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Malignant Brain Glioma

MedGen UID:
578810
•Concept ID:
C0349541
•
Neoplastic Process
Synonyms: Brain High Grade Glioma; Brain High-Grade Glioma; Brain Malignant Glioma; High Grade Brain Glioma; High-Grade Brain Glioma; Malignant glioma of brain
SNOMED CT: Malignant glioma of brain (276826005)

Definition

A grade 3 or 4 glioma that arises from the brain. This category includes anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligoastrocytoma, anaplastic oligodendroglioma, anaplastic pleomorphic xanthoastrocytoma (all grade 3 gliomas), and glioblastoma (grade 4 glioma). [from NCI]

Professional guidelines

PubMed

Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment.
Cui Y, Xu Q, Chow PK, Wang D, Wang CH
Biomaterials 2013 Nov;34(33):8511-20. Epub 2013 Aug 6 doi: 10.1016/j.biomaterials.2013.07.075. PMID: 23932498
Fotemustine in the treatment of brain primary tumors and metastases.
Khayat D, Giroux B, Berille J, Cour V, Gerard B, Sarkany M, Bertrand P, Bizzari JP
Cancer Invest 1994;12(4):414-20. doi: 10.3109/07357909409038234. PMID: 8032964

Recent clinical studies

Etiology

Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma.
Bai R, Zhu J, Bai Z, Mao Q, Zhang Y, Hui Z, Luo X, Ye XY, Xie T
J Enzyme Inhib Med Chem 2022 Dec;37(1):379-385. doi: 10.1080/14756366.2021.2016734. PMID: 35012394Free PMC Article
Prognostic value of MGMT promoter status in non-resectable glioblastoma after adjuvant therapy.
Iaccarino C, Orlandi E, Ruggeri F, Nicoli D, Torricelli F, Maggi M, Cerasti D, Pisanello A, Pedrazzi G, Froio E, Crafa P, D'Abbiero N, Michiara M, Ghadirpour R, Servadei F
Clin Neurol Neurosurg 2015 May;132:1-8. Epub 2015 Feb 7 doi: 10.1016/j.clineuro.2015.01.029. PMID: 25723791
The value of stereotactic biopsy in improving survival and quality of life for malignant brain glioma patients.
Lakicević G, Splavski B, Brekalo Z
Coll Antropol 2010 Mar;34 Suppl 1:93-7. PMID: 20402303
Effect of CCNU on survival rate of objective remission and duration of free interval in patients with malignant brain glioma--final evaluation. E.O.R.T.C. Brain Tumor Group.
Eur J Cancer (1965) 1978 Aug;14(8):851-6. doi: 10.1016/0014-2964(78)90100-7. PMID: 357162

Diagnosis

Prognostic value of MGMT promoter status in non-resectable glioblastoma after adjuvant therapy.
Iaccarino C, Orlandi E, Ruggeri F, Nicoli D, Torricelli F, Maggi M, Cerasti D, Pisanello A, Pedrazzi G, Froio E, Crafa P, D'Abbiero N, Michiara M, Ghadirpour R, Servadei F
Clin Neurol Neurosurg 2015 May;132:1-8. Epub 2015 Feb 7 doi: 10.1016/j.clineuro.2015.01.029. PMID: 25723791

Therapy

Prognostic value of MGMT promoter status in non-resectable glioblastoma after adjuvant therapy.
Iaccarino C, Orlandi E, Ruggeri F, Nicoli D, Torricelli F, Maggi M, Cerasti D, Pisanello A, Pedrazzi G, Froio E, Crafa P, D'Abbiero N, Michiara M, Ghadirpour R, Servadei F
Clin Neurol Neurosurg 2015 May;132:1-8. Epub 2015 Feb 7 doi: 10.1016/j.clineuro.2015.01.029. PMID: 25723791
Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment.
Cui Y, Xu Q, Chow PK, Wang D, Wang CH
Biomaterials 2013 Nov;34(33):8511-20. Epub 2013 Aug 6 doi: 10.1016/j.biomaterials.2013.07.075. PMID: 23932498
A case of relapsing glioblastoma multiforme responding to vinorelbine.
Biassoni V, Casanova M, Spreafico F, Gandola L, Massimino M
J Neurooncol 2006 Nov;80(2):195-201. Epub 2006 May 3 doi: 10.1007/s11060-006-9176-3. PMID: 16670944
Effect of CCNU on survival rate of objective remission and duration of free interval in patients with malignant brain glioma--final evaluation. E.O.R.T.C. Brain Tumor Group.
Eur J Cancer (1965) 1978 Aug;14(8):851-6. doi: 10.1016/0014-2964(78)90100-7. PMID: 357162
Effect of CCNU on survival, rate of objective remission and duration of free interval in patients with malignant brain glioma--first evaluation.
Eur J Cancer (1965) 1976 Jan;12(1):41-5. doi: 10.1016/0014-2964(76)90122-5. PMID: 1269526

Prognosis

Gamma Knife Radiosurgery for High-Grade Gliomas: Single-Center Experience of Six Years in China.
Zhao M, Fu X, Zhang Z, Ma L, Wang X, Li X
Stereotact Funct Neurosurg 2021;99(3):181-186. Epub 2021 Mar 23 doi: 10.1159/000509782. PMID: 33756470
Prognostic value of MGMT promoter status in non-resectable glioblastoma after adjuvant therapy.
Iaccarino C, Orlandi E, Ruggeri F, Nicoli D, Torricelli F, Maggi M, Cerasti D, Pisanello A, Pedrazzi G, Froio E, Crafa P, D'Abbiero N, Michiara M, Ghadirpour R, Servadei F
Clin Neurol Neurosurg 2015 May;132:1-8. Epub 2015 Feb 7 doi: 10.1016/j.clineuro.2015.01.029. PMID: 25723791
The value of stereotactic biopsy in improving survival and quality of life for malignant brain glioma patients.
Lakicević G, Splavski B, Brekalo Z
Coll Antropol 2010 Mar;34 Suppl 1:93-7. PMID: 20402303
A case of relapsing glioblastoma multiforme responding to vinorelbine.
Biassoni V, Casanova M, Spreafico F, Gandola L, Massimino M
J Neurooncol 2006 Nov;80(2):195-201. Epub 2006 May 3 doi: 10.1007/s11060-006-9176-3. PMID: 16670944
Effect of CCNU on survival rate of objective remission and duration of free interval in patients with malignant brain glioma--final evaluation. E.O.R.T.C. Brain Tumor Group.
Eur J Cancer (1965) 1978 Aug;14(8):851-6. doi: 10.1016/0014-2964(78)90100-7. PMID: 357162

Clinical prediction guides

Gamma Knife Radiosurgery for High-Grade Gliomas: Single-Center Experience of Six Years in China.
Zhao M, Fu X, Zhang Z, Ma L, Wang X, Li X
Stereotact Funct Neurosurg 2021;99(3):181-186. Epub 2021 Mar 23 doi: 10.1159/000509782. PMID: 33756470
Prognostic value of MGMT promoter status in non-resectable glioblastoma after adjuvant therapy.
Iaccarino C, Orlandi E, Ruggeri F, Nicoli D, Torricelli F, Maggi M, Cerasti D, Pisanello A, Pedrazzi G, Froio E, Crafa P, D'Abbiero N, Michiara M, Ghadirpour R, Servadei F
Clin Neurol Neurosurg 2015 May;132:1-8. Epub 2015 Feb 7 doi: 10.1016/j.clineuro.2015.01.029. PMID: 25723791

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