x. PMID: 33713282Free PMC Article

Recent clinical studies

Etiology

Neutrophils in chronic inflammatory diseases.
Herrero-Cervera A, Soehnlein O, Kenne E
Cell Mol Immunol 2022 Feb;19(2):177-191. Epub 2022 Jan 17 doi: 10.1038/s41423-021-00832-3. PMID: 35039631Free PMC Article
Platelet-derived exosomes promote neutrophil extracellular trap formation during septic shock.
Jiao Y, Li W, Wang W, Tong X, Xia R, Fan J, Du J, Zhang C, Shi X
Crit Care 2020 Jun 29;24(1):380. doi: 10.1186/s13054-020-03082-3. PMID: 32600436Free PMC Article
Neutrophils as regulators of cardiovascular inflammation.
Silvestre-Roig C, Braster Q, Ortega-Gomez A, Soehnlein O
Nat Rev Cardiol 2020 Jun;17(6):327-340. Epub 2020 Jan 29 doi: 10.1038/s41569-019-0326-7. PMID: 31996800
DAMPs and NETs in Sepsis.
Denning NL, Aziz M, Gurien SD, Wang P
Front Immunol 2019;10:2536. Epub 2019 Oct 30 doi: 10.3389/fimmu.2019.02536. PMID: 31736963Free PMC Article
Heterogeneity Among Neutrophils.
Garley M, Jabłońska E
Arch Immunol Ther Exp (Warsz) 2018 Feb;66(1):21-30. Epub 2017 May 30 doi: 10.1007/s00005-017-0476-4. PMID: 28560557Free PMC Article

Diagnosis

NETosis in Acute Thrombotic Disorders.
Bressan A, Faggin E, Donato M, Tonon L, Buso R, Nardin C, Tiepolo M, Cinetto F, Scarpa R, Agostini C, Pauletto P, Ventura L, Fusaro M, Felice C, Rattazzi M
Semin Thromb Hemost 2023 Oct;49(7):709-715. Epub 2023 Jun 12 doi: 10.1055/s-0043-1769510. PMID: 37308098
IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy.
Teijeira A, Garasa S, Ochoa MC, Villalba M, Olivera I, Cirella A, Eguren-Santamaria I, Berraondo P, Schalper KA, de Andrea CE, Sanmamed MF, Melero I
Clin Cancer Res 2021 May 1;27(9):2383-2393. Epub 2020 Dec 29 doi: 10.1158/1078-0432.CCR-20-1319. PMID: 33376096
Neutrophil Diversity in Health and Disease.
Silvestre-Roig C, Fridlender ZG, Glogauer M, Scapini P
Trends Immunol 2019 Jul;40(7):565-583. Epub 2019 May 31 doi: 10.1016/j.it.2019.04.012. PMID: 31160207Free PMC Article
Inflammatory endotypes in COPD.
Barnes PJ
Allergy 2019 Jul;74(7):1249-1256. Epub 2019 Mar 31 doi: 10.1111/all.13760. PMID: 30834543
Pyoderma Gangrenosum: An Update on Pathophysiology, Diagnosis and Treatment.
Alavi A, French LE, Davis MD, Brassard A, Kirsner RS
Am J Clin Dermatol 2017 Jun;18(3):355-372. doi: 10.1007/s40257-017-0251-7. PMID: 28224502

Therapy

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis.
Masucci MT, Minopoli M, Del Vecchio S, Carriero MV
Front Immunol 2020;11:1749. Epub 2020 Sep 16 doi: 10.3389/fimmu.2020.01749. PMID: 33042107Free PMC Article
The Contribution of Neutrophils to the Pathogenesis of RSV Bronchiolitis.
Sebina I, Phipps S
Viruses 2020 Jul 27;12(8) doi: 10.3390/v12080808. PMID: 32726921Free PMC Article
Airway inflammation in COPD: progress to precision medicine.
Brightling C, Greening N
Eur Respir J 2019 Aug;54(2) Epub 2019 Aug 1 doi: 10.1183/13993003.00651-2019. PMID: 31073084
Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis.
van der Windt DJ, Sud V, Zhang H, Varley PR, Goswami J, Yazdani HO, Tohme S, Loughran P, O'Doherty RM, Minervini MI, Huang H, Simmons RL, Tsung A
Hepatology 2018 Oct;68(4):1347-1360. Epub 2018 Jul 16 doi: 10.1002/hep.29914. PMID: 29631332Free PMC Article
The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases.
Russo RC, Garcia CC, Teixeira MM, Amaral FA
Expert Rev Clin Immunol 2014 May;10(5):593-619. Epub 2014 Mar 29 doi: 10.1586/1744666X.2014.894886. PMID: 24678812

Prognosis

Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment.
Wang L, Liu Y, Dai Y, Tang X, Yin T, Wang C, Wang T, Dong L, Shi M, Qin J, Xue M, Cao Y, Liu J, Liu P, Huang J, Wen C, Zhang J, Xu Z, Bai F, Deng X, Peng C, Chen H, Jiang L, Chen S, Shen B
Gut 2023 May;72(5):958-971. Epub 2022 Jun 10 doi: 10.1136/gutjnl-2021-326070. PMID: 35688610Free PMC Article
Neutrophils in cancer carcinogenesis and metastasis.
Xiong S, Dong L, Cheng L
J Hematol Oncol 2021 Oct 21;14(1):173. doi: 10.1186/s13045-021-01187-y. PMID: 34674757Free PMC Article
Systemic inflammation markers and cancer incidence in the UK Biobank.
Nøst TH, Alcala K, Urbarova I, Byrne KS, Guida F, Sandanger TM, Johansson M
Eur J Epidemiol 2021 Aug;36(8):841-848. Epub 2021 May 25 doi: 10.1007/s10654-021-00752-6. PMID: 34036468Free PMC Article
IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy.
Teijeira A, Garasa S, Ochoa MC, Villalba M, Olivera I, Cirella A, Eguren-Santamaria I, Berraondo P, Schalper KA, de Andrea CE, Sanmamed MF, Melero I
Clin Cancer Res 2021 May 1;27(9):2383-2393. Epub 2020 Dec 29 doi: 10.1158/1078-0432.CCR-20-1319. PMID: 33376096
Inflammatory endotypes in COPD.
Barnes PJ
Allergy 2019 Jul;74(7):1249-1256. Epub 2019 Mar 31 doi: 10.1111/all.13760. PMID: 30834543

Clinical prediction guides

NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond.
Zhu Y, Chen X, Liu X
Front Immunol 2022;13:838011. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.838011. PMID: 35309344Free PMC Article
The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis.
Masucci MT, Minopoli M, Del Vecchio S, Carriero MV
Front Immunol 2020;11:1749. Epub 2020 Sep 16 doi: 10.3389/fimmu.2020.01749. PMID: 33042107Free PMC Article
Tumour-associated neutrophils in patients with cancer.
Shaul ME, Fridlender ZG
Nat Rev Clin Oncol 2019 Oct;16(10):601-620. doi: 10.1038/s41571-019-0222-4. PMID: 31160735
Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.
Genschmer KR, Russell DW, Lal C, Szul T, Bratcher PE, Noerager BD, Abdul Roda M, Xu X, Rezonzew G, Viera L, Dobosh BS, Margaroli C, Abdalla TH, King RW, McNicholas CM, Wells JM, Dransfield MT, Tirouvanziam R, Gaggar A, Blalock JE
Cell 2019 Jan 10;176(1-2):113-126.e15. doi: 10.1016/j.cell.2018.12.002. PMID: 30633902Free PMC Article
Heterogeneity Among Neutrophils.
Garley M, Jabłońska E
Arch Immunol Ther Exp (Warsz) 2018 Feb;66(1):21-30. Epub 2017 May 30 doi: 10.1007/s00005-017-0476-4. PMID: 28560557Free PMC Article

Recent systematic reviews

A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury.
Yang K, Zeng L, Ge A, Wang S, Zeng J, Yuan X, Mei Z, Wang G, Ge J
Front Immunol 2022;13:930171. Epub 2022 Oct 7 doi: 10.3389/fimmu.2022.930171. PMID: 36275741Free PMC Article
Neutrophil gelatinase-associated lipocalin (NGAL) in kidney injury - A systematic review.
Marakala V
Clin Chim Acta 2022 Nov 1;536:135-141. Epub 2022 Sep 21 doi: 10.1016/j.cca.2022.08.029. PMID: 36150522
Anti-Desmocollin Autoantibodies in Autoimmune Blistering Diseases.
Bosch-Amate X, Iranzo P, Ivars M, Mascaró Galy JM, España A
Front Immunol 2021;12:740820. Epub 2021 Sep 10 doi: 10.3389/fimmu.2021.740820. PMID: 34567003Free PMC Article
Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies.
Cupp MA, Cariolou M, Tzoulaki I, Aune D, Evangelou E, Berlanga-Taylor AJ
BMC Med 2020 Nov 20;18(1):360. doi: 10.1186/s12916-020-01817-1. PMID: 33213430Free PMC Article
Neutrophil-to-lymphocyte ratio predicts acute appendicitis and distinguishes between complicated and uncomplicated appendicitis: A systematic review and meta-analysis.
Hajibandeh S, Hajibandeh S, Hobbs N, Mansour M
Am J Surg 2020 Jan;219(1):154-163. Epub 2019 Apr 27 doi: 10.1016/j.amjsurg.2019.04.018. PMID: 31056211

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