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Kidney Transplant Rejection

MedGen UID:
536781
•Concept ID:
C0238217
•
Pathologic Function
Synonyms: Acute Allograft Nephropathy; Renal transplant rejection
SNOMED CT: Renal transplant rejection (236570004)

Definition

A sudden immune response occurring after transplantation, directed against donor kidney alloantigens. [from NCI]

Professional guidelines

PubMed

Investigational drugs for the treatment of kidney transplant rejection.
van Vugt LK, Schagen MR, de Weerd A, Reinders ME, de Winter BC, Hesselink DA
Expert Opin Investig Drugs 2022 Oct;31(10):1087-1100. Epub 2022 Oct 7 doi: 10.1080/13543784.2022.2130751. PMID: 36175360
Maintenance immunosuppressants in the management of antibody-mediated renal allograft rejection: which regimen is best?
Zhou Y, Li X, Liu Y, Sun Q
Immunotherapy 2017 Jan;9(1):47-55. doi: 10.2217/imt-2016-0096. PMID: 28000532
Mechanisms and risk assessment of steroid resistance in acute kidney transplant rejection.
Rekers NV, de Fijter JW, Claas FH, Eikmans M
Transpl Immunol 2016 Sep;38:3-14. Epub 2016 Jul 29 doi: 10.1016/j.trim.2016.07.005. PMID: 27480047

Recent clinical studies

Etiology

Alloimmune Risk Stratification for Kidney Transplant Rejection.
Bestard O, Thaunat O, Bellini MI, Böhmig GA, Budde K, Claas F, Couzi L, Furian L, Heemann U, Mamode N, Oberbauer R, Pengel L, Schneeberger S, Naesens M
Transpl Int 2022;35:10138. Epub 2022 May 20 doi: 10.3389/ti.2022.10138. PMID: 35669972Free PMC Article
Thirty years of the International Banff Classification for Allograft Pathology: the past, present, and future of kidney transplant diagnostics.
Loupy A, Mengel M, Haas M
Kidney Int 2022 Apr;101(4):678-691. Epub 2021 Dec 17 doi: 10.1016/j.kint.2021.11.028. PMID: 34922989
Allorecognition and the spectrum of kidney transplant rejection.
Callemeyn J, Lamarthée B, Koenig A, Koshy P, Thaunat O, Naesens M
Kidney Int 2022 Apr;101(4):692-710. Epub 2021 Dec 13 doi: 10.1016/j.kint.2021.11.029. PMID: 34915041
Incidence, risk factors, treatment, and consequences of antibody-mediated kidney transplant rejection: A systematic review.
Hart A, Singh D, Brown SJ, Wang JH, Kasiske BL
Clin Transplant 2021 Jul;35(7):e14320. Epub 2021 May 5 doi: 10.1111/ctr.14320. PMID: 33864724
Advances in pharmacotherapy to treat kidney transplant rejection.
Bamoulid J, Staeck O, Halleck F, Dürr M, Paliege A, Lachmann N, Brakemeier S, Liefeldt L, Budde K
Expert Opin Pharmacother 2015;16(11):1627-48. doi: 10.1517/14656566.2015.1056734. PMID: 26159444

Diagnosis

Neutrophil gelatinase-associated lipocalin (NGAL) in kidney injury - A systematic review.
Marakala V
Clin Chim Acta 2022 Nov 1;536:135-141. Epub 2022 Sep 21 doi: 10.1016/j.cca.2022.08.029. PMID: 36150522
Thirty years of the International Banff Classification for Allograft Pathology: the past, present, and future of kidney transplant diagnostics.
Loupy A, Mengel M, Haas M
Kidney Int 2022 Apr;101(4):678-691. Epub 2021 Dec 17 doi: 10.1016/j.kint.2021.11.028. PMID: 34922989
Allorecognition and the spectrum of kidney transplant rejection.
Callemeyn J, Lamarthée B, Koenig A, Koshy P, Thaunat O, Naesens M
Kidney Int 2022 Apr;101(4):692-710. Epub 2021 Dec 13 doi: 10.1016/j.kint.2021.11.029. PMID: 34915041
Tackling Chronic Kidney Transplant Rejection: Challenges and Promises.
Lai X, Zheng X, Mathew JM, Gallon L, Leventhal JR, Zhang ZJ
Front Immunol 2021;12:661643. Epub 2021 May 20 doi: 10.3389/fimmu.2021.661643. PMID: 34093552Free PMC Article
Mechanisms and risk assessment of steroid resistance in acute kidney transplant rejection.
Rekers NV, de Fijter JW, Claas FH, Eikmans M
Transpl Immunol 2016 Sep;38:3-14. Epub 2016 Jul 29 doi: 10.1016/j.trim.2016.07.005. PMID: 27480047

Therapy

Allorecognition and the spectrum of kidney transplant rejection.
Callemeyn J, Lamarthée B, Koenig A, Koshy P, Thaunat O, Naesens M
Kidney Int 2022 Apr;101(4):692-710. Epub 2021 Dec 13 doi: 10.1016/j.kint.2021.11.029. PMID: 34915041
Tackling Chronic Kidney Transplant Rejection: Challenges and Promises.
Lai X, Zheng X, Mathew JM, Gallon L, Leventhal JR, Zhang ZJ
Front Immunol 2021;12:661643. Epub 2021 May 20 doi: 10.3389/fimmu.2021.661643. PMID: 34093552Free PMC Article
Incidence, risk factors, treatment, and consequences of antibody-mediated kidney transplant rejection: A systematic review.
Hart A, Singh D, Brown SJ, Wang JH, Kasiske BL
Clin Transplant 2021 Jul;35(7):e14320. Epub 2021 May 5 doi: 10.1111/ctr.14320. PMID: 33864724
Monoclonal Antibodies: A Review.
Singh S, Kumar NK, Dwiwedi P, Charan J, Kaur R, Sidhu P, Chugh VK
Curr Clin Pharmacol 2018;13(2):85-99. doi: 10.2174/1574884712666170809124728. PMID: 28799485
Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids.
Czock D, Keller F, Rasche FM, Häussler U
Clin Pharmacokinet 2005;44(1):61-98. doi: 10.2165/00003088-200544010-00003. PMID: 15634032

Prognosis

Neutrophil gelatinase-associated lipocalin (NGAL) in kidney injury - A systematic review.
Marakala V
Clin Chim Acta 2022 Nov 1;536:135-141. Epub 2022 Sep 21 doi: 10.1016/j.cca.2022.08.029. PMID: 36150522
Allorecognition and the spectrum of kidney transplant rejection.
Callemeyn J, Lamarthée B, Koenig A, Koshy P, Thaunat O, Naesens M
Kidney Int 2022 Apr;101(4):692-710. Epub 2021 Dec 13 doi: 10.1016/j.kint.2021.11.029. PMID: 34915041
Incidence, risk factors, treatment, and consequences of antibody-mediated kidney transplant rejection: A systematic review.
Hart A, Singh D, Brown SJ, Wang JH, Kasiske BL
Clin Transplant 2021 Jul;35(7):e14320. Epub 2021 May 5 doi: 10.1111/ctr.14320. PMID: 33864724
Activity-based Protein Profiling Approaches for Transplantation.
Navarrete M, Wilkins JA, Lao Y, Rush DN, Nickerson PW, Ho J
Transplantation 2019 Sep;103(9):1790-1798. doi: 10.1097/TP.0000000000002752. PMID: 30985576
Advances in pharmacotherapy to treat kidney transplant rejection.
Bamoulid J, Staeck O, Halleck F, Dürr M, Paliege A, Lachmann N, Brakemeier S, Liefeldt L, Budde K
Expert Opin Pharmacother 2015;16(11):1627-48. doi: 10.1517/14656566.2015.1056734. PMID: 26159444

Clinical prediction guides

Neutrophil gelatinase-associated lipocalin (NGAL) in kidney injury - A systematic review.
Marakala V
Clin Chim Acta 2022 Nov 1;536:135-141. Epub 2022 Sep 21 doi: 10.1016/j.cca.2022.08.029. PMID: 36150522
Allorecognition and the spectrum of kidney transplant rejection.
Callemeyn J, Lamarthée B, Koenig A, Koshy P, Thaunat O, Naesens M
Kidney Int 2022 Apr;101(4):692-710. Epub 2021 Dec 13 doi: 10.1016/j.kint.2021.11.029. PMID: 34915041
A Randomized Clinical Trial of Anti-IL-6 Antibody Clazakizumab in Late Antibody-Mediated Kidney Transplant Rejection.
Doberer K, Duerr M, Halloran PF, Eskandary F, Budde K, Regele H, Reeve J, Borski A, Kozakowski N, Reindl-Schwaighofer R, Waiser J, Lachmann N, Schranz S, Firbas C, Mühlbacher J, Gelbenegger G, Perkmann T, Wahrmann M, Kainz A, Ristl R, Halleck F, Bond G, Chong E, Jilma B, Böhmig GA
J Am Soc Nephrol 2021 Mar;32(3):708-722. Epub 2020 Dec 18 doi: 10.1681/ASN.2020071106. PMID: 33443079Free PMC Article
Activity-based Protein Profiling Approaches for Transplantation.
Navarrete M, Wilkins JA, Lao Y, Rush DN, Nickerson PW, Ho J
Transplantation 2019 Sep;103(9):1790-1798. doi: 10.1097/TP.0000000000002752. PMID: 30985576
Mechanisms and risk assessment of steroid resistance in acute kidney transplant rejection.
Rekers NV, de Fijter JW, Claas FH, Eikmans M
Transpl Immunol 2016 Sep;38:3-14. Epub 2016 Jul 29 doi: 10.1016/j.trim.2016.07.005. PMID: 27480047

Recent systematic reviews

Donor-derived cell-free DNA as a diagnostic marker for kidney-allograft rejection: A systematic review and meta-analysis.
Xing Y, Guo Q, Wang C, Shi H, Zheng J, Jia Y, Li C, Hao C
Biomol Biomed 2024 Feb 20;24(4):731-740. doi: 10.17305/bb.2024.10049. PMID: 38386614Free PMC Article
Neutrophil gelatinase-associated lipocalin (NGAL) in kidney injury - A systematic review.
Marakala V
Clin Chim Acta 2022 Nov 1;536:135-141. Epub 2022 Sep 21 doi: 10.1016/j.cca.2022.08.029. PMID: 36150522
Incidence, risk factors, treatment, and consequences of antibody-mediated kidney transplant rejection: A systematic review.
Hart A, Singh D, Brown SJ, Wang JH, Kasiske BL
Clin Transplant 2021 Jul;35(7):e14320. Epub 2021 May 5 doi: 10.1111/ctr.14320. PMID: 33864724
Transplant rejections associated with immune checkpoint inhibitors: A pharmacovigilance study and systematic literature review.
Nguyen LS, Ortuno S, Lebrun-Vignes B, Johnson DB, Moslehi JJ, Hertig A, Salem JE
Eur J Cancer 2021 May;148:36-47. Epub 2021 Mar 12 doi: 10.1016/j.ejca.2021.01.038. PMID: 33721705
Plasmapheresis Therapy in Kidney Transplant Rejection.
Xie P, Tao M, Peng K, Zhao H, Zhang K, Sheng Y, Ankawi G, Ronco C
Blood Purif 2019;47(1-3):73-84. Epub 2018 Sep 25 doi: 10.1159/000493521. PMID: 30253400

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