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Neonatal jaundice

MedGen UID:
5923
•Concept ID:
C0022353
•
Disease or Syndrome
Synonyms: Jaundice, Neonatal; Neonatal Jaundice
SNOMED CT: Neonatal jaundice (387712008); Icterus neonatorum (387712008)

Definition

Jaundice that appears during the neonatal period. In the majority of cases, it appears in the first week of life and is classified as physiologic due to accelerated destruction of erythrocytes and liver immaturity. In a minority of cases it is classified as non-physiologic, appearing in the first twenty four hours after birth, and is associated with underlying diseases including hemolytic disorders, polycythemia, and cephalohematoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal jaundice

Professional guidelines

PubMed

Neonatal Hyperbilirubinemia: Evaluation and Treatment.
Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Neonatal jaundice: aetiology, diagnosis and treatment.
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507
Evaluation and treatment of neonatal hyperbilirubinemia.
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393

Recent clinical studies

Etiology

Neonatal Hyperbilirubinemia: Evaluation and Treatment.
Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Jack Aviv and brains of children.
Lamola AA
Biopolymers 2018 Aug;109(8):e23092. Epub 2017 Dec 4 doi: 10.1002/bip.23092. PMID: 29205278
Neonatal jaundice: aetiology, diagnosis and treatment.
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507
Neonatal jaundice.
Dean E
Nurs Stand 2016 Jun 29;30(44):15. doi: 10.7748/ns.30.44.15.s17. PMID: 27353908
Neonatal jaundice.
Gartner LM
Pediatr Rev 1994 Nov;15(11):422-32. PMID: 7824404

Diagnosis

Neonatal jaundice: aetiology, diagnosis and treatment.
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507
Neonatal jaundice.
Dean E
Nurs Stand 2016 Jun 29;30(44):15. doi: 10.7748/ns.30.44.15.s17. PMID: 27353908
Neonatal jaundice.
Simkiss D, Martin R
J Trop Pediatr 2012 Oct;58(5):339-40. doi: 10.1093/tropej/fms051. PMID: 23038698
Bilirubin-induced neurological damage.
Gazzin S, Tiribelli C
J Matern Fetal Neonatal Med 2011 Oct;24 Suppl 1:154-5. doi: 10.3109/14767058.2011.607590. PMID: 21942616
Pediatric hepatic imaging.
Donnelly LF, Bisset GS 3rd
Radiol Clin North Am 1998 Mar;36(2):413-27. doi: 10.1016/s0033-8389(05)70032-4. PMID: 9520992

Therapy

Bronze Baby Syndrome.
Le TN, Reese J
J Pediatr 2017 Sep;188:301-301.e1. Epub 2017 Jun 2 doi: 10.1016/j.jpeds.2017.05.005. PMID: 28583706
Bilirubin-induced neurological damage.
Gazzin S, Tiribelli C
J Matern Fetal Neonatal Med 2011 Oct;24 Suppl 1:154-5. doi: 10.3109/14767058.2011.607590. PMID: 21942616
Metformin versus insulin for the treatment of gestational diabetes.
Rowan JA, Hague WM, Gao W, Battin MR, Moore MP; MiG Trial Investigators
N Engl J Med 2008 May 8;358(19):2003-15. doi: 10.1056/NEJMoa0707193. PMID: 18463376
Phototherapy for neonatal jaundice.
Maisels MJ, McDonagh AF
N Engl J Med 2008 Feb 28;358(9):920-8. doi: 10.1056/NEJMct0708376. PMID: 18305267
Neonatal jaundice.
Scheig R
Am Fam Physician 1974 Oct;10(4):158-64. PMID: 4414786

Prognosis

Noninvasive, continuous fluorescence monitoring of bilirubin photodegradation.
Perkov S, Gorin D
Phys Chem Chem Phys 2023 Feb 8;25(6):4460-4466. doi: 10.1039/d2cp03733e. PMID: 36723008
Bronze Baby Syndrome.
Le TN, Reese J
J Pediatr 2017 Sep;188:301-301.e1. Epub 2017 Jun 2 doi: 10.1016/j.jpeds.2017.05.005. PMID: 28583706
Biliary atresia: A comprehensive review.
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
A Pharmacologic View of Phototherapy.
Lamola AA
Clin Perinatol 2016 Jun;43(2):259-76. Epub 2016 Feb 15 doi: 10.1016/j.clp.2016.01.004. PMID: 27235206
Vigintiphobia revisited.
Watchko JF
Pediatrics 2005 Jun;115(6):1747-53. doi: 10.1542/peds.2004-1748. PMID: 15930239

Clinical prediction guides

Noninvasive, continuous fluorescence monitoring of bilirubin photodegradation.
Perkov S, Gorin D
Phys Chem Chem Phys 2023 Feb 8;25(6):4460-4466. doi: 10.1039/d2cp03733e. PMID: 36723008
Neonatal hyperbilirubinemia and the role of unbound bilirubin.
Hegyi T, Kleinfeld A
J Matern Fetal Neonatal Med 2022 Dec;35(25):9201-9207. Epub 2021 Dec 26 doi: 10.1080/14767058.2021.2021177. PMID: 34957902
Evaluation and treatment of neonatal hyperbilirubinemia.
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393
Is neonatal jaundice associated with Autism Spectrum Disorders: a systematic review.
Amin SB, Smith T, Wang H
J Autism Dev Disord 2011 Nov;41(11):1455-63. doi: 10.1007/s10803-010-1169-6. PMID: 22009628Free PMC Article
Understanding and managing breast milk jaundice.
Preer GL, Philipp BL
Arch Dis Child Fetal Neonatal Ed 2011 Nov;96(6):F461-6. Epub 2010 Aug 5 doi: 10.1136/adc.2010.184416. PMID: 20688866

Recent systematic reviews

Transcutaneous bilirubinometry versus total serum bilirubin measurement for newborns.
Okwundu CI, Olowoyeye A, Uthman OA, Smith J, Wiysonge CS, Bhutani VK, Fiander M, Gautham KS
Cochrane Database Syst Rev 2023 May 9;5(5):CD012660. doi: 10.1002/14651858.CD012660.pub2. PMID: 37158489Free PMC Article
Intermittent phototherapy versus continuous phototherapy for neonatal jaundice.
Gottimukkala SB, Lobo L, Gautham KS, Bolisetty S, Fiander M, Schindler T
Cochrane Database Syst Rev 2023 Mar 2;3(3):CD008168. doi: 10.1002/14651858.CD008168.pub2. PMID: 36867730Free PMC Article
Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis.
Ye W, Luo C, Huang J, Li C, Liu Z, Liu F
BMJ 2022 May 25;377:e067946. doi: 10.1136/bmj-2021-067946. PMID: 35613728Free PMC Article
Neonatal jaundice: phototherapy.
Woodgate P, Jardine LA
BMJ Clin Evid 2015 May 22;2015 PMID: 25998618Free PMC Article
Neonatal jaundice.
Woodgate P, Jardine LA
BMJ Clin Evid 2011 Sep 15;2011 PMID: 21920055Free PMC Article

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