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Heartburn

MedGen UID:
5465
•Concept ID:
C0018834
•
Sign or Symptom
Synonyms: Pyroses; Pyrosis
SNOMED CT: Heartburn (16331000); Pyrosis (16331000); Burning reflux (16331000)

Definition

Abdominal discomfort with retrosternal pain usually associated with gastroesophageal reflux. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeartburn

Professional guidelines

PubMed

Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021.
Iwakiri K, Fujiwara Y, Manabe N, Ihara E, Kuribayashi S, Akiyama J, Kondo T, Yamashita H, Ishimura N, Kitasako Y, Iijima K, Koike T, Omura N, Nomura T, Kawamura O, Ohara S, Ozawa S, Kinoshita Y, Mochida S, Enomoto N, Shimosegawa T, Koike K
J Gastroenterol 2022 Apr;57(4):267-285. Epub 2022 Feb 28 doi: 10.1007/s00535-022-01861-z. PMID: 35226174Free PMC Article
AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review.
Yadlapati R, Gyawali CP, Pandolfino JE; CGIT GERD Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 May;20(5):984-994.e1. Epub 2022 Feb 2 doi: 10.1016/j.cgh.2022.01.025. PMID: 35123084Free PMC Article
Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment.
Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703

Recent clinical studies

Etiology

Randomised clinical trial: Efficacy and safety of on-demand vonoprazan versus placebo for non-erosive reflux disease.
Fass R, Vaezi M, Sharma P, Yadlapati R, Hunt B, Harris T, Smith N, Leifke E, Armstrong D
Aliment Pharmacol Ther 2023 Nov;58(10):1016-1027. Epub 2023 Sep 26 doi: 10.1111/apt.17728. PMID: 37750406
Gastroesophageal Reflux Disease and Probiotics: A Systematic Review.
Cheng J, Ouwehand AC
Nutrients 2020 Jan 2;12(1) doi: 10.3390/nu12010132. PMID: 31906573Free PMC Article
Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn.
Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, Sanchez VM, Dunbar KB, Pham TH, Murthy UK, Kim T, Jackson CS, Wallen JM, von Rosenvinge EC, Pearl JP, Laine L, Kim AW, Kaz AM, Tatum RP, Gellad ZF, Lagoo-Deenadayalan S, Rubenstein JH, Ghaferi AA, Lo WK, Fernando RS, Chan BS, Paski SC, Provenzale D, Castell DO, Lieberman D, Souza RF, Chey WD, Warren SR, Davis-Karim A, Melton SD, Genta RM, Serpi T, Biswas K, Huang GD
N Engl J Med 2019 Oct 17;381(16):1513-1523. doi: 10.1056/NEJMoa1811424. PMID: 31618539
Functional Dyspepsia: Advances in Diagnosis and Therapy.
Talley NJ
Gut Liver 2017 May 15;11(3):349-357. doi: 10.5009/gnl16055. PMID: 28452210Free PMC Article
Diagnosis and Management of Functional Heartburn.
Hachem C, Shaheen NJ
Am J Gastroenterol 2016 Jan;111(1):53-61; quiz 62. Epub 2016 Jan 5 doi: 10.1038/ajg.2015.376. PMID: 26729546

Diagnosis

Randomised clinical trial: Efficacy and safety of on-demand vonoprazan versus placebo for non-erosive reflux disease.
Fass R, Vaezi M, Sharma P, Yadlapati R, Hunt B, Harris T, Smith N, Leifke E, Armstrong D
Aliment Pharmacol Ther 2023 Nov;58(10):1016-1027. Epub 2023 Sep 26 doi: 10.1111/apt.17728. PMID: 37750406
How safe are heartburn medications and who should use them?
Savarino V, Marabotto E, Zentilin P, De Bortoli N, Visaggi P, Furnari M, Bodini G, Giannini E, Savarino E
Expert Opin Drug Saf 2023 Jul-Dec;22(8):643-652. Epub 2023 Jul 21 doi: 10.1080/14740338.2023.2238592. PMID: 37477199
Diagnosis and Management of Functional Heartburn.
Hachem C, Shaheen NJ
Am J Gastroenterol 2016 Jan;111(1):53-61; quiz 62. Epub 2016 Jan 5 doi: 10.1038/ajg.2015.376. PMID: 26729546
Gastroesophageal reflux disease.
Fock KM, Poh CH
J Gastroenterol 2010 Aug;45(8):808-15. Epub 2010 Jun 29 doi: 10.1007/s00535-010-0274-9. PMID: 20585811
Functional esophageal disorders.
Galmiche JP, Clouse RE, Bálint A, Cook IJ, Kahrilas PJ, Paterson WG, Smout AJ
Gastroenterology 2006 Apr;130(5):1459-65. doi: 10.1053/j.gastro.2005.08.060. PMID: 16678559

Therapy

Daily versus alternate day oral iron therapy in iron deficiency anemia: a systematic review.
Kamath S, Parveen RS, Hegde S, Mathias EG, Nayak V, Boloor A
Naunyn Schmiedebergs Arch Pharmacol 2024 May;397(5):2701-2714. Epub 2023 Nov 18 doi: 10.1007/s00210-023-02817-7. PMID: 37979057
Long-term outcomes following Dor, Toupet, and Nissen fundoplication: a network meta-analysis of randomized controlled trials.
Lee Y, Tahir U, Tessier L, Yang K, Hassan T, Dang J, Kroh M, Hong D
Surg Endosc 2023 Jul;37(7):5052-5064. Epub 2023 Jun 12 doi: 10.1007/s00464-023-10151-5. PMID: 37308760
Enteral nutritional therapy for induction of remission in Crohn's disease.
Narula N, Dhillon A, Zhang D, Sherlock ME, Tondeur M, Zachos M
Cochrane Database Syst Rev 2018 Apr 1;4(4):CD000542. doi: 10.1002/14651858.CD000542.pub3. PMID: 29607496Free PMC Article
Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis.
Khanna R, MacDonald JK, Levesque BG
J Clin Gastroenterol 2014 Jul;48(6):505-12. doi: 10.1097/MCG.0b013e3182a88357. PMID: 24100754
Dyspepsia: organic versus functional.
Oustamanolakis P, Tack J
J Clin Gastroenterol 2012 Mar;46(3):175-90. doi: 10.1097/MCG.0b013e318241b335. PMID: 22327302

Prognosis

Epidemiology, Diagnosis, and Management of Esophageal Adenocarcinoma.
Rubenstein JH, Shaheen NJ
Gastroenterology 2015 Aug;149(2):302-17.e1. Epub 2015 May 7 doi: 10.1053/j.gastro.2015.04.053. PMID: 25957861Free PMC Article
Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review.
El-Serag HB, Sweet S, Winchester CC, Dent J
Gut 2014 Jun;63(6):871-80. Epub 2013 Jul 13 doi: 10.1136/gutjnl-2012-304269. PMID: 23853213Free PMC Article
Constipation, haemorrhoids, and heartburn in pregnancy.
Vazquez JC
BMJ Clin Evid 2010 Aug 3;2010 PMID: 21418682Free PMC Article
Gastroesophageal reflux disease.
Frost-Rude J
Home Care Provid 1999 Jun;4(3):110-3; quiz 114-5. doi: 10.1016/s1084-628x(99)90069-2. PMID: 11982098
Gastrointestinal manifestations of systemic sclerosis.
Abu-Shakra M, Guillemin F, Lee P
Semin Arthritis Rheum 1994 Aug;24(1):29-39. doi: 10.1016/0049-0172(94)90097-3. PMID: 7985035

Clinical prediction guides

Lymphocytic oesophagitis: diagnosis and management.
Hussein M, Mitchison M, Sweis R
Clin Med (Lond) 2023 Nov;23(6):540-544. doi: 10.7861/clinmed.2023-0440. PMID: 38065611Free PMC Article
Laparoscopic Nissen Versus Toupet Fundoplication for Short- and Long-Term Treatment of Gastroesophageal Reflux Disease: A Meta-Analysis and Systematic Review.
Li G, Jiang N, Chendaer N, Hao Y, Zhang W, Peng C
Surg Innov 2023 Dec;30(6):745-757. Epub 2023 Mar 30 doi: 10.1177/15533506231165829. PMID: 36998190Free PMC Article
Efficacy and safety comparative study of dexrabeprazole vs. esomeprazole for the treatment of gastroesophageal reflux disease.
Abdo-Francis JM, Cabrera-Álvarez G, Martínez-Torres H, Remes-Troche JM
Gac Med Mex 2022;158(6):423-429. doi: 10.24875/GMM.M22000722. PMID: 36657136
Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn.
Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, Sanchez VM, Dunbar KB, Pham TH, Murthy UK, Kim T, Jackson CS, Wallen JM, von Rosenvinge EC, Pearl JP, Laine L, Kim AW, Kaz AM, Tatum RP, Gellad ZF, Lagoo-Deenadayalan S, Rubenstein JH, Ghaferi AA, Lo WK, Fernando RS, Chan BS, Paski SC, Provenzale D, Castell DO, Lieberman D, Souza RF, Chey WD, Warren SR, Davis-Karim A, Melton SD, Genta RM, Serpi T, Biswas K, Huang GD
N Engl J Med 2019 Oct 17;381(16):1513-1523. doi: 10.1056/NEJMoa1811424. PMID: 31618539
Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification.
Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, Tytgat GN, Wallin L
Gut 1999 Aug;45(2):172-80. doi: 10.1136/gut.45.2.172. PMID: 10403727Free PMC Article

Recent systematic reviews

Laparoscopic Nissen Versus Toupet Fundoplication for Short- and Long-Term Treatment of Gastroesophageal Reflux Disease: A Meta-Analysis and Systematic Review.
Li G, Jiang N, Chendaer N, Hao Y, Zhang W, Peng C
Surg Innov 2023 Dec;30(6):745-757. Epub 2023 Mar 30 doi: 10.1177/15533506231165829. PMID: 36998190Free PMC Article
Gastroesophageal Reflux Disease and Probiotics: A Systematic Review.
Cheng J, Ouwehand AC
Nutrients 2020 Jan 2;12(1) doi: 10.3390/nu12010132. PMID: 31906573Free PMC Article
Lifestyle Intervention in Gastroesophageal Reflux Disease.
Ness-Jensen E, Hveem K, El-Serag H, Lagergren J
Clin Gastroenterol Hepatol 2016 Feb;14(2):175-82.e1-3. Epub 2015 May 6 doi: 10.1016/j.cgh.2015.04.176. PMID: 25956834Free PMC Article
A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting.
Viljoen E, Visser J, Koen N, Musekiwa A
Nutr J 2014 Mar 19;13:20. doi: 10.1186/1475-2891-13-20. PMID: 24642205Free PMC Article
Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review.
El-Serag HB, Sweet S, Winchester CC, Dent J
Gut 2014 Jun;63(6):871-80. Epub 2013 Jul 13 doi: 10.1136/gutjnl-2012-304269. PMID: 23853213Free PMC Article

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