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Telangiectatic osteogenic sarcoma

MedGen UID:
78059
•Concept ID:
C0259782
•
Neoplastic Process
Synonyms: Malignant Bone Aneurysm; malignant bone aneurysm; Telangiectatic Osteogenic Sarcoma; telangiectatic osteogenic sarcoma; Telangiectatic osteosarcoma; Telangiectatic Osteosarcoma; telangiectatic osteosarcoma; telangiectatic osteosarcoma (morphologic abnormality); TEOS
SNOMED CT: Telangiectatic osteosarcoma (78453009); Telangiectatic osteosarcoma (1290873005)
 
Monarch Initiative: MONDO:0004050

Definition

An osteosarcoma usually arising from the metaphysis of long bones. It is characterized by the presence of a cystic architecture with blood-filled spaces. The prognosis is similar to that of conventional osteosarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTelangiectatic osteogenic sarcoma

Professional guidelines

PubMed

Update on aneurysmal bone cyst: pathophysiology, histology, imaging and treatment.
Restrepo R, Zahrah D, Pelaez L, Temple HT, Murakami JW
Pediatr Radiol 2022 Aug;52(9):1601-1614. Epub 2022 Aug 9 doi: 10.1007/s00247-022-05396-6. PMID: 35941207Free PMC Article
KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimics.
Jiang L, Liu J, Wei Q, Wang Y
Diagn Pathol 2020 Nov 11;15(1):135. doi: 10.1186/s13000-020-01051-6. PMID: 33176814Free PMC Article
Osteosarcoma subtypes: Magnetic resonance and quantitative diffusion weighted imaging criteria.
Zeitoun R, Shokry AM, Ahmed Khaleel S, Mogahed SM
J Egypt Natl Canc Inst 2018 Mar;30(1):39-44. Epub 2018 Feb 21 doi: 10.1016/j.jnci.2018.01.006. PMID: 29429892

Recent clinical studies

Etiology

Primary chemotherapy and delayed surgery for non-metastatic telangiectatic osteosarcoma of the extremities. Results in 28 patients.
Bacci G, Picci P, Ferrari S, Sangiorgi L, Zanone A, Brach del Prever A
Eur J Cancer 1994;30A(5):620-6. doi: 10.1016/0959-8049(94)90532-0. PMID: 8080676
Telangiectatic osteogenic sarcoma of the extremities. Results in 17 patients treated with neoadjuvant chemotherapy.
Pignatti G, Bacci G, Picci P, Dallari D, Bertoni F, Bacchini P, Capanna R
Clin Orthop Relat Res 1991 Sep;(270):99-106. PMID: 1884565
Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for telangiectatic osteogenic sarcoma of the extremities.
Bacci G, Pignatti G, Dallari D, Mercuri M, Bertoni F, Bacchini P, Fontana M, Avella M, Campanacci M
J Chemother 1989 Jun;1(3):190-6. doi: 10.1080/1120009x.1989.11738889. PMID: 2477510
Telangiectatic osteogenic sarcoma. Improved survival with combination chemotherapy.
Rosen G, Huvos AG, Marcove R, Nirenberg A
Clin Orthop Relat Res 1986 Jun;(207):164-73. PMID: 2424660
Telangiectatic osteogenic sarcoma: a clinicopathologic study of 124 patients.
Huvos AG, Rosen G, Bretsky SS, Butler A
Cancer 1982 Apr 15;49(8):1679-89. doi: 10.1002/1097-0142(19820415)49:8<1679::aid-cncr2820490824>3.0.co;2-2. PMID: 6950802

Diagnosis

Telangiectatic osteogenic sarcoma: an unusual presentation.
Simoens CJ, De Man RF, Van Herck GW, Roussel EO, Tanghe WF
J Belge Radiol 1992 Jun;75(3):188-90. PMID: 1400148
Telangiectatic osteogenic sarcoma. Improved survival with combination chemotherapy.
Rosen G, Huvos AG, Marcove R, Nirenberg A
Clin Orthop Relat Res 1986 Jun;(207):164-73. PMID: 2424660
Telangiectatic osteogenic sarcoma: a clinicopathologic study of 124 patients.
Huvos AG, Rosen G, Bretsky SS, Butler A
Cancer 1982 Apr 15;49(8):1679-89. doi: 10.1002/1097-0142(19820415)49:8<1679::aid-cncr2820490824>3.0.co;2-2. PMID: 6950802
Telangiectatic osteogenic sarcoma.
Matsuno T, Unni KK, McLeod RA, Dahlin DC
Cancer 1976 Dec;38(6):2538-47. doi: 10.1002/1097-0142(197612)38:6<2538::aid-cncr2820380643>3.0.co;2-1. PMID: 1069603
Telangiectatic osteogenic sarcoma. A review of twenty-eight cases.
Farr GH, Huvos AG, Marcove RC, Higinbotham NL, Foote FW Jr
Cancer 1974 Oct;34(4):1150-8. doi: 10.1002/1097-0142(197410)34:4<1150::aid-cncr2820340426>3.0.co;2-s. PMID: 4529332

Therapy

Primary chemotherapy and delayed surgery for non-metastatic telangiectatic osteosarcoma of the extremities. Results in 28 patients.
Bacci G, Picci P, Ferrari S, Sangiorgi L, Zanone A, Brach del Prever A
Eur J Cancer 1994;30A(5):620-6. doi: 10.1016/0959-8049(94)90532-0. PMID: 8080676
Telangiectatic osteogenic sarcoma of the extremities. Results in 17 patients treated with neoadjuvant chemotherapy.
Pignatti G, Bacci G, Picci P, Dallari D, Bertoni F, Bacchini P, Capanna R
Clin Orthop Relat Res 1991 Sep;(270):99-106. PMID: 1884565
Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for telangiectatic osteogenic sarcoma of the extremities.
Bacci G, Pignatti G, Dallari D, Mercuri M, Bertoni F, Bacchini P, Fontana M, Avella M, Campanacci M
J Chemother 1989 Jun;1(3):190-6. doi: 10.1080/1120009x.1989.11738889. PMID: 2477510
Telangiectatic osteogenic sarcoma. Improved survival with combination chemotherapy.
Rosen G, Huvos AG, Marcove R, Nirenberg A
Clin Orthop Relat Res 1986 Jun;(207):164-73. PMID: 2424660
Telangiectatic osteogenic sarcoma: a clinicopathologic study of 124 patients.
Huvos AG, Rosen G, Bretsky SS, Butler A
Cancer 1982 Apr 15;49(8):1679-89. doi: 10.1002/1097-0142(19820415)49:8<1679::aid-cncr2820490824>3.0.co;2-2. PMID: 6950802

Prognosis

Analysis of a Preliminary microRNA Expression Signature in a Human Telangiectatic Osteogenic Sarcoma Cancer Cell Line.
Palmini G, Romagnoli C, Donati S, Zonefrati R, Galli G, Marini F, Iantomasi T, Aldinucci A, Leoncini G, Franchi A, Beltrami G, Campanacci DA, Capanna R, Brandi ML
Int J Mol Sci 2021 Jan 25;22(3) doi: 10.3390/ijms22031163. PMID: 33503899Free PMC Article
Primary chemotherapy and delayed surgery for non-metastatic telangiectatic osteosarcoma of the extremities. Results in 28 patients.
Bacci G, Picci P, Ferrari S, Sangiorgi L, Zanone A, Brach del Prever A
Eur J Cancer 1994;30A(5):620-6. doi: 10.1016/0959-8049(94)90532-0. PMID: 8080676
Telangiectatic osteogenic sarcoma. Improved survival with combination chemotherapy.
Rosen G, Huvos AG, Marcove R, Nirenberg A
Clin Orthop Relat Res 1986 Jun;(207):164-73. PMID: 2424660
Telangiectatic osteogenic sarcoma: a clinicopathologic study of 124 patients.
Huvos AG, Rosen G, Bretsky SS, Butler A
Cancer 1982 Apr 15;49(8):1679-89. doi: 10.1002/1097-0142(19820415)49:8<1679::aid-cncr2820490824>3.0.co;2-2. PMID: 6950802
Telangiectatic osteogenic sarcoma.
Matsuno T, Unni KK, McLeod RA, Dahlin DC
Cancer 1976 Dec;38(6):2538-47. doi: 10.1002/1097-0142(197612)38:6<2538::aid-cncr2820380643>3.0.co;2-1. PMID: 1069603

Clinical prediction guides

Primary chemotherapy and delayed surgery for non-metastatic telangiectatic osteosarcoma of the extremities. Results in 28 patients.
Bacci G, Picci P, Ferrari S, Sangiorgi L, Zanone A, Brach del Prever A
Eur J Cancer 1994;30A(5):620-6. doi: 10.1016/0959-8049(94)90532-0. PMID: 8080676
Telangiectatic osteogenic sarcoma of the extremities. Results in 17 patients treated with neoadjuvant chemotherapy.
Pignatti G, Bacci G, Picci P, Dallari D, Bertoni F, Bacchini P, Capanna R
Clin Orthop Relat Res 1991 Sep;(270):99-106. PMID: 1884565
Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for telangiectatic osteogenic sarcoma of the extremities.
Bacci G, Pignatti G, Dallari D, Mercuri M, Bertoni F, Bacchini P, Fontana M, Avella M, Campanacci M
J Chemother 1989 Jun;1(3):190-6. doi: 10.1080/1120009x.1989.11738889. PMID: 2477510

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