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Macular hole

MedGen UID:
6176
•Concept ID:
C0024441
•
Disease or Syndrome
Synonyms: Hole, Macular; Holes, Macular; Macular Hole; Macular Holes
SNOMED CT: Macular hole (232006002)
 
HPO: HP:0011508
Monarch Initiative: MONDO:0006843

Definition

A macular hole is a small break in the macula, located in the center of the retina. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMacular hole

Professional guidelines

PubMed

Foveal photoreceptor disruption in ocular diseases: An optical coherence tomography-based differential diagnosis.
Singh SR, Vaidya H, Borrelli E, Chhablani J
Surv Ophthalmol 2023 Jul-Aug;68(4):655-668. Epub 2023 Mar 18 doi: 10.1016/j.survophthal.2023.03.003. PMID: 36934831
Treatment of Inflammatory Macular Hole: Case Series and Review of Literature.
Ebrahimi Z, Torkashvand A, Zarei M, Faghihi H, Khalili Pour E, Imani Fooldi M, Ebrahimiadib N
Ocul Immunol Inflamm 2022 May 19;30(4):966-972. Epub 2021 Apr 7 doi: 10.1080/09273948.2020.1867871. PMID: 33826475
Idiopathic Macular Hole Preferred Practice Pattern®.
Flaxel CJ, Adelman RA, Bailey ST, Fawzi A, Lim JI, Vemulakonda GA, Ying GS
Ophthalmology 2020 Feb;127(2):P184-P222. Epub 2019 Sep 25 doi: 10.1016/j.ophtha.2019.09.026. PMID: 31757499

Recent clinical studies

Etiology

Internal limiting membrane peeling in macular hole surgery.
Pradhan D, Agarwal L, Joshi I, Kushwaha A, Aditya K, Kumari A
Ger Med Sci 2022;20:Doc07. Epub 2022 Jun 2 doi: 10.3205/000309. PMID: 35813123Free PMC Article
Treatment of Inflammatory Macular Hole: Case Series and Review of Literature.
Ebrahimi Z, Torkashvand A, Zarei M, Faghihi H, Khalili Pour E, Imani Fooldi M, Ebrahimiadib N
Ocul Immunol Inflamm 2022 May 19;30(4):966-972. Epub 2021 Apr 7 doi: 10.1080/09273948.2020.1867871. PMID: 33826475
SPONTANEOUS LAMELLAR MACULAR HOLES CLOSURE.
Chehaibou I, Manoharan N, Govetto A, Tsui I, Hubschman JP
Retin Cases Brief Rep 2022 Jul 1;16(4):397-400. Epub 2020 Sep 7 doi: 10.1097/ICB.0000000000001029. PMID: 32910024
MACULAR HOLE CLOSURE WITH TOPICAL STEROIDS.
Bonnell AC, Prenner S, Weinstein MS, Fine HF
Retin Cases Brief Rep 2022 May 1;16(3):351-354. Epub 2020 Mar 2 doi: 10.1097/ICB.0000000000000979. PMID: 32132390
Idiopathic macular hole.
Mann DF
Optom Clin 1996;5(1):95-110. PMID: 8963081

Diagnosis

An evidence-based review of the epidemiology of myopic traction maculopathy.
Cheong KX, Xu L, Ohno-Matsui K, Sabanayagam C, Saw SM, Hoang QV
Surv Ophthalmol 2022 Nov-Dec;67(6):1603-1630. Epub 2022 Mar 31 doi: 10.1016/j.survophthal.2022.03.007. PMID: 35367479
Idiopathic macular hole.
Oh H
Dev Ophthalmol 2014;54:150-8. Epub 2014 Aug 26 doi: 10.1159/000360461. PMID: 25196764
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995
Macular hole.
Ho AC, Guyer DR, Fine SL
Surv Ophthalmol 1998 Mar-Apr;42(5):393-416. doi: 10.1016/s0039-6257(97)00132-x. PMID: 9548570
Idiopathic macular hole.
Mann DF
Optom Clin 1996;5(1):95-110. PMID: 8963081

Therapy

Internal limiting membrane peeling in macular hole surgery.
Pradhan D, Agarwal L, Joshi I, Kushwaha A, Aditya K, Kumari A
Ger Med Sci 2022;20:Doc07. Epub 2022 Jun 2 doi: 10.3205/000309. PMID: 35813123Free PMC Article
An evidence-based review of the epidemiology of myopic traction maculopathy.
Cheong KX, Xu L, Ohno-Matsui K, Sabanayagam C, Saw SM, Hoang QV
Surv Ophthalmol 2022 Nov-Dec;67(6):1603-1630. Epub 2022 Mar 31 doi: 10.1016/j.survophthal.2022.03.007. PMID: 35367479
Treatment of Inflammatory Macular Hole: Case Series and Review of Literature.
Ebrahimi Z, Torkashvand A, Zarei M, Faghihi H, Khalili Pour E, Imani Fooldi M, Ebrahimiadib N
Ocul Immunol Inflamm 2022 May 19;30(4):966-972. Epub 2021 Apr 7 doi: 10.1080/09273948.2020.1867871. PMID: 33826475
Ocriplasmin for vitreoretinal diseases.
Tsui I, Pan CK, Rahimy E, Schwartz SD
J Biomed Biotechnol 2012;2012:354979. Epub 2012 Oct 14 doi: 10.1155/2012/354979. PMID: 23193358Free PMC Article
Macular holes.
Landolfi M, Zarbin MA, Bhagat N
Ophthalmol Clin North Am 2002 Dec;15(4):565-72. doi: 10.1016/s0896-1549(02)00047-0. PMID: 12515088

Prognosis

SPONTANEOUS LAMELLAR MACULAR HOLES CLOSURE.
Chehaibou I, Manoharan N, Govetto A, Tsui I, Hubschman JP
Retin Cases Brief Rep 2022 Jul 1;16(4):397-400. Epub 2020 Sep 7 doi: 10.1097/ICB.0000000000001029. PMID: 32910024
Lamellar macular hole in diabetic retinopathy.
Kuo BI, Yang CM, Hsieh YT
Eur J Ophthalmol 2021 Jan;31(1):166-172. Epub 2019 Oct 9 doi: 10.1177/1120672119879665. PMID: 31595782
OVERVIEW OF THE COMPLICATIONS OF HIGH MYOPIA.
Ikuno Y
Retina 2017 Dec;37(12):2347-2351. doi: 10.1097/IAE.0000000000001489. PMID: 28590964
Suprachoroidal buckling.
El Rayes EN
Dev Ophthalmol 2014;54:135-46. Epub 2014 Aug 26 doi: 10.1159/000360459. PMID: 25196762
Idiopathic macular hole.
Mann DF
Optom Clin 1996;5(1):95-110. PMID: 8963081

Clinical prediction guides

Face-down positioning or posturing after macular hole surgery.
Cundy O, Lange CA, Bunce C, Bainbridge JW, Solebo AL
Cochrane Database Syst Rev 2023 Nov 21;11(11):CD008228. doi: 10.1002/14651858.CD008228.pub3. PMID: 37987517Free PMC Article
Logbook of a Retinal Autograft.
Güven D, Gül C, Yılmaz Z, Karataş ME
Turk J Ophthalmol 2022 Oct 28;52(5):360-365. doi: 10.4274/tjo.galenos.2022.52333. PMID: 36317828Free PMC Article
SPONTANEOUS LAMELLAR MACULAR HOLES CLOSURE.
Chehaibou I, Manoharan N, Govetto A, Tsui I, Hubschman JP
Retin Cases Brief Rep 2022 Jul 1;16(4):397-400. Epub 2020 Sep 7 doi: 10.1097/ICB.0000000000001029. PMID: 32910024
Macular associations of tilted disc syndrome.
Kumar V, Surve A, Kumawat D, Azad S, Vohra R, Venkatesh P
Indian J Ophthalmol 2021 Jun;69(6):1451-1456. doi: 10.4103/ijo.IJO_1902_20. PMID: 34011719Free PMC Article
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995

Recent systematic reviews

Face-down positioning or posturing after macular hole surgery.
Cundy O, Lange CA, Bunce C, Bainbridge JW, Solebo AL
Cochrane Database Syst Rev 2023 Nov 21;11(11):CD008228. doi: 10.1002/14651858.CD008228.pub3. PMID: 37987517Free PMC Article
Pars plana vitrectomy with internal limiting membrane flap versus pars plana vitrectomy with conventional internal limiting membrane peeling for large macular hole.
Ghoraba H, Rittiphairoj T, Akhavanrezayat A, Karaca I, Matsumiya W, Pham B, Mishra K, Yasar C, Mobasserian A, Abdelkarem AA, Nguyen QD
Cochrane Database Syst Rev 2023 Aug 7;8(8):CD015031. doi: 10.1002/14651858.CD015031.pub2. PMID: 37548231Free PMC Article
Human amniotic membrane graft for refractory macular hole: A single-arm meta-analysis and systematic review.
Zhang H, Li Y, Chen G, Han F, Jiang W
J Fr Ophtalmol 2023 Mar;46(3):276-286. Epub 2023 Feb 2 doi: 10.1016/j.jfo.2022.07.001. PMID: 36739260
Role of Positioning after Full-Thickness Macular Hole Surgery: A Systematic Review and Meta-Analysis.
Chaudhary V, Sarohia GS, Phillips MR, Zeraatkar D, Xie JS, Nanji K, Mustafa RA, Kaiser PK, Loewenstein A, Garg SJ, Bakri SJ, Holz FG, Sivaprasad S, Bhandari M, Steel DH, Wykoff CC
Ophthalmol Retina 2023 Jan;7(1):33-43. Epub 2022 Jul 1 doi: 10.1016/j.oret.2022.06.015. PMID: 35781067
Management Modalities for Traumatic Macular Hole: A Systematic Review and Single-Arm Meta-Analysis.
Gao M, Liu K, Lin Q, Liu H
Curr Eye Res 2017 Feb;42(2):287-296. Epub 2016 Jul 15 doi: 10.1080/02713683.2016.1175021. PMID: 27420902

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