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Typical Acute Promyelocytic Leukemia

MedGen UID:
578867
•Concept ID:
C0349675
•
Neoplastic Process
Synonyms: Hypergranular Acute Promyelocytic Leukemia; Hypergranular promyelocytic leukemia
SNOMED CT: Hypergranular promyelocytic leukemia (278189009)

Definition

Acute Promyelocytic leukemia characterized by the presence of hypergranular promyelocytes and characteristic cells that contain bundles of Auer rods. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTypical Acute Promyelocytic Leukemia

Professional guidelines

PubMed

Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.
Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A
Blood 1998 Apr 15;91(8):2634-42. PMID: 9531570

Recent clinical studies

Diagnosis

A rare case with typical acute promyelocytic leukemia morphology associated with isolated isochromosome 17q without RARα rearrangement.
Duan Y, Nie J, Zhang Z, Zhou L, Zhu F, Zhang H, Zhu H, Shang W
Hematol Oncol Stem Cell Ther 2013 Mar;6(1):42-5. Epub 2013 Mar 5 doi: 10.1016/j.hemonc.2013.02.004. PMID: 23664605
Atypical response to all-trans retinoic acid in a der(5)t(5;17) acute promyelocytic leukemia.
Mozziconacci MJ, Liberatore C, Grignani F, Sainty D, Pelicci PG, Birg F, Lafage-Pochitaloff M
Leukemia 1999 Jun;13(6):862-8. doi: 10.1038/sj.leu.2401412. PMID: 10360373
Light scatter and immunophenotypic characteristics of blast cells in typical acute promyelocytic leukemia and its variant.
Piedras J, López-Karpovitch X, Cárdenas R
Cytometry 1998 Aug 1;32(4):286-90. PMID: 9701397
Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.
Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A
Blood 1998 Apr 15;91(8):2634-42. PMID: 9531570

Therapy

A rare case with typical acute promyelocytic leukemia morphology associated with isolated isochromosome 17q without RARα rearrangement.
Duan Y, Nie J, Zhang Z, Zhou L, Zhu F, Zhang H, Zhu H, Shang W
Hematol Oncol Stem Cell Ther 2013 Mar;6(1):42-5. Epub 2013 Mar 5 doi: 10.1016/j.hemonc.2013.02.004. PMID: 23664605
Atypical response to all-trans retinoic acid in a der(5)t(5;17) acute promyelocytic leukemia.
Mozziconacci MJ, Liberatore C, Grignani F, Sainty D, Pelicci PG, Birg F, Lafage-Pochitaloff M
Leukemia 1999 Jun;13(6):862-8. doi: 10.1038/sj.leu.2401412. PMID: 10360373
Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.
Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A
Blood 1998 Apr 15;91(8):2634-42. PMID: 9531570

Prognosis

Light scatter and immunophenotypic characteristics of blast cells in typical acute promyelocytic leukemia and its variant.
Piedras J, López-Karpovitch X, Cárdenas R
Cytometry 1998 Aug 1;32(4):286-90. PMID: 9701397
Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.
Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A
Blood 1998 Apr 15;91(8):2634-42. PMID: 9531570

Clinical prediction guides

Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.
Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A
Blood 1998 Apr 15;91(8):2634-42. PMID: 9531570
Unbalanced translocation t(5;17) in an typical acute promyelocytic leukemia.
Brunel V, Sainty D, Carbuccia N, Arnoulet C, Costello R, Mozziconacci MJ, Simonetti J, Coignet L, Gabert J, Stoppa AM
Genes Chromosomes Cancer 1995 Dec;14(4):307-12. doi: 10.1002/gcc.2870140410. PMID: 8605120
Association of t(15;17) and t(8;21) in the initial phase of an acute promyelocytic leukemia.
Charrin C, Ritouet D, Campos L, Devaux Y, Archimbaud E, Fraisse J, Fiere D, Germain D
Cancer Genet Cytogenet 1992 Feb;58(2):177-80. doi: 10.1016/0165-4608(92)90108-k. PMID: 1551085

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