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Metastatic malignant neoplasm in the colon

MedGen UID:
83432
•Concept ID:
C0346974
•
Neoplastic Process
Synonyms: Metastatic Malignant Neoplasm in the Colon; metastatic malignant neoplasm in the colon; Metastatic malignant neoplasm of colon; Metastatic malignant neoplasm to colon; Metastatic Malignant Neoplasm to the Colon; metastatic malignant neoplasm to the colon; Metastatic Neoplasm to the Colon; metastatic neoplasm to the colon; Metastatic Tumor to the Colon; metastatic tumor to the colon; metastatic tumour to the colon; Secondary malignant neoplasm of colon
SNOMED CT: Secondary malignant neoplasm of colon (94260004); Metastatic malignant neoplasm to colon (94260004); Metastatic malignant neoplasm of colon (94260004)
 
Monarch Initiative: MONDO:0041447

Definition

The spread of a malignant neoplasm to the colon. This may be from a primary large intestine malignant neoplasm, or from a malignant neoplasm at a distant site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic malignant neoplasm in the colon

Professional guidelines

PubMed

Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Cervantes A, Adam R, Roselló S, Arnold D, Normanno N, Taïeb J, Seligmann J, De Baere T, Osterlund P, Yoshino T, Martinelli E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Jan;34(1):10-32. Epub 2022 Oct 25 doi: 10.1016/j.annonc.2022.10.003. PMID: 36307056
Treatment of Metastatic Colorectal Cancer: ASCO Guideline.
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Farkas L, Garrido-Laguna I, Grem JL, Gunn A, Hecht JR, Hoffe S, Hubbard J, Hunt S, Johung KL, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen K, Saltz L, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2021 Mar 2;19(3):329-359. doi: 10.6004/jnccn.2021.0012. PMID: 33724754

Recent clinical studies

Etiology

Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Randomized Trial.
Repici A, Badalamenti M, Maselli R, Correale L, Radaelli F, Rondonotti E, Ferrara E, Spadaccini M, Alkandari A, Fugazza A, Anderloni A, Galtieri PA, Pellegatta G, Carrara S, Di Leo M, Craviotto V, Lamonaca L, Lorenzetti R, Andrealli A, Antonelli G, Wallace M, Sharma P, Rosch T, Hassan C
Gastroenterology 2020 Aug;159(2):512-520.e7. Epub 2020 May 1 doi: 10.1053/j.gastro.2020.04.062. PMID: 32371116
Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis.
Kim EK, Song MJ, Jung Y, Lee WS, Jang HH
Cancer Genomics Proteomics 2019 Nov-Dec;16(6):583-592. doi: 10.21873/cgp.20161. PMID: 31659112Free PMC Article
Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer.
Zeng H, Umar S, Rust B, Lazarova D, Bordonaro M
Int J Mol Sci 2019 Mar 11;20(5) doi: 10.3390/ijms20051214. PMID: 30862015Free PMC Article
Treatment sequence of synchronously (liver) metastasized colon cancer.
Gruenberger T, Beets G, Van Laethem JL, Rougier P, Cervantes A, Douillard JY, Figueras J, Gruenberger B, Haller DG, Labianca R, Maleux G, Roth A, Ducreux M, Schmiegel W, Seufferlein T, Van Cutsem E
Dig Liver Dis 2016 Oct;48(10):1119-23. Epub 2016 Jun 17 doi: 10.1016/j.dld.2016.06.009. PMID: 27375207
Scan? Cure? Sure!
Goldberg RM, Ryan DP
Oncologist 2011;16(2):254-6. doi: 10.1634/theoncologist.2011-0014. PMID: 21349952Free PMC Article

Diagnosis

Metastatic squamous cell carcinoma of the colon: a conundrum in colorectal malignancies.
Singhal S, Singh RB, Potdar R
BMJ Case Rep 2021 Apr 15;14(4) doi: 10.1136/bcr-2020-240573. PMID: 33858889Free PMC Article
Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Randomized Trial.
Repici A, Badalamenti M, Maselli R, Correale L, Radaelli F, Rondonotti E, Ferrara E, Spadaccini M, Alkandari A, Fugazza A, Anderloni A, Galtieri PA, Pellegatta G, Carrara S, Di Leo M, Craviotto V, Lamonaca L, Lorenzetti R, Andrealli A, Antonelli G, Wallace M, Sharma P, Rosch T, Hassan C
Gastroenterology 2020 Aug;159(2):512-520.e7. Epub 2020 May 1 doi: 10.1053/j.gastro.2020.04.062. PMID: 32371116
Validation of diagnosis codes to identify side of colon in an electronic health record registry.
Luhn P, Kuk D, Carrigan G, Nussbaum N, Sorg R, Rohrer R, Tucker MG, Arnieri B, Taylor MD, Meropol NJ
BMC Med Res Methodol 2019 Aug 19;19(1):177. doi: 10.1186/s12874-019-0824-7. PMID: 31426736Free PMC Article
Treatment sequence of synchronously (liver) metastasized colon cancer.
Gruenberger T, Beets G, Van Laethem JL, Rougier P, Cervantes A, Douillard JY, Figueras J, Gruenberger B, Haller DG, Labianca R, Maleux G, Roth A, Ducreux M, Schmiegel W, Seufferlein T, Van Cutsem E
Dig Liver Dis 2016 Oct;48(10):1119-23. Epub 2016 Jun 17 doi: 10.1016/j.dld.2016.06.009. PMID: 27375207
Scan? Cure? Sure!
Goldberg RM, Ryan DP
Oncologist 2011;16(2):254-6. doi: 10.1634/theoncologist.2011-0014. PMID: 21349952Free PMC Article

Therapy

FRESCO-2: a global Phase III study investigating the efficacy and safety of fruquintinib in metastatic colorectal cancer.
Dasari A, Sobrero A, Yao J, Yoshino T, Schelman W, Yang Z, Chien C, Kania M, Tabernero J, Eng C
Future Oncol 2021 Aug;17(24):3151-3162. Epub 2021 May 17 doi: 10.2217/fon-2021-0202. PMID: 33993740
Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis.
Kim EK, Song MJ, Jung Y, Lee WS, Jang HH
Cancer Genomics Proteomics 2019 Nov-Dec;16(6):583-592. doi: 10.21873/cgp.20161. PMID: 31659112Free PMC Article
Scan? Cure? Sure!
Goldberg RM, Ryan DP
Oncologist 2011;16(2):254-6. doi: 10.1634/theoncologist.2011-0014. PMID: 21349952Free PMC Article
Modifiable risk factors for colon cancer.
Giovannucci E
Gastroenterol Clin North Am 2002 Dec;31(4):925-43. doi: 10.1016/s0889-8553(02)00057-2. PMID: 12489270
Current status of radioimmunodetection.
Larson SM, Divgi C, Scott A, Daghighian F, Macapinlac H, Welt S
Nucl Med Biol 1994 Jul;21(5):721-9. doi: 10.1016/0969-8051(94)90043-4. PMID: 9241648

Prognosis

Synovial sarcoma of the transverse colon metastatic to the chest wall after 3 years of follow-up.
Hidalgo Mora VM, Baquero Zamarra DR, Cendales MA, Figueroa Avendaño CE
BMJ Case Rep 2021 Jul 2;14(7) doi: 10.1136/bcr-2020-239088. PMID: 34215633Free PMC Article
Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer.
Ma WR, Xu P, Liu ZJ, Zhou J, Gu LK, Zhang J, Deng DJ
World J Gastroenterol 2020 Jan 14;26(2):184-198. doi: 10.3748/wjg.v26.i2.184. PMID: 31988584Free PMC Article
Prevalence of RAS and BRAF mutations in metastatic colorectal cancer patients by tumor sidedness: A systematic review and meta-analysis.
Bylsma LC, Gillezeau C, Garawin TA, Kelsh MA, Fryzek JP, Sangaré L, Lowe KA
Cancer Med 2020 Feb;9(3):1044-1057. Epub 2019 Dec 19 doi: 10.1002/cam4.2747. PMID: 31856410Free PMC Article
Predictive Nomograms for Synchronous Liver and Lung Metastasis in Colon Cancer.
Gaitanidis A, Machairas N, Alevizakos M, Tsalikidis C, Tsaroucha A, Pitiakoudis M
J Gastrointest Cancer 2020 Sep;51(3):925-931. doi: 10.1007/s12029-019-00325-7. PMID: 31713813
Scan? Cure? Sure!
Goldberg RM, Ryan DP
Oncologist 2011;16(2):254-6. doi: 10.1634/theoncologist.2011-0014. PMID: 21349952Free PMC Article

Clinical prediction guides

Surgical management of splenic flexure colon cancer: a retrospective propensity-matched study comparing open and minimally invasive approaches using the national cancer database.
Horsey ML, Sparks AD, Lai D, Herur-Raman A, Ng M, Obias V
Int J Colorectal Dis 2021 Dec;36(12):2739-2747. Epub 2021 Sep 18 doi: 10.1007/s00384-021-04029-y. PMID: 34536115
Prevalence of RAS and BRAF mutations in metastatic colorectal cancer patients by tumor sidedness: A systematic review and meta-analysis.
Bylsma LC, Gillezeau C, Garawin TA, Kelsh MA, Fryzek JP, Sangaré L, Lowe KA
Cancer Med 2020 Feb;9(3):1044-1057. Epub 2019 Dec 19 doi: 10.1002/cam4.2747. PMID: 31856410Free PMC Article
Does enhanced recovery improve the survival rates of patients 3 years after undergoing surgery to remove a tumor in the colon?
Viannay P, Hamy A, Jaouen R, Caroli-Bosc FX, Luel C, Vasseur S, Levaillant M, Hamel JF, Venara A
Int J Colorectal Dis 2019 Mar;34(3):441-449. Epub 2018 Dec 7 doi: 10.1007/s00384-018-3205-5. PMID: 30536115
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.
Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO
Mol Cell Proteomics 2012 Apr;11(4):M111.014647. Epub 2011 Dec 9 doi: 10.1074/mcp.M111.014647. PMID: 22159717Free PMC Article

Recent systematic reviews

Treatment of Metastatic Colorectal Cancer: ASCO Guideline.
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
Short-term outcomes in robot-assisted compared to laparoscopic colon cancer resections: a systematic review and meta-analysis.
Cuk P, Kjær MD, Mogensen CB, Nielsen MF, Pedersen AK, Ellebæk MB
Surg Endosc 2022 Jan;36(1):32-46. Epub 2021 Nov 1 doi: 10.1007/s00464-021-08782-7. PMID: 34724576Free PMC Article
Risk Factors for Early-Onset Colorectal Cancer: A Systematic Review and Meta-analysis.
O'Sullivan DE, Sutherland RL, Town S, Chow K, Fan J, Forbes N, Heitman SJ, Hilsden RJ, Brenner DR
Clin Gastroenterol Hepatol 2022 Jun;20(6):1229-1240.e5. Epub 2021 Jan 29 doi: 10.1016/j.cgh.2021.01.037. PMID: 33524598
Performance of artificial intelligence in colonoscopy for adenoma and polyp detection: a systematic review and meta-analysis.
Hassan C, Spadaccini M, Iannone A, Maselli R, Jovani M, Chandrasekar VT, Antonelli G, Yu H, Areia M, Dinis-Ribeiro M, Bhandari P, Sharma P, Rex DK, Rösch T, Wallace M, Repici A
Gastrointest Endosc 2021 Jan;93(1):77-85.e6. Epub 2020 Jun 26 doi: 10.1016/j.gie.2020.06.059. PMID: 32598963
Hypomagnesemia and clinical benefits of anti-EGFR monoclonal antibodies in wild-type KRAS metastatic colorectal cancer: a systematic review and meta-analysis.
Hsieh MC, Wu CF, Chen CW, Shi CS, Huang WS, Kuan FC
Sci Rep 2018 Feb 1;8(1):2047. doi: 10.1038/s41598-018-19835-8. PMID: 29391418Free PMC Article

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