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Abnormal nipple morphology

MedGen UID:
824919
•Concept ID:
C3839073
•
Finding
Synonym: Nipple abnormalities
SNOMED CT: Nipple abnormality (700153004); Abnormal nipple (700153004)
 
HPO: HP:0004404

Definition

An abnormality of the nipple. [from HPO]

Professional guidelines

PubMed

Treatment of the benign inverted nipple: A systematic review and recommendations for future therapy.
Hernandez Yenty QM, Jurgens WJ, van Zuijlen PP, de Vet HC, Verhaegen PD
Breast 2016 Oct;29:82-9. Epub 2016 Jul 29 doi: 10.1016/j.breast.2016.07.011. PMID: 27476082
Diagnosis and surgical treatment of nipple adenoma.
Wang C, Wang X, Ma R
ANZ J Surg 2015 Jun;85(6):444-7. Epub 2014 Jun 27 doi: 10.1111/ans.12744. PMID: 24975720
Prevalence, diagnosis, and treatment of ankyloglossia: methodologic review.
Segal LM, Stephenson R, Dawes M, Feldman P
Can Fam Physician 2007 Jun;53(6):1027-33. PMID: 17872781Free PMC Article

Recent clinical studies

Etiology

Multimodality Imaging of Benign and Malignant Diseases of the Nipple-Areolar Complex.
Guirguis MS, Arribas EM, Kapoor MM, Patel MM, Perez F, Nia ES, Ding Q, Moseley TW, Adrada BE
Radiographics 2024 Apr;44(4):e230113. doi: 10.1148/rg.230113. PMID: 38483829
Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis.
Koo MM, von Wagner C, Abel GA, McPhail S, Rubin GP, Lyratzopoulos G
Cancer Epidemiol 2017 Jun;48:140-146. Epub 2017 May 23 doi: 10.1016/j.canep.2017.04.010. PMID: 28549339Free PMC Article
Benign breast disorders.
Onstad M, Stuckey A
Obstet Gynecol Clin North Am 2013 Sep;40(3):459-73. Epub 2013 Jul 24 doi: 10.1016/j.ogc.2013.05.004. PMID: 24021252
Dermatopathology of the female breast.
Peters MS, Lehman JS, Comfere NI
Am J Dermatopathol 2013 May;35(3):289-304; quiz 305-7. doi: 10.1097/DAD.0b013e318267caa3. PMID: 23598853
Male breast cancer.
Reis LO, Dias FG, Castro MA, Ferreira U
Aging Male 2011 Jun;14(2):99-109. Epub 2011 Jan 4 doi: 10.3109/13685538.2010.535048. PMID: 21204612

Diagnosis

Skin diseases of the breast and nipple: Benign and malignant tumors.
Waldman RA, Finch J, Grant-Kels JM, Stevenson C, Whitaker-Worth D
J Am Acad Dermatol 2019 Jun;80(6):1467-1481. Epub 2018 Nov 16 doi: 10.1016/j.jaad.2018.08.066. PMID: 30452954
Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis.
Koo MM, von Wagner C, Abel GA, McPhail S, Rubin GP, Lyratzopoulos G
Cancer Epidemiol 2017 Jun;48:140-146. Epub 2017 May 23 doi: 10.1016/j.canep.2017.04.010. PMID: 28549339Free PMC Article
Cat eye syndrome.
Sharma D, Murki S, Pratap T, Vasikarla M
BMJ Case Rep 2014 May 19;2014 doi: 10.1136/bcr-2014-203923. PMID: 24842361Free PMC Article
Male breast cancer.
Reis LO, Dias FG, Castro MA, Ferreira U
Aging Male 2011 Jun;14(2):99-109. Epub 2011 Jan 4 doi: 10.3109/13685538.2010.535048. PMID: 21204612
Nipple discharge screening.
Zervoudis S, Iatrakis G, Economides P, Polyzos D, Navrozoglou I
Womens Health (Lond) 2010 Jan;6(1):135-51. doi: 10.2217/whe.09.81. PMID: 20050819

Therapy

Masculinizing Mammoplasty for Female-to-Male Transgenders: 10 Years' Experience.
Huber PD, Bittencourt RC, Jeziorowski A
Aesthetic Plast Surg 2024 Oct;48(19):3825-3835. Epub 2024 Mar 12 doi: 10.1007/s00266-024-03931-4. PMID: 38472348
Severe gestational gigantomastia: management challenges.
Rooi A, Botha A, Ndobe E, Nel M
S Afr J Surg 2021 Dec;59(4):195a-195c. PMID: 34889547
Nipple-Areola Complex Reconstruction.
Sisti A
Medicina (Kaunas) 2020 Jun 16;56(6) doi: 10.3390/medicina56060296. PMID: 32560062Free PMC Article
Bipedicle Vertical Mammoplasty Associated with Liposuction/Lipotunnelization.
Maia M, Pinto C
Aesthetic Plast Surg 2017 Jun;41(3):499-506. Epub 2017 Feb 2 doi: 10.1007/s00266-017-0795-1. PMID: 28155062
Management of Recurrent or Persistent Macromastia.
Austin RE, Lista F, Ahmad J
Clin Plast Surg 2016 Apr;43(2):383-93. Epub 2016 Feb 11 doi: 10.1016/j.cps.2015.12.004. PMID: 27012797

Prognosis

Skin diseases of the breast and nipple: Benign and malignant tumors.
Waldman RA, Finch J, Grant-Kels JM, Stevenson C, Whitaker-Worth D
J Am Acad Dermatol 2019 Jun;80(6):1467-1481. Epub 2018 Nov 16 doi: 10.1016/j.jaad.2018.08.066. PMID: 30452954
Cat eye syndrome.
Sharma D, Murki S, Pratap T, Vasikarla M
BMJ Case Rep 2014 May 19;2014 doi: 10.1136/bcr-2014-203923. PMID: 24842361Free PMC Article
Dermatopathology of the female breast.
Peters MS, Lehman JS, Comfere NI
Am J Dermatopathol 2013 May;35(3):289-304; quiz 305-7. doi: 10.1097/DAD.0b013e318267caa3. PMID: 23598853
Breast imaging for interventional pathologists.
Lieu D
Arch Pathol Lab Med 2013 Jan;137(1):100-19. Epub 2012 Apr 26 doi: 10.5858/arpa.2012-0081-RA. PMID: 22536979
Male breast cancer.
Reis LO, Dias FG, Castro MA, Ferreira U
Aging Male 2011 Jun;14(2):99-109. Epub 2011 Jan 4 doi: 10.3109/13685538.2010.535048. PMID: 21204612

Clinical prediction guides

Masculinizing Mammoplasty for Female-to-Male Transgenders: 10 Years' Experience.
Huber PD, Bittencourt RC, Jeziorowski A
Aesthetic Plast Surg 2024 Oct;48(19):3825-3835. Epub 2024 Mar 12 doi: 10.1007/s00266-024-03931-4. PMID: 38472348
Inverted Nipple Treatment and Poliglecaprone Spacer.
Dessena L, Dast S, Perez S, Mercut R, Herlin C, Sinna R
Aesthetic Plast Surg 2018 Aug;42(4):958-963. Epub 2018 May 1 doi: 10.1007/s00266-018-1139-5. PMID: 29717339
Inverted Nipple With Nipple-Sparing Mastectomy.
Yim JH, Lee TJ
Ann Plast Surg 2016 Aug;77(2):153-5. doi: 10.1097/SAP.0000000000000639. PMID: 26545213
Dermatopathology of the female breast.
Peters MS, Lehman JS, Comfere NI
Am J Dermatopathol 2013 May;35(3):289-304; quiz 305-7. doi: 10.1097/DAD.0b013e318267caa3. PMID: 23598853
Diseases of the male nipple and areola.
Krause W
J Dtsch Dermatol Ges 2011 Dec;9(12):1004-9. Epub 2011 Jun 9 doi: 10.1111/j.1610-0387.2011.07720.x. PMID: 21651722

Recent systematic reviews

Role of duct excision surgery in the treatment of pathological nipple discharge and detection of breast carcinoma: systematic review.
Makineli S, van Wijnbergen JWM, Vriens MR, van Diest PJ, Witkamp AJ
BJS Open 2023 Jul 10;7(4) doi: 10.1093/bjsopen/zrad066. PMID: 37459137Free PMC Article
Diagnostic Performance of MRI Versus Galactography in Women With Pathologic Nipple Discharge: A Systematic Review and Meta-Analysis.
Berger N, Luparia A, Di Leo G, Carbonaro LA, Trimboli RM, Ambrogi F, Sardanelli F
AJR Am J Roentgenol 2017 Aug;209(2):465-471. Epub 2017 May 24 doi: 10.2214/AJR.16.16682. PMID: 28537847
Treatment of the benign inverted nipple: A systematic review and recommendations for future therapy.
Hernandez Yenty QM, Jurgens WJ, van Zuijlen PP, de Vet HC, Verhaegen PD
Breast 2016 Oct;29:82-9. Epub 2016 Jul 29 doi: 10.1016/j.breast.2016.07.011. PMID: 27476082
Systematic review and meta-analysis of the diagnostic accuracy of ductoscopy in patients with pathological nipple discharge.
Waaijer L, Simons JM, Borel Rinkes IH, van Diest PJ, Verkooijen HM, Witkamp AJ
Br J Surg 2016 May;103(6):632-643. Epub 2016 Mar 23 doi: 10.1002/bjs.10125. PMID: 27004588
Proliferative epithelial disease identified in nipple aspirate fluid and risk of developing breast cancer: a systematic review.
Hornberger J, Chen SC, Li Q, Kakad P, Quay SC
Curr Med Res Opin 2015 Feb;31(2):253-62. Epub 2014 Dec 3 doi: 10.1185/03007995.2014.988209. PMID: 25405383

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