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Benign neoplasm of epididymis

MedGen UID:
57578
•Concept ID:
C0154010
•
Neoplastic Process
Synonyms: Benign Epididymal Neoplasm; benign epididymal neoplasm; Benign Epididymal Tumor; benign epididymal tumor; benign epididymal tumour; Benign Neoplasm of Epididymis; benign neoplasm of epididymis; Benign Neoplasm of the Epididymis; benign neoplasm of the epididymis; Benign tumor of epididymis; Benign Tumor of Epididymis; benign tumor of epididymis; Benign Tumor of the Epididymis; benign tumor of the epididymis; benign tumour of epididymis; benign tumour of the epididymis; epididymis benign neoplasm
SNOMED CT: Benign tumor of epididymis (92088003); Benign neoplasm of epididymis (92088003)
 
Monarch Initiative: MONDO:0021473

Definition

A neoplasm that arises from the epididymis and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include adenomatoid tumor and leiomyoma. [from NCI]

Professional guidelines

PubMed

Nanotechnological approaches for diagnosis and treatment of ovarian cancer: a review of recent trends.
Ding H, Zhang J, Zhang F, Xu Y, Liang W, Yu Y
Drug Deliv 2022 Dec;29(1):3218-3232. doi: 10.1080/10717544.2022.2132032. PMID: 36259505Free PMC Article
Nanotechnology in ovarian cancer: Diagnosis and treatment.
Barani M, Bilal M, Sabir F, Rahdar A, Kyzas GZ
Life Sci 2021 Feb 1;266:118914. Epub 2020 Dec 16 doi: 10.1016/j.lfs.2020.118914. PMID: 33340527
The role of novel biomarker HE4 in the diagnosis, prognosis and follow-up of ovarian cancer: a systematic review.
Scaletta G, Plotti F, Luvero D, Capriglione S, Montera R, Miranda A, Lopez S, Terranova C, De Cicco Nardone C, Angioli R
Expert Rev Anticancer Ther 2017 Sep;17(9):827-839. Epub 2017 Aug 3 doi: 10.1080/14737140.2017.1360138. PMID: 28756722

Recent clinical studies

Etiology

Molecular Biomarkers for the Early Detection of Ovarian Cancer.
Zhang R, Siu MKY, Ngan HYS, Chan KKL
Int J Mol Sci 2022 Oct 10;23(19) doi: 10.3390/ijms231912041. PMID: 36233339Free PMC Article
The epididymal immune balance: a key to preserving male fertility.
Voisin A, Saez F, Drevet JR, Guiton R
Asian J Androl 2019 Nov-Dec;21(6):531-539. doi: 10.4103/aja.aja_11_19. PMID: 30924450Free PMC Article
Ovarian cancer: screening and future directions.
Gupta KK, Gupta VK, Naumann RW
Int J Gynecol Cancer 2019 Jan;29(1):195-200. doi: 10.1136/ijgc-2018-000016. PMID: 30640704
HE4-test of urine and body fluids for diagnosis of gynecologic cancer.
Qu W, Gao Q, Chen H, Tang Z, Zhu X, Jiang SW
Expert Rev Mol Diagn 2017 Mar;17(3):239-244. Epub 2017 Jan 29 doi: 10.1080/14737159.2017.1282824. PMID: 28117603
Male sterilization.
Davis JE
Curr Opin Obstet Gynecol 1992 Aug;4(4):522-6. PMID: 1324023

Diagnosis

Molecular Biomarkers for the Early Detection of Ovarian Cancer.
Zhang R, Siu MKY, Ngan HYS, Chan KKL
Int J Mol Sci 2022 Oct 10;23(19) doi: 10.3390/ijms231912041. PMID: 36233339Free PMC Article
The role of the prostate in male fertility, health and disease.
Verze P, Cai T, Lorenzetti S
Nat Rev Urol 2016 Jul;13(7):379-86. Epub 2016 Jun 1 doi: 10.1038/nrurol.2016.89. PMID: 27245504
von Hippel-Lindau syndrome.
Chou A, Toon C, Pickett J, Gill AJ
Front Horm Res 2013;41:30-49. Epub 2013 Mar 19 doi: 10.1159/000345668. PMID: 23652669
von Hippel-Lindau disease.
Singh AD, Shields CL, Shields JA
Surv Ophthalmol 2001 Sep-Oct;46(2):117-42. doi: 10.1016/s0039-6257(01)00245-4. PMID: 11578646
von Hippel-Lindau disease.
Couch V, Lindor NM, Karnes PS, Michels VV
Mayo Clin Proc 2000 Mar;75(3):265-72. doi: 10.4065/75.3.265. PMID: 10725953

Therapy

Nanotechnological approaches for diagnosis and treatment of ovarian cancer: a review of recent trends.
Ding H, Zhang J, Zhang F, Xu Y, Liang W, Yu Y
Drug Deliv 2022 Dec;29(1):3218-3232. doi: 10.1080/10717544.2022.2132032. PMID: 36259505Free PMC Article
Nanotechnology in ovarian cancer: Diagnosis and treatment.
Barani M, Bilal M, Sabir F, Rahdar A, Kyzas GZ
Life Sci 2021 Feb 1;266:118914. Epub 2020 Dec 16 doi: 10.1016/j.lfs.2020.118914. PMID: 33340527
Aspiration and sclerotherapy of hydroceles and spermatoceles/epididymal cysts with 100% alcohol.
Low LS, Nair SM, Davies AJW, Akapita T, Holmes MA
ANZ J Surg 2020 Jan;90(1-2):57-61. Epub 2019 Oct 18 doi: 10.1111/ans.15467. PMID: 31628703
Vasectomy.
Weiske WH
Andrologia 2001 May;33(3):125-34. doi: 10.1046/j.1439-0272.2001.00445.x. PMID: 11380327
Male sterilization.
Davis JE
Curr Opin Obstet Gynecol 1992 Aug;4(4):522-6. PMID: 1324023

Prognosis

Molecular Biomarkers for the Early Detection of Ovarian Cancer.
Zhang R, Siu MKY, Ngan HYS, Chan KKL
Int J Mol Sci 2022 Oct 10;23(19) doi: 10.3390/ijms231912041. PMID: 36233339Free PMC Article
Application of serum markers in diagnosis and staging of ovarian endometriosis.
Tang T, Lai H, Huang X, Gu L, Shi H
J Obstet Gynaecol Res 2021 Apr;47(4):1441-1450. Epub 2021 Jan 14 doi: 10.1111/jog.14654. PMID: 33448139
Ovarian cancer: screening and future directions.
Gupta KK, Gupta VK, Naumann RW
Int J Gynecol Cancer 2019 Jan;29(1):195-200. doi: 10.1136/ijgc-2018-000016. PMID: 30640704
Clinicopathological Characteristics, Treatment, and Prognosis of Rarely Primary Epididymal Adenocarcinoma: A Review and Update.
Zou ZJ, Xiao YM, Liu ZH, Zhang RC, Liang JY, Tang YQ, Lu YP
Biomed Res Int 2017;2017:4126740. Epub 2017 Dec 20 doi: 10.1155/2017/4126740. PMID: 29423406Free PMC Article
Intrascrotal adenomatoid tumors.
Tammela TL, Karttunen TJ, Mäkäräinen HP, Hellström PA, Mattila SI, Kontturi MJ
J Urol 1991 Jul;146(1):61-5. doi: 10.1016/s0022-5347(17)37715-7. PMID: 2056607

Clinical prediction guides

Combination of serum CST1 and HE4 for early diagnosis of endometrial cancer.
Zhong W, Liu Y, Zhang L, Zhuang W, Chen J, Huang Z, Zheng Y, Huang Y
PeerJ 2023;11:e16424. Epub 2023 Dec 5 doi: 10.7717/peerj.16424. PMID: 38077439Free PMC Article
Application of serum markers in diagnosis and staging of ovarian endometriosis.
Tang T, Lai H, Huang X, Gu L, Shi H
J Obstet Gynaecol Res 2021 Apr;47(4):1441-1450. Epub 2021 Jan 14 doi: 10.1111/jog.14654. PMID: 33448139
The epididymal immune balance: a key to preserving male fertility.
Voisin A, Saez F, Drevet JR, Guiton R
Asian J Androl 2019 Nov-Dec;21(6):531-539. doi: 10.4103/aja.aja_11_19. PMID: 30924450Free PMC Article
Ovarian cancer: screening and future directions.
Gupta KK, Gupta VK, Naumann RW
Int J Gynecol Cancer 2019 Jan;29(1):195-200. doi: 10.1136/ijgc-2018-000016. PMID: 30640704
von Hippel-Lindau disease.
Singh AD, Shields CL, Shields JA
Surv Ophthalmol 2001 Sep-Oct;46(2):117-42. doi: 10.1016/s0039-6257(01)00245-4. PMID: 11578646

Recent systematic reviews

Protective effects of exogenous melatonin therapy against oxidative stress to male reproductive tissue caused by anti-cancer chemical and radiation therapy: a systematic review and meta-analysis of animal studies.
Dehdari Ebrahimi N, Sadeghi A, Shojaei-Zarghani S, Shahlaee MA, Taherifard E, Rahimian Z, Eghlidos Z, Azarpira N, Safarpour AR
Front Endocrinol (Lausanne) 2023;14:1184745. Epub 2023 Aug 28 doi: 10.3389/fendo.2023.1184745. PMID: 37701901Free PMC Article
Prognostic values of human epididymis protein 4 expression in patients with endometrial cancer: A systematic review and meta-analysis.
Han LN, Han YW, Yan P
J Obstet Gynaecol Res 2022 Sep;48(9):2255-2269. Epub 2022 Jul 17 doi: 10.1111/jog.15356. PMID: 35844088
Endometrial cancer: A systematic review of HE4, REM and REM-B.
Degez M, Caillon H, Chauviré-Drouard A, Leroy M, Lair D, Winer N, Thubert T, Dochez V
Clin Chim Acta 2021 Apr;515:27-36. Epub 2020 Dec 31 doi: 10.1016/j.cca.2020.12.029. PMID: 33388311
The role of novel biomarker HE4 in the diagnosis, prognosis and follow-up of ovarian cancer: a systematic review.
Scaletta G, Plotti F, Luvero D, Capriglione S, Montera R, Miranda A, Lopez S, Terranova C, De Cicco Nardone C, Angioli R
Expert Rev Anticancer Ther 2017 Sep;17(9):827-839. Epub 2017 Aug 3 doi: 10.1080/14737140.2017.1360138. PMID: 28756722
Accuracy of serum human epididymis protein 4 in ovarian cancer diagnosis: a systematic review and meta-analysis.
Macedo AC, da Rosa MI, Lumertz S, Medeiros LR
Int J Gynecol Cancer 2014 Sep;24(7):1222-31. doi: 10.1097/IGC.0000000000000192. PMID: 25078339

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