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Benign neoplasm of spinal cord

MedGen UID:
56329
•Concept ID:
C0154034
•
Neoplastic Process
Synonym: Spinal Cord Neoplasms, Benign
SNOMED CT: Benign tumor of spinal cord (92405007); Benign neoplasm of spinal cord (92405007)
 
Monarch Initiative: MONDO:0021506

Definition

A neoplasm that arises from the spinal cord and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of spinal cord

Professional guidelines

PubMed

Ependymoma: Evaluation and Management Updates.
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.
Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT
Neuro Oncol 2019 Feb 19;21(3):296-305. doi: 10.1093/neuonc/noy192. PMID: 30418592Free PMC Article
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954

Recent clinical studies

Etiology

Comparison of Effectiveness, Feasibility, Indications, and Limitations of Different Intraoperative Dyes in Spinal Neuro-Oncologic Surgery. A Systematic Review.
Mattogno PP, Menna G, Pennisi G, Corbi L, Sturiale CL, Polli FM, Olivi A, Della Pepa GM
World Neurosurg 2022 Dec;168:146-153. Epub 2022 Oct 3 doi: 10.1016/j.wneu.2022.09.117. PMID: 36195181
Paediatric spinal cord low-grade gliomas-evaluation and management of post-surgical residual disease.
Silva AHD, Constantinides M, Valetopoulou A, Sgardelis P, Mankad K, D'Arco F, Jankovic I, Thompson D
Childs Nerv Syst 2022 Mar;38(3):577-586. Epub 2021 Dec 2 doi: 10.1007/s00381-021-05412-4. PMID: 34855000
Metastases of spinal myxopapillary ependymoma: unique characteristics and clinical management.
Kraetzig T, McLaughlin L, Bilsky MH, Laufer I
J Neurosurg Spine 2018 Feb;28(2):201-208. Epub 2017 Dec 8 doi: 10.3171/2017.5.SPINE161164. PMID: 29219779
Spinal meningiomas: surgical outcome and literature review.
Riad H, Knafo S, Segnarbieux F, Lonjon N
Neurochirurgie 2013 Feb;59(1):30-4. Epub 2013 Feb 8 doi: 10.1016/j.neuchi.2012.10.137. PMID: 23395186
Teratomas in childhood.
Bale PM, Painter DM, Cohen D
Pathology 1975 Jul;7(3):209-18. doi: 10.3109/00313027509094411. PMID: 1196679

Diagnosis

Spinal Cord Neoplasms.
McFaline-Figueroa JR
Continuum (Minneap Minn) 2024 Feb 1;30(1):99-118. doi: 10.1212/CON.0000000000001375. PMID: 38330474
Primary spinal primitive neuroectodermal tumor: A single center series with literature review.
Ma J, Ma S, Yang J, Jia G, Jia W
J Spinal Cord Med 2020 Nov;43(6):895-903. Epub 2018 Dec 18 doi: 10.1080/10790268.2018.1547862. PMID: 30561250Free PMC Article
Intradural spinal tumors in adults-update on management and outcome.
Ottenhausen M, Ntoulias G, Bodhinayake I, Ruppert FH, Schreiber S, Förschler A, Boockvar JA, Jödicke A
Neurosurg Rev 2019 Jun;42(2):371-388. Epub 2018 Feb 17 doi: 10.1007/s10143-018-0957-x. PMID: 29455369
Spine intervention.
Muto M
Eur J Radiol 2015 May;84(5):745. Epub 2014 Jul 11 doi: 10.1016/j.ejrad.2014.07.001. PMID: 25064662
Intradural extension of a sacrococcygeal teratoma.
Powell RW, Weber ED, Manci EA
J Pediatr Surg 1993 Jun;28(6):770-2. doi: 10.1016/0022-3468(93)90322-c. PMID: 8331500

Therapy

Comparison of Effectiveness, Feasibility, Indications, and Limitations of Different Intraoperative Dyes in Spinal Neuro-Oncologic Surgery. A Systematic Review.
Mattogno PP, Menna G, Pennisi G, Corbi L, Sturiale CL, Polli FM, Olivi A, Della Pepa GM
World Neurosurg 2022 Dec;168:146-153. Epub 2022 Oct 3 doi: 10.1016/j.wneu.2022.09.117. PMID: 36195181
GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas.
Majzner RG, Ramakrishna S, Yeom KW, Patel S, Chinnasamy H, Schultz LM, Richards RM, Jiang L, Barsan V, Mancusi R, Geraghty AC, Good Z, Mochizuki AY, Gillespie SM, Toland AMS, Mahdi J, Reschke A, Nie EH, Chau IJ, Rotiroti MC, Mount CW, Baggott C, Mavroukakis S, Egeler E, Moon J, Erickson C, Green S, Kunicki M, Fujimoto M, Ehlinger Z, Reynolds W, Kurra S, Warren KE, Prabhu S, Vogel H, Rasmussen L, Cornell TT, Partap S, Fisher PG, Campen CJ, Filbin MG, Grant G, Sahaf B, Davis KL, Feldman SA, Mackall CL, Monje M
Nature 2022 Mar;603(7903):934-941. Epub 2022 Feb 7 doi: 10.1038/s41586-022-04489-4. PMID: 35130560Free PMC Article
Targeting and Therapeutic Monitoring of H3K27M-Mutant Glioma.
Wierzbicki K, Ravi K, Franson A, Bruzek A, Cantor E, Harris M, Homan MJ, Marini BL, Kawakibi AR, Ravindran R, Teodoro R, Yadav VN, Koschmann C
Curr Oncol Rep 2020 Feb 6;22(2):19. doi: 10.1007/s11912-020-0877-0. PMID: 32030483Free PMC Article
Various shades of red-a systematic analysis of qualitative estimation of ALA-derived fluorescence in neurosurgery.
Kamp MA, Krause Molle Z, Munoz-Bendix C, Rapp M, Sabel M, Steiger HJ, Cornelius JF
Neurosurg Rev 2018 Jan;41(1):3-18. Epub 2016 May 25 doi: 10.1007/s10143-016-0745-4. PMID: 27225452
Neurosurgery issues in oncology.
Sawaya R
Curr Opin Oncol 1991 Jun;3(3):459-66. doi: 10.1097/00001622-199106000-00004. PMID: 1892915

Prognosis

Leptomeningeal Metastases of the Spine: A Systematic Review.
Palmisciano P, Sagoo NS, Kharbat AF, Kenfack YJ, Bin Alamer O, Scalia G, Umana GE, Aoun SG, Haider AS
Anticancer Res 2022 Feb;42(2):619-628. doi: 10.21873/anticanres.15519. PMID: 35093859
Paediatric spinal cord low-grade gliomas-evaluation and management of post-surgical residual disease.
Silva AHD, Constantinides M, Valetopoulou A, Sgardelis P, Mankad K, D'Arco F, Jankovic I, Thompson D
Childs Nerv Syst 2022 Mar;38(3):577-586. Epub 2021 Dec 2 doi: 10.1007/s00381-021-05412-4. PMID: 34855000
Metastases of spinal myxopapillary ependymoma: unique characteristics and clinical management.
Kraetzig T, McLaughlin L, Bilsky MH, Laufer I
J Neurosurg Spine 2018 Feb;28(2):201-208. Epub 2017 Dec 8 doi: 10.3171/2017.5.SPINE161164. PMID: 29219779
Spinal meningiomas: surgical outcome and literature review.
Riad H, Knafo S, Segnarbieux F, Lonjon N
Neurochirurgie 2013 Feb;59(1):30-4. Epub 2013 Feb 8 doi: 10.1016/j.neuchi.2012.10.137. PMID: 23395186
Cavernous haemangiomas of the spinal cord. A review of 117 cases.
Zevgaridis D, Medele RJ, Hamburger C, Steiger HJ, Reulen HJ
Acta Neurochir (Wien) 1999;141(3):237-45. doi: 10.1007/s007010050293. PMID: 10214479

Clinical prediction guides

Clinical outcomes and a therapeutic indication of intramedullary spinal cord astrocytoma.
Nagoshi N, Tsuji O, Suzuki S, Nori S, Yagi M, Okada E, Okita H, Fujita N, Ishii K, Matsumoto M, Nakamura M, Watanabe K
Spinal Cord 2022 Mar;60(3):216-222. Epub 2021 Jul 26 doi: 10.1038/s41393-021-00676-8. PMID: 34312493
Laminectomy versus Unilateral Hemilaminectomy for the Removal of Intraspinal Schwannoma: Experience of a Single Institution and Review of Literature.
Dobran M, Paracino R, Nasi D, Aiudi D, Capece M, Carrassi E, Lattanzi S, Rienzo AD, Iacoangeli M
J Neurol Surg A Cent Eur Neurosurg 2021 Nov;82(6):552-555. Epub 2021 Apr 12 doi: 10.1055/s-0041-1722968. PMID: 33845505
Lumbar paraganglioma.
Dillard-Cannon E, Atsina KB, Ghobrial G, Gnass E, Curtis MT, Heller J
J Clin Neurosci 2016 Aug;30:149-151. Epub 2016 Mar 28 doi: 10.1016/j.jocn.2016.01.019. PMID: 27032749
Spinal ependymomas. Part 1: Intramedullary ependymomas.
Klekamp J
Neurosurg Focus 2015 Aug;39(2):E6. doi: 10.3171/2015.5.FOCUS15161. PMID: 26235023
Surveying and optimizing the predictors for ependymoma specific survival using SEER data.
Cheung MR
Asian Pac J Cancer Prev 2014;15(2):867-70. doi: 10.7314/apjcp.2014.15.2.867. PMID: 24568509

Recent systematic reviews

Non-demyelinating disorders mimicking and misdiagnosed as NMOSD: a literature review.
Zara P, Dinoto A, Carta S, Floris V, Turilli D, Budhram A, Ferrari S, Milia S, Solla P, Mariotto S, Flanagan EP, Lopez Chiriboga AS, Sechi E
Eur J Neurol 2023 Oct;30(10):3367-3376. Epub 2023 Jul 19 doi: 10.1111/ene.15983. PMID: 37433584Free PMC Article
MRI-Negative Cushing's Disease: A Review on Therapeutic Management.
Sabahi M, Shahbazi T, Maroufi SF, Vidal K, Recinos PF, Kshettry VR, Roser F, Adada B, Borghei-Razavi H
World Neurosurg 2022 Jun;162:126-137.e1. Epub 2022 Mar 22 doi: 10.1016/j.wneu.2022.03.076. PMID: 35338018
Systematic review of urological followup after spinal cord injury.
Cameron AP, Rodriguez GM, Schomer KG
J Urol 2012 Feb;187(2):391-7. Epub 2011 Dec 15 doi: 10.1016/j.juro.2011.10.020. PMID: 22177149
Breast cancer (metastatic).
Stebbing J, Ngan S
BMJ Clin Evid 2010 Sep 8;2010 PMID: 21418674Free PMC Article
A systematic review of the role of bisphosphonates in metastatic disease.
Ross JR, Saunders Y, Edmonds PM, Patel S, Wonderling D, Normand C, Broadley K
Health Technol Assess 2004;8(4):1-176. doi: 10.3310/hta8040. PMID: 14960258

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