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Benign neoplasm of corpus uteri

MedGen UID:
57808
•Concept ID:
C0153998
•
Neoplastic Process
Synonyms: Benign Corpus Uteri Neoplasm; benign corpus uteri neoplasm; Benign Corpus Uteri Tumor; benign corpus uteri tumor; benign corpus uteri tumour; Benign neoplasm of body of uterus; Benign Neoplasm of Body of Uterus; benign neoplasm of body of uterus; Benign Neoplasm of Corpus Uteri; benign neoplasm of corpus uteri; Benign Neoplasm of the Body of Uterus; benign neoplasm of the body of uterus; Benign Neoplasm of the Corpus Uteri; benign neoplasm of the corpus uteri; Benign Neoplasm of the Uterine Body; benign neoplasm of the uterine body; Benign Neoplasm of the Uterine Corpus; benign neoplasm of the uterine corpus; Benign Neoplasm of Uterine Body; benign neoplasm of uterine body; Benign Neoplasm of Uterine Corpus; benign neoplasm of uterine corpus; Benign Tumor of Body of Uterus; benign tumor of body of uterus; Benign Tumor of Corpus Uteri; benign tumor of corpus uteri; Benign Tumor of the Body of Uterus; benign tumor of the body of uterus; Benign Tumor of the Corpus Uteri; benign tumor of the corpus uteri; Benign Tumor of the Uterine Body; benign tumor of the uterine body; Benign Tumor of the Uterine Corpus; benign tumor of the uterine corpus; Benign Tumor of Uterine Body; benign tumor of uterine body; Benign Tumor of Uterine Corpus; benign tumor of uterine corpus; benign tumour of body of uterus; benign tumour of corpus uteri; benign tumour of the body of uterus; benign tumour of the corpus uteri; benign tumour of the uterine body; benign tumour of the uterine corpus; benign tumour of uterine body; benign tumour of uterine corpus; Benign Uterine Body Neoplasm; benign uterine body neoplasm; Benign Uterine Body Tumor; benign uterine body tumor; benign uterine body tumour; Benign Uterine Corpus Neoplasm; benign uterine corpus neoplasm; Benign Uterine Corpus Tumor; benign uterine corpus tumor; benign uterine corpus tumour; body of uterus benign neoplasm
SNOMED CT: Benign neoplasm of body of uterus (92021007); Benign neoplasm of corpus uteri (92021007)
 
Monarch Initiative: MONDO:0021525

Definition

A neoplasm that arises from the uterine corpus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include leiomyoma, adenomyoma, endometrial stromal nodule, and endometrial polyp. [from NCI]

Professional guidelines

PubMed

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
FIGO staging for carcinoma of the vulva, cervix, and corpus uteri.
FIGO Committee on Gynecologic Oncology
Int J Gynaecol Obstet 2014 May;125(2):97-8. Epub 2014 Feb 22 doi: 10.1016/j.ijgo.2014.02.003. PMID: 24630859
Cancer incidence following treatment for infertility at a clinic in the UK.
Doyle P, Maconochie N, Beral V, Swerdlow AJ, Tan SL
Hum Reprod 2002 Aug;17(8):2209-13. doi: 10.1093/humrep/17.8.2209. PMID: 12151460

Recent clinical studies

Etiology

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Cancer of the corpus uteri: 2021 update.
Koskas M, Amant F, Mirza MR, Creutzberg CL
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):45-60. doi: 10.1002/ijgo.13866. PMID: 34669196Free PMC Article
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Predicting the Behavior of Perivascular Epithelioid Cell Tumors of the Uterine Corpus.
Acosta AM, Adley BP
Arch Pathol Lab Med 2017 Mar;141(3):463-469. doi: 10.5858/arpa.2016-0092-RS. PMID: 28234575
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article

Diagnosis

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Cytological features of mesonephric-like adenocarcinoma of the uterine corpus.
Seo Y, Park E, Kim HS
Diagn Cytopathol 2023 May;51(5):294-306. Epub 2023 Feb 8 doi: 10.1002/dc.25111. PMID: 36756667
Mucinous Proliferations of the Uterine Corpus: Comprehensive Appraisal of an Evolving Spectrum of Neoplasms.
Fadare O
Adv Anat Pathol 2022 Sep 1;29(5):275-296. Epub 2022 May 3 doi: 10.1097/PAP.0000000000000348. PMID: 35499137
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article

Therapy

The role of serum interleukins in Cancer: A Multi-center Mendelian Randomization study.
Zhang Z, Wang J, Teng M, Yan X, Liu Q
Int Immunopharmacol 2024 Aug 20;137:112520. Epub 2024 Jun 19 doi: 10.1016/j.intimp.2024.112520. PMID: 38901247
Mitochondrial DNA copy number and cancer risks: A comprehensive Mendelian randomization analysis.
Cai X, Liang C, Zhang M, Dong Z, Weng Y, Yu W
Int J Cancer 2024 Apr 15;154(8):1504-1513. Epub 2023 Dec 27 doi: 10.1002/ijc.34833. PMID: 38151753
Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
Tailored Therapy Based on Molecular Characteristics in Endometrial Cancer.
Lee SY
Biomed Res Int 2021;2021:2068023. Epub 2021 May 5 doi: 10.1155/2021/2068023. PMID: 34036097Free PMC Article
A contemporary review of uterine cancer management.
Carter J
Aust N Z J Obstet Gynaecol 2013 Dec;53(6):517-24. Epub 2013 Jul 6 doi: 10.1111/ajo.12109. PMID: 23829412

Prognosis

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Cancer of the corpus uteri: 2021 update.
Koskas M, Amant F, Mirza MR, Creutzberg CL
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):45-60. doi: 10.1002/ijgo.13866. PMID: 34669196Free PMC Article
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Predicting the Behavior of Perivascular Epithelioid Cell Tumors of the Uterine Corpus.
Acosta AM, Adley BP
Arch Pathol Lab Med 2017 Mar;141(3):463-469. doi: 10.5858/arpa.2016-0092-RS. PMID: 28234575
Gynecological sarcomas.
DiSaia PJ, Pecorelli S
Semin Surg Oncol 1994 Sep-Oct;10(5):369-73. doi: 10.1002/ssu.2980100510. PMID: 7997731

Clinical prediction guides

Mitochondrial DNA copy number and cancer risks: A comprehensive Mendelian randomization analysis.
Cai X, Liang C, Zhang M, Dong Z, Weng Y, Yu W
Int J Cancer 2024 Apr 15;154(8):1504-1513. Epub 2023 Dec 27 doi: 10.1002/ijc.34833. PMID: 38151753
Cytological features of mesonephric-like adenocarcinoma of the uterine corpus.
Seo Y, Park E, Kim HS
Diagn Cytopathol 2023 May;51(5):294-306. Epub 2023 Feb 8 doi: 10.1002/dc.25111. PMID: 36756667
The five major autoimmune diseases increase the risk of cancer: epidemiological data from a large-scale cohort study in China.
Zhou Z, Liu H, Yang Y, Zhou J, Zhao L, Chen H, Fei Y, Zhang W, Li M, Zhao Y, Zeng X, Zhang F, Yang H, Zhang X
Cancer Commun (Lond) 2022 May;42(5):435-446. Epub 2022 Mar 31 doi: 10.1002/cac2.12283. PMID: 35357093Free PMC Article
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article

Recent systematic reviews

Risks of second non-breast primaries following breast cancer in women: a systematic review and meta-analysis.
Allen I, Hassan H, Sofianopoulou E, Eccles D, Turnbull C, Tischkowitz M, Pharoah P, Antoniou AC
Breast Cancer Res 2023 Feb 10;25(1):18. doi: 10.1186/s13058-023-01610-x. PMID: 36765408Free PMC Article
Clinico-pathological features associated with mismatch repair deficiency in endometrial undifferentiated/dedifferentiated carcinoma: A systematic review and meta-analysis.
Travaglino A, Raffone A, Gencarelli A, Saracinelli S, Riccardi C, Mollo A, Zullo F, Insabato L
Gynecol Oncol 2021 Feb;160(2):579-585. Epub 2020 Dec 1 doi: 10.1016/j.ygyno.2020.11.015. PMID: 33276986
Is periodontitis a risk indicator for cancer? A meta-analysis.
Corbella S, Veronesi P, Galimberti V, Weinstein R, Del Fabbro M, Francetti L
PLoS One 2018;13(4):e0195683. Epub 2018 Apr 17 doi: 10.1371/journal.pone.0195683. PMID: 29664916Free PMC Article
Role of MRI in detecting involvement of the uterine internal os in uterine cervical cancer: systematic review of diagnostic test accuracy.
de Boer P, Adam JA, Buist MR, van de Vijver MJ, Rasch CR, Stoker J, Bipat S, Stalpers LJ
Eur J Radiol 2013 Sep;82(9):e422-8. Epub 2013 May 25 doi: 10.1016/j.ejrad.2013.04.027. PMID: 23711423
A systematic overview of radiation therapy effects in uterine cancer (corpus uteri).
Einhorn N, Tropé C, Ridderheim M, Boman K, Sorbe B, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):557-61. doi: 10.1080/02841860310014417. PMID: 14596513

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