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Plaque morphea

MedGen UID:
712436
•Concept ID:
C1290049
•
Disease or Syndrome
Synonyms: Morphea, plaque form; Plaque Morphea; Superficial Circumscribed Morphea
SNOMED CT: Morphea, plaque form (128458002); Plaque morphea (128458002)

Definition

Circumscribed morphea in which the lesions are restricted to the skin and the immediately underlying subcutaneous tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlaque morphea

Professional guidelines

PubMed

Update on the classification and treatment of localized scleroderma.
Bielsa Marsol I
Actas Dermosifiliogr 2013 Oct;104(8):654-66. Epub 2013 Aug 13 doi: 10.1016/j.adengl.2012.10.012. PMID: 23948159

Recent clinical studies

Therapy

Nivolumab-induced plaque morphea in a malign melanoma patient.
Acar A, Oraloglu G, Yaman B, Karaarslan I
J Cosmet Dermatol 2021 Aug;20(8):2645-2647. Epub 2020 Dec 28 doi: 10.1111/jocd.13914. PMID: 33355973
Update on the classification and treatment of localized scleroderma.
Bielsa Marsol I
Actas Dermosifiliogr 2013 Oct;104(8):654-66. Epub 2013 Aug 13 doi: 10.1016/j.adengl.2012.10.012. PMID: 23948159
Topical imiquimod 5% cream for pediatric plaque morphea: a prospective, multiple-baseline, open-label pilot study.
Pope E, Doria AS, Theriault M, Mohanta A, Laxer RM
Dermatology 2011;223(4):363-9. Epub 2012 Feb 8 doi: 10.1159/000335560. PMID: 22327486
Localized scleroderma: a series of 52 patients.
Toledano C, Rabhi S, Kettaneh A, Fabre B, Fardet L, Tiev KP, Cabane J
Eur J Intern Med 2009 May;20(3):331-6. Epub 2008 Sep 17 doi: 10.1016/j.ejim.2008.07.011. PMID: 19393504
Localized and systemic scleroderma.
Hawk A, English JC 3rd
Semin Cutan Med Surg 2001 Mar;20(1):27-37. doi: 10.1053/sder.2001.23093. PMID: 11308134

Prognosis

Novel multispectral imaging to predict disease progression in pediatric morphea.
O'Connor C, McCarthy S, Kiely L, McAuliffe MAP, Bennett M
Pediatr Dermatol 2024 Mar-Apr;41(2):229-233. Epub 2024 Feb 2 doi: 10.1111/pde.15485. PMID: 38305508
Clinico-epidemiological Study of Morphea from a Tertiary Care Hospital.
Arif T, Adil M, Amin SS, Tahseen M, Dorjay K, Mohtashim M, Singh M, Bansal R, Raj D
Curr Rheumatol Rev 2018;14(3):251-254. doi: 10.2174/1573397114666180410115553. PMID: 29637865
Localized scleroderma: a series of 52 patients.
Toledano C, Rabhi S, Kettaneh A, Fabre B, Fardet L, Tiev KP, Cabane J
Eur J Intern Med 2009 May;20(3):331-6. Epub 2008 Sep 17 doi: 10.1016/j.ejim.2008.07.011. PMID: 19393504
Localized and systemic scleroderma.
Hawk A, English JC 3rd
Semin Cutan Med Surg 2001 Mar;20(1):27-37. doi: 10.1053/sder.2001.23093. PMID: 11308134
Localized scleroderma.
Tuffanelli DL
Semin Cutan Med Surg 1998 Mar;17(1):27-33. doi: 10.1016/s1085-5629(98)80059-x. PMID: 9512104

Clinical prediction guides

Novel multispectral imaging to predict disease progression in pediatric morphea.
O'Connor C, McCarthy S, Kiely L, McAuliffe MAP, Bennett M
Pediatr Dermatol 2024 Mar-Apr;41(2):229-233. Epub 2024 Feb 2 doi: 10.1111/pde.15485. PMID: 38305508
Morphea disease activity during pregnancy: A case series.
Walker AM, Bermas BL, Jacobe HT
J Dermatol 2022 Dec;49(12):1278-1283. Epub 2022 Sep 12 doi: 10.1111/1346-8138.16572. PMID: 36093764
An Evaluation of the Performance of Current Morphea Subtype Classifications.
Prasad S, Zhu JL, Schollaert-Fitch K, Torok KS, Jacobe HT
JAMA Dermatol 2021 Apr 1;157(4):1-8. doi: 10.1001/jamadermatol.2020.5809. PMID: 33595618Free PMC Article
Topical imiquimod 5% cream for pediatric plaque morphea: a prospective, multiple-baseline, open-label pilot study.
Pope E, Doria AS, Theriault M, Mohanta A, Laxer RM
Dermatology 2011;223(4):363-9. Epub 2012 Feb 8 doi: 10.1159/000335560. PMID: 22327486
Efficacy of topical tacrolimus 0.1% in active plaque morphea: randomized, double-blind, emollient-controlled pilot study.
Kroft EB, Groeneveld TJ, Seyger MM, de Jong EM
Am J Clin Dermatol 2009;10(3):181-7. doi: 10.2165/00128071-200910030-00004. PMID: 19354332

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