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Marek Disease

MedGen UID:
6219
•Concept ID:
C0024793
•
Neoplastic Process
Synonyms: Fowl Paralyses; Fowl Paralysis; Marek's Disease; Mareks Disease; Paralyses, Fowl; Paralysis, Fowl

Definition

A viral infection in chickens caused by the herpes virus. It is characterized by tissue lymphocytic infiltration, limb paralysis and development of tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMarek Disease

Professional guidelines

PubMed

A(2)BCD: a concise guide for asthma management.
Lommatzsch M, Brusselle GG, Levy ML, Canonica GW, Pavord ID, Schatz M, Virchow JC
Lancet Respir Med 2023 Jun;11(6):573-576. Epub 2023 Jan 27 doi: 10.1016/S2213-2600(22)00490-8. PMID: 36716752
MDS research criteria for prodromal Parkinson's disease.
Berg D, Postuma RB, Adler CH, Bloem BR, Chan P, Dubois B, Gasser T, Goetz CG, Halliday G, Joseph L, Lang AE, Liepelt-Scarfone I, Litvan I, Marek K, Obeso J, Oertel W, Olanow CW, Poewe W, Stern M, Deuschl G
Mov Disord 2015 Oct;30(12):1600-11. doi: 10.1002/mds.26431. PMID: 26474317
MDS clinical diagnostic criteria for Parkinson's disease.
Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G
Mov Disord 2015 Oct;30(12):1591-601. doi: 10.1002/mds.26424. PMID: 26474316

Recent clinical studies

Etiology

FDG PET-CT evaluation in neurolymphomatosis: imaging characteristics and clinical outcomes.
Davidson T, Kedmi M, Avigdor A, Komisar O, Chikman B, Lidar M, Goshen E, Tzila Zwas S, Ben-Haim S
Leuk Lymphoma 2018 Feb;59(2):348-356. Epub 2017 Jul 28 doi: 10.1080/10428194.2017.1352096. PMID: 28750592
INFECTIOUS DISEASES. Risk of 'leaky' vaccines debated.
Kupferschmidt K
Science 2015 Jul 31;349(6247):461-2. doi: 10.1126/science.349.6247.461. PMID: 26228119
gga-miR-26a targets NEK6 and suppresses Marek's disease lymphoma cell proliferation.
Li X, Lian L, Zhang D, Qu L, Yang N
Poult Sci 2014 May;93(5):1097-105. doi: 10.3382/ps.2013-03656. PMID: 24795301
Detection of avian oncogenic Marek's disease herpesvirus DNA in human sera.
Laurent S, Esnault E, Dambrine G, Goudeau A, Choudat D, Rasschaert D
J Gen Virol 2001 Jan;82(Pt 1):233-240. doi: 10.1099/0022-1317-82-1-233. PMID: 11125176
Lessons for atherosclerosis research from tuberculosis and peptic ulcer.
Sutter MC
CMAJ 1995 Mar 1;152(5):667-70. PMID: 7882229Free PMC Article

Diagnosis

Investigation of a herpesvirus outbreak in mixed breeds of adult domestic ducks using next generation sequencing.
Damir HA, Ahmad W, Panicker NG, Mohamed LI, Omer EA, Kinne J, Wernery U, Adem A, Ali MA, Mustafa F
PLoS One 2023;18(1):e0280923. Epub 2023 Jan 27 doi: 10.1371/journal.pone.0280923. PMID: 36706167Free PMC Article
Plexus and peripheral nerve metastasis.
Gwathmey KG
Handb Clin Neurol 2018;149:257-279. doi: 10.1016/B978-0-12-811161-1.00017-7. PMID: 29307357
FDG PET/CT in Pediatric Neurolymphomatosis.
de Vaugelade C, de Clermont-Gallerande H, Meyer M, My Duyen Tiphaine A, Benjamin A, Ducassou S, Chateil JF, Fernandez P
Clin Nucl Med 2017 May;42(5):e255-e257. doi: 10.1097/RLU.0000000000001624. PMID: 28288046
(89) Zr-rituximab PET/CT to detect neurolymphomatosis.
de Jong A, Mous R, van Dongen GA, Hoekstra OS, Nievelstein RA, de Keizer B
Am J Hematol 2016 Jun;91(6):649-50. Epub 2016 Apr 13 doi: 10.1002/ajh.24328. PMID: 26872558
Detection of Marek's disease virus DNA in chicken but not in human plasma.
Hennig H, Osterrieder N, Müller-Steinhardt M, Teichert HM, Kirchner H, Wandinger KP
J Clin Microbiol 2003 Jun;41(6):2428-32. doi: 10.1128/JCM.41.6.2428-2432.2003. PMID: 12791859Free PMC Article

Therapy

Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization.
Eschke K, Trimpert J, Osterrieder N, Kunec D
PLoS Pathog 2018 Jan;14(1):e1006857. Epub 2018 Jan 29 doi: 10.1371/journal.ppat.1006857. PMID: 29377958Free PMC Article
Splenic marginal zone lymphoma: An indolent malignancy leading to the development of neurolymphomatosis.
Groth CL, Nevel KS, Gwathmey KG, Bafakih F, Jones DE
Muscle Nerve 2017 Mar;55(3):440-444. Epub 2016 Sep 29 doi: 10.1002/mus.25404. PMID: 27625159
INFECTIOUS DISEASES. Risk of 'leaky' vaccines debated.
Kupferschmidt K
Science 2015 Jul 31;349(6247):461-2. doi: 10.1126/science.349.6247.461. PMID: 26228119
Fowlpox virus as a recombinant vaccine vector for use in mammals and poultry.
Skinner MA, Laidlaw SM, Eldaghayes I, Kaiser P, Cottingham MG
Expert Rev Vaccines 2005 Feb;4(1):63-76. doi: 10.1586/14760584.4.1.63. PMID: 15757474
Lessons for atherosclerosis research from tuberculosis and peptic ulcer.
Sutter MC
CMAJ 1995 Mar 1;152(5):667-70. PMID: 7882229Free PMC Article

Prognosis

Acute demyelinating neuropathy in a patient with neurolymphomatosis.
Mahmoud RA, Abrams CK
BMJ Case Rep 2018 Mar 5;2018 doi: 10.1136/bcr-2017-222814. PMID: 29507018Free PMC Article
Gga-miR-219b targeting BCL11B suppresses proliferation, migration and invasion of Marek's disease tumor cell MSB1.
Zhao C, Li X, Han B, You Z, Qu L, Liu C, Song J, Lian L, Yang N
Sci Rep 2017 Jun 26;7(1):4247. doi: 10.1038/s41598-017-04434-w. PMID: 28652615Free PMC Article
Chicken gga-miR-103-3p Targets CCNE1 and TFDP2 and Inhibits MDCC-MSB1 Cell Migration.
Han B, Lian L, Li X, Zhao C, Qu L, Liu C, Song J, Yang N
G3 (Bethesda) 2016 May 3;6(5):1277-85. doi: 10.1534/g3.116.028498. PMID: 26935418Free PMC Article
Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30).
Burgess SC, Young JR, Baaten BJ, Hunt L, Ross LN, Parcells MS, Kumar PM, Tregaskes CA, Lee LF, Davison TF
Proc Natl Acad Sci U S A 2004 Sep 21;101(38):13879-84. Epub 2004 Sep 8 doi: 10.1073/pnas.0305789101. PMID: 15356338Free PMC Article
Marek's disease and new approaches to its control.
Zelník V
Acta Virol 1995 Feb;39(1):53-63. PMID: 7572471

Clinical prediction guides

Purinergic signaling during Marek's disease in chickens.
Akbar H, Fasick JJ, Ponnuraj N, Jarosinski KW
Sci Rep 2023 Feb 4;13(1):2044. doi: 10.1038/s41598-023-29210-x. PMID: 36739336Free PMC Article
Abrogation of Marek's disease virus replication using CRISPR/Cas9.
Hagag IT, Wight DJ, Bartsch D, Sid H, Jordan I, Bertzbach LD, Schusser B, Kaufer BB
Sci Rep 2020 Jul 2;10(1):10919. doi: 10.1038/s41598-020-67951-1. PMID: 32616820Free PMC Article
Gga-miR-219b targeting BCL11B suppresses proliferation, migration and invasion of Marek's disease tumor cell MSB1.
Zhao C, Li X, Han B, You Z, Qu L, Liu C, Song J, Lian L, Yang N
Sci Rep 2017 Jun 26;7(1):4247. doi: 10.1038/s41598-017-04434-w. PMID: 28652615Free PMC Article
The conservation and signatures of lincRNAs in Marek's disease of chicken.
He Y, Ding Y, Zhan F, Zhang H, Han B, Hu G, Zhao K, Yang N, Yu Y, Mao L, Song J
Sci Rep 2015 Oct 16;5:15184. doi: 10.1038/srep15184. PMID: 26471251Free PMC Article
Cytomegalovirus and atherosclerosis.
Melnick JL, Adam E, Debakey ME
Eur Heart J 1993 Dec;14 Suppl K:30-8. PMID: 8131785

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