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Gastrointestinal ulcer

MedGen UID:
536742
•Concept ID:
C0237938
•
Disease or Syndrome
Synonym: Gastrointestinal ulcers
SNOMED CT: Gastrointestinal ulcer (40845000)
 
HPO: HP:0034274

Definition

A deep defect in the esophageal, gastric, duodenal or intestinal wall involving the entire mucosal thickness and penetrating through the muscularis mucosae. [from HPO]

Professional guidelines

PubMed

Effects of high-dose versus low-dose proton pump inhibitors for treatment of gastrointestinal ulcer bleeding: a meta-analysis of randomized controlled trials.
Zhu W, Chen L, Zhang J, Wang P
J Int Med Res 2022 Apr;50(4):3000605211067396. doi: 10.1177/03000605211067396. PMID: 35414289Free PMC Article
Recognition and management of polymyalgia rheumatica and giant cell arteritis.
Caylor TL, Perkins A
Am Fam Physician 2013 Nov 15;88(10):676-84. PMID: 24364483
Evaluation of patterns and appropriate gastro protection in Albanian primary health care users.
Kellici S, Dibra A, Dracini XH, Deda L, Fida M, Burazeri G
J Biol Regul Homeost Agents 2013 Jan-Mar;27(1):247-51. PMID: 23489704

Recent clinical studies

Etiology

Prescribing PPIs.
Drug Ther Bull 2017 Oct;55(10):117-120. doi: 10.1136/dtb.2017.10.0541. PMID: 29021249
Prevention of Upper Gastrointestinal Ulcer and Complications in Low-Dose Aspirin Users.
Sugano K
Curr Pharm Des 2015;21(35):5082-8. doi: 10.2174/1381612821666150915105834. PMID: 26369684
How do we manage serious gastrointestinal adverse events associated with anti-thrombotic therapy?
Sugano K
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):5-8. Epub 2014 Aug 6 doi: 10.1586/17474124.2014.945913. PMID: 25096360
Drug interaction between clopidogrel and proton pump inhibitors.
Khalique SC, Cheng-Lai A
Cardiol Rev 2009 Jul-Aug;17(4):198-200. doi: 10.1097/CRD.0b013e3181a857ba. PMID: 19525682
NSAIDs and gastrointestinal complications: new clinical challenges.
Abraham NS, Graham DY
Expert Opin Pharmacother 2005 Dec;6(15):2681-9. doi: 10.1517/14656566.6.15.2681. PMID: 16316306

Diagnosis

Oxidative Stress in Gastrointestinal Ulcer Disease: A Gastroenterologist's View.
Popovic D, Stojanovic M, Milosavljevic T, Stojkovic-Lalosevic M, Glisic T, Savic P, Filipovic B
J Gastrointestin Liver Dis 2023 Sep 28;32(3):277-282. doi: 10.15403/jgld-5172. PMID: 37774208
Computer-Aided Diagnosis of Gastrointestinal Ulcer and Hemorrhage Using Wireless Capsule Endoscopy: Systematic Review and Diagnostic Test Accuracy Meta-analysis.
Bang CS, Lee JJ, Baik GH
J Med Internet Res 2021 Dec 14;23(12):e33267. doi: 10.2196/33267. PMID: 34904949Free PMC Article
Headache in transient ischemic attacks.
Lebedeva ER, Gurary NM, Olesen J
J Headache Pain 2018 Jul 27;19(1):60. doi: 10.1186/s10194-018-0888-5. PMID: 30054753Free PMC Article
Vitamin D levels in systemic sclerosis patients: a meta-analysis.
An L, Sun MH, Chen F, Li JR
Drug Des Devel Ther 2017;11:3119-3125. Epub 2017 Oct 27 doi: 10.2147/DDDT.S144860. PMID: 29138534Free PMC Article
How do we manage serious gastrointestinal adverse events associated with anti-thrombotic therapy?
Sugano K
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):5-8. Epub 2014 Aug 6 doi: 10.1586/17474124.2014.945913. PMID: 25096360

Therapy

Prescribing PPIs.
Drug Ther Bull 2017 Oct;55(10):117-120. doi: 10.1136/dtb.2017.10.0541. PMID: 29021249
Prevention of Upper Gastrointestinal Ulcer and Complications in Low-Dose Aspirin Users.
Sugano K
Curr Pharm Des 2015;21(35):5082-8. doi: 10.2174/1381612821666150915105834. PMID: 26369684
Esomeprazole and aspirin fixed combination for the prevention of cardiovascular events.
Sylvester KW, Cheng JW, Mehra MR
Vasc Health Risk Manag 2013;9:245-54. Epub 2013 May 16 doi: 10.2147/VHRM.S44265. PMID: 23696706Free PMC Article
NSAIDs and gastrointestinal complications: new clinical challenges.
Abraham NS, Graham DY
Expert Opin Pharmacother 2005 Dec;6(15):2681-9. doi: 10.1517/14656566.6.15.2681. PMID: 16316306
Lumiracoxib.
Lyseng-Williamson KA, Curran MP
Drugs 2004;64(19):2237-46; discussion 2247-8. doi: 10.2165/00003495-200464190-00008. PMID: 15456339

Prognosis

Network Analysis and Nomogram in the Novel Classification and Prognosis Prediction of Advanced Schistosomiasis Japonica.
Liu XF, Li Y, Ju S, Zhou YL, Qiang JW
Am J Trop Med Hyg 2023 Mar 1;108(3):569-577. Epub 2023 Jan 23 doi: 10.4269/ajtmh.22-0267. PMID: 36689944Free PMC Article
Computer-Aided Diagnosis of Gastrointestinal Ulcer and Hemorrhage Using Wireless Capsule Endoscopy: Systematic Review and Diagnostic Test Accuracy Meta-analysis.
Bang CS, Lee JJ, Baik GH
J Med Internet Res 2021 Dec 14;23(12):e33267. doi: 10.2196/33267. PMID: 34904949Free PMC Article
How do we manage serious gastrointestinal adverse events associated with anti-thrombotic therapy?
Sugano K
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):5-8. Epub 2014 Aug 6 doi: 10.1586/17474124.2014.945913. PMID: 25096360
Recognition and management of polymyalgia rheumatica and giant cell arteritis.
Caylor TL, Perkins A
Am Fam Physician 2013 Nov 15;88(10):676-84. PMID: 24364483
Visual loss as a complication of nonophthalmologic surgery: a review of the literature.
Rupp-Montpetit K, Moody ML
AANA J 2004 Aug;72(4):285-92. PMID: 15354918

Clinical prediction guides

Network Analysis and Nomogram in the Novel Classification and Prognosis Prediction of Advanced Schistosomiasis Japonica.
Liu XF, Li Y, Ju S, Zhou YL, Qiang JW
Am J Trop Med Hyg 2023 Mar 1;108(3):569-577. Epub 2023 Jan 23 doi: 10.4269/ajtmh.22-0267. PMID: 36689944Free PMC Article
Computer-Aided Diagnosis of Gastrointestinal Ulcer and Hemorrhage Using Wireless Capsule Endoscopy: Systematic Review and Diagnostic Test Accuracy Meta-analysis.
Bang CS, Lee JJ, Baik GH
J Med Internet Res 2021 Dec 14;23(12):e33267. doi: 10.2196/33267. PMID: 34904949Free PMC Article
Headache in transient ischemic attacks.
Lebedeva ER, Gurary NM, Olesen J
J Headache Pain 2018 Jul 27;19(1):60. doi: 10.1186/s10194-018-0888-5. PMID: 30054753Free PMC Article
Vitamin D levels in systemic sclerosis patients: a meta-analysis.
An L, Sun MH, Chen F, Li JR
Drug Des Devel Ther 2017;11:3119-3125. Epub 2017 Oct 27 doi: 10.2147/DDDT.S144860. PMID: 29138534Free PMC Article
Evidence for endoscopic ulcers as meaningful surrogate endpoint for clinically significant upper gastrointestinal harm.
Moore A, Bjarnason I, Cryer B, Garcia-Rodriguez L, Goldkind L, Lanas A, Simon L
Clin Gastroenterol Hepatol 2009 Nov;7(11):1156-63. Epub 2009 Apr 9 doi: 10.1016/j.cgh.2009.03.032. PMID: 19362611

Recent systematic reviews

Computer-Aided Diagnosis of Gastrointestinal Ulcer and Hemorrhage Using Wireless Capsule Endoscopy: Systematic Review and Diagnostic Test Accuracy Meta-analysis.
Bang CS, Lee JJ, Baik GH
J Med Internet Res 2021 Dec 14;23(12):e33267. doi: 10.2196/33267. PMID: 34904949Free PMC Article
Modulation of the pharmacokinetics, therapeutic and adverse effects of NSAIDs by Chinese herbal medicines.
Fong SY, Efferth TH, Zuo Z
Expert Opin Drug Metab Toxicol 2014 Dec;10(12):1711-39. Epub 2014 Oct 11 doi: 10.1517/17425255.2014.970167. PMID: 25307559
Analgesics for pain after traumatic or orthopaedic surgery: what is the evidence--a systematic review.
Montané E, Vallano A, Aguilera C, Vidal X, Laporte JR
Eur J Clin Pharmacol 2006 Nov;62(11):971-88. Epub 2006 Sep 21 doi: 10.1007/s00228-006-0185-0. PMID: 17019588
Incidence of serious upper gastrointestinal bleeding/perforation in the general population: review of epidemiologic studies.
Hernández-Díaz S, Rodríguez LA
J Clin Epidemiol 2002 Feb;55(2):157-63. doi: 10.1016/s0895-4356(01)00461-9. PMID: 11809354

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