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Localized Malignant Gallbladder Neoplasm

MedGen UID:
82987
•Concept ID:
C0278806
•
Neoplastic Process
Synonym: Malignant Neoplasm of Gallbladder Localized

Definition

A malignant neoplasm that arises from the gallbladder and it has not spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Malignant Gallbladder Neoplasm

Professional guidelines

PubMed

Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Vogel A, Bridgewater J, Edeline J, Kelley RK, Klümpen HJ, Malka D, Primrose JN, Rimassa L, Stenzinger A, Valle JW, Ducreux M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Feb;34(2):127-140. Epub 2022 Nov 10 doi: 10.1016/j.annonc.2022.10.506. PMID: 36372281
Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R, Roberts SA
Eur Radiol 2022 May;32(5):3358-3368. Epub 2021 Dec 17 doi: 10.1007/s00330-021-08384-w. PMID: 34918177Free PMC Article
Gallbladder Cancer: Diagnosis, Surgical Management, and Adjuvant Therapies.
Hickman L, Contreras C
Surg Clin North Am 2019 Apr;99(2):337-355. doi: 10.1016/j.suc.2018.12.008. PMID: 30846038

Recent clinical studies

Etiology

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Vogel A, Bridgewater J, Edeline J, Kelley RK, Klümpen HJ, Malka D, Primrose JN, Rimassa L, Stenzinger A, Valle JW, Ducreux M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Feb;34(2):127-140. Epub 2022 Nov 10 doi: 10.1016/j.annonc.2022.10.506. PMID: 36372281
Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R, Roberts SA
Eur Radiol 2022 May;32(5):3358-3368. Epub 2021 Dec 17 doi: 10.1007/s00330-021-08384-w. PMID: 34918177Free PMC Article
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Hepatobiliary surgery.
Bismuth H, Majno PE
J Hepatol 2000;32(1 Suppl):208-24. doi: 10.1016/s0168-8278(00)80427-4. PMID: 10728806

Diagnosis

Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Vogel A, Bridgewater J, Edeline J, Kelley RK, Klümpen HJ, Malka D, Primrose JN, Rimassa L, Stenzinger A, Valle JW, Ducreux M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Feb;34(2):127-140. Epub 2022 Nov 10 doi: 10.1016/j.annonc.2022.10.506. PMID: 36372281
How I treat biliary tract cancer.
Lamarca A, Edeline J, Goyal L
ESMO Open 2022 Feb;7(1):100378. Epub 2022 Jan 13 doi: 10.1016/j.esmoop.2021.100378. PMID: 35032765Free PMC Article
Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R, Roberts SA
Eur Radiol 2022 May;32(5):3358-3368. Epub 2021 Dec 17 doi: 10.1007/s00330-021-08384-w. PMID: 34918177Free PMC Article
Benign gallbladder diseases: Imaging techniques and tips for differentiating with malignant gallbladder diseases.
Yu MH, Kim YJ, Park HS, Jung SI
World J Gastroenterol 2020 Jun 14;26(22):2967-2986. doi: 10.3748/wjg.v26.i22.2967. PMID: 32587442Free PMC Article
Gallbladder Cancer: Diagnosis, Surgical Management, and Adjuvant Therapies.
Hickman L, Contreras C
Surg Clin North Am 2019 Apr;99(2):337-355. doi: 10.1016/j.suc.2018.12.008. PMID: 30846038

Therapy

Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial.
Kelley RK, Ueno M, Yoo C, Finn RS, Furuse J, Ren Z, Yau T, Klümpen HJ, Chan SL, Ozaka M, Verslype C, Bouattour M, Park JO, Barajas O, Pelzer U, Valle JW, Yu L, Malhotra U, Siegel AB, Edeline J, Vogel A; KEYNOTE-966 Investigators
Lancet 2023 Jun 3;401(10391):1853-1865. Epub 2023 Apr 16 doi: 10.1016/S0140-6736(23)00727-4. PMID: 37075781
Role of ion channels in gastrointestinal cancer.
Anderson KJ, Cormier RT, Scott PM
World J Gastroenterol 2019 Oct 14;25(38):5732-5772. doi: 10.3748/wjg.v25.i38.5732. PMID: 31636470Free PMC Article
Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study.
Primrose JN, Fox RP, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, Wasan H, Ross P, Wall L, Wadsley J, Evans JTR, Stocken D, Praseedom R, Ma YT, Davidson B, Neoptolemos JP, Iveson T, Raftery J, Zhu S, Cunningham D, Garden OJ, Stubbs C, Valle JW, Bridgewater J; BILCAP study group
Lancet Oncol 2019 May;20(5):663-673. Epub 2019 Mar 25 doi: 10.1016/S1470-2045(18)30915-X. PMID: 30922733
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer.
Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, Madhusudan S, Iveson T, Hughes S, Pereira SP, Roughton M, Bridgewater J; ABC-02 Trial Investigators
N Engl J Med 2010 Apr 8;362(14):1273-81. doi: 10.1056/NEJMoa0908721. PMID: 20375404

Prognosis

Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Vogel A, Bridgewater J, Edeline J, Kelley RK, Klümpen HJ, Malka D, Primrose JN, Rimassa L, Stenzinger A, Valle JW, Ducreux M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Feb;34(2):127-140. Epub 2022 Nov 10 doi: 10.1016/j.annonc.2022.10.506. PMID: 36372281
Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R, Roberts SA
Eur Radiol 2022 May;32(5):3358-3368. Epub 2021 Dec 17 doi: 10.1007/s00330-021-08384-w. PMID: 34918177Free PMC Article
LncRNA-HGBC stabilized by HuR promotes gallbladder cancer progression by regulating miR-502-3p/SET/AKT axis.
Hu YP, Jin YP, Wu XS, Yang Y, Li YS, Li HF, Xiang SS, Song XL, Jiang L, Zhang YJ, Huang W, Chen SL, Liu FT, Chen C, Zhu Q, Chen HZ, Shao R, Liu YB
Mol Cancer 2019 Nov 21;18(1):167. doi: 10.1186/s12943-019-1097-9. PMID: 31752906Free PMC Article
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer.
Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, Madhusudan S, Iveson T, Hughes S, Pereira SP, Roughton M, Bridgewater J; ABC-02 Trial Investigators
N Engl J Med 2010 Apr 8;362(14):1273-81. doi: 10.1056/NEJMoa0908721. PMID: 20375404

Clinical prediction guides

Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer (TOPAZ-1): patient-reported outcomes from a randomised, double-blind, placebo-controlled, phase 3 trial.
Burris HA 3rd, Okusaka T, Vogel A, Lee MA, Takahashi H, Breder V, Blanc JF, Li J, Bachini M, Żotkiewicz M, Abraham J, Patel N, Wang J, Ali M, Rokutanda N, Cohen G, Oh DY
Lancet Oncol 2024 May;25(5):626-635. doi: 10.1016/S1470-2045(24)00082-2. PMID: 38697156
Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial.
Nakachi K, Ikeda M, Konishi M, Nomura S, Katayama H, Kataoka T, Todaka A, Yanagimoto H, Morinaga S, Kobayashi S, Shimada K, Takahashi Y, Nakagohri T, Gotoh K, Kamata K, Shimizu Y, Ueno M, Ishii H, Okusaka T, Furuse J; Hepatobiliary and Pancreatic Oncology Group of the Japan Clinical Oncology Group (JCOG-HBPOG)
Lancet 2023 Jan 21;401(10372):195-203. doi: 10.1016/S0140-6736(22)02038-4. PMID: 36681415
Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study.
Primrose JN, Fox RP, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, Wasan H, Ross P, Wall L, Wadsley J, Evans JTR, Stocken D, Praseedom R, Ma YT, Davidson B, Neoptolemos JP, Iveson T, Raftery J, Zhu S, Cunningham D, Garden OJ, Stubbs C, Valle JW, Bridgewater J; BILCAP study group
Lancet Oncol 2019 May;20(5):663-673. Epub 2019 Mar 25 doi: 10.1016/S1470-2045(18)30915-X. PMID: 30922733
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article

Recent systematic reviews

Chemoradiation of locally advanced biliary cancer: A PRISMA-compliant systematic review.
Bisello S, Malizia C, Mammini F, Galietta E, Medici F, Mattiucci GC, Cellini F, Palloni A, Tagliaferri L, Macchia G, Deodato F, Cilla S, Brandi G, Arcelli A, Morganti AG
Cancer Med 2024 Dec;13(23):e70196. doi: 10.1002/cam4.70196. PMID: 39659023Free PMC Article
Robotic, laparoscopic and open surgery for gallbladder cancer: a systematic review and network meta-analysis.
Chee MYM, Wu AGR, Fong KY, Yew A, Koh YX, Goh BKP
Surg Endosc 2024 Sep;38(9):4846-4857. Epub 2024 Aug 15 doi: 10.1007/s00464-024-11162-6. PMID: 39148006
Unraveling early recurrence of risk factors in Gallbladder cancer: A systematic review and meta-analysis.
Yang SQ, Feng H, Tian Y, Zou RQ, Dai YS, Hu HJ, Li FY
Eur J Surg Oncol 2024 Jul;50(7):108372. Epub 2024 Apr 26 doi: 10.1016/j.ejso.2024.108372. PMID: 38718620
Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma.
Luvira V, Satitkarnmanee E, Pugkhem A, Kietpeerakool C, Lumbiganon P, Pattanittum P
Cochrane Database Syst Rev 2021 Sep 13;9(9):CD012814. doi: 10.1002/14651858.CD012814.pub2. PMID: 34515993Free PMC Article
Incidence and Preoperative Predictor Factors of Gallbladder Cancer Before Laparoscopic Cholecystectomy: a Systematic Review.
Kellil T, Chaouch MA, Aloui E, Tormane MA, Taieb SK, Noomen F, Zouari K
J Gastrointest Cancer 2021 Mar;52(1):68-72. Epub 2020 Sep 23 doi: 10.1007/s12029-020-00524-7. PMID: 32964323

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