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Pleural adenomatoid tumor

MedGen UID:
83408
•Concept ID:
C0346112
•
Neoplastic Process
Synonyms: Benign mesothelioma of pleura; benign mesothelioma of pleura; benign mesothelioma of the pleura; Benign neoplasm of mesothelial tissue of pleura; Benign Pleural Mesothelioma; pleura adenomatoid tumor; pleura adenomatoid tumour; Pleural Adenomatoid Tumor; pleural adenomatoid tumor; pleural benign mesothelioma; pleural mesothelioma, benign
SNOMED CT: Benign mesothelioma of pleura (109372009); Benign neoplasm of mesothelial tissue of pleura (109372009)
 
Monarch Initiative: MONDO:0024326

Definition

A rare benign neoplasm that arises from the mesothelial cells of the pleura. It is characterized by a proliferation of epithelioid cells forming glandular and tubular patterns in a fibrous stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleural adenomatoid tumor

Professional guidelines

PubMed

Multimodality Imaging of Pleuropulmonary Blastoma: Pearls, Pitfalls, and Differential Diagnosis.
Leung SS, Donuru A, Kandula V, Parekh MR, Saul D
Semin Ultrasound CT MR 2022 Feb;43(1):61-72. Epub 2021 May 15 doi: 10.1053/j.sult.2021.05.007. PMID: 35164911
Adenomatoid Tumor: A Review of Pathology With Focus on Unusual Presentations and Sites, Histogenesis, Differential Diagnosis, and Molecular and Clinical Aspects With a Historic Overview of Its Description.
Karpathiou G, Hiroshima K, Peoc'h M
Adv Anat Pathol 2020 Nov;27(6):394-407. doi: 10.1097/PAP.0000000000000278. PMID: 32769378
Pleuropulmonary blastoma: management and prognosis of 11 cases.
Indolfi P, Casale F, Carli M, Bisogno G, Ninfo V, Cecchetto G, Bagnulo S, Santoro N, Giuliano M, Di Tullio MT
Cancer 2000 Sep 15;89(6):1396-401. PMID: 11002236

Recent clinical studies

Etiology

Multimodality Imaging of Pleuropulmonary Blastoma: Pearls, Pitfalls, and Differential Diagnosis.
Leung SS, Donuru A, Kandula V, Parekh MR, Saul D
Semin Ultrasound CT MR 2022 Feb;43(1):61-72. Epub 2021 May 15 doi: 10.1053/j.sult.2021.05.007. PMID: 35164911
Pleural mesothelioma classification-update and challenges.
Dacic S
Mod Pathol 2022 Jan;35(Suppl 1):51-56. Epub 2021 Aug 31 doi: 10.1038/s41379-021-00895-7. PMID: 34465883
Multiple tumor types including leiomyoma and Wilms tumor in a patient with Gorlin syndrome due to 9q22.3 microdeletion encompassing the PTCH1 and FANC-C loci.
Garavelli L, Piemontese MR, Cavazza A, Rosato S, Wischmeijer A, Gelmini C, Albertini E, Albertini G, Forzano F, Franchi F, Carella M, Zelante L, Superti-Furga A
Am J Med Genet A 2013 Nov;161A(11):2894-901. Epub 2013 Oct 7 doi: 10.1002/ajmg.a.36259. PMID: 24124115
Diffuse mesothelioma of the peritoneum: a pathological study of 64 tumours treated with cytoreductive therapy.
Lee M, Alexander HR, Burke A
Pathology 2013 Aug;45(5):464-73. doi: 10.1097/PAT.0b013e3283631cce. PMID: 23846294
Type I pleuropulmonary blastoma: pathology and biology study of 51 cases from the international pleuropulmonary blastoma registry.
Hill DA, Jarzembowski JA, Priest JR, Williams G, Schoettler P, Dehner LP
Am J Surg Pathol 2008 Feb;32(2):282-95. doi: 10.1097/PAS.0b013e3181484165. PMID: 18223332

Diagnosis

Pleural mesothelioma classification-update and challenges.
Dacic S
Mod Pathol 2022 Jan;35(Suppl 1):51-56. Epub 2021 Aug 31 doi: 10.1038/s41379-021-00895-7. PMID: 34465883
TRAF7 mutations and immunohistochemical study of uterine adenomatoid tumor compared with malignant mesothelioma.
Itami H, Fujii T, Nakai T, Takeda M, Kishi Y, Taniguchi F, Terada C, Okada F, Nitta Y, Matsuoka M, Sasaki S, Sugimoto S, Uchiyama T, Morita K, Kasai T, Kawaguchi R, Ohbayashi C
Hum Pathol 2021 May;111:59-66. Epub 2021 Mar 2 doi: 10.1016/j.humpath.2021.02.007. PMID: 33667423
Peritoneal adenomatoid (microcystic) mesothelioma.
Mori D, Kido S, Hiraki M, Sumi K, Ureshino N, Masuda M, Nabeshima K, Akashi M
Pathol Int 2020 Nov;70(11):876-880. Epub 2020 Sep 3 doi: 10.1111/pin.13006. PMID: 32881200
Adenomatoid Tumor: A Review of Pathology With Focus on Unusual Presentations and Sites, Histogenesis, Differential Diagnosis, and Molecular and Clinical Aspects With a Historic Overview of Its Description.
Karpathiou G, Hiroshima K, Peoc'h M
Adv Anat Pathol 2020 Nov;27(6):394-407. doi: 10.1097/PAP.0000000000000278. PMID: 32769378
Pleural neoplastic pathology.
Karpathiou G, Stefanou D, Froudarakis ME
Respir Med 2015 Aug;109(8):931-43. Epub 2015 May 21 doi: 10.1016/j.rmed.2015.05.014. PMID: 26048082

Therapy

BAP1 Loss is a Useful Adjunct to Distinguish Malignant Mesothelioma Including the Adenomatoid-like Variant From Benign Adenomatoid Tumors.
Erber R, Warth A, Muley T, Hartmann A, Herpel E, Agaimy A
Appl Immunohistochem Mol Morphol 2020 Jan;28(1):67-73. doi: 10.1097/PAI.0000000000000700. PMID: 30640754
USCAP Specialty Conference: case 1-type I pleuropulmonary blastoma.
Hill DA
Pediatr Dev Pathol 2005 Jan-Feb;8(1):77-84. Epub 2005 Feb 23 doi: 10.1007/s10024-004-6069-3. PMID: 15719205
Pathology of malignant mesothelioma.
Attanoos RL, Gibbs AR
Histopathology 1997 May;30(5):403-18. doi: 10.1046/j.1365-2559.1997.5460776.x. PMID: 9181361
Tumors of serosal tissue origin.
Bolen JW
Clin Lab Med 1987 Mar;7(1):31-50. PMID: 3549129

Prognosis

Pleural mesothelioma classification-update and challenges.
Dacic S
Mod Pathol 2022 Jan;35(Suppl 1):51-56. Epub 2021 Aug 31 doi: 10.1038/s41379-021-00895-7. PMID: 34465883
TRAF7 mutations and immunohistochemical study of uterine adenomatoid tumor compared with malignant mesothelioma.
Itami H, Fujii T, Nakai T, Takeda M, Kishi Y, Taniguchi F, Terada C, Okada F, Nitta Y, Matsuoka M, Sasaki S, Sugimoto S, Uchiyama T, Morita K, Kasai T, Kawaguchi R, Ohbayashi C
Hum Pathol 2021 May;111:59-66. Epub 2021 Mar 2 doi: 10.1016/j.humpath.2021.02.007. PMID: 33667423
Peritoneal adenomatoid (microcystic) mesothelioma.
Mori D, Kido S, Hiraki M, Sumi K, Ureshino N, Masuda M, Nabeshima K, Akashi M
Pathol Int 2020 Nov;70(11):876-880. Epub 2020 Sep 3 doi: 10.1111/pin.13006. PMID: 32881200
Pleural neoplastic pathology.
Karpathiou G, Stefanou D, Froudarakis ME
Respir Med 2015 Aug;109(8):931-43. Epub 2015 May 21 doi: 10.1016/j.rmed.2015.05.014. PMID: 26048082
Pathology of malignant mesothelioma.
Attanoos RL, Gibbs AR
Histopathology 1997 May;30(5):403-18. doi: 10.1046/j.1365-2559.1997.5460776.x. PMID: 9181361

Clinical prediction guides

Peritoneal adenomatoid (microcystic) mesothelioma.
Mori D, Kido S, Hiraki M, Sumi K, Ureshino N, Masuda M, Nabeshima K, Akashi M
Pathol Int 2020 Nov;70(11):876-880. Epub 2020 Sep 3 doi: 10.1111/pin.13006. PMID: 32881200
Adenomatoid mesothelioma with intranuclear inclusion bodies: a case report with cytological and histological findings.
Kawai T, Kawashima K, Serizawa H, Miura H, Kyeongil K
Diagn Cytopathol 2014 May;42(5):436-40. Epub 2012 Nov 16 doi: 10.1002/dc.22932. PMID: 23166110
Malignant mesothelioma with prominent adenomatoid features: a clinicopathologic and immunohistochemical study of 10 cases.
Weissferdt A, Kalhor N, Suster S
Ann Diagn Pathol 2011 Feb;15(1):25-9. Epub 2010 Nov 24 doi: 10.1016/j.anndiagpath.2010.08.005. PMID: 21106421
Type I pleuropulmonary blastoma: pathology and biology study of 51 cases from the international pleuropulmonary blastoma registry.
Hill DA, Jarzembowski JA, Priest JR, Williams G, Schoettler P, Dehner LP
Am J Surg Pathol 2008 Feb;32(2):282-95. doi: 10.1097/PAS.0b013e3181484165. PMID: 18223332
Tumors of serosal tissue origin.
Bolen JW
Clin Lab Med 1987 Mar;7(1):31-50. PMID: 3549129

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