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Lentigo Maligna

MedGen UID:
57443
•Concept ID:
C0149722
•
Neoplastic Process
Synonyms: Freckle, Hutchinson's Melanotic; Freckle, Melanotic; Freckles, Melanotic; Hutchinson Melanotic Freckle; Hutchinson's Melanotic Freckle; Hutchinsons Melanotic Freckle; Lentigo, Malignant; Lentigos, Malignant; Malignant Lentigo; Malignant Lentigos; Melanotic Freckle; Melanotic Freckle, Hutchinson's; Melanotic Freckles
SNOMED CT: Hutchinson's melanotic freckle (61217001); Lentigo maligna (61217001); Hutchinson melanotic freckle (61217001); Lentigo maligna (302836005); LM - Lentigo maligna (302836005)

Definition

An atypical proliferation of atypical melanocytes in the dermal-epidermal junction, without infiltration of the papillary or reticular dermis. The melanocytic proliferation is associated with actinic damage and epidermal atrophy. It usually occurs in the sun-exposed skin of elderly people. It is a form of melanoma in situ. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLentigo Maligna

Professional guidelines

PubMed

Validation of a patient decision aid for the treatment of lentigo maligna.
Vaidya TS, Bander TS, Musthaq S, Lampley N 3rd, Lee EH, Nehal KS, Rossi AM
J Am Acad Dermatol 2021 Jun;84(6):1751-1753. Epub 2020 Oct 23 doi: 10.1016/j.jaad.2020.10.043. PMID: 33470203Free PMC Article
Guidelines of care for the management of primary cutaneous melanoma.
Swetter SM, Tsao H, Bichakjian CK, Curiel-Lewandrowski C, Elder DE, Gershenwald JE, Guild V, Grant-Kels JM, Halpern AC, Johnson TM, Sober AJ, Thompson JA, Wisco OJ, Wyatt S, Hu S, Lamina T
J Am Acad Dermatol 2019 Jan;80(1):208-250. Epub 2018 Nov 1 doi: 10.1016/j.jaad.2018.08.055. PMID: 30392755
Intralesional interferon treatment of lentigo maligna.
Cornejo P, Vanaclocha F, Polimon I, Del Rio R
Arch Dermatol 2000 Mar;136(3):428-30. doi: 10.1001/archderm.136.3.428. PMID: 10724220

Recent clinical studies

Etiology

Introduction to Head and Neck Melanoma: A Dermatologist's Perspective.
Faraj Y, Beltrani VP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):213-220. doi: 10.1016/j.coms.2021.11.007. PMID: 35491078
Molecular Markers and Targets in Melanoma.
Teixido C, Castillo P, Martinez-Vila C, Arance A, Alos L
Cells 2021 Sep 5;10(9) doi: 10.3390/cells10092320. PMID: 34571969Free PMC Article
Histopathologic classification and prognostic factors of melanoma: a 2021 update.
Bobos M
Ital J Dermatol Venerol 2021 Jun;156(3):300-321. Epub 2021 May 13 doi: 10.23736/S2784-8671.21.06958-3. PMID: 33982546
The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway.
Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RA
Arch Pathol Lab Med 2020 Apr;144(4):500-522. Epub 2020 Feb 14 doi: 10.5858/arpa.2019-0561-RA. PMID: 32057276
Melanomas.
Longo C, Pellacani G
Dermatol Clin 2016 Oct;34(4):411-419. doi: 10.1016/j.det.2016.05.004. PMID: 27692447

Diagnosis

Histopathologic classification and prognostic factors of melanoma: a 2021 update.
Bobos M
Ital J Dermatol Venerol 2021 Jun;156(3):300-321. Epub 2021 May 13 doi: 10.23736/S2784-8671.21.06958-3. PMID: 33982546
Melanomas.
Longo C, Pellacani G
Dermatol Clin 2016 Oct;34(4):411-419. doi: 10.1016/j.det.2016.05.004. PMID: 27692447
The morphologic universe of melanoma.
Jaimes N, Marghoob AA
Dermatol Clin 2013 Oct;31(4):599-613, viii-ix. doi: 10.1016/j.det.2013.06.010. PMID: 24075548
Lentigo maligna.
Samaniego E, Redondo P
Actas Dermosifiliogr 2013 Nov;104(9):757-75. Epub 2012 Jul 31 doi: 10.1016/j.ad.2012.05.006. PMID: 22857817
Precursors to skin cancer.
Sober AJ, Burstein JM
Cancer 1995 Jan 15;75(2 Suppl):645-50. doi: 10.1002/1097-0142(19950115)75:2+<645::aid-cncr2820751405>3.0.co;2-1. PMID: 7804989

Therapy

Molecular Markers and Targets in Melanoma.
Teixido C, Castillo P, Martinez-Vila C, Arance A, Alos L
Cells 2021 Sep 5;10(9) doi: 10.3390/cells10092320. PMID: 34571969Free PMC Article
Topical treatments for skin cancer.
Cullen JK, Simmons JL, Parsons PG, Boyle GM
Adv Drug Deliv Rev 2020 Jan 1;153:54-64. Epub 2019 Nov 6 doi: 10.1016/j.addr.2019.11.002. PMID: 31705912
Lentigo maligna.
Samaniego E, Redondo P
Actas Dermosifiliogr 2013 Nov;104(9):757-75. Epub 2012 Jul 31 doi: 10.1016/j.ad.2012.05.006. PMID: 22857817
Precursors to skin cancer.
Sober AJ, Burstein JM
Cancer 1995 Jan 15;75(2 Suppl):645-50. doi: 10.1002/1097-0142(19950115)75:2+<645::aid-cncr2820751405>3.0.co;2-1. PMID: 7804989
Chemosurgery for melanoma.
Mohs FE
Arch Dermatol 1977 Mar;113(3):285-91. PMID: 843093

Prognosis

Classification and Staging of Melanoma in the Head and Neck.
Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Molecular Markers and Targets in Melanoma.
Teixido C, Castillo P, Martinez-Vila C, Arance A, Alos L
Cells 2021 Sep 5;10(9) doi: 10.3390/cells10092320. PMID: 34571969Free PMC Article
Histopathologic classification and prognostic factors of melanoma: a 2021 update.
Bobos M
Ital J Dermatol Venerol 2021 Jun;156(3):300-321. Epub 2021 May 13 doi: 10.23736/S2784-8671.21.06958-3. PMID: 33982546
Melanoma in situ: Part II. Histopathology, treatment, and clinical management.
Higgins HW 2nd, Lee KC, Galan A, Leffell DJ
J Am Acad Dermatol 2015 Aug;73(2):193-203; quiz 203-4. doi: 10.1016/j.jaad.2015.03.057. PMID: 26183968
Topical pharmacotherapy for skin cancer: part II. Clinical applications.
Micali G, Lacarrubba F, Nasca MR, Ferraro S, Schwartz RA
J Am Acad Dermatol 2014 Jun;70(6):979.e1-12; quiz 9912. doi: 10.1016/j.jaad.2013.12.037. PMID: 24831325

Clinical prediction guides

Classification and Staging of Melanoma in the Head and Neck.
Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Histopathologic classification and prognostic factors of melanoma: a 2021 update.
Bobos M
Ital J Dermatol Venerol 2021 Jun;156(3):300-321. Epub 2021 May 13 doi: 10.23736/S2784-8671.21.06958-3. PMID: 33982546
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807
Precursors to skin cancer.
Sober AJ, Burstein JM
Cancer 1995 Jan 15;75(2 Suppl):645-50. doi: 10.1002/1097-0142(19950115)75:2+<645::aid-cncr2820751405>3.0.co;2-1. PMID: 7804989
Chemosurgery for melanoma.
Mohs FE
Arch Dermatol 1977 Mar;113(3):285-91. PMID: 843093

Recent systematic reviews

The use of immunohistochemical staining in Mohs micrographic surgery for melanoma: a systematic review.
Xia J, Patel H, Guo L, Hsu C, Revankar R, Torbeck R
Arch Dermatol Res 2023 Dec;315(10):2769-2772. Epub 2023 Aug 21 doi: 10.1007/s00403-023-02711-5. PMID: 37603089
Mohs surgery for the treatment of lentigo maligna and lentigo maligna melanoma - a systematic review.
Sharma AN, Foulad DP, Doan L, Lee PK, Atanaskova Mesinkovska N
J Dermatolog Treat 2021 Mar;32(2):157-163. Epub 2019 Nov 20 doi: 10.1080/09546634.2019.1690624. PMID: 31696746
Radiotherapy for lentigo maligna and lentigo maligna melanoma - a systematic review.
Hendrickx A, Cozzio A, Plasswilm L, Panje CM
Radiat Oncol 2020 Jul 14;15(1):174. doi: 10.1186/s13014-020-01615-2. PMID: 32664998Free PMC Article
Topical treatments for skin cancer.
Cullen JK, Simmons JL, Parsons PG, Boyle GM
Adv Drug Deliv Rev 2020 Jan 1;153:54-64. Epub 2019 Nov 6 doi: 10.1016/j.addr.2019.11.002. PMID: 31705912
A systematic review of non-surgical treatments for lentigo maligna.
Read T, Noonan C, David M, Wagels M, Foote M, Schaider H, Soyer HP, Smithers BM
J Eur Acad Dermatol Venereol 2016 May;30(5):748-53. Epub 2015 Aug 24 doi: 10.1111/jdv.13252. PMID: 26299846

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