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Agenesis of larynx

MedGen UID:
687905
•Concept ID:
C1261566
•
Congenital Abnormality
Synonyms: Congenital absence of larynx; Laryngeal Agenesis
SNOMED CT: Agenesis of larynx (204535000); Congenital absence of larynx (204535000)

Definition

A congenital deformity in which there is no laryngeal structure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAgenesis of larynx

Professional guidelines

PubMed

Medical management of rhinitis in pregnancy.
Gupta KK, Anari S
Auris Nasus Larynx 2022 Dec;49(6):905-911. Epub 2022 Feb 4 doi: 10.1016/j.anl.2022.01.014. PMID: 35131140
The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.
Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Diagnosis and Management of Laryngotracheoesophageal Cleft.
Sobol SE
Curr Probl Pediatr Adolesc Health Care 2018 Mar;48(3):82-84. doi: 10.1016/j.cppeds.2018.01.007. PMID: 29571545

Recent clinical studies

Therapy

Medical management of rhinitis in pregnancy.
Gupta KK, Anari S
Auris Nasus Larynx 2022 Dec;49(6):905-911. Epub 2022 Feb 4 doi: 10.1016/j.anl.2022.01.014. PMID: 35131140
Neonatal Lateral Epiglottic Defects.
Peterson JD, Goyal V, Puricelli MD, Thatcher A, Smith RJ
Ann Otol Rhinol Laryngol 2021 Mar;130(3):311-313. Epub 2020 Aug 8 doi: 10.1177/0003489420948546. PMID: 32772542
The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.
Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Relapsing polychondritis: A clinical update.
Longo L, Greco A, Rea A, Lo Vasco VR, De Virgilio A, De Vincentiis M
Autoimmun Rev 2016 Jun;15(6):539-43. Epub 2016 Feb 11 doi: 10.1016/j.autrev.2016.02.013. PMID: 26876384
Endogenous ochronosis.
Turgay E, Canat D, Gurel MS, Yuksel T, Baran MF, Demirkesen C
Clin Exp Dermatol 2009 Dec;34(8):e865-8. doi: 10.1111/j.1365-2230.2009.03618.x. PMID: 20055850

Prognosis

Vocal Fold Paresis.
Ivey CM
Otolaryngol Clin North Am 2019 Aug;52(4):637-648. Epub 2019 May 11 doi: 10.1016/j.otc.2019.03.008. PMID: 31088695
Airway Anomalies.
Landry AM, Rutter MJ
Clin Perinatol 2018 Dec;45(4):597-607. Epub 2018 Sep 11 doi: 10.1016/j.clp.2018.07.002. PMID: 30396407
Diagnosis and Management of Laryngotracheoesophageal Cleft.
Sobol SE
Curr Probl Pediatr Adolesc Health Care 2018 Mar;48(3):82-84. doi: 10.1016/j.cppeds.2018.01.007. PMID: 29571545
Pediatric airway surgery.
Maeda K
Pediatr Surg Int 2017 Apr;33(4):435-443. Epub 2017 Jan 28 doi: 10.1007/s00383-016-4050-7. PMID: 28132084
Laryngo-tracheo-oesophageal clefts.
Leboulanger N, Garabédian EN
Orphanet J Rare Dis 2011 Dec 7;6:81. doi: 10.1186/1750-1172-6-81. PMID: 22151899Free PMC Article

Clinical prediction guides

Characterization of Vocal Fold Pathology in Military Drill Instructors.
Duvall A, Dion GR
J Voice 2023 Nov;37(6):907-912. Epub 2021 Jul 10 doi: 10.1016/j.jvoice.2021.05.013. PMID: 34256981
Histology of Barrett's Metaplasia: Do Goblet Cells Matter?
Odze R
Dig Dis Sci 2018 Aug;63(8):2042-2051. doi: 10.1007/s10620-018-5151-z. PMID: 29998421
Laryngomalacia, Tracheomalacia and Bronchomalacia.
Hysinger EB
Curr Probl Pediatr Adolesc Health Care 2018 Apr;48(4):113-118. Epub 2018 Apr 3 doi: 10.1016/j.cppeds.2018.03.002. PMID: 29622320
Relapsing polychondritis: A clinical update.
Longo L, Greco A, Rea A, Lo Vasco VR, De Virgilio A, De Vincentiis M
Autoimmun Rev 2016 Jun;15(6):539-43. Epub 2016 Feb 11 doi: 10.1016/j.autrev.2016.02.013. PMID: 26876384
Ankyloglossia with deviation of the epiglottis and larynx.
Mukai S, Mukai C, Asaoka K
Ann Otol Rhinol Laryngol Suppl 1991 May;153:3-20. doi: 10.1177/00034894911000s501. PMID: 2024905

Recent systematic reviews

Tracheal anomalies associated with Down syndrome: A systematic review.
Fockens MM, Hölscher M, Limpens J, Dikkers FG
Pediatr Pulmonol 2021 May;56(5):814-822. Epub 2021 Jan 12 doi: 10.1002/ppul.25203. PMID: 33434377Free PMC Article
Presentation and management of type 1 laryngeal clefts: A systematic review and meta-analysis.
Reddy P, Byun YJ, Downs J, Nguyen SA, White DR
Int J Pediatr Otorhinolaryngol 2020 Nov;138:110370. Epub 2020 Sep 9 doi: 10.1016/j.ijporl.2020.110370. PMID: 33152963
Laryngomalacia: is there an evidence base for management?
McCaffer C, Blackmore K, Flood LM
J Laryngol Otol 2017 Nov;131(11):946-954. Epub 2017 Oct 25 doi: 10.1017/S0022215117002092. PMID: 29067893
Physiological factors related to aspiration risk: a systematic review.
Steele CM, Cichero JA
Dysphagia 2014 Jun;29(3):295-304. Epub 2014 Feb 23 doi: 10.1007/s00455-014-9516-y. PMID: 24562507Free PMC Article
Paralyzed neonatal larynx in adduction. Case series, systematic review and analysis.
Nisa L, Holtz F, Sandu K
Int J Pediatr Otorhinolaryngol 2013 Jan;77(1):13-8. Epub 2012 Nov 17 doi: 10.1016/j.ijporl.2012.10.020. PMID: 23164501

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