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Lyme arthritis

MedGen UID:
66074
•Concept ID:
C0242381
•
Disease or Syndrome
Synonyms: Arthritis, Lyme; Lyme Arthritis
SNOMED CT: Arthritis in Lyme disease (33937009); Lyme arthritis (33937009)

Definition

Joint inflammation, most often affecting large joints, associated with Lyme disease, presenting months after infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLyme arthritis

Professional guidelines

PubMed

Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Challenges in the Diagnosis and Treatment of Lyme Disease.
Schoen RT
Curr Rheumatol Rep 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2. PMID: 31912251
Diagnosis and treatment of Lyme arthritis.
Arvikar SL, Steere AC
Infect Dis Clin North Am 2015 Jun;29(2):269-80. doi: 10.1016/j.idc.2015.02.004. PMID: 25999223Free PMC Article

Recent clinical studies

Etiology

Sleep fragmentation disrupts Lyme arthritis resolution in mice.
Jackson CD, Badran M, Gozal D, Brown CR, Khalyfa A
Sleep Med 2024 Feb;114:196-202. Epub 2024 Jan 11 doi: 10.1016/j.sleep.2024.01.011. PMID: 38219655
Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme disease.
Chomel B
Rev Sci Tech 2015 Aug;34(2):569-76. doi: 10.20506/rst.34.2.2380. PMID: 26601457
Vitamin D and autoimmune disease.
Ginanjar E, Sumariyono, Setiati S, Setiyohadi B
Acta Med Indones 2007 Jul-Sep;39(3):133-41. PMID: 17699936
Lyme disease.
Evans J
Curr Opin Rheumatol 2000 Jul;12(4):311-7. doi: 10.1097/00002281-200007000-00014. PMID: 10910185

Diagnosis

Lyme Arthritis.
Arvikar SL, Steere AC
Infect Dis Clin North Am 2022 Sep;36(3):563-577. doi: 10.1016/j.idc.2022.03.006. PMID: 36116835Free PMC Article
Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Challenges in the Diagnosis and Treatment of Lyme Disease.
Schoen RT
Curr Rheumatol Rep 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2. PMID: 31912251
Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme disease.
Chomel B
Rev Sci Tech 2015 Aug;34(2):569-76. doi: 10.20506/rst.34.2.2380. PMID: 26601457

Therapy

Lyme Arthritis.
Arvikar SL, Steere AC
Infect Dis Clin North Am 2022 Sep;36(3):563-577. doi: 10.1016/j.idc.2022.03.006. PMID: 36116835Free PMC Article
Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Challenges in the Diagnosis and Treatment of Lyme Disease.
Schoen RT
Curr Rheumatol Rep 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2. PMID: 31912251
Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme disease.
Chomel B
Rev Sci Tech 2015 Aug;34(2):569-76. doi: 10.20506/rst.34.2.2380. PMID: 26601457

Prognosis

Trauma-related Lyme arthritis.
Roberts J 4th, Merchant E
BMJ Case Rep 2023 Jul 5;16(7) doi: 10.1136/bcr-2023-255532. PMID: 37407232Free PMC Article
Challenges in the Diagnosis and Treatment of Lyme Disease.
Schoen RT
Curr Rheumatol Rep 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2. PMID: 31912251
Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme disease in children.
Sood SK
Infect Dis Clin North Am 2015 Jun;29(2):281-94. doi: 10.1016/j.idc.2015.02.011. PMID: 25999224
Lyme disease.
Evans J
Curr Opin Rheumatol 2000 Jul;12(4):311-7. doi: 10.1097/00002281-200007000-00014. PMID: 10910185

Clinical prediction guides

Sleep fragmentation disrupts Lyme arthritis resolution in mice.
Jackson CD, Badran M, Gozal D, Brown CR, Khalyfa A
Sleep Med 2024 Feb;114:196-202. Epub 2024 Jan 11 doi: 10.1016/j.sleep.2024.01.011. PMID: 38219655
Profiling disease burden and Borrelia seroprevalence in Canadians with complex and chronic illness.
Sanderson VP, Miller JC, Bamm VV, Tilak M, Lloyd VK, Singh-Ranger G, Wills MKB
PLoS One 2023;18(11):e0291382. Epub 2023 Nov 8 doi: 10.1371/journal.pone.0291382. PMID: 37939060Free PMC Article
Lyme arthritis: pathogenesis, clinical presentation, and management.
Puius YA, Kalish RA
Infect Dis Clin North Am 2008 Jun;22(2):289-300, vi-vii. doi: 10.1016/j.idc.2007.12.014. PMID: 18452802
Immunology of reactive arthritides.
Burmester GR, Daser A, Kamradt T, Krause A, Mitchison NA, Sieper J, Wolf N
Annu Rev Immunol 1995;13:229-50. doi: 10.1146/annurev.iy.13.040195.001305. PMID: 7612222
Lyme arthritis.
Kahan A, Amor B, Menkes CJ
Biomed Pharmacother 1989;43(6):401-3. doi: 10.1016/0753-3322(89)90236-9. PMID: 2686765

Recent systematic reviews

Combining primary care surveillance and a meta-analysis to estimate the incidence of the clinical manifestations of Lyme borreliosis in Belgium, 2015-2017.
Geebelen L, Van Cauteren D, Devleesschauwer B, Moreels S, Tersago K, Van Oyen H, Speybroeck N, Lernout T
Ticks Tick Borne Dis 2019 Apr;10(3):598-605. Epub 2018 Dec 28 doi: 10.1016/j.ttbdis.2018.12.007. PMID: 30772196
Metabolites of prostaglandin synthases as potential biomarkers of Lyme disease severity and symptom resolution.
Jarosz AC, Badawi A
Inflamm Res 2019 Jan;68(1):7-17. Epub 2018 Aug 18 doi: 10.1007/s00011-018-1180-5. PMID: 30121835Free PMC Article

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