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Placental Malformation

MedGen UID:
770944
•Concept ID:
C3642304
•
Disease or Syndrome

Definition

A non-neoplastic abnormality that affects the placenta. Representative examples include multi-lobed and bilobed placenta. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlacental Malformation

Professional guidelines

PubMed

Optimal management of postpartum hemorrhage.
Liu J, Han F, Bian X
Chin Med J (Engl) 2001 Dec;114(12):1280-2. PMID: 11793853

Recent clinical studies

Etiology

Advanced maternal age causes premature placental senescence and malformation via dysregulated α-Klotho expression in trophoblasts.
Chen Z, Xiong L, Jin H, Yu J, Li X, Fu H, Wen L, Qi H, Tong C, Saffery R, Kilby MD, Baker PN
Aging Cell 2021 Jul;20(7):e13417. Epub 2021 Jun 9 doi: 10.1111/acel.13417. PMID: 34105233Free PMC Article
Cord insertion into the lower third of the uterus in the first trimester is associated with placental and umbilical cord abnormalities.
Hasegawa J, Matsuoka R, Ichizuka K, Otsuki K, Sekizawa A, Farina A, Okai T
Ultrasound Obstet Gynecol 2006 Aug;28(2):183-6. doi: 10.1002/uog.2839. PMID: 16858739
Polyhydramnios and associated maternal and fetal complications in singleton pregnancies.
Desmedt EJ, Henry OA, Beischer NA
Br J Obstet Gynaecol 1990 Dec;97(12):1115-22. doi: 10.1111/j.1471-0528.1990.tb02499.x. PMID: 2279018

Diagnosis

Placental mesenchymal dysplasia and an estimation of the population incidence.
Zeng X, Chen MF, Bureau YA, Brown R
Acta Obstet Gynecol Scand 2012 Jun;91(6):754-7. Epub 2012 May 1 doi: 10.1111/j.1600-0412.2012.01397.x. PMID: 22428924

Therapy

Tenofovir disoproxil fumarate in pregnancy and prevention of mother-to-child transmission of HIV-1: is it time to move on from zidovudine?
Foster C, Lyall H, Olmscheid B, Pearce G, Zhang S, Gibb DM
HIV Med 2009 Aug;10(7):397-406. Epub 2009 May 12 doi: 10.1111/j.1468-1293.2009.00709.x. PMID: 19459986

Prognosis

Placental mesenchymal dysplasia and an estimation of the population incidence.
Zeng X, Chen MF, Bureau YA, Brown R
Acta Obstet Gynecol Scand 2012 Jun;91(6):754-7. Epub 2012 May 1 doi: 10.1111/j.1600-0412.2012.01397.x. PMID: 22428924
Cord insertion into the lower third of the uterus in the first trimester is associated with placental and umbilical cord abnormalities.
Hasegawa J, Matsuoka R, Ichizuka K, Otsuki K, Sekizawa A, Farina A, Okai T
Ultrasound Obstet Gynecol 2006 Aug;28(2):183-6. doi: 10.1002/uog.2839. PMID: 16858739
Polyhydramnios and associated maternal and fetal complications in singleton pregnancies.
Desmedt EJ, Henry OA, Beischer NA
Br J Obstet Gynaecol 1990 Dec;97(12):1115-22. doi: 10.1111/j.1471-0528.1990.tb02499.x. PMID: 2279018

Clinical prediction guides

Cord insertion into the lower third of the uterus in the first trimester is associated with placental and umbilical cord abnormalities.
Hasegawa J, Matsuoka R, Ichizuka K, Otsuki K, Sekizawa A, Farina A, Okai T
Ultrasound Obstet Gynecol 2006 Aug;28(2):183-6. doi: 10.1002/uog.2839. PMID: 16858739

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