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Urethral diverticulum

MedGen UID:
57776
•Concept ID:
C0152443
•
Disease or Syndrome
Synonym: Urethral Diverticulum
SNOMED CT: Urethral diverticulum (90531003)
 
HPO: HP:0008722

Definition

The presence of a diverticulum (sac or pouch) in the wall of the urethra. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrethral diverticulum

Conditions with this feature

Cardiac valvular defect, developmental
MedGen UID:
1823949
•Concept ID:
C5774175
•
Disease or Syndrome
Cardiac valvular dysplasia-1 (CVDP1) is characterized by congenital malformations of the pulmonic, tricuspid, and mitral valves. Structural cardiac defects, including atrial and ventricular septal defects, single left ventricle, and hypoplastic right ventricle have also been observed in affected individuals (Ta-Shma et al., 2017). Genetic Heterogeneity of Cardiac Valvular Dysplasia CVDP2 (620067) is caused by mutation in the ADAMTS19 gene (607513) on chromosome 5q23.
See: Condition Record
Cardiac valvular defect, developmental

Professional guidelines

PubMed

Female Urethral Diverticulum: Current Diagnosis and Management.
Crescenze IM, Goldman HB
Curr Urol Rep 2015 Oct;16(10):71. doi: 10.1007/s11934-015-0540-8. PMID: 26267225
Utility of clinical parameters, cystourethroscopy, and magnetic resonance imaging in the preoperative diagnosis of urethral diverticula.
Pathi SD, Rahn DD, Sailors JL, Graziano VA, Sims RD, Stone RJ, McIntire DD, Wai CY
Int Urogynecol J 2013 Feb;24(2):319-23. Epub 2012 Jun 16 doi: 10.1007/s00192-012-1841-9. PMID: 22707007
Radiologic diagnosis and surgical treatment of urethral diverticulum in women. A reappraisal of voiding cystourethrography and positive pressure urethrography.
Wang AC, Wang CR
J Reprod Med 2000 May;45(5):377-82. PMID: 10845169

Recent clinical studies

Etiology

Are anterior urethral valve and anterior urethral diverticulum two separate entities: A radiological and endoscopic review.
Jain P, Prasad A, Jain S
J Pediatr Urol 2021 Feb;17(1):101.e1-101.e9. Epub 2020 Nov 4 doi: 10.1016/j.jpurol.2020.11.002. PMID: 33229229
Anterior urethral valves - A rare but challenging congenital pathology.
Sheth KR, White JT, Bilgutay AN, Seth A, Mittal AG
J Pediatr Urol 2020 Oct;16(5):585.e1-585.e7. Epub 2020 Apr 4 doi: 10.1016/j.jpurol.2020.03.024. PMID: 32340880
Female Urethral Diverticulum: Presentation, Diagnosis, and Predictors of Outcomes After Surgery.
El-Nashar SA, Singh R, Bacon MM, Kim-Fine S, Occhino JA, Gebhart JB, Klingele CJ
Female Pelvic Med Reconstr Surg 2016 Nov/Dec;22(6):447-452. doi: 10.1097/SPV.0000000000000312. PMID: 27636213Free PMC Article
Skene's gland cyst excision.
Foster J, Lemack G, Zimmern P
Int Urogynecol J 2016 May;27(5):817-20. Epub 2015 Dec 15 doi: 10.1007/s00192-015-2872-9. PMID: 26670578
Laparoscopy and its use in the repair of anorectal malformations.
Bischoff A, Levitt MA, Peña A
J Pediatr Surg 2011 Aug;46(8):1609-17. doi: 10.1016/j.jpedsurg.2011.03.068. PMID: 21843731

Diagnosis

Urethral Masses.
Serrell EC, McAchran SE
Obstet Gynecol Clin North Am 2021 Sep;48(3):599-616. doi: 10.1016/j.ogc.2021.05.011. PMID: 34416940
Stress Urinary Incontinence After Urethral Diverticulum Repair Without Concomitant Anti-Incontinence Procedure.
Chavez JA, Fuentes JL, Christie AL, Alhalabi F, Carmel ME, Lemack GE, Zimmern PE
Urology 2021 Aug;154:103-108. Epub 2021 Apr 11 doi: 10.1016/j.urology.2021.03.034. PMID: 33852920
Are anterior urethral valve and anterior urethral diverticulum two separate entities: A radiological and endoscopic review.
Jain P, Prasad A, Jain S
J Pediatr Urol 2021 Feb;17(1):101.e1-101.e9. Epub 2020 Nov 4 doi: 10.1016/j.jpurol.2020.11.002. PMID: 33229229
Female Urethral Diverticulum: Current Diagnosis and Management.
Crescenze IM, Goldman HB
Curr Urol Rep 2015 Oct;16(10):71. doi: 10.1007/s11934-015-0540-8. PMID: 26267225
Laparoscopy and its use in the repair of anorectal malformations.
Bischoff A, Levitt MA, Peña A
J Pediatr Surg 2011 Aug;46(8):1609-17. doi: 10.1016/j.jpedsurg.2011.03.068. PMID: 21843731

Therapy

Analysis in the influence factors of urethroplasty in DSD.
Yu J, Sun N, Song H, Li M, Li L, Gong C, Zhang W
BMC Urol 2022 Aug 10;22(1):124. doi: 10.1186/s12894-022-01080-x. PMID: 35948888Free PMC Article
Stress Urinary Incontinence After Urethral Diverticulum Repair Without Concomitant Anti-Incontinence Procedure.
Chavez JA, Fuentes JL, Christie AL, Alhalabi F, Carmel ME, Lemack GE, Zimmern PE
Urology 2021 Aug;154:103-108. Epub 2021 Apr 11 doi: 10.1016/j.urology.2021.03.034. PMID: 33852920
Comparison of continuous eversion and inverting subepithelial suture in transverse preputial island flap urethroplasty in proximal hypospadias repair: A retrospective study.
Han W, Zhang W, Sun N, Yang Y
Int Braz J Urol 2020 Sep-Oct;46(5):772-777. doi: 10.1590/S1677-5538.IBJU.2019.0484. PMID: 32648417Free PMC Article
Urethral Diverticulum following Polypropylene Mesh Midurethral Slings: A Literature Review.
Pacer E, Duenas-Garcia OF, Hota L, Hornsby K, Shapiro R
Biomed Res Int 2020;2020:6761581. Epub 2020 May 11 doi: 10.1155/2020/6761581. PMID: 32462011Free PMC Article
Management of symptomatic urethral diverticula in women: a single-centre experience.
Reeves FA, Inman RD, Chapple CR
Eur Urol 2014 Jul;66(1):164-72. Epub 2014 Feb 26 doi: 10.1016/j.eururo.2014.02.041. PMID: 24636677

Prognosis

Complex Urethral Diverticulectomy: Is a Synchronous Prophylactic Autologous Fascial Sling Needed?
Schaaf AL, Lee YS, Myers AA, Schommer J, Gonzalez G, Chen A, Petrou S
Urogynecology (Phila) 2023 Jun 1;29(6):552-557. Epub 2023 Feb 4 doi: 10.1097/SPV.0000000000001311. PMID: 37235804
Robotic assisted proximal dorsal urethral diverticulectomy.
Mozafarpour S, Nwaoha N, Pucheril D, De EJB
Int Urogynecol J 2021 Oct;32(10):2863-2866. Epub 2021 Feb 26 doi: 10.1007/s00192-021-04716-y. PMID: 33635350
Surgical excision of paraurethral cyst.
Milani R, Manodoro S, Cola A, Palmieri S, Reato C, Frigerio M
Int Braz J Urol 2020 Mar-Apr;46(2):298-299. doi: 10.1590/S1677-5538.IBJU.2018.0761. PMID: 32022530Free PMC Article
Female Urethral Diverticulum: Presentation, Diagnosis, and Predictors of Outcomes After Surgery.
El-Nashar SA, Singh R, Bacon MM, Kim-Fine S, Occhino JA, Gebhart JB, Klingele CJ
Female Pelvic Med Reconstr Surg 2016 Nov/Dec;22(6):447-452. doi: 10.1097/SPV.0000000000000312. PMID: 27636213Free PMC Article
Skene's gland cyst excision.
Foster J, Lemack G, Zimmern P
Int Urogynecol J 2016 May;27(5):817-20. Epub 2015 Dec 15 doi: 10.1007/s00192-015-2872-9. PMID: 26670578

Clinical prediction guides

Complex Urethral Diverticulectomy: Is a Synchronous Prophylactic Autologous Fascial Sling Needed?
Schaaf AL, Lee YS, Myers AA, Schommer J, Gonzalez G, Chen A, Petrou S
Urogynecology (Phila) 2023 Jun 1;29(6):552-557. Epub 2023 Feb 4 doi: 10.1097/SPV.0000000000001311. PMID: 37235804
Urethral Masses.
Serrell EC, McAchran SE
Obstet Gynecol Clin North Am 2021 Sep;48(3):599-616. doi: 10.1016/j.ogc.2021.05.011. PMID: 34416940
Stress Urinary Incontinence After Urethral Diverticulum Repair Without Concomitant Anti-Incontinence Procedure.
Chavez JA, Fuentes JL, Christie AL, Alhalabi F, Carmel ME, Lemack GE, Zimmern PE
Urology 2021 Aug;154:103-108. Epub 2021 Apr 11 doi: 10.1016/j.urology.2021.03.034. PMID: 33852920
Surgical excision of paraurethral cyst.
Milani R, Manodoro S, Cola A, Palmieri S, Reato C, Frigerio M
Int Braz J Urol 2020 Mar-Apr;46(2):298-299. doi: 10.1590/S1677-5538.IBJU.2018.0761. PMID: 32022530Free PMC Article
In Search of Mobile Applications for Urogynecology Providers.
Wallace SL, Mehta S, Farag S, Kelley RS, Chen KT
Female Pelvic Med Reconstr Surg 2019 Nov/Dec;25(6):439-442. doi: 10.1097/SPV.0000000000000580. PMID: 29649079

Recent systematic reviews

Should endoscopic laser excision be offered as the first-line management for patients with eroded mesh? Outcomes of a systematic review of literature.
Ripa F, Enikeev D, Talyshinskii A, Juliebø-Jones P, Tzelves L, Kallidonis P, Somani B
Curr Opin Urol 2024 Mar 1;34(2):135-144. Epub 2023 Nov 6 doi: 10.1097/MOU.0000000000001146. PMID: 37933676
Meta-analysis comparing the outcomes of single stage (foreskin pedicled tube) versus two stage (foreskin free graft & foreskin pedicled flap) repair for proximal hypospadias in the last decade.
Babu R, Chandrasekharam VVS
J Pediatr Urol 2021 Oct;17(5):681-689. Epub 2021 May 17 doi: 10.1016/j.jpurol.2021.05.014. PMID: 34099397
Postoperative "complications" following laparoscopic-assisted anorectoplasty: A systematic review.
Pathak M, Saxena AK
Pediatr Surg Int 2020 Nov;36(11):1299-1307. Epub 2020 Sep 26 doi: 10.1007/s00383-020-04748-3. PMID: 32980932
Surgical management of urethral diverticula in women: a systematic review.
Bodner-Adler B, Halpern K, Hanzal E
Int Urogynecol J 2016 Jul;27(7):993-1001. Epub 2015 Nov 13 doi: 10.1007/s00192-015-2862-y. PMID: 26564222

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