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Malignant Gastrinoma

MedGen UID:
83121
•Concept ID:
C0334283
•
Neoplastic Process
Synonyms: G cell tumor, malignant; Gastrin cell tumor, malignant; Gastrinoma, malignant; Malignant G cell tumor; Malignant gastrinoma
SNOMED CT: Malignant G cell tumor (19756007); Malignant gastrinoma (19756007); Gastrin cell tumor, malignant (19756007); Gastrinoma, malignant (19756007); G cell tumor, malignant (19756007)

Definition

A gastrin-producing neuroendocrine tumor. It is characterized by inappropriate secretion of gastrin and associated with Zollinger Ellison syndrome. It displays vascular invasion and metastasizes to other anatomic sites. [from NCI]

Professional guidelines

PubMed

Prospective study of the antitumor efficacy of long-term octreotide treatment in patients with progressive metastatic gastrinoma.
Shojamanesh H, Gibril F, Louie A, Ojeaburu JV, Bashir S, Abou-Saif A, Jensen RT
Cancer 2002 Jan 15;94(2):331-43. doi: 10.1002/cncr.10195. PMID: 11900219

Recent clinical studies

Etiology

Prospective study of the antitumor efficacy of long-term octreotide treatment in patients with progressive metastatic gastrinoma.
Shojamanesh H, Gibril F, Louie A, Ojeaburu JV, Bashir S, Abou-Saif A, Jensen RT
Cancer 2002 Jan 15;94(2):331-43. doi: 10.1002/cncr.10195. PMID: 11900219
Malignant endocrine tumors in patients with MEN 1 disease.
Dotzenrath C, Goretzki PE, Cupisti K, Yang Q, Simon D, Röher HD
Surgery 2001 Jan;129(1):91-5. doi: 10.1067/msy.2001.109500. PMID: 11150038
Aggressive resection of metastatic disease in selected patients with malignant gastrinoma.
Norton JA, Sugarbaker PH, Doppman JL, Wesley RA, Maton PN, Gardner JD, Jensen RT
Ann Surg 1986 Apr;203(4):352-9. doi: 10.1097/00000658-198604000-00003. PMID: 2938550Free PMC Article
Benign and malignant gastrinoma.
Stabile BE, Passaro E Jr
Am J Surg 1985 Jan;149(1):144-50. doi: 10.1016/s0002-9610(85)80024-6. PMID: 2857072
The Zollinger-Ellison syndrome--23 years later.
Deveney CW, Deveney KS, Way LW
Ann Surg 1978 Sep;188(3):384-93. doi: 10.1097/00000658-197809000-00014. PMID: 686901Free PMC Article

Diagnosis

MEN1 clinical background.
Igaz P
Adv Exp Med Biol 2009;668:1-15. doi: 10.1007/978-1-4419-1664-8_1. PMID: 20175448
Pancreatic endocrine tumour: a 22-year clinico-pathological experience with morphological, immunohistochemical observation and a review of the literature.
Lam KY, Lo CY
Eur J Surg Oncol 1997 Feb;23(1):36-42. doi: 10.1016/s0748-7983(97)80140-0. PMID: 9066745
Gastric gastrinoma.
Liu TH, Zhong SX, Chen YF, Lin Y, Chen J, Li DC, Wang DT, Gu CF, Yie SF
Chin Med J (Engl) 1989 Oct;102(10):774-82. PMID: 2517058
Bone metastases in malignant gastrinoma.
Barton JC, Hirschowitz BI, Maton PN, Jensen RT
Gastroenterology 1986 Nov;91(5):1179-85. doi: 10.1016/s0016-5085(86)80014-2. PMID: 3758610
The Zollinger-Ellison syndrome--23 years later.
Deveney CW, Deveney KS, Way LW
Ann Surg 1978 Sep;188(3):384-93. doi: 10.1097/00000658-197809000-00014. PMID: 686901Free PMC Article

Therapy

Toxicity of high-activity 111In-Octreotide therapy in patients with disseminated neuroendocrine tumours.
Caplin ME, Mielcarek W, Buscombe JR, Jones AL, Croasdale PL, Cooper MS, Burroughs AK, Hilson AW
Nucl Med Commun 2000 Jan;21(1):97-102. doi: 10.1097/00006231-200001000-00016. PMID: 10717909
Aggressive resection of metastatic disease in selected patients with malignant gastrinoma.
Norton JA, Sugarbaker PH, Doppman JL, Wesley RA, Maton PN, Gardner JD, Jensen RT
Ann Surg 1986 Apr;203(4):352-9. doi: 10.1097/00000658-198604000-00003. PMID: 2938550Free PMC Article
Benign and malignant gastrinoma.
Stabile BE, Passaro E Jr
Am J Surg 1985 Jan;149(1):144-50. doi: 10.1016/s0002-9610(85)80024-6. PMID: 2857072
The Zollinger-Ellison syndrome--23 years later.
Deveney CW, Deveney KS, Way LW
Ann Surg 1978 Sep;188(3):384-93. doi: 10.1097/00000658-197809000-00014. PMID: 686901Free PMC Article
Successful treatment of a malignant gastrinoma with streptozotocin.
Hayes JR, O'Connell N, O'Neill T, Fennelly JJ, Weir DG
Gut 1976 Apr;17(4):285-8. doi: 10.1136/gut.17.4.285. PMID: 178577Free PMC Article

Prognosis

Bone metastases in malignant gastrinoma.
Barton JC, Hirschowitz BI, Maton PN, Jensen RT
Gastroenterology 1986 Nov;91(5):1179-85. doi: 10.1016/s0016-5085(86)80014-2. PMID: 3758610
Aggressive resection of metastatic disease in selected patients with malignant gastrinoma.
Norton JA, Sugarbaker PH, Doppman JL, Wesley RA, Maton PN, Gardner JD, Jensen RT
Ann Surg 1986 Apr;203(4):352-9. doi: 10.1097/00000658-198604000-00003. PMID: 2938550Free PMC Article
Benign and malignant gastrinoma.
Stabile BE, Passaro E Jr
Am J Surg 1985 Jan;149(1):144-50. doi: 10.1016/s0002-9610(85)80024-6. PMID: 2857072
The Zollinger-Ellison syndrome--23 years later.
Deveney CW, Deveney KS, Way LW
Ann Surg 1978 Sep;188(3):384-93. doi: 10.1097/00000658-197809000-00014. PMID: 686901Free PMC Article
Successful treatment of a malignant gastrinoma with streptozotocin.
Hayes JR, O'Connell N, O'Neill T, Fennelly JJ, Weir DG
Gut 1976 Apr;17(4):285-8. doi: 10.1136/gut.17.4.285. PMID: 178577Free PMC Article

Clinical prediction guides

MEN1 clinical background.
Igaz P
Adv Exp Med Biol 2009;668:1-15. doi: 10.1007/978-1-4419-1664-8_1. PMID: 20175448
Prospective study of the antitumor efficacy of long-term octreotide treatment in patients with progressive metastatic gastrinoma.
Shojamanesh H, Gibril F, Louie A, Ojeaburu JV, Bashir S, Abou-Saif A, Jensen RT
Cancer 2002 Jan 15;94(2):331-43. doi: 10.1002/cncr.10195. PMID: 11900219
Pancreatic endocrine tumour: a 22-year clinico-pathological experience with morphological, immunohistochemical observation and a review of the literature.
Lam KY, Lo CY
Eur J Surg Oncol 1997 Feb;23(1):36-42. doi: 10.1016/s0748-7983(97)80140-0. PMID: 9066745
Bone metastases in malignant gastrinoma.
Barton JC, Hirschowitz BI, Maton PN, Jensen RT
Gastroenterology 1986 Nov;91(5):1179-85. doi: 10.1016/s0016-5085(86)80014-2. PMID: 3758610
Pylorus preserving pancreatoduodenectomy for gastrinoma. A case report.
Cavina E, Pagliai EF, Goletti O, Chiarugi M, Chirico A
Ital J Surg Sci 1986;16(4):291-5. PMID: 3557935

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