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Thyroid gland papillary and follicular carcinoma

MedGen UID:
64631
•Concept ID:
C0206683
•
Neoplastic Process
Synonym: Carcinoma, Papillary, Follicular
SNOMED CT: Papillary adenocarcinoma - follicular variant (21968007); Papillary carcinoma - follicular variant (21968007); Papillary and follicular adenocarcinoma (189643000); Papillary carcinoma, follicular variant (21968007); Papillary and follicular carcinoma (21968007); Papillary adenocarcinoma, follicular variant (21968007)
 
Monarch Initiative: MONDO:0006886

Definition

A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid gland papillary and follicular carcinoma

Professional guidelines

PubMed

Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Haddad RI, Bischoff L, Ball D, Bernet V, Blomain E, Busaidy NL, Campbell M, Dickson P, Duh QY, Ehya H, Goldner WS, Guo T, Haymart M, Holt S, Hunt JP, Iagaru A, Kandeel F, Lamonica DM, Mandel S, Markovina S, McIver B, Raeburn CD, Rezaee R, Ridge JA, Roth MY, Scheri RP, Shah JP, Sipos JA, Sippel R, Sturgeon C, Wang TN, Wirth LJ, Wong RJ, Yeh M, Cassara CJ, Darlow S
J Natl Compr Canc Netw 2022 Aug;20(8):925-951. doi: 10.6004/jnccn.2022.0040. PMID: 35948029
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Recent clinical studies

Etiology

Cytologic features of aggressive variants of follicular-derived thyroid carcinoma.
Rossi ED, Faquin WC, Pantanowitz L
Cancer Cytopathol 2019 Jul;127(7):432-446. Epub 2019 May 31 doi: 10.1002/cncy.22136. PMID: 31150164Free PMC Article
Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): Update and Diagnostic Considerations-a Review.
Rossi ED, Faquin WC, Baloch Z, Fadda G, Thompson L, Larocca LM, Pantanowitz L
Endocr Pathol 2019 Jun;30(2):155-162. doi: 10.1007/s12022-019-9574-7. PMID: 30953289Free PMC Article
Follicular cell-derived thyroid cancer.
Dralle H, Machens A, Basa J, Fatourechi V, Franceschi S, Hay ID, Nikiforov YE, Pacini F, Pasieka JL, Sherman SI
Nat Rev Dis Primers 2015 Dec 10;1:15077. doi: 10.1038/nrdp.2015.77. PMID: 27188261
Evaluation of a thyroid nodule.
Bomeli SR, LeBeau SO, Ferris RL
Otolaryngol Clin North Am 2010 Apr;43(2):229-38, vii. doi: 10.1016/j.otc.2010.01.002. PMID: 20510711Free PMC Article
Follicular variant of papillary thyroid carcinoma: a diagnostic challenge for clinicians and pathologists.
Salajegheh A, Petcu EB, Smith RA, Lam AK
Postgrad Med J 2008 Feb;84(988):78-82. doi: 10.1136/pgmj.2007.064881. PMID: 18322127

Diagnosis

Thyroid cancer in lingual thyroid and thyroglossal duct cyst.
Sturniolo G, Vermiglio F, Moleti M
Endocrinol Diabetes Nutr 2017 Jan;64(1):40-43. Epub 2016 Nov 4 doi: 10.1016/j.endonu.2016.07.010. PMID: 27825535
Follicular Variant of Papillary Thyroid Carcinoma: Hybrid or Mixture?
Daniels GH
Thyroid 2016 Jul;26(7):872-4. Epub 2016 Jun 22 doi: 10.1089/thy.2016.0244. PMID: 27214083Free PMC Article
Molecular genetics and diagnosis of thyroid cancer.
Nikiforov YE, Nikiforova MN
Nat Rev Endocrinol 2011 Aug 30;7(10):569-80. doi: 10.1038/nrendo.2011.142. PMID: 21878896
Papillary thyroid carcinoma variants.
Lloyd RV, Buehler D, Khanafshar E
Head Neck Pathol 2011 Mar;5(1):51-6. Epub 2011 Jan 8 doi: 10.1007/s12105-010-0236-9. PMID: 21221869Free PMC Article
Thyroid cancer.
Gimm O
Cancer Lett 2001 Feb 26;163(2):143-56. doi: 10.1016/s0304-3835(00)00697-2. PMID: 11165748

Therapy

Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma.
Waguespack SG, Drilon A, Lin JJ, Brose MS, McDermott R, Almubarak M, Bauman J, Casanova M, Krishnamurthy A, Kummar S, Leyvraz S, Oh DY, Park K, Sohal D, Sherman E, Norenberg R, Silvertown JD, Brega N, Hong DS, Cabanillas ME
Eur J Endocrinol 2022 Apr 29;186(6):631-643. doi: 10.1530/EJE-21-1259. PMID: 35333737Free PMC Article
Follicular cell-derived thyroid cancer.
Dralle H, Machens A, Basa J, Fatourechi V, Franceschi S, Hay ID, Nikiforov YE, Pacini F, Pasieka JL, Sherman SI
Nat Rev Dis Primers 2015 Dec 10;1:15077. doi: 10.1038/nrdp.2015.77. PMID: 27188261
Papillary thyroid cancer.
Caron NR, Clark OH
Curr Treat Options Oncol 2006 Jul;7(4):309-19. doi: 10.1007/s11864-006-0040-7. PMID: 16916491
Iodine and cancer.
Feldt-Rasmussen U
Thyroid 2001 May;11(5):483-6. doi: 10.1089/105072501300176435. PMID: 11396706
Thyroid cancer.
Gimm O
Cancer Lett 2001 Feb 26;163(2):143-56. doi: 10.1016/s0304-3835(00)00697-2. PMID: 11165748

Prognosis

The History of the Follicular Variant of Papillary Thyroid Carcinoma.
Tallini G, Tuttle RM, Ghossein RA
J Clin Endocrinol Metab 2017 Jan 1;102(1):15-22. doi: 10.1210/jc.2016-2976. PMID: 27732333
Follicular Variant of Papillary Thyroid Carcinoma: Hybrid or Mixture?
Daniels GH
Thyroid 2016 Jul;26(7):872-4. Epub 2016 Jun 22 doi: 10.1089/thy.2016.0244. PMID: 27214083Free PMC Article
Follicular cell-derived thyroid cancer.
Dralle H, Machens A, Basa J, Fatourechi V, Franceschi S, Hay ID, Nikiforov YE, Pacini F, Pasieka JL, Sherman SI
Nat Rev Dis Primers 2015 Dec 10;1:15077. doi: 10.1038/nrdp.2015.77. PMID: 27188261
Molecular genetics and diagnosis of thyroid cancer.
Nikiforov YE, Nikiforova MN
Nat Rev Endocrinol 2011 Aug 30;7(10):569-80. doi: 10.1038/nrendo.2011.142. PMID: 21878896
Thyroid cancer.
Gimm O
Cancer Lett 2001 Feb 26;163(2):143-56. doi: 10.1016/s0304-3835(00)00697-2. PMID: 11165748

Clinical prediction guides

Updates in Thyroid Cytology.
Nishino M, Krane JF
Surg Pathol Clin 2018 Sep;11(3):467-487. doi: 10.1016/j.path.2018.05.002. PMID: 30190135
Follicular Variant of Papillary Thyroid Carcinoma: Hybrid or Mixture?
Daniels GH
Thyroid 2016 Jul;26(7):872-4. Epub 2016 Jun 22 doi: 10.1089/thy.2016.0244. PMID: 27214083Free PMC Article
Familial nonmedullary thyroid carcinoma.
Mazeh H, Sippel RS
Thyroid 2013 Sep;23(9):1049-56. Epub 2013 Aug 3 doi: 10.1089/thy.2013.0079. PMID: 23734600
Elastography of the thyroid.
Monpeyssen H, Tramalloni J, Poirée S, Hélénon O, Correas JM
Diagn Interv Imaging 2013 May;94(5):535-44. Epub 2013 Apr 25 doi: 10.1016/j.diii.2013.01.023. PMID: 23623210
Follicular patterned lesions of the thyroid gland: a practical algorithmic approach.
Chetty R
J Clin Pathol 2011 Sep;64(9):737-41. Epub 2011 May 18 doi: 10.1136/jclinpath-2011-200121. PMID: 21593347

Recent systematic reviews

Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis.
Moleti M, Aversa T, Crisafulli S, Trifirò G, Corica D, Pepe G, Cannavò L, Di Mauro M, Paola G, Fontana A, Calapai F, Cannavò S, Wasniewska M
Front Endocrinol (Lausanne) 2023;14:1270518. Epub 2023 Sep 19 doi: 10.3389/fendo.2023.1270518. PMID: 37795368Free PMC Article
Incidence, Recurrence and Mortality Among Filipinos With Differentiated Thyroid Cancer: A Systematic Review.
San Juan MD, Paz-Pacheco E
J ASEAN Fed Endocr Soc 2023;38(1):100-107. Epub 2023 Mar 2 doi: 10.15605/jafes.038.01.14. PMID: 37252408Free PMC Article
Selenium and thyroid cancer: a systematic review.
de Oliveira Maia M, Batista BAM, Sousa MP, de Souza LM, Maia CSC
Nutr Cancer 2020;72(8):1255-1263. Epub 2019 Oct 22 doi: 10.1080/01635581.2019.1679194. PMID: 31635488
Differentiated Thyroid Cancer-Treatment: State of the Art.
Schmidbauer B, Menhart K, Hellwig D, Grosse J
Int J Mol Sci 2017 Jun 17;18(6) doi: 10.3390/ijms18061292. PMID: 28629126Free PMC Article
External beam radiotherapy in differentiated thyroid carcinoma: A systematic review.
Fussey JM, Crunkhorn R, Tedla M, Weickert MO, Mehanna H
Head Neck 2016 Apr;38 Suppl 1:E2297-305. Epub 2015 Sep 3 doi: 10.1002/hed.24218. PMID: 26335228

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