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Premature aging syndrome

MedGen UID:
65416
Concept ID:
C0231341
Disease or Syndrome
Synonym: Premature aging
SNOMED CT: Premature aging (88587007); Physiologically old for age (88587007); Premature aging syndrome (399959003)
 
Monarch Initiative: MONDO:0019303
Orphanet: ORPHA79389

Definition

Changes in the organism associated with senescence, occurring at an accelerated rate. [from MONDO]

Professional guidelines

PubMed

Scharner J, Lu HC, Fraternali F, Ellis JA, Zammit PS
Proteins 2014 Jun;82(6):904-15. Epub 2013 Dec 26 doi: 10.1002/prot.24465. PMID: 24375749
Columbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G
Cell Mol Life Sci 2005 Nov;62(22):2669-78. doi: 10.1007/s00018-005-5318-6. PMID: 16261260Free PMC Article

Recent clinical studies

Etiology

Tokita M, Kennedy SR, Risques RA, Chun SG, Pritchard C, Oshima J, Liu Y, Bryant-Greenwood PK, Welcsh P, Monnat RJ
Sci Rep 2016 Aug 25;6:32038. doi: 10.1038/srep32038. PMID: 27559010Free PMC Article
Aamann MD, Muftuoglu M, Bohr VA, Stevnsner T
Mech Ageing Dev 2013 May-Jun;134(5-6):212-24. Epub 2013 Apr 9 doi: 10.1016/j.mad.2013.03.009. PMID: 23583689Free PMC Article
Lauper JM, Krause A, Vaughan TL, Monnat RJ Jr
PLoS One 2013;8(4):e59709. Epub 2013 Apr 1 doi: 10.1371/journal.pone.0059709. PMID: 23573208Free PMC Article
Kuro-o M
Pediatr Nephrol 2010 Apr;25(4):583-90. Epub 2009 Jul 22 doi: 10.1007/s00467-009-1260-4. PMID: 19626341
Licht CL, Stevnsner T, Bohr VA
Am J Hum Genet 2003 Dec;73(6):1217-39. Epub 2003 Nov 24 doi: 10.1086/380399. PMID: 14639525Free PMC Article

Diagnosis

Chenbhanich J, Hu Y, Hetts S, Cooke D, Dowd C, Devine P; UCLA Clinical Genomics Center, Russell B, Kang SHL, Chang VY, Abla AA, Cornett P, Yeh I, Lee H, Martinez-Agosto JA, Frieden IJ, Shieh JT
Am J Med Genet A 2021 May;185(5):1430-1436. Epub 2021 Mar 8 doi: 10.1002/ajmg.a.62126. PMID: 33683022
Aamann MD, Muftuoglu M, Bohr VA, Stevnsner T
Mech Ageing Dev 2013 May-Jun;134(5-6):212-24. Epub 2013 Apr 9 doi: 10.1016/j.mad.2013.03.009. PMID: 23583689Free PMC Article
Coppedè F
Adv Exp Med Biol 2012;724:317-31. doi: 10.1007/978-1-4614-0653-2_24. PMID: 22411253
Murillo-Ortiz B, Albarrán-Tamayo F, Arenas-Aranda D, Benítez-Bribiesca L, Malacara-Hernández JM, Martínez-Garza S, Hernández-González M, Solorio S, Garay-Sevilla ME, Mora-Villalpando C
Aging Male 2012 Mar;15(1):54-8. Epub 2011 Aug 9 doi: 10.3109/13685538.2011.593658. PMID: 21824049
Zalla JA
Cutis 1980 Mar;25(3):275-8. PMID: 7357890

Therapy

Fujita H, Sasaki T, Miyamoto T, Akutsu SN, Sato S, Mori T, Nakabayashi K, Hata K, Suzuki H, Kosaki K, Matsuura S, Matsubara Y, Amagai M, Kubo A
Aging Cell 2020 Nov;19(11):e13251. Epub 2020 Oct 23 doi: 10.1111/acel.13251. PMID: 33094908Free PMC Article
Gordon LB, Campbell SE, Massaro JM, D'Agostino RB Sr, Kleinman ME, Kieran MW, Moses MA
Pediatr Res 2018 May;83(5):982-992. Epub 2018 Feb 28 doi: 10.1038/pr.2018.9. PMID: 29342131
Gordon LB, Kleinman ME, Massaro J, D'Agostino RB Sr, Shappell H, Gerhard-Herman M, Smoot LB, Gordon CM, Cleveland RH, Nazarian A, Snyder BD, Ullrich NJ, Silvera VM, Liang MG, Quinn N, Miller DT, Huh SY, Dowton AA, Littlefield K, Greer MM, Kieran MW
Circulation 2016 Jul 12;134(2):114-25. doi: 10.1161/CIRCULATIONAHA.116.022188. PMID: 27400896Free PMC Article
Gordon LB, Kleinman ME, Miller DT, Neuberg DS, Giobbie-Hurder A, Gerhard-Herman M, Smoot LB, Gordon CM, Cleveland R, Snyder BD, Fligor B, Bishop WR, Statkevich P, Regen A, Sonis A, Riley S, Ploski C, Correia A, Quinn N, Ullrich NJ, Nazarian A, Liang MG, Huh SY, Schwartzman A, Kieran MW
Proc Natl Acad Sci U S A 2012 Oct 9;109(41):16666-71. Epub 2012 Sep 24 doi: 10.1073/pnas.1202529109. PMID: 23012407Free PMC Article
Gerhard-Herman M, Smoot LB, Wake N, Kieran MW, Kleinman ME, Miller DT, Schwartzman A, Giobbie-Hurder A, Neuberg D, Gordon LB
Hypertension 2012 Jan;59(1):92-7. Epub 2011 Nov 14 doi: 10.1161/HYPERTENSIONAHA.111.180919. PMID: 22083160Free PMC Article

Prognosis

Jaafar B, Nasrallah M, Sievers B, Oshima J, Lessel D
Am J Med Genet A 2022 May;188(5):1630-1634. Epub 2022 Jan 17 doi: 10.1002/ajmg.a.62654. PMID: 35037378Free PMC Article
Tiwari V, Baptiste BA, Okur MN, Bohr VA
Nucleic Acids Res 2021 Mar 18;49(5):2418-2434. doi: 10.1093/nar/gkab085. PMID: 33590097Free PMC Article
Lauper JM, Krause A, Vaughan TL, Monnat RJ Jr
PLoS One 2013;8(4):e59709. Epub 2013 Apr 1 doi: 10.1371/journal.pone.0059709. PMID: 23573208Free PMC Article
Murillo-Ortiz B, Albarrán-Tamayo F, Arenas-Aranda D, Benítez-Bribiesca L, Malacara-Hernández JM, Martínez-Garza S, Hernández-González M, Solorio S, Garay-Sevilla ME, Mora-Villalpando C
Aging Male 2012 Mar;15(1):54-8. Epub 2011 Aug 9 doi: 10.3109/13685538.2011.593658. PMID: 21824049
Wu J, Hatamochi A
J Dermatol 2004 Jul;31(7):535-9. doi: 10.1111/j.1346-8138.2004.tb00550.x. PMID: 15492417

Clinical prediction guides

Díez-Díez M, Amorós-Pérez M, de la Barrera J, Vázquez E, Quintas A, Pascual-Figal DA, Dopazo A, Sánchez-Cabo F, Kleinman ME, Gordon LB, Fuster V, Andrés V, Fuster JJ
Geroscience 2023 Apr;45(2):1231-1236. Epub 2022 Jun 25 doi: 10.1007/s11357-022-00607-2. PMID: 35752705Free PMC Article
Chenbhanich J, Hu Y, Hetts S, Cooke D, Dowd C, Devine P; UCLA Clinical Genomics Center, Russell B, Kang SHL, Chang VY, Abla AA, Cornett P, Yeh I, Lee H, Martinez-Agosto JA, Frieden IJ, Shieh JT
Am J Med Genet A 2021 May;185(5):1430-1436. Epub 2021 Mar 8 doi: 10.1002/ajmg.a.62126. PMID: 33683022
Tiwari V, Baptiste BA, Okur MN, Bohr VA
Nucleic Acids Res 2021 Mar 18;49(5):2418-2434. doi: 10.1093/nar/gkab085. PMID: 33590097Free PMC Article
Elouej S, Harhouri K, Le Mao M, Baujat G, Nampoothiri S, Kayserili H, Menabawy NA, Selim L, Paneque AL, Kubisch C, Lessel D, Rubinsztajn R, Charar C, Bartoli C, Airault C, Deleuze JF, Rötig A, Bauer P, Pereira C, Loh A, Escande-Beillard N, Muchir A, Martino L, Gruenbaum Y, Lee SH, Manivet P, Lenaers G, Reversade B, Lévy N, De Sandre-Giovannoli A
Nat Commun 2020 Sep 11;11(1):4589. doi: 10.1038/s41467-020-18146-9. PMID: 32917887Free PMC Article
Kuro-o M
Pediatr Nephrol 2010 Apr;25(4):583-90. Epub 2009 Jul 22 doi: 10.1007/s00467-009-1260-4. PMID: 19626341

Recent systematic reviews

Lauper JM, Krause A, Vaughan TL, Monnat RJ Jr
PLoS One 2013;8(4):e59709. Epub 2013 Apr 1 doi: 10.1371/journal.pone.0059709. PMID: 23573208Free PMC Article

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