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Submacular hemorrhage

MedGen UID:
633878
•Concept ID:
C0474361
•
Pathologic Function
Synonyms: Macular subretinal hemorrhage; Sub-macular haemorrhage; Sub-macular hemorrhage; Submacular haemorrhage
SNOMED CT: Macular subretinal hemorrhage (247161000); Submacular hemorrhage (247161000)
 
HPO: HP:0025582

Definition

Bleeding between the neurosensory retina and the retinal pigment epithelium (RPE) arising from the choroidal or retinal circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubmacular hemorrhage

Professional guidelines

PubMed

Polypoidal choroidal vasculopathy: Pearls in diagnosis and management.
Anantharaman G, Sheth J, Bhende M, Narayanan R, Natarajan S, Rajendran A, Manayath G, Sen P, Biswas R, Banker A, Gupta C
Indian J Ophthalmol 2018 Jul;66(7):896-908. doi: 10.4103/ijo.IJO_1136_17. PMID: 29941728Free PMC Article
Management of submacular hemorrhage.
Malik FF, Poulaki V
Int Ophthalmol Clin 2014 Spring;54(2):51-9. doi: 10.1097/IIO.0000000000000018. PMID: 24613884
Management of submacular hemorrhage.
Tennant MT, Borrillo JL, Regillo CD
Ophthalmol Clin North Am 2002 Dec;15(4):445-52, vi. doi: 10.1016/s0896-1549(02)00049-4. PMID: 12515076

Recent clinical studies

Etiology

Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents, and Age-Related Macular Degeneration Study: A Randomized Controlled Trial for Submacular Hemorrhage Secondary to Age-Related Macular Degeneration.
Gabrielle PH, Delyfer MN, Glacet-Bernard A, Conart JB, Uzzan J, Kodjikian L, Arndt C, Tadayoni R, Soudry-Faure A, Creuzot Garcher CP
Ophthalmology 2023 Sep;130(9):947-957. Epub 2023 Apr 22 doi: 10.1016/j.ophtha.2023.04.014. PMID: 37088447
Simultaneous intravitreal aflibercept and gas injections for submacular hemorrhage secondary to polypoidal choroidal vasculopathy.
Wakabayashi T, Hara C, Shiraki A, Shiraki N, Sayanagi K, Sakimoto S, Sato S, Sakaguchi H, Nishida K
Graefes Arch Clin Exp Ophthalmol 2023 Jun;261(6):1545-1552. Epub 2022 Dec 7 doi: 10.1007/s00417-022-05922-0. PMID: 36473986
Antiplatelet and anticoagulant therapy in patients with submacular hemorrhage caused by neovascular age-related macular degeneration.
Weber C, Bertelsmann M, Kiy Z, Stasik I, Holz FG, Liegl R
Graefes Arch Clin Exp Ophthalmol 2023 May;261(5):1413-1421. Epub 2022 Nov 29 doi: 10.1007/s00417-022-05885-2. PMID: 36445445Free PMC Article
Submacular Hemorrhage: Visual Outcomes and Prognostic Factors.
Kunavisarut P, Thithuan T, Patikulsila D, Choovuthayakorn J, Watanachai N, Chaikitmongkol V, Pathanapitoon K, Rothova A
Asia Pac J Ophthalmol (Phila) 2018 Mar-Apr;7(2):109-113. Epub 2017 Oct 23 doi: 10.22608/APO.2017389. PMID: 29063740
Submacular hemorrhage removal.
Lim JI, Drews-Botsch C, Sternberg P Jr, Capone A Jr, Aaberg TM Sr
Ophthalmology 1995 Sep;102(9):1393-9. doi: 10.1016/s0161-6420(95)30858-5. PMID: 9097779

Diagnosis

Antiplatelet and anticoagulant therapy in patients with submacular hemorrhage caused by neovascular age-related macular degeneration.
Weber C, Bertelsmann M, Kiy Z, Stasik I, Holz FG, Liegl R
Graefes Arch Clin Exp Ophthalmol 2023 May;261(5):1413-1421. Epub 2022 Nov 29 doi: 10.1007/s00417-022-05885-2. PMID: 36445445Free PMC Article
INFUSION-ASSISTED EVACUATION OF SUBMACULAR HEMORRHAGE.
Park JG, Wolfe JD
Retin Cases Brief Rep 2023 Nov 1;17(6):788-790. doi: 10.1097/ICB.0000000000001300. PMID: 35858278
Polypoidal choroidal vasculopathy: Pearls in diagnosis and management.
Anantharaman G, Sheth J, Bhende M, Narayanan R, Natarajan S, Rajendran A, Manayath G, Sen P, Biswas R, Banker A, Gupta C
Indian J Ophthalmol 2018 Jul;66(7):896-908. doi: 10.4103/ijo.IJO_1136_17. PMID: 29941728Free PMC Article
Submacular Hemorrhage: Visual Outcomes and Prognostic Factors.
Kunavisarut P, Thithuan T, Patikulsila D, Choovuthayakorn J, Watanachai N, Chaikitmongkol V, Pathanapitoon K, Rothova A
Asia Pac J Ophthalmol (Phila) 2018 Mar-Apr;7(2):109-113. Epub 2017 Oct 23 doi: 10.22608/APO.2017389. PMID: 29063740
Subretinal hemorrhage.
Yiu G, Mahmoud TH
Dev Ophthalmol 2014;54:213-22. Epub 2014 Aug 26 doi: 10.1159/000360469. PMID: 25196772

Therapy

Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents, and Age-Related Macular Degeneration Study: A Randomized Controlled Trial for Submacular Hemorrhage Secondary to Age-Related Macular Degeneration.
Gabrielle PH, Delyfer MN, Glacet-Bernard A, Conart JB, Uzzan J, Kodjikian L, Arndt C, Tadayoni R, Soudry-Faure A, Creuzot Garcher CP
Ophthalmology 2023 Sep;130(9):947-957. Epub 2023 Apr 22 doi: 10.1016/j.ophtha.2023.04.014. PMID: 37088447
Antiplatelet and anticoagulant therapy in patients with submacular hemorrhage caused by neovascular age-related macular degeneration.
Weber C, Bertelsmann M, Kiy Z, Stasik I, Holz FG, Liegl R
Graefes Arch Clin Exp Ophthalmol 2023 May;261(5):1413-1421. Epub 2022 Nov 29 doi: 10.1007/s00417-022-05885-2. PMID: 36445445Free PMC Article
INFUSION-ASSISTED EVACUATION OF SUBMACULAR HEMORRHAGE.
Park JG, Wolfe JD
Retin Cases Brief Rep 2023 Nov 1;17(6):788-790. doi: 10.1097/ICB.0000000000001300. PMID: 35858278
Management of submacular hemorrhage.
Malik FF, Poulaki V
Int Ophthalmol Clin 2014 Spring;54(2):51-9. doi: 10.1097/IIO.0000000000000018. PMID: 24613884
Management of submacular hemorrhage.
Tennant MT, Borrillo JL, Regillo CD
Ophthalmol Clin North Am 2002 Dec;15(4):445-52, vi. doi: 10.1016/s0896-1549(02)00049-4. PMID: 12515076

Prognosis

Visual Recovery and Prognosis in the Treatment of Submacular Hemorrhage due to Polypoidal Choroidal Vasculopathy and Retinal Arterial Macroaneurysm: A Retrospective Study.
Wu J, Yan T, Zhang R, Feng C, Xu C, Xu T, Li Y, Wang S, He J
Int J Clin Pract 2023;2023:3880297. Epub 2023 Jun 12 doi: 10.1155/2023/3880297. PMID: 37342617Free PMC Article
Antiplatelet and anticoagulant therapy in patients with submacular hemorrhage caused by neovascular age-related macular degeneration.
Weber C, Bertelsmann M, Kiy Z, Stasik I, Holz FG, Liegl R
Graefes Arch Clin Exp Ophthalmol 2023 May;261(5):1413-1421. Epub 2022 Nov 29 doi: 10.1007/s00417-022-05885-2. PMID: 36445445Free PMC Article
Submacular Hemorrhage: Visual Outcomes and Prognostic Factors.
Kunavisarut P, Thithuan T, Patikulsila D, Choovuthayakorn J, Watanachai N, Chaikitmongkol V, Pathanapitoon K, Rothova A
Asia Pac J Ophthalmol (Phila) 2018 Mar-Apr;7(2):109-113. Epub 2017 Oct 23 doi: 10.22608/APO.2017389. PMID: 29063740
Pneumatic displacement of submacular hemorrhage.
Johnson MW
Curr Opin Ophthalmol 2000 Jun;11(3):201-6. doi: 10.1097/00055735-200006000-00009. PMID: 10977228
Submacular hemorrhage removal.
Lim JI, Drews-Botsch C, Sternberg P Jr, Capone A Jr, Aaberg TM Sr
Ophthalmology 1995 Sep;102(9):1393-9. doi: 10.1016/s0161-6420(95)30858-5. PMID: 9097779

Clinical prediction guides

Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents, and Age-Related Macular Degeneration Study: A Randomized Controlled Trial for Submacular Hemorrhage Secondary to Age-Related Macular Degeneration.
Gabrielle PH, Delyfer MN, Glacet-Bernard A, Conart JB, Uzzan J, Kodjikian L, Arndt C, Tadayoni R, Soudry-Faure A, Creuzot Garcher CP
Ophthalmology 2023 Sep;130(9):947-957. Epub 2023 Apr 22 doi: 10.1016/j.ophtha.2023.04.014. PMID: 37088447
Simultaneous intravitreal aflibercept and gas injections for submacular hemorrhage secondary to polypoidal choroidal vasculopathy.
Wakabayashi T, Hara C, Shiraki A, Shiraki N, Sayanagi K, Sakimoto S, Sato S, Sakaguchi H, Nishida K
Graefes Arch Clin Exp Ophthalmol 2023 Jun;261(6):1545-1552. Epub 2022 Dec 7 doi: 10.1007/s00417-022-05922-0. PMID: 36473986
Visual prognosis of submacular hemorrhage secondary to age-related macular degeneration: A retrospective multicenter survey.
Inoue N, Kato A, Araki T, Kimura T, Kinoshita T, Okamoto F, Murakami T, Mitamura Y, Sakamoto T, Miki A, Takamura Y, Matsubara H, Tsujinaka H, Gomi F, Yasukawa T
PLoS One 2022;17(7):e0271447. Epub 2022 Jul 21 doi: 10.1371/journal.pone.0271447. PMID: 35862313Free PMC Article
Characteristics of Submacular Hemorrhages in Age-Related Macular Degeneration.
Kim JH, Chang YS, Kim JW, Kim CG
Optom Vis Sci 2017 May;94(5):556-563. doi: 10.1097/OPX.0000000000001066. PMID: 28403037
Management of submacular hemorrhage.
Tennant MT, Borrillo JL, Regillo CD
Ophthalmol Clin North Am 2002 Dec;15(4):445-52, vi. doi: 10.1016/s0896-1549(02)00049-4. PMID: 12515076

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