U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hypocellular bone marrow

MedGen UID:
56245
•Concept ID:
C0151773
•
Disease or Syndrome
Synonym: Bone marrow hypoplasia
SNOMED CT: Hypocellular bone marrow (416995001); Bone marrow hypoplasia (416995001); Medullary hypoplasia (416995001); Bone marrow depression (307762000)

Definition

A laboratory finding indicating decreased number of hematopoietic cells in the bone marrow. It may result from decreased proliferation of all or part of the hematopoietic series (erythroid, myeloid, and megakaryocytic). Microscopically, the hematopoietic cells are replaced by adipocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypocellular bone marrow

Professional guidelines

PubMed

Aplastic anemia: history and recent developments in diagnosis and treatment.
Onishi Y
Int J Hematol 2024 Mar;119(3):217-219. Epub 2024 Feb 4 doi: 10.1007/s12185-024-03715-1. PMID: 38310173
Guidelines for the diagnosis and management of adult aplastic anaemia: A British Society for Haematology Guideline.
Kulasekararaj A, Cavenagh J, Dokal I, Foukaneli T, Gandhi S, Garg M, Griffin M, Hillmen P, Ireland R, Killick S, Mansour S, Mufti G, Potter V, Snowden J, Stanworth S, Zuha R, Marsh J; BSH Committee
Br J Haematol 2024 Mar;204(3):784-804. Epub 2024 Jan 21 doi: 10.1111/bjh.19236. PMID: 38247114
Clinical management of aplastic anemia.
Dezern AE, Brodsky RA
Expert Rev Hematol 2011 Apr;4(2):221-30. doi: 10.1586/ehm.11.11. PMID: 21495931Free PMC Article

Recent clinical studies

Etiology

Inherited human Apollo deficiency causes severe bone marrow failure and developmental defects.
Kermasson L, Churikov D, Awad A, Smoom R, Lainey E, Touzot F, Audebert-Bellanger S, Haro S, Roger L, Costa E, Mouf M, Bottero A, Oleastro M, Abdo C, de Villartay JP, Géli V, Tzfati Y, Callebaut I, Danielian S, Soares G, Kannengiesser C, Revy P
Blood 2022 Apr 21;139(16):2427-2440. doi: 10.1182/blood.2021010791. PMID: 35007328Free PMC Article
How I treat myelodysplastic syndromes of childhood.
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960
Pediatric myelodysplastic syndromes: they do exist!
Glaubach T, Robinson LJ, Corey SJ
J Pediatr Hematol Oncol 2014 Jan;36(1):1-7. doi: 10.1097/MPH.0000000000000046. PMID: 24345881
Incidence, etiology and bone marrow characteristics of non-chemotherapy-induced agranulocytosis.
Apinantriyo B, Lekhakula A, Rujirojindakul P
Hematology 2011 Jan;16(1):50-3. doi: 10.1179/102453311X12902908411715. PMID: 21269568
Hypoplastic acute leukemia.
Needleman SW, Burns CP, Dick FR, Armitage JO
Cancer 1981 Sep 15;48(6):1410-4. doi: 10.1002/1097-0142(19810915)48:6<1410::aid-cncr2820480624>3.0.co;2-4. PMID: 7272965

Diagnosis

Aplastic anemia: history and recent developments in diagnosis and treatment.
Onishi Y
Int J Hematol 2024 Mar;119(3):217-219. Epub 2024 Feb 4 doi: 10.1007/s12185-024-03715-1. PMID: 38310173
Guidelines for the diagnosis and management of adult aplastic anaemia: A British Society for Haematology Guideline.
Kulasekararaj A, Cavenagh J, Dokal I, Foukaneli T, Gandhi S, Garg M, Griffin M, Hillmen P, Ireland R, Killick S, Mansour S, Mufti G, Potter V, Snowden J, Stanworth S, Zuha R, Marsh J; BSH Committee
Br J Haematol 2024 Mar;204(3):784-804. Epub 2024 Jan 21 doi: 10.1111/bjh.19236. PMID: 38247114
Diagnostic evaluation and considerations in hypocellular bone marrow failure-A focus on genomics.
Fox LC, Wood EM, Ritchie DS, Blombery P
Int J Lab Hematol 2020 Jun;42 Suppl 1:82-89. Epub 2020 Mar 5 doi: 10.1111/ijlh.13179. PMID: 32134198
How I treat myelodysplastic syndromes of childhood.
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960
Aplastic anaemia.
Brodsky RA, Jones RJ
Lancet 2005 May 7-13;365(9471):1647-56. doi: 10.1016/S0140-6736(05)66515-4. PMID: 15885298

Therapy

Guidelines for the diagnosis and management of adult aplastic anaemia: A British Society for Haematology Guideline.
Kulasekararaj A, Cavenagh J, Dokal I, Foukaneli T, Gandhi S, Garg M, Griffin M, Hillmen P, Ireland R, Killick S, Mansour S, Mufti G, Potter V, Snowden J, Stanworth S, Zuha R, Marsh J; BSH Committee
Br J Haematol 2024 Mar;204(3):784-804. Epub 2024 Jan 21 doi: 10.1111/bjh.19236. PMID: 38247114
Nonsense Suppression Therapy: New Hypothesis for the Treatment of Inherited Bone Marrow Failure Syndromes.
Bezzerri V, Api M, Allegri M, Fabrizzi B, Corey SJ, Cipolli M
Int J Mol Sci 2020 Jun 30;21(13) doi: 10.3390/ijms21134672. PMID: 32630050Free PMC Article
Clinical management of aplastic anemia.
Dezern AE, Brodsky RA
Expert Rev Hematol 2011 Apr;4(2):221-30. doi: 10.1586/ehm.11.11. PMID: 21495931Free PMC Article
Aplastic anaemia.
Brodsky RA, Jones RJ
Lancet 2005 May 7-13;365(9471):1647-56. doi: 10.1016/S0140-6736(05)66515-4. PMID: 15885298
Hypoplastic acute leukemia.
Needleman SW, Burns CP, Dick FR, Armitage JO
Cancer 1981 Sep 15;48(6):1410-4. doi: 10.1002/1097-0142(19810915)48:6<1410::aid-cncr2820480624>3.0.co;2-4. PMID: 7272965

Prognosis

Aplastic anemia: history and recent developments in diagnosis and treatment.
Onishi Y
Int J Hematol 2024 Mar;119(3):217-219. Epub 2024 Feb 4 doi: 10.1007/s12185-024-03715-1. PMID: 38310173
Guidelines for the diagnosis and management of adult aplastic anaemia: A British Society for Haematology Guideline.
Kulasekararaj A, Cavenagh J, Dokal I, Foukaneli T, Gandhi S, Garg M, Griffin M, Hillmen P, Ireland R, Killick S, Mansour S, Mufti G, Potter V, Snowden J, Stanworth S, Zuha R, Marsh J; BSH Committee
Br J Haematol 2024 Mar;204(3):784-804. Epub 2024 Jan 21 doi: 10.1111/bjh.19236. PMID: 38247114
Diagnostic evaluation and considerations in hypocellular bone marrow failure-A focus on genomics.
Fox LC, Wood EM, Ritchie DS, Blombery P
Int J Lab Hematol 2020 Jun;42 Suppl 1:82-89. Epub 2020 Mar 5 doi: 10.1111/ijlh.13179. PMID: 32134198
Pediatric myelodysplastic syndromes: they do exist!
Glaubach T, Robinson LJ, Corey SJ
J Pediatr Hematol Oncol 2014 Jan;36(1):1-7. doi: 10.1097/MPH.0000000000000046. PMID: 24345881
Aplastic anaemia.
Brodsky RA, Jones RJ
Lancet 2005 May 7-13;365(9471):1647-56. doi: 10.1016/S0140-6736(05)66515-4. PMID: 15885298

Clinical prediction guides

Interleukin-6 and interleukin-8 levels in children with aplastic anemia and its correlation with disease severity and response to immunosuppressive therapy.
Singh A, Bhargawa SK, Yadav G, Kushwaha R, Verma SP, Tripathi T, Singh US, Tripathi AK
Ann Afr Med 2023 Oct-Dec;22(4):446-450. doi: 10.4103/aam.aam_106_22. PMID: 38358144Free PMC Article
Utility of clinical comprehensive genomic characterization for diagnostic categorization in patients presenting with hypocellular bone marrow failure syndromes.
Blombery P, Fox L, Ryland GL, Thompson ER, Lickiss J, McBean M, Yerneni S, Trainer A, Hughes D, Greenway A, Mechinaud F, Wood EM, Lieschke GJ, Szer J, Barbaro P, Roy J, Wight J, Lynch E, Martyn M, Gaff C, Ritchie D
Haematologica 2021 Jan 1;106(1):64-73. doi: 10.3324/haematol.2019.237693. [Epub ahead of print] PMID: 32054657Free PMC Article
Bone marrow suppression in pediatric patients with differentiated thyroid cancer following empirical radioiodine therapy.
Dong P, Wang L, Huang R, Li L
Medicine (Baltimore) 2020 Jul 31;99(31):e21398. doi: 10.1097/MD.0000000000021398. PMID: 32756134Free PMC Article
How I treat myelodysplastic syndromes of childhood.
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960
Hypoplastic acute leukemia.
Needleman SW, Burns CP, Dick FR, Armitage JO
Cancer 1981 Sep 15;48(6):1410-4. doi: 10.1002/1097-0142(19810915)48:6<1410::aid-cncr2820480624>3.0.co;2-4. PMID: 7272965

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...