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Androgen excess

MedGen UID:
810567
Concept ID:
C0235461
Disease or Syndrome
Synonym: Androgen Excess
SNOMED CT: Androgen excess (131074001)

Definition

Excessive secretion of androgens from the adrenal glands or gonads. Clinical manifestations may include virilization. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Belenkaia LV, Lazareva LM, Walker W, Lizneva DV, Suturina LV
Minerva Ginecol 2019 Jun;71(3):211-223. doi: 10.23736/S0026-4784.19.04404-6. PMID: 31089072
Escobar-Morreale HF
Nat Rev Endocrinol 2018 May;14(5):270-284. Epub 2018 Mar 23 doi: 10.1038/nrendo.2018.24. PMID: 29569621
Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Hum Reprod 2004 Jan;19(1):41-7. doi: 10.1093/humrep/deh098. PMID: 14688154

Recent clinical studies

Etiology

Fraga NR, Minaeian N, Kim MS
Pediatr Rev 2024 Feb 1;45(2):74-84. doi: 10.1542/pir.2022-005617. PMID: 38296783
Cussen L, McDonnell T, Bennett G, Thompson CJ, Sherlock M, O'Reilly MW
Clin Endocrinol (Oxf) 2022 Aug;97(2):174-186. Epub 2022 Mar 29 doi: 10.1111/cen.14710. PMID: 35349173Free PMC Article
Escobar-Morreale HF
Nat Rev Endocrinol 2018 May;14(5):270-284. Epub 2018 Mar 23 doi: 10.1038/nrendo.2018.24. PMID: 29569621
Kautzky-Willer A, Harreiter J, Pacini G
Endocr Rev 2016 Jun;37(3):278-316. Epub 2016 May 9 doi: 10.1210/er.2015-1137. PMID: 27159875Free PMC Article
Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Hum Reprod 2004 Jan;19(1):41-7. doi: 10.1093/humrep/deh098. PMID: 14688154

Diagnosis

Ibáñez L, de Zegher F
Trends Mol Med 2023 May;29(5):354-363. Epub 2023 Mar 22 doi: 10.1016/j.molmed.2023.02.006. PMID: 36964058
Hirschberg AL
J Clin Endocrinol Metab 2023 Apr 13;108(5):1243-1253. doi: 10.1210/clinem/dgac673. PMID: 36409990Free PMC Article
Cussen L, McDonnell T, Bennett G, Thompson CJ, Sherlock M, O'Reilly MW
Clin Endocrinol (Oxf) 2022 Aug;97(2):174-186. Epub 2022 Mar 29 doi: 10.1111/cen.14710. PMID: 35349173Free PMC Article
Escobar-Morreale HF
Nat Rev Endocrinol 2018 May;14(5):270-284. Epub 2018 Mar 23 doi: 10.1038/nrendo.2018.24. PMID: 29569621
Kautzky-Willer A, Harreiter J, Pacini G
Endocr Rev 2016 Jun;37(3):278-316. Epub 2016 May 9 doi: 10.1210/er.2015-1137. PMID: 27159875Free PMC Article

Therapy

Liu Y, Jiang JJ, Du SY, Mu LS, Fan JJ, Hu JC, Ye Y, Ding M, Zhou WY, Yu QH, Xia YF, Xu HY, Shi YJ, Qian SW, Tang Y, Li W, Dang YJ, Dong X, Li XY, Xu CJ, Tang QQ
Science 2024 Jun 14;384(6701):eadk5382. doi: 10.1126/science.adk5382. PMID: 38870290
Fraga NR, Minaeian N, Kim MS
Pediatr Rev 2024 Feb 1;45(2):74-84. doi: 10.1542/pir.2022-005617. PMID: 38296783
Wang K, Li Y
Front Endocrinol (Lausanne) 2023;14:1191759. Epub 2023 Oct 19 doi: 10.3389/fendo.2023.1191759. PMID: 37929034Free PMC Article
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Hum Reprod 2004 Jan;19(1):41-7. doi: 10.1093/humrep/deh098. PMID: 14688154

Prognosis

Kumariya S, Ubba V, Jha RK, Gayen JR
Autophagy 2021 Oct;17(10):2706-2733. Epub 2021 Jun 23 doi: 10.1080/15548627.2021.1938914. PMID: 34161185Free PMC Article
Merke DP, Mallappa A, Arlt W, Brac de la Perriere A, Lindén Hirschberg A, Juul A, Newell-Price J, Perry CG, Prete A, Rees DA, Reisch N, Stikkelbroeck N, Touraine P, Maltby K, Treasure FP, Porter J, Ross RJ
J Clin Endocrinol Metab 2021 Apr 23;106(5):e2063-e2077. doi: 10.1210/clinem/dgab051. PMID: 33527139Free PMC Article
Stener-Victorin E, Padmanabhan V, Walters KA, Campbell RE, Benrick A, Giacobini P, Dumesic DA, Abbott DH
Endocr Rev 2020 Jul 1;41(4) doi: 10.1210/endrev/bnaa010. PMID: 32310267Free PMC Article
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF; Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society
Fertil Steril 2009 Feb;91(2):456-88. Epub 2008 Oct 23 doi: 10.1016/j.fertnstert.2008.06.035. PMID: 18950759

Clinical prediction guides

Kumariya S, Ubba V, Jha RK, Gayen JR
Autophagy 2021 Oct;17(10):2706-2733. Epub 2021 Jun 23 doi: 10.1080/15548627.2021.1938914. PMID: 34161185Free PMC Article
Stener-Victorin E, Padmanabhan V, Walters KA, Campbell RE, Benrick A, Giacobini P, Dumesic DA, Abbott DH
Endocr Rev 2020 Jul 1;41(4) doi: 10.1210/endrev/bnaa010. PMID: 32310267Free PMC Article
Kautzky-Willer A, Harreiter J, Pacini G
Endocr Rev 2016 Jun;37(3):278-316. Epub 2016 May 9 doi: 10.1210/er.2015-1137. PMID: 27159875Free PMC Article
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF; Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society
Fertil Steril 2009 Feb;91(2):456-88. Epub 2008 Oct 23 doi: 10.1016/j.fertnstert.2008.06.035. PMID: 18950759

Recent systematic reviews

Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Sanchez-Garrido MA, Tena-Sempere M
Mol Metab 2020 May;35:100937. Epub 2020 Feb 5 doi: 10.1016/j.molmet.2020.01.001. PMID: 32244180Free PMC Article
Layton AM, Eady EA, Whitehouse H, Del Rosso JQ, Fedorowicz Z, van Zuuren EJ
Am J Clin Dermatol 2017 Apr;18(2):169-191. doi: 10.1007/s40257-016-0245-x. PMID: 28155090Free PMC Article
Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO
Hum Reprod 2016 Dec;31(12):2841-2855. Epub 2016 Sep 22 doi: 10.1093/humrep/dew218. PMID: 27664216
Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF; Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society
Fertil Steril 2009 Feb;91(2):456-88. Epub 2008 Oct 23 doi: 10.1016/j.fertnstert.2008.06.035. PMID: 18950759

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