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Recurrent Nasopharyngeal Carcinoma

MedGen UID:
83013
•Concept ID:
C0278952
•
Neoplastic Process
Synonyms: Nasopharyngeal Cancer, Recurrent; Recurrent Cancer of Nasopharynx; Recurrent Cancer of the Nasopharynx; Recurrent Carcinoma of Nasopharynx; Recurrent Carcinoma of the Nasopharynx; Recurrent Nasopharyngeal Cancer; Relapsed Cancer of Nasopharynx; Relapsed Cancer of the Nasopharynx; Relapsed Carcinoma of Nasopharynx; Relapsed Carcinoma of the Nasopharynx; Relapsed Nasopharyngeal Cancer; Relapsed Nasopharyngeal Carcinoma; Relapsed Nasopharynx Carcinoma

Definition

The reemergence of nasopharyngeal carcinoma after a period of remission. [from NCI]

Professional guidelines

PubMed

International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma.
Ng WT, Soong YL, Ahn YC, AlHussain H, Choi HCW, Corry J, Grégoire V, Harrington KJ, Hu CS, Jensen K, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Pan JJ, Peters LJ, Poh SS, Rosenthal DI, Sanguineti G, Tao Y, Wee JT, Yom SS, Chua MLK, Lee AWM
Int J Radiat Oncol Biol Phys 2021 Jul 1;110(3):682-695. Epub 2021 Feb 9 doi: 10.1016/j.ijrobp.2021.01.041. PMID: 33571626
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Surgical management of recurrent nasopharyngeal carcinoma.
Hao SP, Tsang NM
Chang Gung Med J 2010 Jul-Aug;33(4):361-9. PMID: 20804665

Recent clinical studies

Etiology

Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma.
Ng WT, Soong YL, Ahn YC, AlHussain H, Choi HCW, Corry J, Grégoire V, Harrington KJ, Hu CS, Jensen K, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Pan JJ, Peters LJ, Poh SS, Rosenthal DI, Sanguineti G, Tao Y, Wee JT, Yom SS, Chua MLK, Lee AWM
Int J Radiat Oncol Biol Phys 2021 Jul 1;110(3):682-695. Epub 2021 Feb 9 doi: 10.1016/j.ijrobp.2021.01.041. PMID: 33571626
Salvage Endoscopic Nasopharyngectomy in Recurrent Nasopharyngeal Carcinoma: Prognostic Factors and Treatment Outcomes.
Li W, Lu H, Wang H, Zhang H, Sun X, Hu L, Zhao W, Gu Y, Li H, Wang D
Am J Rhinol Allergy 2021 Jul;35(4):458-466. Epub 2020 Oct 5 doi: 10.1177/1945892420964054. PMID: 33019819
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Surgical management of recurrent nasopharyngeal carcinoma.
Hao SP, Tsang NM
Chang Gung Med J 2010 Jul-Aug;33(4):361-9. PMID: 20804665

Diagnosis

Image-based diagnosis of residual or recurrent nasopharyngeal carcinoma may be a phantom tumor phenomenon.
Lee CC, Lee JC, Huang WY, Juan CJ, Jen YM, Lin LF
Medicine (Baltimore) 2021 Feb 26;100(8):e24555. doi: 10.1097/MD.0000000000024555. PMID: 33663063Free PMC Article
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
18F-FDG PET/CT for the Diagnosis of Residual or Recurrent Nasopharyngeal Carcinoma After Radiotherapy: A Metaanalysis.
Zhou H, Shen G, Zhang W, Cai H, Zhou Y, Li L
J Nucl Med 2016 Mar;57(3):342-7. Epub 2015 Nov 5 doi: 10.2967/jnumed.115.165407. PMID: 26541775
Imaging appearances for recurrent nasopharyngeal carcinoma and post-salvage nasopharyngectomy.
Teo PT, Tan NC, Khoo JB
Clin Radiol 2013 Nov;68(11):e629-38. Epub 2013 Aug 12 doi: 10.1016/j.crad.2013.06.003. PMID: 23937825
Endoscopic nasopharyngectomy and its role in managing locally recurrent nasopharyngeal carcinoma.
Ong YK, Solares CA, Lee S, Snyderman CH, Fernandez-Miranda J, Gardner PA
Otolaryngol Clin North Am 2011 Oct;44(5):1141-54. doi: 10.1016/j.otc.2011.07.002. PMID: 21978898

Therapy

Robotic stereotactic body radiotherapy for recurrent nasopharyngeal carcinoma.
Uysal E, Aksaray F, Dincer S, Altın S
Indian J Cancer 2023 Jul-Sep;60(3):353-358. doi: 10.4103/ijc.IJC_1414_20. PMID: 36861705
Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
Maintenance metronomic chemotherapy for metastatic/recurrent nasopharyngeal carcinoma.
Twu CW, Lin PJ, Tsou HH, Liu YC, Jiang RS, Liang KL, Lin TY, Wang WY, Lin JC
Head Neck 2022 Jun;44(6):1453-1461. Epub 2022 Apr 1 doi: 10.1002/hed.27044. PMID: 35362634
Comparing endoscopic surgeries with open surgeries in terms of effectiveness and safety in salvaging residual or recurrent nasopharyngeal cancer: Systematic review and meta-analysis.
Li G, Wang J, Tang H, Han R, Zhao Y, Wang X, Zhou H
Head Neck 2020 Nov;42(11):3415-3426. Epub 2020 Aug 17 doi: 10.1002/hed.26397. PMID: 33463833
Clinical results of proton therapy reirradiation for recurrent nasopharyngeal carcinoma.
Dionisi F, Croci S, Giacomelli I, Cianchetti M, Caldara A, Bertolin M, Vanoni V, Pertile R, Widesott L, Farace P, Schwarz M, Amichetti M
Acta Oncol 2019 Sep;58(9):1238-1245. Epub 2019 Jun 3 doi: 10.1080/0284186X.2019.1622772. PMID: 31155998

Prognosis

Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma.
Ng WT, Soong YL, Ahn YC, AlHussain H, Choi HCW, Corry J, Grégoire V, Harrington KJ, Hu CS, Jensen K, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Pan JJ, Peters LJ, Poh SS, Rosenthal DI, Sanguineti G, Tao Y, Wee JT, Yom SS, Chua MLK, Lee AWM
Int J Radiat Oncol Biol Phys 2021 Jul 1;110(3):682-695. Epub 2021 Feb 9 doi: 10.1016/j.ijrobp.2021.01.041. PMID: 33571626
Salvage Endoscopic Nasopharyngectomy in Recurrent Nasopharyngeal Carcinoma: Prognostic Factors and Treatment Outcomes.
Li W, Lu H, Wang H, Zhang H, Sun X, Hu L, Zhao W, Gu Y, Li H, Wang D
Am J Rhinol Allergy 2021 Jul;35(4):458-466. Epub 2020 Oct 5 doi: 10.1177/1945892420964054. PMID: 33019819
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Endoscopic nasopharyngectomy and its role in managing locally recurrent nasopharyngeal carcinoma.
Ong YK, Solares CA, Lee S, Snyderman CH, Fernandez-Miranda J, Gardner PA
Otolaryngol Clin North Am 2011 Oct;44(5):1141-54. doi: 10.1016/j.otc.2011.07.002. PMID: 21978898

Clinical prediction guides

Maintenance metronomic chemotherapy for metastatic/recurrent nasopharyngeal carcinoma.
Twu CW, Lin PJ, Tsou HH, Liu YC, Jiang RS, Liang KL, Lin TY, Wang WY, Lin JC
Head Neck 2022 Jun;44(6):1453-1461. Epub 2022 Apr 1 doi: 10.1002/hed.27044. PMID: 35362634
Comparing endoscopic surgeries with open surgeries in terms of effectiveness and safety in salvaging residual or recurrent nasopharyngeal cancer: Systematic review and meta-analysis.
Li G, Wang J, Tang H, Han R, Zhao Y, Wang X, Zhou H
Head Neck 2020 Nov;42(11):3415-3426. Epub 2020 Aug 17 doi: 10.1002/hed.26397. PMID: 33463833
Dose volume effects of re-irradiation for locally recurrent nasopharyngeal carcinoma.
Ng WT, Lee MC, Fung NT, Wong EC, Cheung AK, Chow JC, Au KH, Poon DM, Lai JW, Chiang CL, Choi HC, Chau TC, Lee VH, Lee AW
Head Neck 2020 Feb;42(2):180-187. Epub 2019 Oct 16 doi: 10.1002/hed.25988. PMID: 31617636
Establishment of prognostic factors in recurrent nasopharyngeal carcinoma patients who received salvage intensity-modulated radiotherapy: A meta-analysis.
Yue Q, Zhang M, Chen Y, Zheng D, Chen Y, Feng M
Oral Oncol 2018 Jun;81:81-88. Epub 2018 May 2 doi: 10.1016/j.oraloncology.2018.04.017. PMID: 29884418
Impact of nodal ratio on survival in recurrent nasopharyngeal carcinoma.
Chan RC, Chan JY
Head Neck 2015 Jan;37(1):12-7. Epub 2014 Jan 29 doi: 10.1002/hed.23544. PMID: 24307492

Recent systematic reviews

Salvage treatments for locally recurrent nasopharyngeal cancer: Systematic review and meta-analysis.
Wang D, Liao M, Wu J, Luo W, Qi S, Liu B, Li J
Head Neck 2023 Feb;45(2):503-520. Epub 2022 Nov 24 doi: 10.1002/hed.27253. PMID: 36420965
Comparing endoscopic surgeries with open surgeries in terms of effectiveness and safety in salvaging residual or recurrent nasopharyngeal cancer: Systematic review and meta-analysis.
Li G, Wang J, Tang H, Han R, Zhao Y, Wang X, Zhou H
Head Neck 2020 Nov;42(11):3415-3426. Epub 2020 Aug 17 doi: 10.1002/hed.26397. PMID: 33463833
Endoscopic nasopharyngectomy in recurrent nasopharyngeal carcinoma: a case series, literature review, and pooled analysis.
Vlantis AC, Lee DL, Wong EW, Chow SM, Ng SK, Chan JY
Int Forum Allergy Rhinol 2017 Apr;7(4):425-432. Epub 2016 Nov 16 doi: 10.1002/alr.21881. PMID: 27865062
Solitary splenic metastasis from nasopharyngeal carcinoma: a case report and systematic review of the literature.
Genova P, Brunetti F, Bequignon E, Landi F, Lizzi V, Esposito F, Charpy C, Calderaro J, Azoulay D, de'Angelis N
World J Surg Oncol 2016 Jul 15;14(1):184. doi: 10.1186/s12957-016-0941-2. PMID: 27422630Free PMC Article
FDG-PET, CT, MRI for diagnosis of local residual or recurrent nasopharyngeal carcinoma, which one is the best? A systematic review.
Liu T, Xu W, Yan WL, Ye M, Bai YR, Huang G
Radiother Oncol 2007 Dec;85(3):327-35. Epub 2007 Nov 26 doi: 10.1016/j.radonc.2007.11.002. PMID: 18037523

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