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Vaginal adenosis

MedGen UID:
541820
•Concept ID:
C0269214
•
Disease or Syndrome
Synonym: Vaginal Adenosis
SNOMED CT: Vaginal adenosis (37956000)
 
HPO: HP:0025485

Definition

Vaginal adenosis is defined by the presence of metaplastic cervical or endometrial epithelium within the vaginal wall, thought to be derived from persistent Müllerian (synonymous with paramesonephric) epithelium islets in postembryonic life. [from HPO]

Professional guidelines

PubMed

Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Value of screening procedures for the detection of vaginal adenosis.
Gunning JE, Ostegard DR
Obstet Gynecol 1976 Mar;47(3):268-71. PMID: 55991
Colposcopic aspects of management of vaginal adenosis in DES children.
Scott JW, Seckinger D, Puente-Duany W
J Reprod Med 1974 May;12(5):187-93. PMID: 4838312

Recent clinical studies

Etiology

Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden: A retrospective study.
Han T, Jin Y, Li Y, Bi Y, Pan L
Medicine (Baltimore) 2018 Dec;97(49):e13470. doi: 10.1097/MD.0000000000013470. PMID: 30544435Free PMC Article
Vulval and vaginal adenosis.
Kranl C, Zelger B, Kofler H, Heim K, Sepp N, Fritsch P
Br J Dermatol 1998 Jul;139(1):128-31. doi: 10.1046/j.1365-2133.1998.02329.x. PMID: 9764164
Teratogen update: carcinogenesis and teratogenesis associated with exposure to diethylstilbestrol (DES) in utero.
Mittendorf R
Teratology 1995 Jun;51(6):435-45. doi: 10.1002/tera.1420510609. PMID: 7502243
The current status of the DES-exposed population.
Herbst AL
Obstet Gynecol Annu 1981;10:267-78. PMID: 7024873
The DES story.
Gunning JE
Obstet Gynecol Surv 1976 Nov;31(11):827-33. doi: 10.1097/00006254-197611000-00026. PMID: 980278

Diagnosis

Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden: A retrospective study.
Han T, Jin Y, Li Y, Bi Y, Pan L
Medicine (Baltimore) 2018 Dec;97(49):e13470. doi: 10.1097/MD.0000000000013470. PMID: 30544435Free PMC Article
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
The development of cervical and vaginal adenosis as a result of diethylstilbestrol exposure in utero.
Laronda MM, Unno K, Butler LM, Kurita T
Differentiation 2012 Oct;84(3):252-60. Epub 2012 Jun 6 doi: 10.1016/j.diff.2012.05.004. PMID: 22682699Free PMC Article
The DES story.
Gunning JE
Obstet Gynecol Surv 1976 Nov;31(11):827-33. doi: 10.1097/00006254-197611000-00026. PMID: 980278
Vaginal adenosis and other diethylstilbestrol-related abnormalities.
Herbst AL, Scully RE, Robboy SJ
Clin Obstet Gynecol 1975 Sep;18(3):185-94. doi: 10.1097/00003081-197509000-00021. PMID: 1157359

Therapy

Malignant transformation of vaginal adenosis to clear cell carcinoma without prenatal diethylstilbestrol exposure: a case report and literature review.
Pang L, Li L, Zhu L, Lang J, Bi Y
BMC Cancer 2019 Aug 13;19(1):798. doi: 10.1186/s12885-019-6026-1. PMID: 31409310Free PMC Article
The development of cervical and vaginal adenosis as a result of diethylstilbestrol exposure in utero.
Laronda MM, Unno K, Butler LM, Kurita T
Differentiation 2012 Oct;84(3):252-60. Epub 2012 Jun 6 doi: 10.1016/j.diff.2012.05.004. PMID: 22682699Free PMC Article
Non diethylstilbesterol induced vaginal adenosis--a case series and review of literature.
Chattopadhyay I, Cruickshan DJ, Packer M
Eur J Gynaecol Oncol 2001;22(4):260-2. PMID: 11695804
The DES story.
Gunning JE
Obstet Gynecol Surv 1976 Nov;31(11):827-33. doi: 10.1097/00006254-197611000-00026. PMID: 980278
Vaginal adenosis and other diethylstilbestrol-related abnormalities.
Herbst AL, Scully RE, Robboy SJ
Clin Obstet Gynecol 1975 Sep;18(3):185-94. doi: 10.1097/00003081-197509000-00021. PMID: 1157359

Prognosis

Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report.
Egger EK, Ralser DJ, Lindner K, Recker F, Marinova M, Savchenko O, Lau JF, Mustea A
Front Immunol 2021;12:686879. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.686879. PMID: 34367146Free PMC Article
Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden: A retrospective study.
Han T, Jin Y, Li Y, Bi Y, Pan L
Medicine (Baltimore) 2018 Dec;97(49):e13470. doi: 10.1097/MD.0000000000013470. PMID: 30544435Free PMC Article
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Primary vaginal adenocarcinoma arising in vaginal adenosis after CO2 laser vaporization and 5-fluorouracil therapy.
Paczos TA, Ackers S, Odunsi K, Lele S, Mhawech-Fauceglia P
Int J Gynecol Pathol 2010 Mar;29(2):193-6. doi: 10.1097/PGP.0b013e3181b6a7d7. PMID: 20173507Free PMC Article
Vaginal adenosis and diethylstilboestrol.
Emens M
Br J Hosp Med 1984 Jan;31(1):42-8. PMID: 6697040

Clinical prediction guides

Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report.
Egger EK, Ralser DJ, Lindner K, Recker F, Marinova M, Savchenko O, Lau JF, Mustea A
Front Immunol 2021;12:686879. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.686879. PMID: 34367146Free PMC Article
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Incidental vaginal müllerianosis.
Val-Bernal JF, Mayorga M
Pathol Res Pract 2016 Jun;212(6):568-72. Epub 2016 Feb 26 doi: 10.1016/j.prp.2016.02.023. PMID: 26970930
The current status of the DES-exposed population.
Herbst AL
Obstet Gynecol Annu 1981;10:267-78. PMID: 7024873
Clinical diagnosis of vaginal adenosis.
Stafl A, Mattingly RF, Foley DV, Fetherston WC
Obstet Gynecol 1974 Jan;43(1):118-28. PMID: 4808952

Recent systematic reviews

The developmental origin of cervical and vaginal epithelium and their clinical consequences: a systematic review.
Reich O, Fritsch H
J Low Genit Tract Dis 2014 Oct;18(4):358-60. doi: 10.1097/LGT.0000000000000023. PMID: 24977630

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