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Adult Acute Myeloid Leukemia with Minimal Differentiation

MedGen UID:
76319
•Concept ID:
C0281641
•
Neoplastic Process
Synonyms: Adult Acute M0 Leukemia; Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Myeloblastic Leukemia with Minimal Differentiation; Adult Acute Myelogenous Leukemia with Minimal Differentiation; Adult Acute Myeloid Leukemia Minimally Differentiated; M0 Adult Acute Leukemia; M0 Adult Acute Myeloblastic Leukemia; M0 Adult Acute Myeloblastic Leukemia with Minimal Differentiation; M0 Adult Acute Myelogenous Leukemia; M0 Adult Acute Myelogenous Leukemia with Minimal Differentiation; M0 Adult Acute Myeloid Leukemia with Minimal Differentiation; M0 Adult AML; M0 Adult ANLL

Definition

An acute myeloid leukemia with minimal differentiation occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Acute Myeloid Leukemia with Minimal Differentiation

Professional guidelines

PubMed

miR-638 in circulating leukaemia cells as a non-invasive biomarker in diagnosis, treatment response and MRD surveillance of acute promyelocytic leukaemia.
Bai Y, Chen C, Guo X, Ding T, Yang X, Yu J, Yang J, Ruan J, Zheng X, Chen Z
Cancer Biomark 2020;29(1):125-137. doi: 10.3233/CBM-190899. PMID: 32568176
Acute promyelocytic leukemia: recent advances in diagnosis and management.
Lo-Coco F, Ammatuna E, Montesinos P, Sanz MA
Semin Oncol 2008 Aug;35(4):401-9. doi: 10.1053/j.seminoncol.2008.04.010. PMID: 18692690
Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor. A phase I-II trial.
Negrin RS, Haeuber DH, Nagler A, Olds LC, Donlon T, Souza LM, Greenberg PL
Ann Intern Med 1989 Jun 15;110(12):976-84. doi: 10.7326/0003-4819-110-12-976. PMID: 2471429

Recent clinical studies

Etiology

Regulation of hematopoietic and leukemia stem cells by regulatory T cells.
Riether C
Front Immunol 2022;13:1049301. Epub 2022 Nov 2 doi: 10.3389/fimmu.2022.1049301. PMID: 36405718Free PMC Article
Acute Myeloid Leukemia With Recurrent Genetic Abnormalities Other Than Translocations.
Lin P, Falini B
Am J Clin Pathol 2015 Jul;144(1):19-28. doi: 10.1309/AJCP97BJBEVZEUIN. PMID: 26071459
Acute myeloid leukemia associated with FGFR1 abnormalities.
Lee H, Kim M, Lim J, Kim Y, Han K, Cho BS, Kim HJ
Int J Hematol 2013 Jun;97(6):808-12. Epub 2013 Apr 23 doi: 10.1007/s12185-013-1337-5. PMID: 23609419
All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4).
Iland HJ, Bradstock K, Supple SG, Catalano A, Collins M, Hertzberg M, Browett P, Grigg A, Firkin F, Hugman A, Reynolds J, Di Iulio J, Tiley C, Taylor K, Filshie R, Seldon M, Taper J, Szer J, Moore J, Bashford J, Seymour JF; Australasian Leukaemia and Lymphoma Group
Blood 2012 Aug 23;120(8):1570-80; quiz 1752. Epub 2012 Jun 19 doi: 10.1182/blood-2012-02-410746. PMID: 22715121
Acute myeloid leukaemia in the elderly: a review.
Pollyea DA, Kohrt HE, Medeiros BC
Br J Haematol 2011 Mar;152(5):524-42. doi: 10.1111/j.1365-2141.2010.08470.x. PMID: 21314823

Diagnosis

Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome.
Xie W, Raess PW, Dunlap J, Hoyos CM, Li H, Li P, Swords R, Olson SB, Yang F, Anekpuritanang T, Hu S, Wiszniewska J, Fan G, Press RD, Moore SR
Leuk Lymphoma 2022 Aug;63(8):1907-1916. Epub 2022 Mar 8 doi: 10.1080/10428194.2022.2047672. PMID: 35258401
Molecular Minimal Residual Disease in Acute Myeloid Leukemia.
Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM
N Engl J Med 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863. PMID: 29601269
Acute myeloid leukemia associated with FGFR1 abnormalities.
Lee H, Kim M, Lim J, Kim Y, Han K, Cho BS, Kim HJ
Int J Hematol 2013 Jun;97(6):808-12. Epub 2013 Apr 23 doi: 10.1007/s12185-013-1337-5. PMID: 23609419
Acute myeloid leukaemia in the elderly: a review.
Pollyea DA, Kohrt HE, Medeiros BC
Br J Haematol 2011 Mar;152(5):524-42. doi: 10.1111/j.1365-2141.2010.08470.x. PMID: 21314823
Acute myeloblastic leukemia with minimal myeloid differentiation: phenotypical and ultrastructural characteristics.
Villamor N, Zarco MA, Rozman M, Ribera JM, Feliu E, Montserrat E
Leukemia 1998 Jul;12(7):1071-5. doi: 10.1038/sj.leu.2401074. PMID: 9665192

Therapy

Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.
Blombery P, Lew TE, Dengler MA, Thompson ER, Lin VS, Chen X, Nguyen T, Panigrahi A, Handunnetti SM, Carney DA, Westerman DA, Tam CS, Adams JM, Wei AH, Huang DCS, Seymour JF, Roberts AW, Anderson MA
Blood 2022 Feb 24;139(8):1198-1207. doi: 10.1182/blood.2021012775. PMID: 34469514Free PMC Article
Monocytes reprogrammed with lentiviral vectors co-expressing GM-CSF, IFN-α2 and antigens for personalized immune therapy of acute leukemia pre- or post-stem cell transplantation.
Bialek-Waldmann JK, Heuser M, Ganser A, Stripecke R
Cancer Immunol Immunother 2019 Nov;68(11):1891-1899. Epub 2019 Oct 18 doi: 10.1007/s00262-019-02406-9. PMID: 31628525Free PMC Article
All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4).
Iland HJ, Bradstock K, Supple SG, Catalano A, Collins M, Hertzberg M, Browett P, Grigg A, Firkin F, Hugman A, Reynolds J, Di Iulio J, Tiley C, Taylor K, Filshie R, Seldon M, Taper J, Szer J, Moore J, Bashford J, Seymour JF; Australasian Leukaemia and Lymphoma Group
Blood 2012 Aug 23;120(8):1570-80; quiz 1752. Epub 2012 Jun 19 doi: 10.1182/blood-2012-02-410746. PMID: 22715121
Acute myeloid leukaemia in the elderly: a review.
Pollyea DA, Kohrt HE, Medeiros BC
Br J Haematol 2011 Mar;152(5):524-42. doi: 10.1111/j.1365-2141.2010.08470.x. PMID: 21314823
Acute myeloblastic leukemia with minimal myeloid differentiation (FAB AML-M0): a study of eleven cases.
Sempere A, Jarque I, Guinot M, Palau J, García R, Sanz GF, Gomis F, Pérez-Sirvent ML, Senent L, Sanz MA
Leuk Lymphoma 1993 Dec;12(1-2):103-8. doi: 10.3109/10428199309059577. PMID: 8161925

Prognosis

Consolidation in AML: Abundant opinion and much unknown.
Weigert N, Rowe JM, Lazarus HM, Salman MY
Blood Rev 2022 Jan;51:100873. Epub 2021 Aug 5 doi: 10.1016/j.blre.2021.100873. PMID: 34483002
Molecular Minimal Residual Disease in Acute Myeloid Leukemia.
Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM
N Engl J Med 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863. PMID: 29601269
Acute Myeloid Leukemia With Recurrent Genetic Abnormalities Other Than Translocations.
Lin P, Falini B
Am J Clin Pathol 2015 Jul;144(1):19-28. doi: 10.1309/AJCP97BJBEVZEUIN. PMID: 26071459
Acute myeloid leukemia associated with FGFR1 abnormalities.
Lee H, Kim M, Lim J, Kim Y, Han K, Cho BS, Kim HJ
Int J Hematol 2013 Jun;97(6):808-12. Epub 2013 Apr 23 doi: 10.1007/s12185-013-1337-5. PMID: 23609419
Acute myeloid leukaemia in the elderly: a review.
Pollyea DA, Kohrt HE, Medeiros BC
Br J Haematol 2011 Mar;152(5):524-42. doi: 10.1111/j.1365-2141.2010.08470.x. PMID: 21314823

Clinical prediction guides

Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.
Blombery P, Lew TE, Dengler MA, Thompson ER, Lin VS, Chen X, Nguyen T, Panigrahi A, Handunnetti SM, Carney DA, Westerman DA, Tam CS, Adams JM, Wei AH, Huang DCS, Seymour JF, Roberts AW, Anderson MA
Blood 2022 Feb 24;139(8):1198-1207. doi: 10.1182/blood.2021012775. PMID: 34469514Free PMC Article
Molecular Minimal Residual Disease in Acute Myeloid Leukemia.
Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM
N Engl J Med 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863. PMID: 29601269
Acute promyelocytic leukemia: recent advances in diagnosis and management.
Lo-Coco F, Ammatuna E, Montesinos P, Sanz MA
Semin Oncol 2008 Aug;35(4):401-9. doi: 10.1053/j.seminoncol.2008.04.010. PMID: 18692690
Acute myeloblastic leukemia with minimal myeloid differentiation: phenotypical and ultrastructural characteristics.
Villamor N, Zarco MA, Rozman M, Ribera JM, Feliu E, Montserrat E
Leukemia 1998 Jul;12(7):1071-5. doi: 10.1038/sj.leu.2401074. PMID: 9665192
Clinical pharmacology of sodium butyrate in patients with acute leukemia.
Miller AA, Kurschel E, Osieka R, Schmidt CG
Eur J Cancer Clin Oncol 1987 Sep;23(9):1283-7. doi: 10.1016/0277-5379(87)90109-x. PMID: 3678322

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