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Crypt abscess

MedGen UID:
83075
•Concept ID:
C0333374
•
Pathologic Function
Synonym: Crypt abscesses
SNOMED CT: Crypt abscess (37771006)

Definition

Accumulation of polymorphonuclear neutrophils in the mucosal crypts of the colon. It occurs in ulcerative colitis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCrypt abscess

Professional guidelines

PubMed

The role of mesalazine co-treatment in the prevention of recurrence in subjects with subclinical inflammatory bowel disease and perianal fistula who are scheduled for surgical intervention.
Akturk R, Serinsöz S
Ann Ital Chir 2022;93:183-187. PMID: 35311735
Advanced criteria for clinicopathological diagnosis of food protein-induced proctocolitis.
Hwang JB, Park MH, Kang YN, Kim SP, Suh SI, Kam S
J Korean Med Sci 2007 Apr;22(2):213-7. doi: 10.3346/jkms.2007.22.2.213. PMID: 17449926Free PMC Article

Recent clinical studies

Etiology

Gastrointestinal Adverse Events Induced by Immune-Checkpoint Inhibitors.
Yanai S, Toya Y, Sugai T, Matsumoto T
Digestion 2021;102(6):965-973. Epub 2021 Sep 2 doi: 10.1159/000518543. PMID: 34515105
Computed tomography enterocolongraphy in assessment of degree of ulcerative colitis activity.
Ahmed EA, Abdelatty K, Mahdy RE, Emara DM, Header DA
Int J Clin Pract 2021 Oct;75(10):e14626. Epub 2021 Jul 28 doi: 10.1111/ijcp.14626. PMID: 34258846
Clinical features and monocyte/macrophage subsets characterization in granulomatous vs non-granulomatous Crohn's disease.
Zhao L, Tang Y, Lei N, Zhou D, Chen B, Gan T, Yang X, Zhang Y
Scand J Gastroenterol 2020 Apr;55(4):442-448. Epub 2020 Apr 14 doi: 10.1080/00365521.2020.1748222. PMID: 32285715
Endocytoscopic classification can be predictive for relapse in ulcerative colitis.
Ueda N, Isomoto H, Ikebuchi Y, Kurumi H, Kawaguchi K, Yashima K, Ueki M, Matsushima K, Akashi T, Uehara R, Takeshima F, Hayashi T, Nakao K
Medicine (Baltimore) 2018 Mar;97(10):e0107. doi: 10.1097/MD.0000000000010107. PMID: 29517688Free PMC Article
Colitis-related rat colon carcinogenesis induced by 1-hydroxy-anthraquinone and methylazoxymethanol acetate (Review).
Tanaka T, Kohno H, Murakami M, Shimada R, Kagami S
Oncol Rep 2000 May-Jun;7(3):501-8. doi: 10.3892/or.7.3.501. PMID: 10767359

Diagnosis

Clinical features of inflammatory bowel disease unclassified: a case-control study.
Shao Y, Zhao Y, Lv H, Yan P, Yang H, Li J, Li J, Qian J
BMC Gastroenterol 2024 Mar 13;24(1):105. doi: 10.1186/s12876-024-03171-5. PMID: 38481157Free PMC Article
Gastrointestinal Adverse Events Induced by Immune-Checkpoint Inhibitors.
Yanai S, Toya Y, Sugai T, Matsumoto T
Digestion 2021;102(6):965-973. Epub 2021 Sep 2 doi: 10.1159/000518543. PMID: 34515105
Computed tomography enterocolongraphy in assessment of degree of ulcerative colitis activity.
Ahmed EA, Abdelatty K, Mahdy RE, Emara DM, Header DA
Int J Clin Pract 2021 Oct;75(10):e14626. Epub 2021 Jul 28 doi: 10.1111/ijcp.14626. PMID: 34258846
Endocytoscopic classification can be predictive for relapse in ulcerative colitis.
Ueda N, Isomoto H, Ikebuchi Y, Kurumi H, Kawaguchi K, Yashima K, Ueki M, Matsushima K, Akashi T, Uehara R, Takeshima F, Hayashi T, Nakao K
Medicine (Baltimore) 2018 Mar;97(10):e0107. doi: 10.1097/MD.0000000000010107. PMID: 29517688Free PMC Article
The Apoptotic Crypt Abscess: An Underappreciated Histologic Finding in Gastrointestinal Pathology.
Talmon G, Manasek T, Miller R, Muirhead D, Lazenby A
Am J Clin Pathol 2017 Nov 20;148(6):538-544. doi: 10.1093/ajcp/aqx100. PMID: 29140405

Therapy

Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss.
Zhang YL, Chen Q, Zheng L, Zhang ZW, Chen YJ, Dai YC, Tang ZP
World J Gastroenterol 2022 Apr 7;28(13):1315-1328. doi: 10.3748/wjg.v28.i13.1315. PMID: 35645540Free PMC Article
The Apoptotic Crypt Abscess: An Underappreciated Histologic Finding in Gastrointestinal Pathology.
Talmon G, Manasek T, Miller R, Muirhead D, Lazenby A
Am J Clin Pathol 2017 Nov 20;148(6):538-544. doi: 10.1093/ajcp/aqx100. PMID: 29140405
Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer.
Prasad VG, Kawade S, Jayashree BS, Reddy ND, Francis A, Nayak PG, Kishore A, Nandakumar K, Rao CM, Shenoy RR
Biomed Res Int 2014;2014:569130. Epub 2014 Jun 5 doi: 10.1155/2014/569130. PMID: 24995310Free PMC Article
Systemic lupus erythematosus complicated by Crohn's disease: a case report and literature review.
Yamashita H, Ueda Y, Kawaguchi H, Suzuki A, Takahashi Y, Kaneko H, Kano T, Mimori A
BMC Gastroenterol 2012 Dec 5;12:174. doi: 10.1186/1471-230X-12-174. PMID: 23216789Free PMC Article
Advanced criteria for clinicopathological diagnosis of food protein-induced proctocolitis.
Hwang JB, Park MH, Kang YN, Kim SP, Suh SI, Kam S
J Korean Med Sci 2007 Apr;22(2):213-7. doi: 10.3346/jkms.2007.22.2.213. PMID: 17449926Free PMC Article

Prognosis

Gastrointestinal Adverse Events Induced by Immune-Checkpoint Inhibitors.
Yanai S, Toya Y, Sugai T, Matsumoto T
Digestion 2021;102(6):965-973. Epub 2021 Sep 2 doi: 10.1159/000518543. PMID: 34515105
Lymphocytic and collagenous colitis in children and adolescents: Comprehensive clinicopathologic analysis with long-term follow-up.
Windon AL, Almazan E, Oliva-Hemker M, Hutchings D, Assarzadegan N, Salimian K, Montgomery EA, Voltaggio L
Hum Pathol 2020 Dec;106:13-22. Epub 2020 Sep 28 doi: 10.1016/j.humpath.2020.09.011. PMID: 32991931
Endocytoscopic classification can be predictive for relapse in ulcerative colitis.
Ueda N, Isomoto H, Ikebuchi Y, Kurumi H, Kawaguchi K, Yashima K, Ueki M, Matsushima K, Akashi T, Uehara R, Takeshima F, Hayashi T, Nakao K
Medicine (Baltimore) 2018 Mar;97(10):e0107. doi: 10.1097/MD.0000000000010107. PMID: 29517688Free PMC Article
Inflammatory bowel disease in children--clinical, endoscopic, radiologic and histopathologic investigation.
Seo JK, Yeon KM, Chi JG
J Korean Med Sci 1992 Sep;7(3):221-35. doi: 10.3346/jkms.1992.7.3.221. PMID: 1285921Free PMC Article
Intestinal mucosa diamine oxidase activity reflects intestinal involvement in Crohn's disease.
Thompson JS, Burnett DA, Markin RS, Vaughan WP
Am J Gastroenterol 1988 Jul;83(7):756-60. PMID: 3132852

Clinical prediction guides

Comparative study between histochemical mucus volume, histopathological findings, and endocytoscopic scores in patients with ulcerative colitis.
Kamitani Y, Kurumi H, Kanda T, Ikebuchi Y, Yoshida A, Kawaguchi K, Yashima K, Umekita Y, Isomoto H
Medicine (Baltimore) 2023 Mar 3;102(9):e33033. doi: 10.1097/MD.0000000000033033. PMID: 36862904Free PMC Article
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss.
Zhang YL, Chen Q, Zheng L, Zhang ZW, Chen YJ, Dai YC, Tang ZP
World J Gastroenterol 2022 Apr 7;28(13):1315-1328. doi: 10.3748/wjg.v28.i13.1315. PMID: 35645540Free PMC Article
Computed tomography enterocolongraphy in assessment of degree of ulcerative colitis activity.
Ahmed EA, Abdelatty K, Mahdy RE, Emara DM, Header DA
Int J Clin Pract 2021 Oct;75(10):e14626. Epub 2021 Jul 28 doi: 10.1111/ijcp.14626. PMID: 34258846
Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer.
Prasad VG, Kawade S, Jayashree BS, Reddy ND, Francis A, Nayak PG, Kishore A, Nandakumar K, Rao CM, Shenoy RR
Biomed Res Int 2014;2014:569130. Epub 2014 Jun 5 doi: 10.1155/2014/569130. PMID: 24995310Free PMC Article
Systemic lupus erythematosus complicated by Crohn's disease: a case report and literature review.
Yamashita H, Ueda Y, Kawaguchi H, Suzuki A, Takahashi Y, Kaneko H, Kano T, Mimori A
BMC Gastroenterol 2012 Dec 5;12:174. doi: 10.1186/1471-230X-12-174. PMID: 23216789Free PMC Article

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