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Blood coagulation disorder due to liver disease

MedGen UID:
543936
•Concept ID:
C0272271
•
Disease or Syndrome
Synonym: Coagulation defects due to liver disease
SNOMED CT: Blood coagulation disorder due to liver disease (69500007)

Definition

A disorder of blood clotting that is attributable to a deficiency in liver function. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBlood coagulation disorder due to liver disease

Professional guidelines

PubMed

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.
Sarin SK, Choudhury A, Sharma MK, Maiwall R, Al Mahtab M, Rahman S, Saigal S, Saraf N, Soin AS, Devarbhavi H, Kim DJ, Dhiman RK, Duseja A, Taneja S, Eapen CE, Goel A, Ning Q, Chen T, Ma K, Duan Z, Yu C, Treeprasertsuk S, Hamid SS, Butt AS, Jafri W, Shukla A, Saraswat V, Tan SS, Sood A, Midha V, Goyal O, Ghazinyan H, Arora A, Hu J, Sahu M, Rao PN, Lee GH, Lim SG, Lesmana LA, Lesmana CR, Shah S, Prasad VGM, Payawal DA, Abbas Z, Dokmeci AK, Sollano JD, Carpio G, Shresta A, Lau GK, Fazal Karim M, Shiha G, Gani R, Kalista KF, Yuen MF, Alam S, Khanna R, Sood V, Lal BB, Pamecha V, Jindal A, Rajan V, Arora V, Yokosuka O, Niriella MA, Li H, Qi X, Tanaka A, Mochida S, Chaudhuri DR, Gane E, Win KM, Chen WT, Rela M, Kapoor D, Rastogi A, Kale P, Rastogi A, Sharma CB, Bajpai M, Singh V, Premkumar M, Maharashi S, Olithselvan A, Philips CA, Srivastava A, Yachha SK, Wani ZA, Thapa BR, Saraya A, Shalimar, Kumar A, Wadhawan M, Gupta S, Madan K, Sakhuja P, Vij V, Sharma BC, Garg H, Garg V, Kalal C, Anand L, Vyas T, Mathur RP, Kumar G, Jain P, Pasupuleti SSR, Chawla YK, Chowdhury A, Alam S, Song DS, Yang JM, Yoon EL; APASL ACLF Research Consortium (AARC) for APASL ACLF working Party.
Hepatol Int 2019 Jul;13(4):353-390. Epub 2019 Jun 6 doi: 10.1007/s12072-019-09946-3. PMID: 31172417Free PMC Article
AGA Clinical Practice Update: Coagulation in Cirrhosis.
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390
Mechanisms and treatment of organ failure in sepsis.
Lelubre C, Vincent JL
Nat Rev Nephrol 2018 Jul;14(7):417-427. doi: 10.1038/s41581-018-0005-7. PMID: 29691495

Recent clinical studies

Etiology

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.
Sarin SK, Choudhury A, Sharma MK, Maiwall R, Al Mahtab M, Rahman S, Saigal S, Saraf N, Soin AS, Devarbhavi H, Kim DJ, Dhiman RK, Duseja A, Taneja S, Eapen CE, Goel A, Ning Q, Chen T, Ma K, Duan Z, Yu C, Treeprasertsuk S, Hamid SS, Butt AS, Jafri W, Shukla A, Saraswat V, Tan SS, Sood A, Midha V, Goyal O, Ghazinyan H, Arora A, Hu J, Sahu M, Rao PN, Lee GH, Lim SG, Lesmana LA, Lesmana CR, Shah S, Prasad VGM, Payawal DA, Abbas Z, Dokmeci AK, Sollano JD, Carpio G, Shresta A, Lau GK, Fazal Karim M, Shiha G, Gani R, Kalista KF, Yuen MF, Alam S, Khanna R, Sood V, Lal BB, Pamecha V, Jindal A, Rajan V, Arora V, Yokosuka O, Niriella MA, Li H, Qi X, Tanaka A, Mochida S, Chaudhuri DR, Gane E, Win KM, Chen WT, Rela M, Kapoor D, Rastogi A, Kale P, Rastogi A, Sharma CB, Bajpai M, Singh V, Premkumar M, Maharashi S, Olithselvan A, Philips CA, Srivastava A, Yachha SK, Wani ZA, Thapa BR, Saraya A, Shalimar, Kumar A, Wadhawan M, Gupta S, Madan K, Sakhuja P, Vij V, Sharma BC, Garg H, Garg V, Kalal C, Anand L, Vyas T, Mathur RP, Kumar G, Jain P, Pasupuleti SSR, Chawla YK, Chowdhury A, Alam S, Song DS, Yang JM, Yoon EL; APASL ACLF Research Consortium (AARC) for APASL ACLF working Party.
Hepatol Int 2019 Jul;13(4):353-390. Epub 2019 Jun 6 doi: 10.1007/s12072-019-09946-3. PMID: 31172417Free PMC Article
Current concepts in acute liver failure.
Rovegno M, Vera M, Ruiz A, Benítez C
Ann Hepatol 2019 Jul-Aug;18(4):543-552. Epub 2019 May 10 doi: 10.1016/j.aohep.2019.04.008. PMID: 31126880
AGA Clinical Practice Update: Coagulation in Cirrhosis.
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390
Diagnosis, Development, and Treatment of Portal Vein Thrombosis in Patients With and Without Cirrhosis.
Intagliata NM, Caldwell SH, Tripodi A
Gastroenterology 2019 May;156(6):1582-1599.e1. Epub 2019 Feb 13 doi: 10.1053/j.gastro.2019.01.265. PMID: 30771355
Coagulation disorders in liver disease.
Amitrano L, Guardascione MA, Brancaccio V, Balzano A
Semin Liver Dis 2002 Feb;22(1):83-96. doi: 10.1055/s-2002-23205. PMID: 11928081

Diagnosis

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.
Sarin SK, Choudhury A, Sharma MK, Maiwall R, Al Mahtab M, Rahman S, Saigal S, Saraf N, Soin AS, Devarbhavi H, Kim DJ, Dhiman RK, Duseja A, Taneja S, Eapen CE, Goel A, Ning Q, Chen T, Ma K, Duan Z, Yu C, Treeprasertsuk S, Hamid SS, Butt AS, Jafri W, Shukla A, Saraswat V, Tan SS, Sood A, Midha V, Goyal O, Ghazinyan H, Arora A, Hu J, Sahu M, Rao PN, Lee GH, Lim SG, Lesmana LA, Lesmana CR, Shah S, Prasad VGM, Payawal DA, Abbas Z, Dokmeci AK, Sollano JD, Carpio G, Shresta A, Lau GK, Fazal Karim M, Shiha G, Gani R, Kalista KF, Yuen MF, Alam S, Khanna R, Sood V, Lal BB, Pamecha V, Jindal A, Rajan V, Arora V, Yokosuka O, Niriella MA, Li H, Qi X, Tanaka A, Mochida S, Chaudhuri DR, Gane E, Win KM, Chen WT, Rela M, Kapoor D, Rastogi A, Kale P, Rastogi A, Sharma CB, Bajpai M, Singh V, Premkumar M, Maharashi S, Olithselvan A, Philips CA, Srivastava A, Yachha SK, Wani ZA, Thapa BR, Saraya A, Shalimar, Kumar A, Wadhawan M, Gupta S, Madan K, Sakhuja P, Vij V, Sharma BC, Garg H, Garg V, Kalal C, Anand L, Vyas T, Mathur RP, Kumar G, Jain P, Pasupuleti SSR, Chawla YK, Chowdhury A, Alam S, Song DS, Yang JM, Yoon EL; APASL ACLF Research Consortium (AARC) for APASL ACLF working Party.
Hepatol Int 2019 Jul;13(4):353-390. Epub 2019 Jun 6 doi: 10.1007/s12072-019-09946-3. PMID: 31172417Free PMC Article
Current concepts in acute liver failure.
Rovegno M, Vera M, Ruiz A, Benítez C
Ann Hepatol 2019 Jul-Aug;18(4):543-552. Epub 2019 May 10 doi: 10.1016/j.aohep.2019.04.008. PMID: 31126880
Diagnosis, Development, and Treatment of Portal Vein Thrombosis in Patients With and Without Cirrhosis.
Intagliata NM, Caldwell SH, Tripodi A
Gastroenterology 2019 May;156(6):1582-1599.e1. Epub 2019 Feb 13 doi: 10.1053/j.gastro.2019.01.265. PMID: 30771355
Acute Liver Failure: An Update.
Squires JE, McKiernan P, Squires RH
Clin Liver Dis 2018 Nov;22(4):773-805. Epub 2018 Aug 22 doi: 10.1016/j.cld.2018.06.009. PMID: 30266162
Coagulation disorders in liver disease.
Amitrano L, Guardascione MA, Brancaccio V, Balzano A
Semin Liver Dis 2002 Feb;22(1):83-96. doi: 10.1055/s-2002-23205. PMID: 11928081

Therapy

Haemostatic alterations and management of haemostasis in patients with cirrhosis.
Lisman T, Caldwell SH, Intagliata NM
J Hepatol 2022 Jun;76(6):1291-1305. doi: 10.1016/j.jhep.2021.11.004. PMID: 35589251
Acquired bleeding disorders.
Tiede A, Zieger B, Lisman T
Haemophilia 2022 May;28 Suppl 4:68-76. doi: 10.1111/hae.14548. PMID: 35521729
Albumin in Advanced Liver Diseases: The Good and Bad of a Drug!
Jagdish RK, Maras JS, Sarin SK
Hepatology 2021 Nov;74(5):2848-2862. Epub 2021 Sep 12 doi: 10.1002/hep.31836. PMID: 33772846
Current concepts in acute liver failure.
Rovegno M, Vera M, Ruiz A, Benítez C
Ann Hepatol 2019 Jul-Aug;18(4):543-552. Epub 2019 May 10 doi: 10.1016/j.aohep.2019.04.008. PMID: 31126880
AGA Clinical Practice Update: Coagulation in Cirrhosis.
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390

Prognosis

Acquired bleeding disorders.
Tiede A, Zieger B, Lisman T
Haemophilia 2022 May;28 Suppl 4:68-76. doi: 10.1111/hae.14548. PMID: 35521729
Albumin in Advanced Liver Diseases: The Good and Bad of a Drug!
Jagdish RK, Maras JS, Sarin SK
Hepatology 2021 Nov;74(5):2848-2862. Epub 2021 Sep 12 doi: 10.1002/hep.31836. PMID: 33772846
Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.
Sarin SK, Choudhury A, Sharma MK, Maiwall R, Al Mahtab M, Rahman S, Saigal S, Saraf N, Soin AS, Devarbhavi H, Kim DJ, Dhiman RK, Duseja A, Taneja S, Eapen CE, Goel A, Ning Q, Chen T, Ma K, Duan Z, Yu C, Treeprasertsuk S, Hamid SS, Butt AS, Jafri W, Shukla A, Saraswat V, Tan SS, Sood A, Midha V, Goyal O, Ghazinyan H, Arora A, Hu J, Sahu M, Rao PN, Lee GH, Lim SG, Lesmana LA, Lesmana CR, Shah S, Prasad VGM, Payawal DA, Abbas Z, Dokmeci AK, Sollano JD, Carpio G, Shresta A, Lau GK, Fazal Karim M, Shiha G, Gani R, Kalista KF, Yuen MF, Alam S, Khanna R, Sood V, Lal BB, Pamecha V, Jindal A, Rajan V, Arora V, Yokosuka O, Niriella MA, Li H, Qi X, Tanaka A, Mochida S, Chaudhuri DR, Gane E, Win KM, Chen WT, Rela M, Kapoor D, Rastogi A, Kale P, Rastogi A, Sharma CB, Bajpai M, Singh V, Premkumar M, Maharashi S, Olithselvan A, Philips CA, Srivastava A, Yachha SK, Wani ZA, Thapa BR, Saraya A, Shalimar, Kumar A, Wadhawan M, Gupta S, Madan K, Sakhuja P, Vij V, Sharma BC, Garg H, Garg V, Kalal C, Anand L, Vyas T, Mathur RP, Kumar G, Jain P, Pasupuleti SSR, Chawla YK, Chowdhury A, Alam S, Song DS, Yang JM, Yoon EL; APASL ACLF Research Consortium (AARC) for APASL ACLF working Party.
Hepatol Int 2019 Jul;13(4):353-390. Epub 2019 Jun 6 doi: 10.1007/s12072-019-09946-3. PMID: 31172417Free PMC Article
Current concepts in acute liver failure.
Rovegno M, Vera M, Ruiz A, Benítez C
Ann Hepatol 2019 Jul-Aug;18(4):543-552. Epub 2019 May 10 doi: 10.1016/j.aohep.2019.04.008. PMID: 31126880
Acute Liver Failure: An Update.
Squires JE, McKiernan P, Squires RH
Clin Liver Dis 2018 Nov;22(4):773-805. Epub 2018 Aug 22 doi: 10.1016/j.cld.2018.06.009. PMID: 30266162

Clinical prediction guides

Acquired bleeding disorders.
Tiede A, Zieger B, Lisman T
Haemophilia 2022 May;28 Suppl 4:68-76. doi: 10.1111/hae.14548. PMID: 35521729
Acquired bleeding disorders.
Tiede A, Zieger B, Lisman T
Haemophilia 2021 Feb;27 Suppl 3:5-13. Epub 2020 Jun 1 doi: 10.1111/hae.14033. PMID: 32476241
AGA Clinical Practice Update: Coagulation in Cirrhosis.
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390
Diagnosis, Development, and Treatment of Portal Vein Thrombosis in Patients With and Without Cirrhosis.
Intagliata NM, Caldwell SH, Tripodi A
Gastroenterology 2019 May;156(6):1582-1599.e1. Epub 2019 Feb 13 doi: 10.1053/j.gastro.2019.01.265. PMID: 30771355
Acute Liver Failure: An Update.
Squires JE, McKiernan P, Squires RH
Clin Liver Dis 2018 Nov;22(4):773-805. Epub 2018 Aug 22 doi: 10.1016/j.cld.2018.06.009. PMID: 30266162

Recent systematic reviews

Anticoagulation for splanchnic vein thrombosis in myeloproliferative neoplasms: a systematic review and meta-analysis.
Chrysafi P, Barnum K, Gerhard GM, Chiasakul T, Narang A, Mcnichol M, Riva N, Semmler G, Scheiner B, Acosta S, Rautou PE, Lauw MN, Berry J, Ageno W, Zwicker JI, Patell R
J Thromb Haemost 2024 Dec;22(12):3479-3489. Epub 2024 Aug 8 doi: 10.1016/j.jtha.2024.06.029. PMID: 39127323
A systematic review and meta-analysis of recombinant human soluble thrombomodulin for the treatment of DIC associated with hematological malignancies.
Kawano N, Fukatsu M, Yamakawa K, Seki Y, Wada H, Okamoto K, Ikezoe T
Int J Hematol 2024 Apr;119(4):416-425. Epub 2024 Jan 25 doi: 10.1007/s12185-023-03704-w. PMID: 38270783
All-cause mortality and causes of death in persons with haemophilia: A systematic review and meta-analysis.
Alam AU, Karkhaneh M, Attia T, Wu C, Sun HL
Haemophilia 2021 Nov;27(6):897-910. Epub 2021 Sep 30 doi: 10.1111/hae.14423. PMID: 34592037
AGA Clinical Practice Guideline on the Management of Coagulation Disorders in Patients With Cirrhosis.
O'Shea RS, Davitkov P, Ko CW, Rajasekhar A, Su GL, Sultan S, Allen AM, Falck-Ytter Y
Gastroenterology 2021 Nov;161(5):1615-1627.e1. Epub 2021 Sep 25 doi: 10.1053/j.gastro.2021.08.015. PMID: 34579936
Utility of viscoelastic coagulation testing in liver surgery: a systematic review.
Mpaili E, Tsilimigras DI, Moris D, Sigala F, Frank SM, Hartmann J, Pawlik TM
HPB (Oxford) 2021 Mar;23(3):331-343. Epub 2020 Nov 21 doi: 10.1016/j.hpb.2020.10.023. PMID: 33229277

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