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Radiation cystitis

MedGen UID:
510221
•Concept ID:
C0156270
•
Disease or Syndrome
Synonyms: Irradiation cystitis; irradiation cystitis; Radiation Cystitis; radiation cystitis
SNOMED CT: Irradiation cystitis (11251000); Radiation cystitis (11251000)
 
Monarch Initiative: MONDO:0004112

Definition

Inflammation of the bladder due to irradiation. [from NCI]

Professional guidelines

PubMed

Current management of radiation cystitis: a review and practical guide to clinical management.
Pascoe C, Duncan C, Lamb BW, Davis NF, Lynch TH, Murphy DG, Lawrentschuk N
BJU Int 2019 Apr;123(4):585-594. Epub 2018 Nov 28 doi: 10.1111/bju.14516. PMID: 30113758
Modeling and Treatment of Radiation Cystitis.
Zwaans BM, Chancellor MB, Lamb LE
Urology 2016 Feb;88:14-21. Epub 2015 Nov 10 doi: 10.1016/j.urology.2015.11.001. PMID: 26571081
Management of radiation cystitis.
Smit SG, Heyns CF
Nat Rev Urol 2010 Apr;7(4):206-14. Epub 2010 Mar 9 doi: 10.1038/nrurol.2010.23. PMID: 20212517

Recent clinical studies

Etiology

Advances in the management of radiation-induced cystitis in patients with pelvic malignancies.
Wang Y, Zhu Y, Xu X
Int J Radiat Biol 2023;99(9):1307-1319. Epub 2023 Mar 20 doi: 10.1080/09553002.2023.2181996. PMID: 36940182
Development of a Management Algorithm for Acute and Chronic Radiation Urethritis and Cystitis.
Vanneste BGL, Van Limbergen EJ, Marcelissen TA, van Roermund JGH, Lutgens LC, Arnoldussen CWKP, Lambin P, Oelke M
Urol Int 2022;106(1):63-74. Epub 2021 Jun 15 doi: 10.1159/000515716. PMID: 34130300
Current management of radiation cystitis: a review and practical guide to clinical management.
Pascoe C, Duncan C, Lamb BW, Davis NF, Lynch TH, Murphy DG, Lawrentschuk N
BJU Int 2019 Apr;123(4):585-594. Epub 2018 Nov 28 doi: 10.1111/bju.14516. PMID: 30113758
Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies.
Zwaans BMM, Lamb LE, Bartolone S, Nicolai HE, Chancellor MB, Klaudia SW
Int Urol Nephrol 2018 Oct;50(10):1745-1751. Epub 2018 Aug 21 doi: 10.1007/s11255-018-1970-2. PMID: 30132277Free PMC Article
Salvage radical prostatectomy.
Shekarriz B, Upadhyay J, Pontes JE
Urol Clin North Am 2001 Aug;28(3):545-53. doi: 10.1016/s0094-0143(05)70162-2. PMID: 11590813

Diagnosis

Advances in the management of radiation-induced cystitis in patients with pelvic malignancies.
Wang Y, Zhu Y, Xu X
Int J Radiat Biol 2023;99(9):1307-1319. Epub 2023 Mar 20 doi: 10.1080/09553002.2023.2181996. PMID: 36940182
Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies.
Zwaans BMM, Lamb LE, Bartolone S, Nicolai HE, Chancellor MB, Klaudia SW
Int Urol Nephrol 2018 Oct;50(10):1745-1751. Epub 2018 Aug 21 doi: 10.1007/s11255-018-1970-2. PMID: 30132277Free PMC Article
Urologic Complications Following Pelvic Radiotherapy.
Lobo N, Kulkarni M, Hughes S, Nair R, Khan MS, Thurairaja R
Urology 2018 Dec;122:1-9. Epub 2018 Jul 20 doi: 10.1016/j.urology.2018.07.017. PMID: 30036617
Complicated Genitourinary Tract Infections and Mimics.
Yu M, Robinson K, Siegel C, Menias C
Curr Probl Diagn Radiol 2017 Jan-Feb;46(1):74-83. Epub 2016 Feb 11 doi: 10.1067/j.cpradiol.2016.02.004. PMID: 26995297
Management of radiation cystitis.
Smit SG, Heyns CF
Nat Rev Urol 2010 Apr;7(4):206-14. Epub 2010 Mar 9 doi: 10.1038/nrurol.2010.23. PMID: 20212517

Therapy

Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives.
Helissey C, Cavallero S, Brossard C, Dusaud M, Chargari C, François S
Cells 2020 Dec 24;10(1) doi: 10.3390/cells10010021. PMID: 33374374Free PMC Article
Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies.
Zwaans BMM, Lamb LE, Bartolone S, Nicolai HE, Chancellor MB, Klaudia SW
Int Urol Nephrol 2018 Oct;50(10):1745-1751. Epub 2018 Aug 21 doi: 10.1007/s11255-018-1970-2. PMID: 30132277Free PMC Article
Scoping Review and Meta-analysis of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis.
Cardinal J, Slade A, McFarland M, Keihani S, Hotaling JN, Myers JB
Curr Urol Rep 2018 Apr 13;19(6):38. doi: 10.1007/s11934-018-0790-3. PMID: 29654564
Hemorrhagic radiation cystitis.
Mendenhall WM, Henderson RH, Costa JA, Hoppe BS, Dagan R, Bryant CM, Nichols RC, Williams CR, Harris SE, Mendenhall NP
Am J Clin Oncol 2015 Jun;38(3):331-6. doi: 10.1097/COC.0000000000000016. PMID: 24322335
Management of radiation cystitis.
Smit SG, Heyns CF
Nat Rev Urol 2010 Apr;7(4):206-14. Epub 2010 Mar 9 doi: 10.1038/nrurol.2010.23. PMID: 20212517

Prognosis

Radiation cystitis in acute admissions for haematuria.
Thompson N, Frampton C, Losco G
N Z Med J 2024 Feb 2;137(1589):39-45. doi: 10.26635/6965.6321. PMID: 38301199
Cumulative Incidence and Clinical Risk Factors of Radiation Cystitis after Radiotherapy for Prostate Cancer.
Makino K, Sato Y, Takenaka R, Yamashita H, Akiyama Y, Yamada Y, Nakamura M, Kawai T, Yamada D, Suzuki M, Kume H
Urol Int 2023;107(5):440-446. Epub 2022 Mar 15 doi: 10.1159/000521723. PMID: 35290980Free PMC Article
LATE RADIATION TOXICITY AFTER RADICAL RADIOTHERAPY FOR GENITAL CANCER.
Sukhina OM, Nemaltsova KV, Panov OV
Probl Radiac Med Radiobiol 2020 Dec;25:130-147. doi: 10.33145/2304-8336-2020-25-130-147. PMID: 33361832
Colovaginal fistulas. Etiology and management.
Bahadursingh AM, Longo WE
J Reprod Med 2003 Jul;48(7):489-95. PMID: 12953321
Salvage radical prostatectomy.
Shekarriz B, Upadhyay J, Pontes JE
Urol Clin North Am 2001 Aug;28(3):545-53. doi: 10.1016/s0094-0143(05)70162-2. PMID: 11590813

Clinical prediction guides

Radiation cystitis in acute admissions for haematuria.
Thompson N, Frampton C, Losco G
N Z Med J 2024 Feb 2;137(1589):39-45. doi: 10.26635/6965.6321. PMID: 38301199
Intravesical IR-780 instillation prevents radiation cystitis by protecting urothelial integrity.
Li J, Shen C, Qiu H, Wang J, Yue X, Dai L, Huang Y, Li T, Fang Q, Zhi Y, Shi C, Li W
Neurourol Urodyn 2023 Jan;42(1):40-48. Epub 2022 Oct 8 doi: 10.1002/nau.25056. PMID: 36208109
Cumulative Incidence and Clinical Risk Factors of Radiation Cystitis after Radiotherapy for Prostate Cancer.
Makino K, Sato Y, Takenaka R, Yamashita H, Akiyama Y, Yamada Y, Nakamura M, Kawai T, Yamada D, Suzuki M, Kume H
Urol Int 2023;107(5):440-446. Epub 2022 Mar 15 doi: 10.1159/000521723. PMID: 35290980Free PMC Article
Development of a Management Algorithm for Acute and Chronic Radiation Urethritis and Cystitis.
Vanneste BGL, Van Limbergen EJ, Marcelissen TA, van Roermund JGH, Lutgens LC, Arnoldussen CWKP, Lambin P, Oelke M
Urol Int 2022;106(1):63-74. Epub 2021 Jun 15 doi: 10.1159/000515716. PMID: 34130300
Salvage radical prostatectomy.
Shekarriz B, Upadhyay J, Pontes JE
Urol Clin North Am 2001 Aug;28(3):545-53. doi: 10.1016/s0094-0143(05)70162-2. PMID: 11590813

Recent systematic reviews

Hyperbaric oxygen therapy for late radiation tissue injury.
Lin ZC, Bennett MH, Hawkins GC, Azzopardi CP, Feldmeier J, Smee R, Milross C
Cochrane Database Syst Rev 2023 Aug 15;8(8):CD005005. doi: 10.1002/14651858.CD005005.pub5. PMID: 37585677Free PMC Article
Current management of radiation cystitis after pelvic radiotherapy: a systematic review.
Marchioni M, DE Francesco P, Campi R, Carbonara U, Ferro M, Schips L, Rivas JG, Papalia R, Scarpa RM, Esperto F
Minerva Urol Nephrol 2022 Jun;74(3):281-291. Epub 2021 Oct 29 doi: 10.23736/S2724-6051.21.04539-0. PMID: 34714035
Complications and side effects of high-dose-rate prostate brachytherapy.
Martell K, Kollmeier MA
Brachytherapy 2021 Sep-Oct;20(5):966-975. Epub 2021 Feb 19 doi: 10.1016/j.brachy.2020.10.007. PMID: 33612395
Hyperbaric oxygen therapy for radiation cystitis after pelvic radiotherapy: Systematic review of the recent literature.
Villeirs L, Tailly T, Ost P, Waterloos M, Decaestecker K, Fonteyne V, Van Praet C, Lumen N
Int J Urol 2020 Feb;27(2):98-107. Epub 2019 Oct 15 doi: 10.1111/iju.14130. PMID: 31617263
The role of cystectomy for non-malignant bladder conditions: a review.
Chong JT, Dolat MT, Klausner AP, Dragoescu E, Hampton LJ
Can J Urol 2014 Oct;21(5):7433-41. PMID: 25347367

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