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Vulvar lichen sclerosus

MedGen UID:
7228
•Concept ID:
C0022783
•
Disease or Syndrome
Synonyms: Kraurosis Vulvae; Lichen Sclerosus of Vulva; Lichen Sclerosus, Vulvar; Sclerosus, Vulvar Lichen; Vulva Lichen Sclerosus; Vulvae, Kraurosis; Vulvar Lichen Sclerosus
SNOMED CT: Leukoplakia of vulva (198380007); Kraurosis of vulva (895491007); Kraurosis vulvae (895491007); Lichen sclerosus of female external genitalia (895491007); Lichen sclerosus of vulva (895491007)
 
Monarch Initiative: MONDO:0006491

Definition

The presence of hyperkeratotic white patches on the vulvar epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar lichen sclerosus

Professional guidelines

PubMed

Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Clinical recommendation: pediatric lichen sclerosus.
Bercaw-Pratt JL, Boardman LA, Simms-Cendan JS; North American Society for Pediatric and Adolescent Gynecology
J Pediatr Adolesc Gynecol 2014 Apr;27(2):111-6. doi: 10.1016/j.jpag.2013.11.004. PMID: 24602304
Management of sexual dysfunction due to vulvar lichen sclerosus in postmenopausal women.
Pinelli S, D'Erme AM, Lotti T
Dermatol Ther 2013 Jan-Feb;26(1):79-82. doi: 10.1111/j.1529-8019.2012.01536.x. PMID: 23384025

Recent clinical studies

Etiology

Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681
Oral and Vulvar Lichen Sclerosus.
Vučićević Boras V, Škrinjar I, Batelja Vuletić L, Bradamante M, Bartenjev I, Ljubojević Hadžavdić S
Acta Dermatovenerol Croat 2019 Sep;27(3):195-197. PMID: 31542067
Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
Vulval lichen sclerosus and lichen planus.
McPherson T, Cooper S
Dermatol Ther 2010 Sep-Oct;23(5):523-32. doi: 10.1111/j.1529-8019.2010.01355.x. PMID: 20868406

Diagnosis

Vulvar Lichen Sclerosus.
Kraus CN
JAMA Dermatol 2022 Sep 1;158(9):1088. doi: 10.1001/jamadermatol.2022.0359. PMID: 35793083
Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Female Genital Itch.
Savas JA, Pichardo RO
Dermatol Clin 2018 Jul;36(3):225-243. Epub 2018 Apr 26 doi: 10.1016/j.det.2018.02.006. PMID: 29929595
Vulvar dermatosis.
Moyal-Barracco M, Wendling J
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):946-58. Epub 2014 Jul 18 doi: 10.1016/j.bpobgyn.2014.07.005. PMID: 25132276
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article

Therapy

Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681
Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Inflammatory Vulvar Dermatoses.
Guerrero A, Venkatesan A
Clin Obstet Gynecol 2015 Sep;58(3):464-75. doi: 10.1097/GRF.0000000000000125. PMID: 26125955
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
Clobetasol propionate--where, when, why?
Pels R, Sterry W, Lademann J
Drugs Today (Barc) 2008 Jul;44(7):547-57. doi: 10.1358/dot.2008.44.7.1122221. PMID: 18806904

Prognosis

Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Lichen sclerosus and lichen planus in women and girls.
Schlosser BJ, Mirowski GW
Clin Obstet Gynecol 2015 Mar;58(1):125-42. doi: 10.1097/GRF.0000000000000090. PMID: 25608255
Vulvar dermatosis.
Moyal-Barracco M, Wendling J
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):946-58. Epub 2014 Jul 18 doi: 10.1016/j.bpobgyn.2014.07.005. PMID: 25132276
Influence of treatments on prognosis for vulvar lichen sclerosus: facts and controversies.
Brodrick B, Belkin ZR, Goldstein AT
Clin Dermatol 2013 Nov-Dec;31(6):780-6. doi: 10.1016/j.clindermatol.2013.05.017. PMID: 24160287
Lichen sclerosus in children and adolescents.
Dendrinos ML, Quint EH
Curr Opin Obstet Gynecol 2013 Oct;25(5):370-4. doi: 10.1097/GCO.0b013e328363a53c. PMID: 23812382

Clinical prediction guides

Vulvar Lichen Sclerosus Clinical Severity Scales and Histopathologic Correlation: A Case Series.
Pyle HJ, Evans JC, Vandergriff TW, Mauskar MM
Am J Dermatopathol 2023 Aug 1;45(8):588-592. doi: 10.1097/DAD.0000000000002471. PMID: 37462209
Vulvar vitiligo and lichen sclerosus in children: A clinical challenge.
Veronesi G, Virdi A, Leuzzi M, Gurioli C, Chessa MA, Guglielmo A, Neri I
Pediatr Dermatol 2021 Sep;38(5):1012-1019. Epub 2021 Sep 24 doi: 10.1111/pde.14771. PMID: 34561885
Vulval lichen planus-lichen sclerosus overlap.
Howard M, Hall A
Int J STD AIDS 2018 Sep;29(10):1017-1023. Epub 2018 Feb 28 doi: 10.1177/0956462418758777. PMID: 29490571
Photodynamic Therapy for Vulvar Lichen Sclerosus-A Systematic Review.
Prodromidou A, Chatziioannou E, Daskalakis G, Stergios K, Pergialiotis V
J Low Genit Tract Dis 2018 Jan;22(1):58-65. doi: 10.1097/LGT.0000000000000362. PMID: 29271859
Clinical and dermoscopic changes of vulvar lichen sclerosus after topical corticosteroid treatment.
Borghi A, Corazza M, Minghetti S, Toni G, Virgili A
J Dermatol 2016 Sep;43(9):1078-82. Epub 2016 Apr 14 doi: 10.1111/1346-8138.13374. PMID: 27075682

Recent systematic reviews

Lichen Sclerosus and Sexual Dysfunction: A Systematic Review and Meta-Analysis.
Pope R, Lee MH, Myers A, Song J, Abou Ghayda R, Kim JY, Hong SH, Lee SB, Koyanagi A, Jacob L, Smith L, Shin JI
J Sex Med 2022 Nov;19(11):1616-1624. Epub 2022 Sep 15 doi: 10.1016/j.jsxm.2022.07.011. PMID: 36115787
Vulvar vitiligo and lichen sclerosus in children: A clinical challenge.
Veronesi G, Virdi A, Leuzzi M, Gurioli C, Chessa MA, Guglielmo A, Neri I
Pediatr Dermatol 2021 Sep;38(5):1012-1019. Epub 2021 Sep 24 doi: 10.1111/pde.14771. PMID: 34561885
Pediatric Vulvar Lichen Sclerosus-A Review of the Literature.
Orszulak D, Dulska A, Niziński K, Skowronek K, Bodziony J, Stojko R, Drosdzol-Cop A
Int J Environ Res Public Health 2021 Jul 4;18(13) doi: 10.3390/ijerph18137153. PMID: 34281089Free PMC Article
Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681
Photodynamic Therapy for Vulvar Lichen Sclerosus-A Systematic Review.
Prodromidou A, Chatziioannou E, Daskalakis G, Stergios K, Pergialiotis V
J Low Genit Tract Dis 2018 Jan;22(1):58-65. doi: 10.1097/LGT.0000000000000362. PMID: 29271859

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