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Infectious anterior uveitis

MedGen UID:
509716
•Concept ID:
C0154911
•
Disease or Syndrome
Synonyms: infectious anterior uveitis; Infectious secondary iridocyclitis; infectious secondary iridocyclitis; Secondary infected iridocyclitis; secondary infected iridocyclitis; secondary iridocyclitis, infectious
SNOMED CT: Infectious secondary iridocyclitis (89114005); Secondary infected iridocyclitis (193487008); Infectious anterior uveitis (89114005)
 
Monarch Initiative: MONDO:0017210
Orphanet: ORPHA279922

Definition

A rare ophthalmic disorder characterized by inflammation primarily of the anterior part of the uvea (iris and ciliary body), due to an infectious etiology. Clinical symptoms are pain, redness, photophobia, and variable visual loss. Signs on examination include presence of inflammatory cells in the anterior chamber and anterior vitreous, keratic precipitates, hypopyon, iris nodules, posterior synechiae, and miosis, among others. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfectious anterior uveitis

Professional guidelines

PubMed

Viral Anterior Uveitis: A Practical and Comprehensive Review of Diagnosis and Treatment.
Feng Y, Garcia R, Rojas-Carabali W, Cifuentes-González C, Putera I, Li J, La Distia Nora R, Mahendradas P, Gupta V, de-la-Torre A, Agrawal R
Ocul Immunol Inflamm 2024 Oct;32(8):1804-1818. Epub 2023 Oct 20 doi: 10.1080/09273948.2023.2271077. PMID: 37862684
Cytomegalovirus Uveitis: Taiwan expert consensus.
Chiang WY, Lin CP, Cho WH, Yang CH, Chen SN, Hwang YS, Hsu SM, Hwang DK, Chen SC, Kuo HK, Sheu SJ
J Formos Med Assoc 2023 Aug;122(8):668-674. Epub 2023 Mar 30 doi: 10.1016/j.jfma.2023.03.014. PMID: 37003913
Treatment recommendations for non-infectious anterior uveitis.
Espinosa G, Muñoz-Fernández S, García Ruiz de Morales JM, Herreras JM, Cordero-Coma M
Med Clin (Barc) 2017 Dec 20;149(12):552.e1-552.e12. Epub 2017 Sep 11 doi: 10.1016/j.medcli.2017.06.059. PMID: 28911893

Recent clinical studies

Etiology

The gut microbiome and HLA-B27-associated anterior uveitis: a case-control study.
Morandi SC, Herzog EL, Munk M, Kreuzer M, Largiadèr CR, Wolf S, Zinkernagel M, Zysset-Burri DC
J Neuroinflammation 2024 May 7;21(1):120. doi: 10.1186/s12974-024-03109-4. PMID: 38715051Free PMC Article
Recurrent and chronic anterior uveitis: Long-term outcome and treatment strategies.
Sharon Y, Goren L, Barayev E, Neumann R, Chu DS, Kramer M
Indian J Ophthalmol 2024 Feb 1;72(Suppl 2):S248-S253. Epub 2023 Dec 26 doi: 10.4103/IJO.IJO_1042_23. PMID: 38146973
Timing of infliximab and adalimumab initiation despite methotrexate in children with chronic non-infectious anterior uveitis.
McCracken C, Yeh S, Jenkins K, Travers C, Stryker D, Tommasello S, Rouster-Stevens KA, Lambert SR, Prahalad S, Drews-Botsch C, Angeles-Han ST
Eye (Lond) 2019 Apr;33(4):629-639. Epub 2018 Nov 28 doi: 10.1038/s41433-018-0283-0. PMID: 30487588Free PMC Article
Superficial and deep retinal foveal avascular zone OCTA findings of non-infectious anterior and posterior uveitis.
Waizel M, Todorova MG, Terrada C, LeHoang P, Massamba N, Bodaghi B
Graefes Arch Clin Exp Ophthalmol 2018 Oct;256(10):1977-1984. Epub 2018 Jul 6 doi: 10.1007/s00417-018-4057-y. PMID: 29980918
Treatment recommendations for non-infectious anterior uveitis.
Espinosa G, Muñoz-Fernández S, García Ruiz de Morales JM, Herreras JM, Cordero-Coma M
Med Clin (Barc) 2017 Dec 20;149(12):552.e1-552.e12. Epub 2017 Sep 11 doi: 10.1016/j.medcli.2017.06.059. PMID: 28911893

Diagnosis

Recurrent and chronic anterior uveitis: Long-term outcome and treatment strategies.
Sharon Y, Goren L, Barayev E, Neumann R, Chu DS, Kramer M
Indian J Ophthalmol 2024 Feb 1;72(Suppl 2):S248-S253. Epub 2023 Dec 26 doi: 10.4103/IJO.IJO_1042_23. PMID: 38146973
Viral Anterior Uveitis: A Practical and Comprehensive Review of Diagnosis and Treatment.
Feng Y, Garcia R, Rojas-Carabali W, Cifuentes-González C, Putera I, Li J, La Distia Nora R, Mahendradas P, Gupta V, de-la-Torre A, Agrawal R
Ocul Immunol Inflamm 2024 Oct;32(8):1804-1818. Epub 2023 Oct 20 doi: 10.1080/09273948.2023.2271077. PMID: 37862684
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis.
Wensing B, Mochizuki M, De Boer JH
Ocul Immunol Inflamm 2018;26(3):333-337. Epub 2018 Jan 18 doi: 10.1080/09273948.2017.1420806. PMID: 29345511
Treatment recommendations for non-infectious anterior uveitis.
Espinosa G, Muñoz-Fernández S, García Ruiz de Morales JM, Herreras JM, Cordero-Coma M
Med Clin (Barc) 2017 Dec 20;149(12):552.e1-552.e12. Epub 2017 Sep 11 doi: 10.1016/j.medcli.2017.06.059. PMID: 28911893
Current diagnostic approaches to infectious anterior uveitis.
Hunter RS, Lobo AM
Int Ophthalmol Clin 2011 Fall;51(4):145-56. doi: 10.1097/IIO.0b013e31822d6807. PMID: 21897147

Therapy

Viral Anterior Uveitis: A Practical and Comprehensive Review of Diagnosis and Treatment.
Feng Y, Garcia R, Rojas-Carabali W, Cifuentes-González C, Putera I, Li J, La Distia Nora R, Mahendradas P, Gupta V, de-la-Torre A, Agrawal R
Ocul Immunol Inflamm 2024 Oct;32(8):1804-1818. Epub 2023 Oct 20 doi: 10.1080/09273948.2023.2271077. PMID: 37862684
Decreased risk of non-infectious anterior uveitis with statin therapy in a large healthcare claims database.
Sobrin L, Yu Y, Han S, Susarla G, Kempen JH, Hubbard RA, VanderBeek BL
Graefes Arch Clin Exp Ophthalmol 2021 Sep;259(9):2783-2793. Epub 2021 May 29 doi: 10.1007/s00417-021-05243-8. PMID: 34050812Free PMC Article
Timing of infliximab and adalimumab initiation despite methotrexate in children with chronic non-infectious anterior uveitis.
McCracken C, Yeh S, Jenkins K, Travers C, Stryker D, Tommasello S, Rouster-Stevens KA, Lambert SR, Prahalad S, Drews-Botsch C, Angeles-Han ST
Eye (Lond) 2019 Apr;33(4):629-639. Epub 2018 Nov 28 doi: 10.1038/s41433-018-0283-0. PMID: 30487588Free PMC Article
Treatment recommendations for non-infectious anterior uveitis.
Espinosa G, Muñoz-Fernández S, García Ruiz de Morales JM, Herreras JM, Cordero-Coma M
Med Clin (Barc) 2017 Dec 20;149(12):552.e1-552.e12. Epub 2017 Sep 11 doi: 10.1016/j.medcli.2017.06.059. PMID: 28911893
Clinical characteristics, treatment and ocular complications of HLA-B27-related anterior uveitis and HLA-B27-non related anterior uveitis.
Valls Pascual E, Fontanilla Ortega P, Vicens Bernabeu E, Martínez-Costa L, Blanco Alonso R
Reumatol Clin 2016 Sep-Oct;12(5):244-7. Epub 2015 Dec 18 doi: 10.1016/j.reuma.2015.11.008. PMID: 26708737

Prognosis

Recurrent and chronic anterior uveitis: Long-term outcome and treatment strategies.
Sharon Y, Goren L, Barayev E, Neumann R, Chu DS, Kramer M
Indian J Ophthalmol 2024 Feb 1;72(Suppl 2):S248-S253. Epub 2023 Dec 26 doi: 10.4103/IJO.IJO_1042_23. PMID: 38146973
Efficacy and safety of adalimumab for inflammatory flare prevention in paediatric non-infectious anterior uveitis with peripheral retinal vascular leakage: a study protocol for a single-centre, randomised controlled trial.
Song H, Zhao C, Zhang Y, Li D, Qian Y, Gao F, Xiao J, Zhang M
BMJ Open 2022 Dec 7;12(12):e062211. doi: 10.1136/bmjopen-2022-062211. PMID: 36600374Free PMC Article
Serum immunoglobulin levels, complement components 3 and 4, HLA-B27 allele and spondyloarthropathy in patients with non-infectious anterior uveites.
Torres Rives B, Martínez Téllez G, Mataran Valdés M, Collazo Mesa T, Colás González R, Frutos Ambou I
Reumatol Clin (Engl Ed) 2021 Dec;17(10):575-581. Epub 2021 Mar 18 doi: 10.1016/j.reumae.2020.07.007. PMID: 34823824
Timing of infliximab and adalimumab initiation despite methotrexate in children with chronic non-infectious anterior uveitis.
McCracken C, Yeh S, Jenkins K, Travers C, Stryker D, Tommasello S, Rouster-Stevens KA, Lambert SR, Prahalad S, Drews-Botsch C, Angeles-Han ST
Eye (Lond) 2019 Apr;33(4):629-639. Epub 2018 Nov 28 doi: 10.1038/s41433-018-0283-0. PMID: 30487588Free PMC Article
Clinical characteristics, treatment and ocular complications of HLA-B27-related anterior uveitis and HLA-B27-non related anterior uveitis.
Valls Pascual E, Fontanilla Ortega P, Vicens Bernabeu E, Martínez-Costa L, Blanco Alonso R
Reumatol Clin 2016 Sep-Oct;12(5):244-7. Epub 2015 Dec 18 doi: 10.1016/j.reuma.2015.11.008. PMID: 26708737

Clinical prediction guides

The gut microbiome and HLA-B27-associated anterior uveitis: a case-control study.
Morandi SC, Herzog EL, Munk M, Kreuzer M, Largiadèr CR, Wolf S, Zinkernagel M, Zysset-Burri DC
J Neuroinflammation 2024 May 7;21(1):120. doi: 10.1186/s12974-024-03109-4. PMID: 38715051Free PMC Article
Serum immunoglobulin levels, complement components 3 and 4, HLA-B27 allele and spondyloarthropathy in patients with non-infectious anterior uveites.
Torres Rives B, Martínez Téllez G, Mataran Valdés M, Collazo Mesa T, Colás González R, Frutos Ambou I
Reumatol Clin (Engl Ed) 2021 Dec;17(10):575-581. Epub 2021 Mar 18 doi: 10.1016/j.reumae.2020.07.007. PMID: 34823824
Decreased risk of non-infectious anterior uveitis with statin therapy in a large healthcare claims database.
Sobrin L, Yu Y, Han S, Susarla G, Kempen JH, Hubbard RA, VanderBeek BL
Graefes Arch Clin Exp Ophthalmol 2021 Sep;259(9):2783-2793. Epub 2021 May 29 doi: 10.1007/s00417-021-05243-8. PMID: 34050812Free PMC Article
The pathogenic role of dendritic cells in non-infectious anterior uveitis.
O'Rourke M, Fearon U, Sweeney CM, Basdeo SA, Fletcher JM, Murphy CC, Canavan M
Exp Eye Res 2018 Aug;173:121-128. Epub 2018 May 25 doi: 10.1016/j.exer.2018.05.008. PMID: 29763582
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis.
Wensing B, Mochizuki M, De Boer JH
Ocul Immunol Inflamm 2018;26(3):333-337. Epub 2018 Jan 18 doi: 10.1080/09273948.2017.1420806. PMID: 29345511

Recent systematic reviews

Treatment recommendations for non-infectious anterior uveitis.
Espinosa G, Muñoz-Fernández S, García Ruiz de Morales JM, Herreras JM, Cordero-Coma M
Med Clin (Barc) 2017 Dec 20;149(12):552.e1-552.e12. Epub 2017 Sep 11 doi: 10.1016/j.medcli.2017.06.059. PMID: 28911893

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