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Amnion nodosum

MedGen UID:
542308
•Concept ID:
C0269802
•
Disease or Syndrome
Synonym: Amnion Nodosum
SNOMED CT: Amnion nodosum (71473008)

Definition

An amnion with nodular deposits of squamous and cellular debris with varying staging of re-epithelialization. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmnion nodosum

Recent clinical studies

Etiology

Patterns of placental injury in various types of fetal congenital heart disease.
Stanek J
J Perinat Med 2023 Jun 27;51(5):704-711. Epub 2022 Dec 28 doi: 10.1515/jpm-2022-0478. PMID: 36573345
Placental examination in nonmacerated stillbirth versus neonatal mortality.
Stanek J
J Perinat Med 2018 Apr 25;46(3):323-331. doi: 10.1515/jpm-2017-0198. PMID: 28915123
Association of coexisting morphological umbilical cord abnormality and clinical cord compromise with hypoxic and thrombotic placental histology.
Stanek J
Virchows Arch 2016 Jun;468(6):723-32. Epub 2016 Mar 16 doi: 10.1007/s00428-016-1921-1. PMID: 26983702
Amnion nodosum revisited: clinicopathologic and placental correlations.
Adeniran AJ, Stanek J
Arch Pathol Lab Med 2007 Dec;131(12):1829-33. doi: 10.5858/2007-131-1829-ANRCAP. PMID: 18081444
Microscopic chorionic pseudocysts in placental membranes: a histologic lesion of in utero hypoxia.
Stanek J, Weng E
Pediatr Dev Pathol 2007 May-Jun;10(3):192-8. doi: 10.2350/06-06-0110.1. PMID: 17535086

Diagnosis

Association of coexisting morphological umbilical cord abnormality and clinical cord compromise with hypoxic and thrombotic placental histology.
Stanek J
Virchows Arch 2016 Jun;468(6):723-32. Epub 2016 Mar 16 doi: 10.1007/s00428-016-1921-1. PMID: 26983702
Pleura nodosum: fetal squamous debris in an unusual location.
Kocovski L, Stein N, Arredondo J
Pediatr Dev Pathol 2015 Mar-Apr;18(2):159-63. Epub 2014 Dec 23 doi: 10.2350/14-11-1567-CR.1. PMID: 25535921
Monozygotic twins discordant for urinary tract anomalies and presenting as hydramnios.
Johnstone H, Benirschke K
Obstet Gynecol 1976 May;47(5):610-4. PMID: 772508

Therapy

Pleura nodosum: fetal squamous debris in an unusual location.
Kocovski L, Stein N, Arredondo J
Pediatr Dev Pathol 2015 Mar-Apr;18(2):159-63. Epub 2014 Dec 23 doi: 10.2350/14-11-1567-CR.1. PMID: 25535921

Prognosis

Placental examination in nonmacerated stillbirth versus neonatal mortality.
Stanek J
J Perinat Med 2018 Apr 25;46(3):323-331. doi: 10.1515/jpm-2017-0198. PMID: 28915123
Pleura nodosum: fetal squamous debris in an unusual location.
Kocovski L, Stein N, Arredondo J
Pediatr Dev Pathol 2015 Mar-Apr;18(2):159-63. Epub 2014 Dec 23 doi: 10.2350/14-11-1567-CR.1. PMID: 25535921

Clinical prediction guides

Pleura nodosum: fetal squamous debris in an unusual location.
Kocovski L, Stein N, Arredondo J
Pediatr Dev Pathol 2015 Mar-Apr;18(2):159-63. Epub 2014 Dec 23 doi: 10.2350/14-11-1567-CR.1. PMID: 25535921
Microscopic chorionic pseudocysts in placental membranes: a histologic lesion of in utero hypoxia.
Stanek J, Weng E
Pediatr Dev Pathol 2007 May-Jun;10(3):192-8. doi: 10.2350/06-06-0110.1. PMID: 17535086
Newborn infant with del(9)(pter----q32:) and multiple congenital anomalies including arrhinencephaly, cardiac malformations, and rudimentary ears.
Kargas SA, Kargas GA, Chandra S, Wu SQ, Meisner LF
Am J Med Genet Suppl 1987;3:161-6. doi: 10.1002/ajmg.1320280520. PMID: 3130851

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