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Skin appendage carcinoma

MedGen UID:
60209
•Concept ID:
C0206697
•
Neoplastic Process
Synonyms: Appendage Carcinoma, Skin; Appendage Carcinomas, Skin; Carcinoma, Skin Appendage; Carcinomas, Skin Appendage; Skin Appendage Carcinoma; Skin Appendage Carcinomas
SNOMED CT: Skin appendage carcinoma (64000002); Adnexal carcinoma (64000002)
 
Monarch Initiative: MONDO:0006973

Definition

A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma. [from NCI]

Professional guidelines

PubMed

Microcystic adnexal carcinoma of the head and neck: Characteristics, treatment, and survival statistics.
Behbahani S, Yeh CJ, Pinto JO, Wassef D, Povolotskiy R, Joseph N, Lambert WC, Schwartz RA
Dermatol Ther 2021 Jan;34(1):e14559. Epub 2020 Dec 3 doi: 10.1111/dth.14559. PMID: 33210380
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Determinants of Microcystic Adnexal Carcinoma Management and Outcomes in British Columbia.
Burleigh A, Zloty D, Crawford RI
J Cutan Med Surg 2020 Sep/Oct;24(5):536-537. Epub 2020 Jun 25 doi: 10.1177/1203475420936646. PMID: 32584171

Recent clinical studies

Etiology

Squamoid Eccrine Ductal Carcinoma: The Scripps Experience.
Chow P, Goddard L, Greenway HT, Kelley BF
Dermatol Surg 2021 Aug 1;47(8):1115-1117. doi: 10.1097/DSS.0000000000002906. PMID: 34115678
Demographics and outcomes of microcystic adnexal carcinoma.
King BJ, Tolkachjov SN, Winchester DS, Baum CL, Brewer JD, Arpey CJ, Otley CC, Roenigk RK
J Am Acad Dermatol 2018 Oct;79(4):756-758. Epub 2018 Mar 17 doi: 10.1016/j.jaad.2018.03.010. PMID: 29559397
Uncommon cutaneous neoplasms of the head and neck.
Reinstadler DR, Sinha UK
Facial Plast Surg Clin North Am 2012 Nov;20(4):483-91. doi: 10.1016/j.fsc.2012.08.002. PMID: 23084300
Extrafacial microcystic adnexal carcinoma: case report and review of the literature.
Hansen T, Kingsley M, Mallatt BD, Krishnan R
Dermatol Surg 2009 Nov;35(11):1835-9. Epub 2009 Aug 18 doi: 10.1111/j.1524-4725.2009.01301.x. PMID: 19691664
Microcystic adnexal carcinoma: review of 51 Japanese patients.
Ohtsuka H, Nagamatsu S
Dermatology 2002;204(3):190-3. doi: 10.1159/000057880. PMID: 12037446

Diagnosis

Update on Molecular Genetic Alterations of Cutaneous Adnexal Neoplasms.
Hile G, Harms PW
Surg Pathol Clin 2021 Jun;14(2):251-272. doi: 10.1016/j.path.2021.03.004. PMID: 34023104
Hidradenocarcinoma.
de Lima AA, Santos M, de Morais PM, Rodrigues CAC
An Bras Dermatol 2021 Mar-Apr;96(2):251-253. Epub 2021 Feb 5 doi: 10.1016/j.abd.2020.03.023. PMID: 33597101Free PMC Article
Locally aggressive trichilemmal carcinoma.
Maya-Rico AM, Jaramillo-Pulgarín C, Londoño-García Á, Peña-Zúñiga B
An Bras Dermatol 2018 Jul-Aug;93(4):579-581. doi: 10.1590/abd1806-4841.20187461. PMID: 30066770Free PMC Article
Appendageal malignancies.
Harwood CA, Proby CM, Cerio R
Cancer Treat Res 2009;146:353-74. doi: 10.1007/978-0-387-78574-5_29. PMID: 19415216
Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge.
Wetter R, Goldstein GD
Dermatol Ther 2008 Nov-Dec;21(6):452-8. doi: 10.1111/j.1529-8019.2008.00246.x. PMID: 19076623

Therapy

Uncommon cutaneous neoplasms of the head and neck.
Reinstadler DR, Sinha UK
Facial Plast Surg Clin North Am 2012 Nov;20(4):483-91. doi: 10.1016/j.fsc.2012.08.002. PMID: 23084300
Appendageal malignancies.
Harwood CA, Proby CM, Cerio R
Cancer Treat Res 2009;146:353-74. doi: 10.1007/978-0-387-78574-5_29. PMID: 19415216
An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis.
Oosterkamp HM, Neering H, Nijman SM, Dirac AM, Mooi WJ, Bernards R, Brummelkamp TR
Br J Dermatol 2006 Jul;155(1):182-5. doi: 10.1111/j.1365-2133.2006.07224.x. PMID: 16792771
High frequency and diversity of cutaneous appendageal tumors in organ transplant recipients.
Harwood CA, McGregor JM, Swale VJ, Proby CM, Leigh IM, Newton R, Khorshid SM, Cerio R
J Am Acad Dermatol 2003 Mar;48(3):401-8. doi: 10.1067/mjd.2003.97. PMID: 12637920
Intraoperative fire with electrocautery.
Brechtelsbauer PB, Carroll WR, Baker S
Otolaryngol Head Neck Surg 1996 Feb;114(2):328-31. doi: 10.1016/S0194-59989670197-3. PMID: 8637764

Prognosis

Update on Molecular Genetic Alterations of Cutaneous Adnexal Neoplasms.
Hile G, Harms PW
Surg Pathol Clin 2021 Jun;14(2):251-272. doi: 10.1016/j.path.2021.03.004. PMID: 34023104
Demographics and outcomes of microcystic adnexal carcinoma.
King BJ, Tolkachjov SN, Winchester DS, Baum CL, Brewer JD, Arpey CJ, Otley CC, Roenigk RK
J Am Acad Dermatol 2018 Oct;79(4):756-758. Epub 2018 Mar 17 doi: 10.1016/j.jaad.2018.03.010. PMID: 29559397
Role of immunohistochemistry in diagnosing tumors of cutaneous appendages.
Hoang MP
Am J Dermatopathol 2011 Dec;33(8):765-71; quiz 772-4. doi: 10.1097/DAD.0b013e31820a4837. PMID: 22112636
Appendageal malignancies.
Harwood CA, Proby CM, Cerio R
Cancer Treat Res 2009;146:353-74. doi: 10.1007/978-0-387-78574-5_29. PMID: 19415216
Microcystic adnexal carcinoma: review of 51 Japanese patients.
Ohtsuka H, Nagamatsu S
Dermatology 2002;204(3):190-3. doi: 10.1159/000057880. PMID: 12037446

Clinical prediction guides

Papillary adnexal neoplasm (aggressive digital papillary adenocarcinoma) on the ankle of a 15-year-old girl: case report and review of literature from a pediatric perspective.
Wu H, Pimpalwar A, Diwan H, Patel KR
J Cutan Pathol 2016 Dec;43(12):1172-1178. Epub 2016 Oct 3 doi: 10.1111/cup.12804. PMID: 27535353
Role of immunohistochemistry in diagnosing tumors of cutaneous appendages.
Hoang MP
Am J Dermatopathol 2011 Dec;33(8):765-71; quiz 772-4. doi: 10.1097/DAD.0b013e31820a4837. PMID: 22112636
Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge.
Wetter R, Goldstein GD
Dermatol Ther 2008 Nov-Dec;21(6):452-8. doi: 10.1111/j.1529-8019.2008.00246.x. PMID: 19076623
Malignant transformation of multiple familial trichoepithelioma: case report and literature review.
Lee KH, Kim JE, Cho BK, Kim YC, Park CJ
Acta Derm Venereol 2008;88(1):43-6. doi: 10.2340/00015555-0322. PMID: 18176750
Microcystic adnexal carcinoma: review of 51 Japanese patients.
Ohtsuka H, Nagamatsu S
Dermatology 2002;204(3):190-3. doi: 10.1159/000057880. PMID: 12037446

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