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Rhesus Hemolytic Disease of the Newborn

MedGen UID:
810688
•Concept ID:
C0853694
•
Disease or Syndrome
Synonyms: Erythroblastosis Fetalis, Rh Disease; RhD Hemolytic Disease of the Newborn; Rhesus D Hemolytic Disease of the Newborn; Rhesus Disease

Definition

A disorder caused when there is a Rh-factor blood-type incompatibility between the mother and fetus, and the mother''s immune system forms antibodies that attack the red blood cells of her unborn child. This disorder can only occur if the mother is Rh-negative and the fetus is Rh-positive. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRhesus Hemolytic Disease of the Newborn

Professional guidelines

PubMed

Jack Bowman: Winnipeg's contributions to the treatment and prevention of Rhesus hemolytic disease of the newborn.
Warren P, Jamieson JC
Transfus Med Rev 2010 Jan;24(1):68-76. doi: 10.1016/j.tmrv.2009.09.007. PMID: 19962577
The impact of phototherapy in the management of neonatal hyperbilirubinemia: comparison of historical cohorts.
Valaes T, Koliopoulos C, Koltsidopoulos A
Acta Paediatr 1996 Mar;85(3):273-6. doi: 10.1111/j.1651-2227.1996.tb14013.x. PMID: 8695978

Recent clinical studies

Etiology

Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
History and current standard of postnatal management in hemolytic disease of the fetus and newborn.
De Winter DP, Hulzebos C, Van 't Oever RM, De Haas M, Verweij EJ, Lopriore E
Eur J Pediatr 2023 Feb;182(2):489-500. Epub 2022 Dec 5 doi: 10.1007/s00431-022-04724-0. PMID: 36469119
The rhesus incompatible pregnancy and its consequences for affected fetuses and neonates.
Tyndall C, Cuzzilla R, Kane SC
Transfus Apher Sci 2020 Oct;59(5):102948. Epub 2020 Sep 16 doi: 10.1016/j.transci.2020.102948. PMID: 33008742
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
Impact of Rhesus disease on the global problem of bilirubin-induced neurologic dysfunction.
Zipursky A, Bhutani VK
Semin Fetal Neonatal Med 2015 Feb;20(1):2-5. Epub 2015 Jan 9 doi: 10.1016/j.siny.2014.12.001. PMID: 25582277

Diagnosis

History and current standard of postnatal management in hemolytic disease of the fetus and newborn.
De Winter DP, Hulzebos C, Van 't Oever RM, De Haas M, Verweij EJ, Lopriore E
Eur J Pediatr 2023 Feb;182(2):489-500. Epub 2022 Dec 5 doi: 10.1007/s00431-022-04724-0. PMID: 36469119
Hemolytic Disease of the Fetus and Newborn: Historical and Current State.
Jackson ME, Baker JM
Clin Lab Med 2021 Mar;41(1):133-151. Epub 2020 Dec 24 doi: 10.1016/j.cll.2020.10.009. PMID: 33494881
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
Detection of fetomaternal hemorrhage.
Kim YA, Makar RS
Am J Hematol 2012 Apr;87(4):417-23. Epub 2012 Jan 9 doi: 10.1002/ajh.22255. PMID: 22231030
Anti-E in pregnancy.
Moran P, Robson SC, Reid MM
BJOG 2000 Nov;107(11):1436-8. doi: 10.1111/j.1471-0528.2000.tb11662.x. PMID: 11117776

Therapy

The rhesus incompatible pregnancy and its consequences for affected fetuses and neonates.
Tyndall C, Cuzzilla R, Kane SC
Transfus Apher Sci 2020 Oct;59(5):102948. Epub 2020 Sep 16 doi: 10.1016/j.transci.2020.102948. PMID: 33008742
RhIg for the prevention Rh immunization and IVIg for the treatment of affected neonates.
Legler TJ
Transfus Apher Sci 2020 Oct;59(5):102950. Epub 2020 Sep 25 doi: 10.1016/j.transci.2020.102950. PMID: 33004277
Anti-D prophylaxis: past, present and future.
de Haas M, Finning K, Massey E, Roberts DJ
Transfus Med 2014 Feb;24(1):1-7. doi: 10.1111/tme.12099. PMID: 25121157
Detection of fetomaternal hemorrhage.
Kim YA, Makar RS
Am J Hematol 2012 Apr;87(4):417-23. Epub 2012 Jan 9 doi: 10.1002/ajh.22255. PMID: 22231030
Rhesus haemolytic disease of the newborn: Postnatal management, associated morbidity and long-term outcome.
Smits-Wintjens VE, Walther FJ, Lopriore E
Semin Fetal Neonatal Med 2008 Aug;13(4):265-71. Epub 2008 Apr 2 doi: 10.1016/j.siny.2008.02.005. PMID: 18387863

Prognosis

The rhesus incompatible pregnancy and its consequences for affected fetuses and neonates.
Tyndall C, Cuzzilla R, Kane SC
Transfus Apher Sci 2020 Oct;59(5):102948. Epub 2020 Sep 16 doi: 10.1016/j.transci.2020.102948. PMID: 33008742
The burden and management of neonatal jaundice in Nigeria: A scoping review of the literature.
Olusanya BO, Osibanjo FB, Mabogunje CA, Slusher TM, Olowe SA
Niger J Clin Pract 2016 Jan-Feb;19(1):1-17. doi: 10.4103/1119-3077.173703. PMID: 26755212
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels.
Bhutani VK, Zipursky A, Blencowe H, Khanna R, Sgro M, Ebbesen F, Bell J, Mori R, Slusher TM, Fahmy N, Paul VK, Du L, Okolo AA, de Almeida MF, Olusanya BO, Kumar P, Cousens S, Lawn JE
Pediatr Res 2013 Dec;74 Suppl 1(Suppl 1):86-100. doi: 10.1038/pr.2013.208. PMID: 24366465Free PMC Article
Management of rhesus alloimmunization in pregnancy.
Moise KJ Jr
Obstet Gynecol 2008 Jul;112(1):164-76. doi: 10.1097/AOG.0b013e31817d453c. PMID: 18591322

Clinical prediction guides

Hemolytic disease of the fetus and newborn: rapid review of postnatal care and outcomes.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D, Lopriore E
BMC Pregnancy Childbirth 2023 Oct 18;23(1):738. doi: 10.1186/s12884-023-06061-y. PMID: 37853331Free PMC Article
Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
Darbepoetin Alfa for Late-onset Anemia in Neonates with Rhesus Hemolytic Disease.
Rv S, S R
Indian J Pediatr 2023 Feb;90(2):184-186. Epub 2022 Dec 3 doi: 10.1007/s12098-022-04411-w. PMID: 36460815
From immune substitution to immunomodulation.
Wahn V
Semin Hematol 2016 Apr;53 Suppl 1:S7-9. Epub 2016 Apr 7 doi: 10.1053/j.seminhematol.2016.04.003. PMID: 27312172
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360

Recent systematic reviews

Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: a systematic review and meta-analysis.
Olusanya BO, Osibanjo FB, Slusher TM
PLoS One 2015;10(2):e0117229. Epub 2015 Feb 12 doi: 10.1371/journal.pone.0117229. PMID: 25675342Free PMC Article
Anti-D administration after spontaneous miscarriage for preventing Rhesus alloimmunisation.
Karanth L, Jaafar SH, Kanagasabai S, Nair NS, Barua A
Cochrane Database Syst Rev 2013 Mar 28;(3):CD009617. doi: 10.1002/14651858.CD009617.pub2. PMID: 23543581
Management and prevention of red cell alloimmunization in pregnancy: a systematic review.
Moise KJ Jr, Argoti PS
Obstet Gynecol 2012 Nov;120(5):1132-9. doi: 10.1097/aog.0b013e31826d7dc1. PMID: 23090532
Etiology of nonimmune hydrops fetalis: a systematic review.
Bellini C, Hennekam RC, Fulcheri E, Rutigliani M, Morcaldi G, Boccardo F, Bonioli E
Am J Med Genet A 2009 May;149A(5):844-51. doi: 10.1002/ajmg.a.32655. PMID: 19334091

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