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Thalamic disorder

MedGen UID:
52693
•Concept ID:
C0039726
•
Disease or Syndrome
Synonym: Thalamic disease
 
Monarch Initiative: MONDO:0003081

Definition

A disorder of the thalamus. Causes include brain neoplasms, cerebrovascular disorders, brain trauma, brain hypoxia, infections, and brain hemorrhage. Signs and symptoms include movement and sensory abnormalities, visual abnormalities, ataxia, and coma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThalamic disorder

Professional guidelines

PubMed

Post-stroke Movement Disorders: Clinical Spectrum, Pathogenesis, and Management.
Tater P, Pandey S
Neurol India 2021 Mar-Apr;69(2):272-283. doi: 10.4103/0028-3886.314574. PMID: 33904435
Neuropathic Pain: From Mechanisms to Treatment.
Finnerup NB, Kuner R, Jensen TS
Physiol Rev 2021 Jan 1;101(1):259-301. Epub 2020 Jun 25 doi: 10.1152/physrev.00045.2019. PMID: 32584191
Essential tremor: diagnosis and management.
Shanker V
BMJ 2019 Aug 5;366:l4485. doi: 10.1136/bmj.l4485. PMID: 31383632

Recent clinical studies

Etiology

Biomarkers.
Konwar S, Bocchetta M, Marco M, Venneri A
Alzheimers Dement 2024 Dec;20 Suppl 2(Suppl 2):e092298. doi: 10.1002/alz.092298. PMID: 39785500Free PMC Article
Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway.
Kim JI, Miura Y, Li MY, Revah O, Selvaraj S, Birey F, Meng X, Thete MV, Pavlov SD, Andersen J, Pașca AM, Porteus MH, Huguenard JR, Pașca SP
Neuron 2024 Dec 18;112(24):4048-4059.e7. Epub 2024 Oct 16 doi: 10.1016/j.neuron.2024.09.020. PMID: 39419023
Advanced Quantitative MRI Unveils Microstructural Thalamic Changes Reflecting Disease Progression in Multiple Sclerosis.
Cagol A, Ocampo-Pineda M, Lu PJ, Weigel M, Barakovic M, Melie-Garcia L, Chen X, Lutti A, Calabrese P, Kuhle J, Kappos L, Sormani MP, Granziera C
Neurol Neuroimmunol Neuroinflamm 2024 Nov;11(6):e200299. Epub 2024 Sep 13 doi: 10.1212/NXI.0000000000200299. PMID: 39270143Free PMC Article
Outcomes of Focused Ultrasound Thalamotomy in Tremor Syndromes.
Peters J, Maamary J, Kyle K, Olsen N, Jones L, Bolitho S, Barnett Y, Jonker B, Tisch S
Mov Disord 2024 Jan;39(1):173-182. Epub 2023 Nov 14 doi: 10.1002/mds.29658. PMID: 37964429
Altered thalamic connectivity in insomnia disorder during wakefulness and sleep.
Zou G, Li Y, Liu J, Zhou S, Xu J, Qin L, Shao Y, Yao P, Sun H, Zou Q, Gao JH
Hum Brain Mapp 2021 Jan;42(1):259-270. Epub 2020 Oct 13 doi: 10.1002/hbm.25221. PMID: 33048406Free PMC Article

Diagnosis

Outcomes of Focused Ultrasound Thalamotomy in Tremor Syndromes.
Peters J, Maamary J, Kyle K, Olsen N, Jones L, Bolitho S, Barnett Y, Jonker B, Tisch S
Mov Disord 2024 Jan;39(1):173-182. Epub 2023 Nov 14 doi: 10.1002/mds.29658. PMID: 37964429
Cheiro-Oral syndrome.
Manning S, King BR, Peffer J, Lescure D
Am J Emerg Med 2021 Jan;39:151-153. Epub 2020 Oct 1 doi: 10.1016/j.ajem.2020.09.064. PMID: 33039224
Cheiro-Oral Syndrome.
Thapa L , Amatya R , Maharjan S , Gaurishankar N , Shrestha AM , Bhattarai S , Singh SN , Gongal DN , Devkota UP
Kathmandu Univ Med J (KUMJ) 2018 Apr-Jun;16(62):196-198. PMID: 30636764
Dopamine, fronto-striato-thalamic circuits and risk for psychosis.
Dandash O, Pantelis C, Fornito A
Schizophr Res 2017 Feb;180:48-57. Epub 2016 Aug 29 doi: 10.1016/j.schres.2016.08.020. PMID: 27595552
Vascular syndromes of the thalamus.
Schmahmann JD
Stroke 2003 Sep;34(9):2264-78. Epub 2003 Aug 21 doi: 10.1161/01.STR.0000087786.38997.9E. PMID: 12933968

Therapy

Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results.
Cosgrove GR, Lipsman N, Lozano AM, Chang JW, Halpern C, Ghanouni P, Eisenberg H, Fishman P, Taira T, Schwartz ML, McDannold N, Hayes M, Ro S, Shah B, Gwinn R, Santini VE, Hynynen K, Elias WJ
J Neurosurg 2023 Apr 1;138(4):1028-1033. Epub 2022 Aug 5 doi: 10.3171/2022.6.JNS212483. PMID: 35932269Free PMC Article
Tremor.
Louis ED
Continuum (Minneap Minn) 2019 Aug;25(4):959-975. doi: 10.1212/CON.0000000000000748. PMID: 31356289
Clinical characteristics of autoimmune GFAP astrocytopathy.
Kimura A, Takekoshi A, Yoshikura N, Hayashi Y, Shimohata T
J Neuroimmunol 2019 Jul 15;332:91-98. Epub 2019 Apr 9 doi: 10.1016/j.jneuroim.2019.04.004. PMID: 30991306
Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor.
Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A
Elife 2018 Oct 25;7 doi: 10.7554/eLife.35082. PMID: 30355445Free PMC Article
Surgery for Tourette syndrome.
Ackermans L, Kuhn J, Neuner I, Temel Y, Visser-Vandewalle V
World Neurosurg 2013 Sep-Oct;80(3-4):S29.e15-22. Epub 2012 Jun 19 doi: 10.1016/j.wneu.2012.06.017. PMID: 22722039

Prognosis

Outcomes of Focused Ultrasound Thalamotomy in Tremor Syndromes.
Peters J, Maamary J, Kyle K, Olsen N, Jones L, Bolitho S, Barnett Y, Jonker B, Tisch S
Mov Disord 2024 Jan;39(1):173-182. Epub 2023 Nov 14 doi: 10.1002/mds.29658. PMID: 37964429
Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results.
Cosgrove GR, Lipsman N, Lozano AM, Chang JW, Halpern C, Ghanouni P, Eisenberg H, Fishman P, Taira T, Schwartz ML, McDannold N, Hayes M, Ro S, Shah B, Gwinn R, Santini VE, Hynynen K, Elias WJ
J Neurosurg 2023 Apr 1;138(4):1028-1033. Epub 2022 Aug 5 doi: 10.3171/2022.6.JNS212483. PMID: 35932269Free PMC Article
Towards network-guided neuromodulation for epilepsy.
Piper RJ, Richardson RM, Worrell G, Carmichael DW, Baldeweg T, Litt B, Denison T, Tisdall MM
Brain 2022 Oct 21;145(10):3347-3362. doi: 10.1093/brain/awac234. PMID: 35771657Free PMC Article
Functional anatomy of thalamus and basal ganglia.
Herrero MT, Barcia C, Navarro JM
Childs Nerv Syst 2002 Aug;18(8):386-404. Epub 2002 Jul 26 doi: 10.1007/s00381-002-0604-1. PMID: 12192499
Thalamotomy.
Tasker RR
Neurosurg Clin N Am 1990 Oct;1(4):841-64. PMID: 2136173

Clinical prediction guides

Biomarkers.
Konwar S, Bocchetta M, Marco M, Venneri A
Alzheimers Dement 2024 Dec;20 Suppl 2(Suppl 2):e092298. doi: 10.1002/alz.092298. PMID: 39785500Free PMC Article
Outcomes of Focused Ultrasound Thalamotomy in Tremor Syndromes.
Peters J, Maamary J, Kyle K, Olsen N, Jones L, Bolitho S, Barnett Y, Jonker B, Tisch S
Mov Disord 2024 Jan;39(1):173-182. Epub 2023 Nov 14 doi: 10.1002/mds.29658. PMID: 37964429
Deep posteromedial cortical rhythm in dissociation.
Vesuna S, Kauvar IV, Richman E, Gore F, Oskotsky T, Sava-Segal C, Luo L, Malenka RC, Henderson JM, Nuyujukian P, Parvizi J, Deisseroth K
Nature 2020 Oct;586(7827):87-94. Epub 2020 Sep 16 doi: 10.1038/s41586-020-2731-9. PMID: 32939091Free PMC Article
Functional anatomy of thalamus and basal ganglia.
Herrero MT, Barcia C, Navarro JM
Childs Nerv Syst 2002 Aug;18(8):386-404. Epub 2002 Jul 26 doi: 10.1007/s00381-002-0604-1. PMID: 12192499
The thalamus and insomnia.
Lugaresi E
Neurology 1992 Jul;42(7 Suppl 6):28-33. PMID: 1630636

Recent systematic reviews

Towards the neurobiology of insomnia: A systematic review of neuroimaging studies.
Aquino G, Benz F, Dressle RJ, Gemignani A, Alfì G, Palagini L, Spiegelhalder K, Riemann D, Feige B
Sleep Med Rev 2024 Feb;73:101878. Epub 2023 Nov 25 doi: 10.1016/j.smrv.2023.101878. PMID: 38056381
Neuroimaging of Anxiety in Parkinson's Disease: A Systematic Review.
Carey G, Görmezoğlu M, de Jong JJA, Hofman PAM, Backes WH, Dujardin K, Leentjens AFG
Mov Disord 2021 Feb;36(2):327-339. Epub 2020 Dec 2 doi: 10.1002/mds.28404. PMID: 33289195Free PMC Article
Comparative meta-analyses of brain structural and functional abnormalities during cognitive control in attention-deficit/hyperactivity disorder and autism spectrum disorder.
Lukito S, Norman L, Carlisi C, Radua J, Hart H, Simonoff E, Rubia K
Psychol Med 2020 Apr;50(6):894-919. Epub 2020 Mar 27 doi: 10.1017/S0033291720000574. PMID: 32216846Free PMC Article
Dystonia.
Snaith A, Wade D
BMJ Clin Evid 2011 Jun 13;2011 PMID: 21663705Free PMC Article
Parkinson's disease.
Clarke CE, Moore AP
BMJ Clin Evid 2007 Aug 1;2007 PMID: 19454106Free PMC Article

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