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Vanishing twin syndrome

MedGen UID:
589306
•Concept ID:
C0404852
•
Disease or Syndrome
Synonyms: Vanishing Twin; Vanishing Twin Syndrome
SNOMED CT: Vanishing twin syndrome (237245006)

Definition

A multiple pregnancy that over time is spontaneously reduced by one or more embryos which are then resorbed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVanishing twin syndrome

Professional guidelines

PubMed

Performance and Diagnostic Value of Genome-Wide Noninvasive Prenatal Testing in Multiple Gestations.
van Riel M, Brison N, Baetens M, Blaumeiser B, Boemer F, Bourlard L, Bulk S, De Leener A, Désir J, Devriendt K, Dheedene A, Duquenne A, Fieremans N, Fieuw A, Gatot JS, Grisart B, Janssens S, Khudashvili N, Lannoo L, Marichal A, Meunier C, Palmeira L, Parijs I, Pichon B, Roets E, Sammels E, Smits G, Suenaert M, Sznajer Y, Van den Bogaert K, Vancoillie L, Vandeputte L, Vantroys E, Vermeesch JR, Janssens K
Obstet Gynecol 2021 Jun 1;137(6):1102-1108. doi: 10.1097/AOG.0000000000004385. PMID: 33957658
Early and late pregnancy loss in women with polycystic ovary syndrome undergoing IVF/ICSI treatment: a retrospective cohort analysis of 21 820 pregnancies.
Cai H, Mol BW, Gordts S, Wang H, Wang T, Li N, Shi J
BJOG 2021 Jun;128(7):1160-1169. Epub 2020 Nov 19 doi: 10.1111/1471-0528.16590. PMID: 33142019
Does a "vanishing twin" affect first-trimester biochemistry in Down syndrome risk assessment?
Chasen ST, Perni SC, Predanic M, Kalish RB, Chervenak FA
Am J Obstet Gynecol 2006 Jul;195(1):236-9. Epub 2006 Apr 19 doi: 10.1016/j.ajog.2006.01.044. PMID: 16626615

Recent clinical studies

Etiology

Placental, maternal, fetal, and technical origins of false-positive cell-free DNA screening results.
Raymond Y, Fernando S, Menezes M, Mol BW, McLennan A, da Silva Costa F, Hardy T, Rolnik DL
Am J Obstet Gynecol 2024 Apr;230(4):381-389. Epub 2023 Nov 25 doi: 10.1016/j.ajog.2023.11.1240. PMID: 38008147
Vanishing twin syndrome is associated with first-trimester intrauterine hematoma in twin pregnancies after in vitro fertilization.
Ge Y, Lai S, Li X, Shi J, Ma C, Zhao J
Front Endocrinol (Lausanne) 2022;13:1062303. Epub 2023 Jan 13 doi: 10.3389/fendo.2022.1062303. PMID: 36714561Free PMC Article
The vanishing twin: Diagnosis and implications.
Batsry L, Yinon Y
Best Pract Res Clin Obstet Gynaecol 2022 Nov;84:66-75. Epub 2022 Mar 30 doi: 10.1016/j.bpobgyn.2022.03.009. PMID: 35450773
Vanishing twin syndrome among ART singletons and pregnancy outcomes.
Magnus MC, Ghaderi S, Morken NH, Magnus P, Bente Romundstad L, Skjærven R, Wilcox AJ, Eldevik Håberg S
Hum Reprod 2017 Nov 1;32(11):2298-2304. doi: 10.1093/humrep/dex277. PMID: 29025107Free PMC Article
Obstetric outcome of vanishing twins syndrome: a systematic review and meta-analysis.
Sun L, Jiang LX, Chen HZ
Arch Gynecol Obstet 2017 Mar;295(3):559-567. Epub 2017 Jan 17 doi: 10.1007/s00404-017-4289-9. PMID: 28097444

Diagnosis

Vanishing twin syndrome is associated with first-trimester intrauterine hematoma in twin pregnancies after in vitro fertilization.
Ge Y, Lai S, Li X, Shi J, Ma C, Zhao J
Front Endocrinol (Lausanne) 2022;13:1062303. Epub 2023 Jan 13 doi: 10.3389/fendo.2022.1062303. PMID: 36714561Free PMC Article
The vanishing twin: Diagnosis and implications.
Batsry L, Yinon Y
Best Pract Res Clin Obstet Gynaecol 2022 Nov;84:66-75. Epub 2022 Mar 30 doi: 10.1016/j.bpobgyn.2022.03.009. PMID: 35450773
Obstetric outcome of vanishing twins syndrome: a systematic review and meta-analysis.
Sun L, Jiang LX, Chen HZ
Arch Gynecol Obstet 2017 Mar;295(3):559-567. Epub 2017 Jan 17 doi: 10.1007/s00404-017-4289-9. PMID: 28097444
Vanishing twin syndrome: is it associated with adverse perinatal outcome?
Evron E, Sheiner E, Friger M, Sergienko R, Harlev A
Fertil Steril 2015 May;103(5):1209-14. Epub 2015 Mar 13 doi: 10.1016/j.fertnstert.2015.02.009. PMID: 25772775
Adverse obstetric outcome for the vanishing twin syndrome.
Almog B, Levin I, Wagman I, Kapustiansky R, Lessing JB, Amit A, Azem F
Reprod Biomed Online 2010 Feb;20(2):256-60. Epub 2009 Dec 3 doi: 10.1016/j.rbmo.2009.11.015. PMID: 20113963

Therapy

Clinical outcomes of vanishing twin syndrome and selective fetal reduction after double embryos transferred in IVF pregnancy: A propensity score matching study.
Li X, Wei Y, Luan T, Zhao C
Eur J Obstet Gynecol Reprod Biol 2023 Oct;289:48-54. Epub 2023 Aug 23 doi: 10.1016/j.ejogrb.2023.08.372. PMID: 37639814
Vanishing twin syndrome is associated with first-trimester intrauterine hematoma in twin pregnancies after in vitro fertilization.
Ge Y, Lai S, Li X, Shi J, Ma C, Zhao J
Front Endocrinol (Lausanne) 2022;13:1062303. Epub 2023 Jan 13 doi: 10.3389/fendo.2022.1062303. PMID: 36714561Free PMC Article
Is vanishing twin syndrome associated with adverse obstetric outcomes of ART singletons? A systematic review and meta-analysis.
Li YX, Sun TZ, Lv MQ, Zhou L, Ge P, Li HN, Zhou DX
J Assist Reprod Genet 2020 Nov;37(11):2783-2796. Epub 2020 Aug 25 doi: 10.1007/s10815-020-01928-x. PMID: 32840763Free PMC Article
Vanishing twin syndrome among ART singletons and pregnancy outcomes.
Magnus MC, Ghaderi S, Morken NH, Magnus P, Bente Romundstad L, Skjærven R, Wilcox AJ, Eldevik Håberg S
Hum Reprod 2017 Nov 1;32(11):2298-2304. doi: 10.1093/humrep/dex277. PMID: 29025107Free PMC Article
Obstetric outcome of vanishing twins syndrome: a systematic review and meta-analysis.
Sun L, Jiang LX, Chen HZ
Arch Gynecol Obstet 2017 Mar;295(3):559-567. Epub 2017 Jan 17 doi: 10.1007/s00404-017-4289-9. PMID: 28097444

Prognosis

Nomogram for predicting the risk of preterm delivery after IVF/ICSI treatment: an analysis of 11513 singleton births.
Liao Z, Cai L, Liu C, Li J, Hu X, Lai Y, Shen L, Sui C, Zhang H, Qian K
Front Endocrinol (Lausanne) 2023;14:1065291. Epub 2023 May 18 doi: 10.3389/fendo.2023.1065291. PMID: 37274330Free PMC Article
Vanishing twin syndrome is associated with first-trimester intrauterine hematoma in twin pregnancies after in vitro fertilization.
Ge Y, Lai S, Li X, Shi J, Ma C, Zhao J
Front Endocrinol (Lausanne) 2022;13:1062303. Epub 2023 Jan 13 doi: 10.3389/fendo.2022.1062303. PMID: 36714561Free PMC Article
The incidence of small for gestational age neonates in singleton IVF pregnancies.
Slavov S, Neykova K, Ingilizova G, Yaneva G, Magunska N, Kostov I
J Matern Fetal Neonatal Med 2022 Dec;35(25):5861-5863. Epub 2021 May 19 doi: 10.1080/14767058.2021.1897785. PMID: 34008463
Applications of noninvasive prenatal testing in vanishing twin syndrome pregnancies after treatment of assisted reproductive technology in a single center.
Zou Y, Cui L, Xue M, Yan J, Huang M, Gao M, Gao X, Gao Y, Chen ZJ
Prenat Diagn 2021 Jan;41(2):226-233. Epub 2020 Nov 30 doi: 10.1002/pd.5836. PMID: 33009680
Vanishing twin syndrome: is it associated with adverse perinatal outcome?
Evron E, Sheiner E, Friger M, Sergienko R, Harlev A
Fertil Steril 2015 May;103(5):1209-14. Epub 2015 Mar 13 doi: 10.1016/j.fertnstert.2015.02.009. PMID: 25772775

Clinical prediction guides

Clinical outcomes of vanishing twin syndrome and selective fetal reduction after double embryos transferred in IVF pregnancy: A propensity score matching study.
Li X, Wei Y, Luan T, Zhao C
Eur J Obstet Gynecol Reprod Biol 2023 Oct;289:48-54. Epub 2023 Aug 23 doi: 10.1016/j.ejogrb.2023.08.372. PMID: 37639814
Vanishing twin syndrome is associated with first-trimester intrauterine hematoma in twin pregnancies after in vitro fertilization.
Ge Y, Lai S, Li X, Shi J, Ma C, Zhao J
Front Endocrinol (Lausanne) 2022;13:1062303. Epub 2023 Jan 13 doi: 10.3389/fendo.2022.1062303. PMID: 36714561Free PMC Article
Vanishing twin syndrome among ART singletons and pregnancy outcomes.
Magnus MC, Ghaderi S, Morken NH, Magnus P, Bente Romundstad L, Skjærven R, Wilcox AJ, Eldevik Håberg S
Hum Reprod 2017 Nov 1;32(11):2298-2304. doi: 10.1093/humrep/dex277. PMID: 29025107Free PMC Article
Obstetric outcome of vanishing twins syndrome: a systematic review and meta-analysis.
Sun L, Jiang LX, Chen HZ
Arch Gynecol Obstet 2017 Mar;295(3):559-567. Epub 2017 Jan 17 doi: 10.1007/s00404-017-4289-9. PMID: 28097444
Vanishing twin syndrome: is it associated with adverse perinatal outcome?
Evron E, Sheiner E, Friger M, Sergienko R, Harlev A
Fertil Steril 2015 May;103(5):1209-14. Epub 2015 Mar 13 doi: 10.1016/j.fertnstert.2015.02.009. PMID: 25772775

Recent systematic reviews

Is vanishing twin syndrome associated with adverse obstetric outcomes of ART singletons? A systematic review and meta-analysis.
Li YX, Sun TZ, Lv MQ, Zhou L, Ge P, Li HN, Zhou DX
J Assist Reprod Genet 2020 Nov;37(11):2783-2796. Epub 2020 Aug 25 doi: 10.1007/s10815-020-01928-x. PMID: 32840763Free PMC Article
Obstetric outcome of vanishing twins syndrome: a systematic review and meta-analysis.
Sun L, Jiang LX, Chen HZ
Arch Gynecol Obstet 2017 Mar;295(3):559-567. Epub 2017 Jan 17 doi: 10.1007/s00404-017-4289-9. PMID: 28097444

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