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Orbit Capillary Hemangioma

MedGen UID:
83421
•Concept ID:
C0346351
•
Neoplastic Process
Synonyms: Capillary Angioma of Orbit; Capillary Angioma of the Orbit; Capillary hemangioma of orbit; Capillary Hemangioma of Orbit; Capillary Hemangioma of the Orbit; Orbit Capillary Angioma
SNOMED CT: Capillary hemangioma of orbit (254997007)

Definition

A capillary hemangioma arising from the orbit. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrbit Capillary Hemangioma

Professional guidelines

PubMed

Treatment of periorbital infantile haemangiomas: a systematic literature review on propranolol or steroids.
Xu S, Jia R, Ge S, Lin M, Fan X
J Paediatr Child Health 2014 Apr;50(4):271-9. Epub 2013 Dec 23 doi: 10.1111/jpc.12464. PMID: 24754793
Oral propranolol for treatment of periocular infantile hemangiomas.
Missoi TG, Lueder GT, Gilbertson K, Bayliss SJ
Arch Ophthalmol 2011 Jul;129(7):899-903. Epub 2011 Mar 14 doi: 10.1001/archophthalmol.2011.40. PMID: 21402978
Reappraisal of astigmatism induced by periocular capillary hemangioma and treatment with intralesional corticosteroid injection.
Weiss AH, Kelly JP
Ophthalmology 2008 Feb;115(2):390-397.e1. Epub 2007 Jun 22 doi: 10.1016/j.ophtha.2007.03.077. PMID: 17588666

Recent clinical studies

Etiology

Prevalence and clinical features of orbital vascular anomalies in children.
Torrado-Cobian LA, Griepentrog GJ, Hodge DO, Mohney BG
Orbit 2023 Dec;42(6):598-602. Epub 2023 Jan 16 doi: 10.1080/01676830.2023.2166081. PMID: 36644978Free PMC Article
Proptosis due to intraorbital space-occupying lesions in children.
Zahavi A, Luckman J, Ben-David GS, Toledano H, Michowiz S, Vardizer Y, Goldenberg-Cohen N
Graefes Arch Clin Exp Ophthalmol 2020 Nov;258(11):2541-2550. Epub 2020 Jul 16 doi: 10.1007/s00417-020-04840-3. PMID: 32676791
Leksell Radiosurgery for the 3 H Tumors: Hemangiomas, Hemangioblastomas, and Hemangiopericytomas.
Johnson S, Niranjan A, Kano H, Lunsford LD
Prog Neurol Surg 2019;34:223-231. Epub 2019 May 16 doi: 10.1159/000493068. PMID: 31096251
Hemangioblastoma of the optic nerve.
McGrath LA, Mudhar HS, Salvi SM
Surv Ophthalmol 2019 Mar-Apr;64(2):175-184. Epub 2018 Oct 13 doi: 10.1016/j.survophthal.2018.10.002. PMID: 30321570
Primary orbital intraosseous hemangioma.
Madge SN, Simon S, Abidin Z, Ghabrial R, Davis G, McNab A, Selva D
Ophthalmic Plast Reconstr Surg 2009 Jan-Feb;25(1):37-41. doi: 10.1097/IOP.0b013e318192a27e. PMID: 19273921

Diagnosis

Ocular adnexal intramuscular hemangioma arising from the eyelid: case report and literature review.
Lai KKH, Li CK, Tsang A, Wong SYS, Ko CKL
Orbit 2023 Jun;42(3):290-294. Epub 2021 Oct 22 doi: 10.1080/01676830.2021.1990352. PMID: 34686104
Hemangioblastoma of the optic nerve.
McGrath LA, Mudhar HS, Salvi SM
Surv Ophthalmol 2019 Mar-Apr;64(2):175-184. Epub 2018 Oct 13 doi: 10.1016/j.survophthal.2018.10.002. PMID: 30321570
Tufted angiomas of the head and neck.
Häußler SM, Uecker FC, Knopke S, Roßner F, Olze H, Böttcher A
HNO 2018 Jan;66(Suppl 1):1-6. doi: 10.1007/s00106-017-0375-3. PMID: 28667388
Periorbital lesions misdiagnosed as dermoid cysts.
Al-Muhaylib A, Alkatan HM, Al-Faky YH, Alsuhaibani AH
J AAPOS 2017 Dec;21(6):509-511. Epub 2017 Oct 28 doi: 10.1016/j.jaapos.2017.07.215. PMID: 29107796
Primary orbital intraosseous hemangioma.
Madge SN, Simon S, Abidin Z, Ghabrial R, Davis G, McNab A, Selva D
Ophthalmic Plast Reconstr Surg 2009 Jan-Feb;25(1):37-41. doi: 10.1097/IOP.0b013e318192a27e. PMID: 19273921

Therapy

β-blockers in the treatment of periocular infantile hemangioma.
Al-Haddad C, El Salloukh NA, El Moussawi Z
Curr Opin Ophthalmol 2019 Sep;30(5):319-325. doi: 10.1097/ICU.0000000000000591. PMID: 31394556
The Use of β-Blockers for the Treatment of Periocular Hemangiomas in Infants: A Report by the American Academy of Ophthalmology.
Hutchinson AK, Kraker RT, Pineles SL, VanderVeen DK, Wilson LB, Galvin JA, Lambert SR
Ophthalmology 2019 Jan;126(1):146-155. Epub 2018 Aug 1 doi: 10.1016/j.ophtha.2018.07.023. PMID: 30075202
Treatment of periorbital infantile haemangiomas: a systematic literature review on propranolol or steroids.
Xu S, Jia R, Ge S, Lin M, Fan X
J Paediatr Child Health 2014 Apr;50(4):271-9. Epub 2013 Dec 23 doi: 10.1111/jpc.12464. PMID: 24754793
Low-dose cyclophosphamide and interferon alfa 2a for the treatment of capillary hemangioma of the orbit.
Wilson MW, Hoehn ME, Haik BG, Rieman M, Reiss U
Ophthalmology 2007 May;114(5):1007-11. Epub 2007 Mar 6 doi: 10.1016/j.ophtha.2006.11.031. PMID: 17337066
Treatment of periocular capillary hemangiomas.
Wasserman BN, Medow NB, Homa-Palladino M, Hoehn ME
J AAPOS 2004 Apr;8(2):175-81. doi: 10.1016/j.jaapos.2003.12.002. PMID: 15088053

Prognosis

Retrobulbar Hemangioblastomas in von Hippel-Lindau Disease: Clinical Course and Management.
Alvarez R, Mastorakos P, Hogan E, Scott G, Lonser RR, Wiley HE, Chew EY, Chittiboina P
Neurosurgery 2021 Apr 15;88(5):1012-1020. doi: 10.1093/neuros/nyaa565. PMID: 33442737Free PMC Article
Proptosis due to intraorbital space-occupying lesions in children.
Zahavi A, Luckman J, Ben-David GS, Toledano H, Michowiz S, Vardizer Y, Goldenberg-Cohen N
Graefes Arch Clin Exp Ophthalmol 2020 Nov;258(11):2541-2550. Epub 2020 Jul 16 doi: 10.1007/s00417-020-04840-3. PMID: 32676791
Optic Nerve Hemangioblastoma: Review.
Darbari S, Meena RK, Sawarkar D, Doddamani RS
World Neurosurg 2019 Aug;128:211-215. Epub 2019 May 1 doi: 10.1016/j.wneu.2019.04.224. PMID: 31054346
Peripheral hemangioblastoma: clinicopathologic characterization in a series of 22 cases.
Doyle LA, Fletcher CD
Am J Surg Pathol 2014 Jan;38(1):119-27. doi: 10.1097/PAS.0b013e3182a266c1. PMID: 24145646
Ophthalmological manifestations in VHL and NF 1: pathological and diagnostic implications.
Kreusel KM
Fam Cancer 2005;4(1):43-7. doi: 10.1007/s10689-004-1327-0. PMID: 15883709

Clinical prediction guides

Ophthalmic involvement in PHACES syndrome: prevalence, spectrum of anomalies, and outcomes.
Soliman SE, Wan MJ, Pennal A, Pope E, Mireskandari K
J AAPOS 2022 Jun;26(3):129.e1-129.e7. Epub 2022 May 10 doi: 10.1016/j.jaapos.2022.01.011. PMID: 35550864
Proptosis due to intraorbital space-occupying lesions in children.
Zahavi A, Luckman J, Ben-David GS, Toledano H, Michowiz S, Vardizer Y, Goldenberg-Cohen N
Graefes Arch Clin Exp Ophthalmol 2020 Nov;258(11):2541-2550. Epub 2020 Jul 16 doi: 10.1007/s00417-020-04840-3. PMID: 32676791
Clinical and Radiological Evaluation of Periocular Infantile Hemangioma Treated With Oral Propranolol: A Case Series.
Ginguerra MA, Saito O, Fernandes JBVD, Castro DS, Matayoshi S
Am J Ophthalmol 2018 Jan;185:48-55. Epub 2017 Nov 15 doi: 10.1016/j.ajo.2017.10.021. PMID: 29103963
Angiomyofibroma of the orbit: a hybrid of vascular leiomyoma and cavernous hemangioma.
Jakobiec FA, Zakka FR, Papakostas TD, Fay A
Ophthalmic Plast Reconstr Surg 2012 Nov-Dec;28(6):438-45. doi: 10.1097/IOP.0b013e318269693e. PMID: 23138203
Intramuscular hemangiomas of extraocular muscles.
Kiratli H, Bilgiç S, Cağlar M, Söylemezoğlu F
Ophthalmology 2003 Mar;110(3):564-8. doi: 10.1016/S0161-6420(02)01887-0. PMID: 12623822

Recent systematic reviews

Treatment of periorbital infantile haemangiomas: a systematic literature review on propranolol or steroids.
Xu S, Jia R, Ge S, Lin M, Fan X
J Paediatr Child Health 2014 Apr;50(4):271-9. Epub 2013 Dec 23 doi: 10.1111/jpc.12464. PMID: 24754793
The use of propranolol in the management of periocular capillary haemangioma--a systematic review.
Spiteri Cornish K, Reddy AR
Eye (Lond) 2011 Oct;25(10):1277-83. Epub 2011 Jul 8 doi: 10.1038/eye.2011.164. PMID: 21738233Free PMC Article

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